Whole-body biodistribution and radiation dosimetry of [18F]PR04.MZ: a new PET radiotracer for clinical management of patients with movement disorders
Conclusion[18F]PR04.MZ has a favourable dosimetry profile, comparable to those of other18F-labelled PET tracers, and is suitable for larger clinical applications.Trial registration CEC SSM Oriente, Santiago, Chile, permit 20140520. (Source: EJNMMI Research)
Source: EJNMMI Research - January 10, 2022 Category: Radiology Source Type: research
CXCR4 peptide-based fluorescence endoscopy in a mouse model of Barrett ’s esophagus
ConclusionsThis preliminary preclinical study shows that CXCR4-targeted fluorescence endoscopy using MK007 can detect dysplastic lesions in a mouse model of Barrett ’s esophagus. Further investigations are needed to assess its use in the clinical setting. (Source: EJNMMI Research)
Source: EJNMMI Research - January 10, 2022 Category: Radiology Source Type: research
Investigation of atovaquone-induced spatial changes in tumour hypoxia assessed by hypoxia PET/CT in non-small cell lung cancer patients
ConclusionsThis study provides insights into the action of atovaquone in tumour subregions that help to better understand its role as a novel tumour radiosensitiser.Trial registration: ClinicalTrials.gov, NCT0262808. Registered 11th December 2015,https://clinicaltrials.gov/ct2/show/NCT02628080 (Source: EJNMMI Research)
Source: EJNMMI Research - December 29, 2021 Category: Radiology Source Type: research
Risk of metastatic disease using [18F]PSMA-1007 PET/CT for primary prostate cancer staging
ConclusionMetastatic disease according to [18F]PSMA-1007 PET/CT was associated with ISUP grade and PSA level. This is the largest study using [18F]PSMA-1007 PET/CT to confirm a positive correlation of PSA level, ISUP grade and stage with primary prostate tumour SUVmax. (Source: EJNMMI Research)
Source: EJNMMI Research - December 20, 2021 Category: Radiology Source Type: research
The usefulness of repeated CMR and FDG PET/CT in the diagnosis of patients with initial possible cardiac sarcoidosis
ConclusionRepeated CMR and FDG PET/CT may be useful in establishing or rejecting CS diagnosis,
when initial diagnosis is uncertain. However, clinical relevance has to be further determined. (Source: EJNMMI Research)
Source: EJNMMI Research - December 20, 2021 Category: Radiology Source Type: research
Dynamic planar scintigraphy for the rapid kinetic measurement of myocardial 123I-MIBG turnover can identify Lewy body disease
Conclusion123I-MIBG turnover can be quantified in 30 min using a three-parameter model based on123I-MIBG TACs. The discriminatory performance of the new model-based indices might help explain the neurotoxicity or neurodegeneration that occurs in LBD patients. (Source: EJNMMI Research)
Source: EJNMMI Research - December 14, 2021 Category: Radiology Source Type: research
First experiences with 177Lu-PSMA-617 therapy for recurrent or metastatic salivary gland cancer
ConclusionsPalliative177Lu-PSMA therapy for salivary gland cancer may lead to rapid relief of tumour-associated discomfort and may even induce disease stabilization. It is safe, relatively well tolerated and can be considered when regular treatment options fail. (Source: EJNMMI Research)
Source: EJNMMI Research - December 14, 2021 Category: Radiology Source Type: research
Magnetic nanoparticles in theranostics of malignant melanoma
AbstractMalignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure and thus the survival rate decrease dramatically after metastatic spread. Conventional treatment options for advanced disease include surgical resection of metastases, chemotherapy, radiation, targeted therapy and immunotherapy. Today, targeted kinase inhibitors and immune checkpoint blockers have for the most part replaced less effective chemotherapies. Magnetic nanoparticles as novel agents for theranostic pu...
Source: EJNMMI Research - December 14, 2021 Category: Radiology Source Type: research
Detection of the sentinel lymph node with hybrid tracer (ICG-[99mTc]Tc-albumin nanocolloid) in intermediate- and high-risk endometrial cancer: a feasibility study
ConclusionTUMIR injection of a hybrid tracer in patients with intermediate- and high-risk EC combines the benefits of the radiotracer and the fluorescence methods with a single tracer. The method increases the paraaortic detection rate and allows a potential increase in SLN detection. Notwithstanding, based on our findings, the radioactive component of the hybrid tracer cannot be obviated. (Source: EJNMMI Research)
Source: EJNMMI Research - December 14, 2021 Category: Radiology Source Type: research
L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas
ConclusionAlthough LAT1 is reported to mediate the uptake of18F-FET into tumour cells, the levels of LAT1 expression do not correlate with the levels of18F-FET uptake inIDH-mutant astrocytomas. In particular, the lack of tracer uptake in18F-FET-negative gliomas cannot be explained by a reduced LAT1 expression. A higher LAT1 expression inIDH-mutant astrocytomas seems to be associated with a short PFS. Further studies regarding mechanisms influencing the uptake of18F-FET are necessary. (Source: EJNMMI Research)
Source: EJNMMI Research - December 14, 2021 Category: Radiology Source Type: research
Amyloid PET quantification using low-dose CT-guided anatomic standardization
ConclusionsLow-dose CT of PET/CT can substitute for MRI in the anatomic standardization used to calculate the CL scale from amyloid PET, although a slight underestimation occurs. (Source: EJNMMI Research)
Source: EJNMMI Research - December 14, 2021 Category: Radiology Source Type: research
Imaging pheochromocytoma in small animals: preclinical models to improve diagnosis and treatment
AbstractPheochromocytomas (PCCs) and paragangliomas (PGLs), together referred to as PPGLs, are rare chromaffin cell-derived tumors. They require timely diagnosis as this is the only way to achieve a cure through surgery and because of the potentially serious cardiovascular complications and sometimes life-threatening comorbidities that can occur if left untreated. The biochemical diagnosis of PPGLs has improved over the last decades, and the knowledge of the underlying genetics has dramatically increased. In addition to conventional anatomical imaging by CT and MRI for PPGL detection, new functional imaging modalities have...
Source: EJNMMI Research - December 11, 2021 Category: Radiology Source Type: research
Native glycan fragments detected by MALDI mass spectrometry imaging are independent prognostic factors in pancreatic ductal adenocarcinoma
ConclusionOur method allows in situ detection of naturally occurring glycans in FFPE samples of human PDAC tissue and highlights the differences among glycans found in stromal and cancer cell compartment offering a basis for further exploration on the role of specific glycans in cancer –stroma communication. (Source: EJNMMI Research)
Source: EJNMMI Research - December 1, 2021 Category: Radiology Source Type: research
[18F]FMCH PET/CT biomarkers and similarity analysis to refine the definition of oligometastatic prostate cancer
ConclusionsWe found a comparable heterogeneity between patients with up to five lesions and plurimetastic patients, while patients with up to three lesions were less heterogeneous than plurimetastatic patients, featuring different cells phenotypes in the two groups. Our results supported the use of a 3-lesion threshold to define oligometastatic PCa. (Source: EJNMMI Research)
Source: EJNMMI Research - November 27, 2021 Category: Radiology Source Type: research
Receptor depletion and recovery in small-intestinal neuroendocrine tumors and normal tissues after administration of a single intravenous dose of octreotide measured by 68Ga-DOTATOC PET/CT
ConclusionSSTR recycling is faster in small-intestinal NETs than in liver, spleen and pancreas. This opens the possibility to protect normal tissues during PRRT by administering a single dose of cold peptide hours before peptide receptor radionuclide therapy (PRRT), and most likely additionally improve the availability and uptake of the therapeutic preparation in the tumors. (Source: EJNMMI Research)
Source: EJNMMI Research - November 25, 2021 Category: Radiology Source Type: research
