Development of [89Zr]Zr-hCD103.Fab01A and [68Ga]Ga-hCD103.Fab01A for PET imaging to noninvasively assess cancer reactive T cell infiltration: Fab-based CD103 immunoPET

Conclusion[89Zr]Zr-hCD103.Fab01A demonstrated a relatively low background and high xenograft uptake in scans as early as 6  h post-injection and could be explored for repeat imaging during immunotherapy in clinical trials.18F or64Cu could be explored as alternative to68Ga in optimizing half-life and radiation burden of the tracer.
Source: EJNMMI Research - Category: Radiology Source Type: research