Use of natural language processing in electronic medical records to identify pregnant women with suicidal behavior: towards a solution to the complex classification problem
AbstractWe developed algorithms to identify pregnant women with suicidal behavior using information extracted from clinical notes by natural language processing (NLP) in electronic medical records. Using both codified data and NLP applied to unstructured clinical notes, we first screened pregnant women in Partners HealthCare for suicidal behavior. Psychiatrists manually reviewed clinical charts to identify relevant features for suicidal behavior and to obtain gold-standard labels. Using the adaptive elastic net, we developed algorithms to classify suicidal behavior. We then validated algorithms in an independent validation...
Source: European Journal of Epidemiology - December 10, 2018 Category: Epidemiology Source Type: research

Contribution of the OC Sensor ® immunoassay in comparison to the Hemoccult II ® guaiac-test in organized colorectal cancer screening
AbstractColorectal cancer (CRC) is a major cause of cancer-related death of worldwide with high incidence and mortality rate, accessible to a screening program in France, first with guaiac- based fecal occult blood test (g-FOBT) then with fecal immunochemical tests (FIT), since 2015, because of better accuracy. The aim of our study was to compare the characteristics of screen-detected lesions in two successive CRC screening campaigns, using two different tests (Hemoccult II® and OC Sensor®) in the department of Maine-et-Loire, and to precise the performance of these tests [participation rate, detection rates (DR), ...
Source: European Journal of Epidemiology - December 8, 2018 Category: Epidemiology Source Type: research

FranceCoag: a 22-year prospective follow-up of the national French cohort of patients with inherited bleeding disorders
AbstractFranceCoag is an ongoing open prospective multicentre cohort project aimed at improving epidemiological knowledge about inherited bleeding disorders in France. The main objective of this article was to evaluate the project ’s progress as of the 30th December 2016. Between 1994 and this date, of the 10,047 patients included in the study, 384 (3.8%) were reported by clinicians to have died and 159 (1.6%) to be lost to follow-up. Among the remaining 9504 patients still being followed up, 5748 (60.5%) had haemophilia A, 1300 (13.7%) haemophilia B, 1980 (20.8%) von Willebrand Disease while 476 (5.0%) had another c...
Source: European Journal of Epidemiology - December 5, 2018 Category: Epidemiology Source Type: research

A note of thanks and an invitation
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - December 5, 2018 Category: Epidemiology Source Type: research

Radiotherapy for childhood cancer and subsequent thyroid cancer risk: a systematic review
AbstractMost of the pooled analyses and reviews reported an association between radiotherapy for childhood cancer and an increased thyroid cancer risk. Up to now this article presents the first systematic literature review on this association combined with a critical assessment of the methodological quality of the included articles. PubMed and Web of Science databases were searched for relevant articles until May 2016. We included peer-reviewed cohort and case –control studies that investigated an association between radiotherapy for childhood cancer and the occurrence of subsequent thyroid cancer. A systematic overv...
Source: European Journal of Epidemiology - December 4, 2018 Category: Epidemiology Source Type: research

Potential causal associations of serum 25-hydroxyvitamin D with lipids: a Mendelian randomization approach of the HUNT study
AbstractObservational studies have shown consistent associations between higher circulating 25-hydroxyvitamin D [25(OH)D] levels and favorable serum lipids. We sought to investigate if such associations were causal. A Mendelian randomization (MR) study was conducted on a population-based cohort comprising 56,435 adults in Norway. A weighted 25(OH)D allele score was generated based on vitamin D-increasing alleles of rs2282679, rs12785878 and rs10741657. Linear regression analyses of serum lipid levels on the allele score were performed to assess the presence of causal associations of serum 25(OH)D with the lipids. To quanti...
Source: European Journal of Epidemiology - November 21, 2018 Category: Epidemiology Source Type: research

Space –time clustering of childhood cancers: a systematic review and pooled analysis
AbstractThe aetiology of childhood cancers remains largely unknown. Space –time clustering of cases might imply an aetiological role of infections. We aimed to review the evidence of space–time clustering of specific childhood cancers. We searched Medline and Embase for population-based studies that covered a pre-defined study area, included cases under 20 years of a ge and were published before July 2016. We extracted all space–time clustering tests and calculated the proportion of positive tests per diagnostic group. In a pooled analysis, we performed a Knox test of the number of pairs of cases clo...
Source: European Journal of Epidemiology - November 16, 2018 Category: Epidemiology Source Type: research

Methods to handle missing values and missing individuals
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - November 14, 2018 Category: Epidemiology Source Type: research

The Gothenburg H70 Birth cohort study 2014 –16: design, methods and study population
In this study, all men and women born 1944 on specific dates, and registered as residents in Gothenburg, were eligible for participation (n = 1839). A total of 1203 (response rate 72.2%; 559 men and 644 women; mean age 70.5 years) agreed to participate in the study. The study comprised s ampling of blood and cerebrospinal fluid, psychiatric, cognitive, and physical health examinations, examinations of genetics and family history, use of medications, social factors, functional ability and disability, physical fitness and activity, body composition, lung function, audiological and oph thalmological examina...
Source: European Journal of Epidemiology - November 13, 2018 Category: Epidemiology Source Type: research

Association between physical activity and sub-types of cardiovascular disease death causes in a general population cohort
We examined associations between physical activity and seven major CVD death causes. The sample comprised 65,093 adults (aged 58  ± 12 years, 45.4% men) followed up over mean [SD] 9.4 ± 4.5 years, recruited from The Health Survey for England and the Scottish Health Surveys. A CVD diagnosis was reported in 9.2% of the sample at baseline. Physical activity was self-reported. Outcomes were subtypes of CVD death; acut e myocardial infarction; chronic ischaemic heart disease; pulmonary heart disease; a composite of cardiac arrest, arrhythmias, and sudden cardiac death; heart f...
Source: European Journal of Epidemiology - November 11, 2018 Category: Epidemiology Source Type: research

Can environment or allergy explain international variation in prevalence of wheeze in childhood?
AbstractAsthma prevalence in children varies substantially around the world, but the contribution of known risk factors to this international variation is uncertain. The International Study of Asthma and Allergies in Childhood (ISAAC) Phase Two studied 8 –12 year old children in 30 centres worldwide with parent-completed symptom and risk factor questionnaires and aeroallergen skin prick testing. We used multilevel logistic regression modelling to investigate the effect of adjustment for individual and ecological risk factors on the between-centre variation in prevalence of recent wheeze. Adjustment for single in...
Source: European Journal of Epidemiology - November 11, 2018 Category: Epidemiology Source Type: research

Association of serum markers of oxidative stress with myocardial infarction and stroke: pooled results from four large European cohort studies
AbstractOxidative stress contributes to endothelial dysfunction and is involved in the pathogenesis of myocardial infarction (MI) and stroke. However, associations of biomarkers of oxidative stress with MI and stroke have not yet been addressed in large cohort studies. A nested case –control design was applied in four population-based cohort studies from Germany, Czech Republic, Poland and Lithuania. Derivatives of reactive oxygen metabolites (d-ROMs) levels, as a proxy for the reactive oxygen species burden, and total thiol levels (TTL), as a proxy for the reductive capacity , were measured in baseline serum samples...
Source: European Journal of Epidemiology - November 7, 2018 Category: Epidemiology Source Type: research

Seeing through a glass darkly and taking the next right steps
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - November 3, 2018 Category: Epidemiology Source Type: research

The Diesel Exhaust in Miners Study provides no evidence for an increase in risk for lung cancer in miners exposed to diesel engine emissions
AbstractThe Diesel Exhaust in Miners Study is unquestionably the most suitable data material to date to examine a possible link between diesel engine emissions and lung cancer risk. But the results do not appear to be consistent in themselves. The crucial methodological problem in this study, however, has yet to be discovered, to which the lack of any description of age related information (year of birth, year of hire, year of first exposure, year of death) for the cohort as well as for the cases might have contributed. This information is important to understand the flaws in the analysis. It turns out that the year of bir...
Source: European Journal of Epidemiology - October 31, 2018 Category: Epidemiology Source Type: research

The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description
AbstractAlthough the incidence of dementia increases exponentially with age, some individuals reach  more than 100 years with fully retained cognitive abilities. To identify the characteristics associated with the escape or delay of cognitive decline, we initiated the 100-plus Study (www.100plus.nl). The 100-plus Study is an on-going prospective cohort study of Dutch centenarians who self-reported to be cognitively healthy, their first-degree family members and their respective partners. We collect demographics, life history, medical history, genealogy, neuropsychological data and blood samples. Centenaria...
Source: European Journal of Epidemiology - October 25, 2018 Category: Epidemiology Source Type: research

Incidence of cardiovascular events in patients with stabilized coronary heart disease: the EUROASPIRE IV follow-up study
AbstractThe EUROASPIRE surveys (EUROpean Action on Secondary Prevention through Intervention to Reduce Events) demonstrated that most European coronary patients fail to achieve lifestyle, risk factor and therapeutic targets. Here we report on the 2-year incidence of hard cardiovascular (CV) endpoints in the EUROASPIRE IV cohort. EUROASPIRE IV (2012 –2013) was a large cross-sectional study undertaken at 78 centres from selected geographical areas in 24 European countries. Patients were interviewed and examined at least 6 months following hospitalization for a coronary event or procedure. Fatal and non-fatal CV ev...
Source: European Journal of Epidemiology - October 23, 2018 Category: Epidemiology Source Type: research

A comparison of different methods to handle missing data in the context of propensity score analysis
AbstractPropensity score analysis is a popular method to control for confounding in observational studies. A challenge in propensity methods is missing values in confounders. Several strategies for handling missing values exist, but guidance in choosing the best method is needed. In this simulation study, we compared four strategies of handling missing covariate values in propensity matching and propensity weighting. These methods include: complete case analysis, missing indicator method, multiple imputation and combining multiple imputation and missing indicator method. Concurrently, we aimed to provide guidance in choosi...
Source: European Journal of Epidemiology - October 19, 2018 Category: Epidemiology Source Type: research

Education modifies the relationship between height and cognitive function in a cross-sectional population-based study of older adults in Rural South Africa
AbstractWe aimed to estimate the relationship between height (a measure of early-life cumulative net nutrition) and later-life cognitive function among older rural South African adults, and whether education modified this relationship. Data were from baseline in-person interviews with 5059 adults  ≥ 40 years in the population-based “Health and Aging in Africa: A Longitudinal Study of an INDEPTH Community in South Africa” (HAALSI) study in Agincourt sub-district, South Africa, in 2015. Linear regression was used to estimate the relationship between height quintile and latent cognit ive func...
Source: European Journal of Epidemiology - October 10, 2018 Category: Epidemiology Source Type: research

Risk of various types of cataracts in a cohort of Mayak workers following chronic occupational exposure to ionizing radiation
This study is the first to report cataract type specific risks in a cohort of Russian Mayak Production Association workers following chronic occupational exposure to ionizing radiation. In this retrospective cohort study, 22,377 workers (females 25.4%) first employed in 1948 –1982 were followed up till the end of 2008. All cataract subtypes were significantly dependent on sex, attained age, diabetes mellitus, myopia and glaucoma. For each of posterior subcapsular (PSC), cortical and nuclear cataracts, the risk of cataract incidence significantly linearly increased wit h increasing radiation dose. Excess relative risk...
Source: European Journal of Epidemiology - October 10, 2018 Category: Epidemiology Source Type: research

Copenhagen Baby Heart Study: a population study of newborns with prenatal inclusion
AbstractCongenital heart diseases (CHDs) are reported in 0.8% of newborns. Numerous factors influence cardiovascular development and CHD prevalence, and possibly also development of cardiovascular disease later in life. However, known factors explain the probable etiology in only a fraction of patients. Past large-scale population-based studies have made invaluable contributions to the understanding of cardiac disease, but none recruited participants prenatally and focused on the neonatal period. The Copenhagen Baby Heart Study (CBHS) is a population-based study of the prevalence, spectrum, and prognosis of structural and ...
Source: European Journal of Epidemiology - October 10, 2018 Category: Epidemiology Source Type: research

Hearing loss, cognitive ability, and dementia in men age 19 –78 years
We examined whether hearing loss diagnosed in midlife was associated with an increased risk of dementia. A cohort comprising 942,567 Danish men enrolled in the mandatory conscription board examination was followed from conscription (age 19). Cognitive ability was measured at conscription, while hearing loss was ascertained either by physicians diagnosis at conscription or by the Danish National Patient Registry from 1977 to 2016 (ICD-8:388; 389; ICD-10:H90; H91). Differences in cognitive ability in relation to hearing loss at conscription were calculated usingt test, while the risk of dementia associated with hearing loss ...
Source: European Journal of Epidemiology - October 10, 2018 Category: Epidemiology Source Type: research

Massive citations to misleading methods and research tools: Matthew effect, quotation error and citation copying
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 6, 2018 Category: Epidemiology Source Type: research

Apgar score and risk of autism
This study suggests that low Apgar score is associated with higher risk of ASD, and in particular AD. We did not observe any major modifying effects of gestational age and sex, although there seems to be substantial confounding by gestational age and birth weight on the observed association. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 5, 2018 Category: Epidemiology Source Type: research

Linkage of the UK Clinical Practice Research Datalink with the national cancer registry
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 5, 2018 Category: Epidemiology Source Type: research

Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study
AbstractWe aimed to investigate physical activity (PA) and risk of different histological subtypes of lung cancer according to smoking status and body mass index using repeated measurements in a large cohort of women in Norway. The study sample for the multiple imputation analyses consisted of 86,499 and for the complete-case analysis 80,802 women. Repeated measurements of PA level, smoking habits, weight, and height were available for 54,691 women (63.2%), who were included in repeated measurement analyses combined with multiple imputation to address attrition. Cox proportional hazards regression models were used to calcu...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Shift work and risk of incident dementia: a study of two population-based cohorts
This study aimed to investigate the association between shift work and incident dementia in two population-based cohorts from the Swedish Twin Registry (STR). The STR-1973 sample included 13,283 participants born 1926 –1943 who received a mailed questionnaire in 1973 that asked about status (ever/never) and duration (years) of shift work employment. The Screening Across the Lifespan Twin (SALT) sample included 41,199 participants born 1900–1958 who participated in a telephone interview in 1998–2002 that ask ed about night work status and duration. Dementia diagnoses came from Swedish patient registers. Co...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

One- and two-stage surgical revision of peri-prosthetic joint infection of the hip: a pooled individual participant data analysis of 44 cohort studies
AbstractOne-stage and two-stage revision strategies are the two main options for treating established chronic peri-prosthetic joint infection (PJI) of the hip; however, there is uncertainty regarding which is the best treatment option. We aimed to compare the risk of re-infection between the two revision strategies using pooled individual participant data (IPD). Observational cohort studies with PJI of the hip treated exclusively by one- or two-stage revision and reporting re-infection outcomes were retrieved by searching MEDLINE, EMBASE, Web of Science, The Cochrane Library, and the WHO International Clinical Trials Regis...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Effect of retirement on cognitive function: the Whitehall II cohort study
In conclusion, these findings are consistent with the hypothesis that retirement accelerates the decline in verbal memory function. This study points to the benefits of cognitively stimulating activities associated with employment that could benefit older people’s memory. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Moderate neonatal hypoglycemia and adverse neurological development at 2 –6 years of age
AbstractTo determine whether moderate neonatal hypoglycemia in otherwise healthy infants is associated with adverse neurodevelopmental outcome in pre-school children. Population-based cohort study with prospectively collected register data from Sweden. All singletons born July 1st 2008 through December 31st 2012 (n  = 101,060) in the region were included. Infants with congenital malformations, infants treated in neonatal intensive care unit, infants with inborn errors of metabolism and infants to mothers with diabetes were excluded. Infants were followed-up until 2014, at 2–6 years of age. Exposure...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Advanced parental age as risk factor for childhood acute lymphoblastic leukemia: results from studies of the Childhood Leukemia International Consortium
AbstractAdvanced parental age has been associated with adverse health effects in the offspring including childhood (0 –14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case–control (CC) st udies (7919 cases and 12,942 controls recruited via interviews) and five nested case–control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based ...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Individually-matched etiologic studies: classical estimators made new again
AbstractWith greater access to regression-based methods for confounder control, the etiologic study with individual matching, analyzed by classical (calculator) methods, lost favor in recent decades. This design was costly, and the data sometimes mis-analyzed. Now, with Big Data, individual matching becomes an economical option. To many, however, conditional logistic regression, commonly used to estimate the incidence density ratio parameter, is somewhat of a black box whose output is not easily checked. An epidemiologist-statistician pair recently proposed a new estimator that is easily applied to data from individually-m...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Risk of lung cancer and physical activity by smoking status and body mass index, the Norwegian Women and Cancer Study
AbstractWe aimed to investigate physical activity (PA) and risk of different histological subtypes of lung cancer according to smoking status and body mass index using repeated measurements in a large cohort of women in Norway. The study sample for the multiple imputation analyses consisted of 86,499 and for the complete-case analysis 80,802 women. Repeated measurements of PA level, smoking habits, weight, and height were available for 54,691 women (63.2%), who were included in repeated measurement analyses combined with multiple imputation to address attrition. Cox proportional hazards regression models were used to calcu...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Evaluating Mediterranean diet and risk of chronic disease in cohort studies: an umbrella review of meta-analyses
AbstractSeveral meta-analyses have been published summarizing the associations of the Mediterranean diet (MedDiet) with chronic diseases. We evaluated the quality and credibility of evidence from these meta-analyses as well as characterized the different indices used to define MedDiet and re-calculated the associations with the different indices identified. We conducted an umbrella review of meta-analyses on cohort studies evaluating the association of the MedDiet with type 2 diabetes, cardiovascular disease, cancer and cognitive-related diseases. We used the AMSTAR (A MeaSurement Tool to Assess systematic Reviews) checkli...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

The combination of cardiorespiratory fitness and muscle strength, and mortality risk
AbstractLittle is known about the combined associations of cardiorespiratory fitness (CRF) and hand grip strength (GS) with mortality in general adult populations. The purpose of this study was to compare the relative risk of mortality for CRF, GS, and their combination. In UK Biobank, a prospective cohort of>  0.5 million adults aged 40–69 years, CRF was measured through submaximal bike tests; GS was measured using a hand-dynamometer. This analysis is based on data from 70,913 men and women (832 all-cause, 177 cardiovascular and 503 cancer deaths over 5.7-year follow-up) who provided valid CRF and G S...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates
AbstractMendelian randomization uses genetic variants to make causal inferences about a modifiable exposure. Subject to a genetic variant satisfying the instrumental variable assumptions, an association between the variant and outcome implies a causal effect of the exposure on the outcome. Complications arise with a binary exposure that is a dichotomization of a continuous risk factor (for example, hypertension is a dichotomization of blood pressure). This can lead to violation of the exclusion restriction assumption: the genetic variant can influence the outcome via the continuous risk factor even if the binary exposure d...
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

The value of pregnancy complication history for 10-year cardiovascular disease risk prediction in middle-aged women
AbstractWomen with a history of hypertensive disorders of pregnancy (HDP; preeclampsia and gestational hypertension) or delivering low birth weight offspring (LBW;
Source: European Journal of Epidemiology - October 1, 2018 Category: Epidemiology Source Type: research

Case study in major quotation errors: a critical commentary on the Newcastle –Ottawa scale
We examined the citation history of this commentary in a random sample of 100 full papers citing it, according to the Web of Science. Of these, 96 were systematic reviews, none of which quoted the commentary directly. All but 2 of the 96 indirect quotations (98%) portrayed the commentary as supporting use of the NOS in systematic reviews when, in fact, the opposite was the case. It appears that the vast majority of systematic review authors who cited this commentary did not read it. Journal reviewers and editors did not recognize and correct these major quotation errors. Authors should read each source they cite to make su...
Source: European Journal of Epidemiology - September 26, 2018 Category: Epidemiology Source Type: research

Serum 25-hydroxyvitamin D 3 is associated with advanced glycation end products (AGEs) measured as skin autofluorescence: The Rotterdam Study
The objective was to investigate the association between serum 25(OH)D3 and SAF in the population-based cohort study. Serum 25(OH)D3 and other covariates were measured at baseline. SAF was measured on average 11.5  years later. Known risk factors for AGE accumulation such as higher age, BMI, and coffee intake, male sex, smoking, diabetes, and decreased renal function were measured at baseline. Linear regression models were adopted to explore the association between 25(OH)D3 and SAF with adjustment for confounders. Interaction terms were tested to identify effect modification. The study was conducted in the general com...
Source: European Journal of Epidemiology - September 25, 2018 Category: Epidemiology Source Type: research

Approach to record linkage of primary care data from Clinical Practice Research Datalink to other health-related patient data: overview and implications
AbstractRecord linkage is increasingly used to expand the information available for public health research. An understanding of record linkage methods and the relevant strengths and limitations is important for robust analysis and interpretation of linked data. Here, we describe the approach used by Clinical Practice Research Datalink (CPRD) to link primary care data to other patient level datasets, and the potential implications of this approach for CPRD data analysis. General practice electronic health record software providers separately submit de-identified data to CPRD and patient identifiers to NHS Digital, excluding...
Source: European Journal of Epidemiology - September 15, 2018 Category: Epidemiology Source Type: research

Understanding the relationship between cognition and death: a within cohort examination of cognitive measures and mortality
AbstractDespite several studies demonstrating an independent and inverse association between cognition and mortality, the nature of this association still remains unclear. To examine the association of cognition and mortality after accounting for sociodemographic, health and lifestyle factors and to explore both test and population characteristics influencing this relationship. In a population based cohort of 8585 men and women aged 48 –92 years, who had cognitive assessments in 2006–2011 and were followed up till 2016 for mortality, we examined the relationship between individual cognitive tests as well a...
Source: European Journal of Epidemiology - September 10, 2018 Category: Epidemiology Source Type: research

Abdominal obesity, glucose intolerance and decreased high-density lipoprotein cholesterol as components of the metabolic syndrome are associated with the development of colorectal cancer
This study aimed to investigate the association between MetS and its components and CRC development by gender and tumor location. We evaluated the data of 22,809,722 Korean individuals of the National semi-compulsive cohort who underwent regular health check-ups between 2009 and 2012. Compared to subjects without MetS components, the hazard ratio for CRC development in patients with MetS was 1.22 (95% Confidence Interval [CI] 1.20 –1.24) and this association was more prominent in men than in women (HR 1.41 95% CI 1.37–1.44 vs. HR 1.23 95% CI 1.20–1.27,P for interaction  
Source: European Journal of Epidemiology - September 8, 2018 Category: Epidemiology Source Type: research

A population based pediatric oncology registry in Southern Sweden: the BORISS registry
AbstractA population based registry, with the acronym BORISS, was established. It contains all individuals (0 –18 years of age at diagnosis) diagnosed with cancer from 1970–01–01 until 2016–12–31 in Southern Sweden. The treatment data has been entered into the registry after confirmation of the diagnosis by the Swedish national cancer registry and updates on vital status from the Swedish populati on registry. The number of individuals with a pediatric cancer diagnosed during these 46 years are 2928. Of these, 2065 are currently alive and 1882 individuals are 5-year survivors. Data on...
Source: European Journal of Epidemiology - September 6, 2018 Category: Epidemiology Source Type: research

The mediating role of the venules between smoking and ischemic stroke
This study was part of a population-based study including 9109 stroke-free persons participated in the study in 1990, 2004, or 2006 (mean age: 63.7  years; 58% women). Smoking behavior (smoking versus non-smoking) was identified by interview. Retinal venular calibers were measured semi-automatically on retinal photographs. Incident strokes were assessed until January 2016. A regression-based approach was used with venular calibers as mediator to decompose the total effect of smoking compared to non-smoking into four components: controlled direct effect (neither mediation nor interaction), pure indirect effect (mediati...
Source: European Journal of Epidemiology - September 4, 2018 Category: Epidemiology Source Type: research

Cancer incidence among Finnish people with type 2 diabetes during 1989 –2014
This study aimed at exploring and describing the association between type 2 diabetes and cancer incidence. A cohort of 428,326 people with type 2 diabetes was identified from the Finnish National Diabetes Register and followed up through a register linkage with the Finnish Cancer Registry for cancer incidence during 1988 –2014. A total of 74,063 cases of cancer occurred in this cohort in 4.48 million person-years. This accounted for 16% more than the expected cancer incidence in the Finnish general population; the standardized incidence ratio (SIR) was 1.16 (95% confidence interval [CI] 1.15–1.16). There was a ...
Source: European Journal of Epidemiology - September 4, 2018 Category: Epidemiology Source Type: research