Simultaneous 18F-FDG PET/MR metabolic and structural changes in visual snow syndrome and diagnostic use
ConclusionPatients with VSS have highly significant structural and metabolic abnormalities in the visual and limbic system. VOI-based discriminant analysis of18F-FDG PET allows reliable individual classification versus controls, whereas visual analysis of experienced observers was highly variable. Further investigation in larger series, also in comparison to VSS mimicking disorders such as migraine, is warranted.Trail registration: Retrospectively registered at clinicaltrials.gov under NCT05569733 on Oct 5, 2022. (Source: EJNMMI Research)
Source: EJNMMI Research - December 30, 2022 Category: Radiology Source Type: research
Deep learning and radiomics framework for PSMA-RADS classification of prostate cancer on PSMA PET
ConclusionThe framework provided lesion-level and patient-level PSMA-RADS and PCa classification on PSMA PET images. The framework was interpretable and provided confidence and probability scores that may assist physicians in making more informed clinical decisions. (Source: EJNMMI Research)
Source: EJNMMI Research - December 29, 2022 Category: Radiology Source Type: research
Relationships between uptake of [68Ga]Ga-DOTA-TATE and absorbed dose in [177Lu]Lu-DOTA-TATE therapy
ConclusionsOn a group level, a high uptake of [68Ga]Ga-DOTA-TATE is associated with high absorbed doses at177Lu-DOTA-TATE therapy, but the relationship has a limited potential with respect to individual absorbed dose planning. Using SUV or SUV normalized to reference tissues do not improve correlations compared with using activity concentration per injected activity. (Source: EJNMMI Research)
Source: EJNMMI Research - December 19, 2022 Category: Radiology Source Type: research
Somatostatin receptor saturation after administration of high peptide amounts of [177Lu]Lu-HA-DOTATATE: when enough is enough
ConclusionsThese findings confirmed a peptide amount-dependent organ and tumor accumulation for [177Lu]Lu-HA-DOTATATE, with receptor saturation in spleen for high and standard peptide amounts, while tumor and kidney receptor saturation occur only with high administered peptide amounts. A high peptide amount (~ 350 µg) is not recommended for standard-dose PRRT and standard amounts (~ 200 µg) seem more suitable to achieve optimal tumor accumulation with limited organ uptake. (Source: EJNMMI Research)
Source: EJNMMI Research - December 14, 2022 Category: Radiology Source Type: research
Phantom and clinical evaluation of the effect of a new Bayesian penalized likelihood reconstruction algorithm (HYPER Iterative) on 68Ga-DOTA-NOC PET/CT image quality
ConclusionsThe HYPER Iterative algorithm with a penalization factor of 0.2 resulted in higher lesion contrast and lower image noise than OSEM for68Ga-DOTA-NOC PET/CT, allowing the same image quality to be achieved with less injected radioactivity and a shorter acquisition time. (Source: EJNMMI Research)
Source: EJNMMI Research - December 12, 2022 Category: Radiology Source Type: research
Validation of dynamic [18F]FE-PE2I PET for estimation of relative regional cerebral blood flow: a comparison with [15O]H2O PET
ConclusionsOur results suggest that FE-PE2I may be used as a proxy for cerebral perfusion, thus potentially serving as a radiotracer for assessment of both DAT availability and rCBFR in one single dynamic scan. This could be valuable in the differential diagnosis of parkinsonian syndromes.Trial registration: EUDRA-CT 2015-003045-26. Registered 23 October 2015https://www.clinicaltrialsregister.eu/ctr-search/search?query=2015-003045-26 (Source: EJNMMI Research)
Source: EJNMMI Research - November 17, 2022 Category: Radiology Source Type: research
Drug characteristics derived from kinetic modeling: combined 11C-UCB-J human PET imaging with levetiracetam and brivaracetam occupancy of SV2A
ConclusionsUnder appropriate conditions, this advanced nonlinear model can directly estimate entry rates of drugs into tissue by analysis of PET TACs. Using a conservative statistical cutoff, BRV enters the brain at least sevenfold faster than LEV. (Source: EJNMMI Research)
Source: EJNMMI Research - November 8, 2022 Category: Radiology Source Type: research
Diagnostic models for fever of unknown origin based on 18F-FDG PET/CT: a prospective study in China
Conclusions18F-FDG PET/CT has a certain level of sensitivity and accuracy in diagnosing FUO, which can be further improved by combining it with clinical parameters. Diagnostic models based on PET/CT show excellent performance and can be used as reliable tools to discriminate the cause of FUO.Trial registration This study (a two-step method apparently improved the physicians ’ level of diagnosis decision-making for adult patients with FUO) was registered on the websitehttp://www.clinical-trials.gov on January 14, 2014, with registration number NCT02035670. (Source: EJNMMI Research)
Source: EJNMMI Research - October 28, 2022 Category: Radiology Source Type: research
Radioimmunotherapy study of 131I-labeled Atezolizumab in preclinical models of colorectal cancer
Conclusion131I-Atezolizumab can be used as a CLI agent for screening PD-L1 expression levels. It may be used as a radioimmunotherapy drug target for PD- L1 overexpressing tumors. (Source: EJNMMI Research)
Source: EJNMMI Research - October 28, 2022 Category: Radiology Source Type: research
Comparison of [18F]-FDOPA PET and [123I]-FP-CIT SPECT acquired in clinical practice for assessing nigrostriatal degeneration in patients with a clinically uncertain parkinsonian syndrome
ConclusionsIn this case series of CUPS patients, DAT-SPECT was more often rated as abnormal than FDOPA-PET. The striatal loss of FDOPA uptake can be less pronounced than that of DAT binding in CUPS patients in early disease stages. Consequently, the interpretation of FDOPA-PET scans in CUPS can sometimes be challenging in routine practice. (Source: EJNMMI Research)
Source: EJNMMI Research - October 22, 2022 Category: Radiology Source Type: research
Correlation between molar activity, injection mass and uptake of the PARP targeting radiotracer [18F]olaparib in mouse models of glioma
ConclusionOur findings show that the injected mass of [TotalF]olaparib has significant effects on tumour uptake. Moderate injected masses of PARP inhibitor-derived radiopharmaceuticals may lead to improved relative tumour uptake and tumour-to-background ratio for cancer diagnosis and radionuclide therapy. (Source: EJNMMI Research)
Source: EJNMMI Research - October 9, 2022 Category: Radiology Source Type: research
Evaluation of [68 Ga]Ga-PSMA-I & amp;T PET/CT with additional late scans of the pelvis in prostate-specific antigen recurrence using the PROMISE criteria
ConclusionsAdditional late scans of the pelvis in [68 Ga]Ga-PSMA-I&T PET/CT detected more lesions and an increasing contrast compared to early imaging. This influenced the final miTNM-staging substantially. (Source: EJNMMI Research)
Source: EJNMMI Research - October 9, 2022 Category: Radiology Source Type: research
Comparison of PSMA-TO-1 and PSMA-617 labeled with gallium-68, lutetium-177 and actinium-225
ConclusionsPSMA-TO-1 tumor uptake tended to be greater than that of PSMA-617 in both preclinical and clinical settings. Mice treated with225Ac-PSMA-TO-1 conferred a significant survival benefit compared to225Ac-PSMA-617 despite the accompanying increased kidney uptake. In humans, PSMA-TO-1 dosimetry estimates suggest increased tumor absorbed doses; however, the kidneys, salivary glands and bone marrow are also exposed to higher radiation doses. Thus, additional preclinical studies are needed before further clinical use. (Source: EJNMMI Research)
Source: EJNMMI Research - October 1, 2022 Category: Radiology Source Type: research
Development and validation of 68Ga-PSMA-11 PET/CT-based radiomics model to detect primary prostate cancer
ConclusionRadiomics analysis based on68Ga-PSMA-11 PET may non-invasively predict intraprostatic lesions in patients with PCa. (Source: EJNMMI Research)
Source: EJNMMI Research - September 30, 2022 Category: Radiology Source Type: research
First-in-human use of 11C-CPPC with positron emission tomography for imaging the macrophage colony-stimulating factor 1 receptor
ConclusionOur results extend support for the use of11C-CPPC with PET to study microglia in the human brain. (Source: EJNMMI Research)
Source: EJNMMI Research - September 30, 2022 Category: Radiology Source Type: research
