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Condition: Alzheimer's

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Total 2642 results found since Jan 2013.

Research on Diagnostic Markers for Post-Stroke Cognitive Impairment
CONCLUSION: Aβ42 and Hb in patients with PSCI were significantly lower than in the AD and PSCN groups, and were risk factors for PSCI. When the two are combined, the differential diagnosis performance may be improved.PMID:36795525
Source: Alternative Therapies in Health and Medicine - February 16, 2023 Category: Complementary Medicine Authors: Min Xu Lanqing Yang Zhe Zhong Min Ye Source Type: research

Hypoxia inducible factor prolyl hydroxylases as targets for neuroprotection by "antioxidant" metal chelators: From ferroptosis to stroke.
Abstract Neurologic conditions including stroke, Alzheimer's disease, Parkinson's disease and Huntington's disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for these conditions have historically had poor success in translating from bench to bedside. Hypoxia Inducible Factor-1alpha (HIF-1α) mediates a broad, evolutionarily conserved, endogenous adaptive program to hypoxia, and manipulation of components of the HIF pathway are neuroprotective in a number of human neurological diseases and experimental models. In this review, we discuss mole...
Source: Free Radical Biology and Medicine - January 31, 2013 Category: Biology Authors: Speer RE, Karuppagounder SS, Basso M, Sleiman S, Kumar A, Brand D, Smirnova N, Gazaryan I, Khim SJ, Ratan RR Tags: Free Radic Biol Med Source Type: research

Role of HIF-1α-activated Epac1 on HSC-mediated neuroplasticity in stroke model.
We report here that hypoxia upregulated Epac1 through HIF-1α induction in the CD34-immunosorted human umbilical cord blood hematopoietic stem cells (hUCB(34)). Importantly, implantation of hUCB(34) subjected to hypoxia-preconditioning (HP-hUCB(34)) improved stroke outcome, more than did implantation of untreated hUCB(34), in rodents subjected to cerebral ischemia, and this required Epac1-to-matrix metalloproteases (MMPs) signaling. This improved therapeutic efficacy correlated with better engraftment and differentiation of these cells in the ischemic host brain. In addition, more than did implantation of untreated HP-hUCB...
Source: Neurobiology of Disease - May 20, 2013 Category: Neurology Authors: Lin CH, Lee HT, Lee SD, Lee W, Cho CW, Lin SZ, Wang HJ, Okano H, Su CY, Yu YL, Hsu CY, Shyu WC Tags: Neurobiol Dis Source Type: research