Assessing the importance of primary care diagnoses in the UK Biobank
In conclusion, it is desirable to extend both the coverage and follow-up period of GP data to allow researchers to maximise case ascertainment of chronic health conditions in the UK. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 16, 2024 Category: Epidemiology Source Type: research
Population-based analysis of the number of thrombectomies performed after cerebral ischemic stroke and prognostic factors of mortality in France
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 14, 2024 Category: Epidemiology Source Type: research
Vitamin D and human health: evidence from Mendelian randomization studies
AbstractWe summarized the current evidence on vitamin D and major health outcomes from Mendelian randomization (MR) studies. PubMed and Embase were searched for original MR studies on vitamin D in relation to any health outcome from inception to September 1, 2022. Nonlinear MR findings were excluded due to concerns about the validity of the statistical methods used. A meta-analysis was preformed to synthesize study-specific estimates after excluding overlapping samples, where applicable. The methodological quality of the included studies was evaluated according to the STROBE-MR checklist. A total of 133 MR publications wer...
Source: European Journal of Epidemiology - January 12, 2024 Category: Epidemiology Source Type: research
Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case –control study in Sweden
AbstractSarcoidosis incidence peaks in women between 50 and 60 years old, which coincides with menopause, suggesting that certain sex hormones, mainly estrogen, may play a role in disease development. We investigated whether menopausal hormone therapy (MHT) was associated with sarcoidosis risk in women and whether the risk varied by treatment type. We performed a nested case –control study (2007–2020) including incident sarcoidosis cases from the Swedish National Patient Register (n = 2593) and matched (1:10) to general population controls (n = 20,003) on birth year, county, and living in Sweden at the time of ...
Source: European Journal of Epidemiology - January 12, 2024 Category: Epidemiology Source Type: research
Vitamin D and human health: evidence from Mendelian randomization studies
AbstractWe summarized the current evidence on vitamin D and major health outcomes from Mendelian randomization (MR) studies. PubMed and Embase were searched for original MR studies on vitamin D in relation to any health outcome from inception to September 1, 2022. Nonlinear MR findings were excluded due to concerns about the validity of the statistical methods used. A meta-analysis was preformed to synthesize study-specific estimates after excluding overlapping samples, where applicable. The methodological quality of the included studies was evaluated according to the STROBE-MR checklist. A total of 133 MR publications wer...
Source: European Journal of Epidemiology - January 12, 2024 Category: Epidemiology Source Type: research
Menopausal hormone therapy and risk of sarcoidosis: a population-based nested case –control study in Sweden
AbstractSarcoidosis incidence peaks in women between 50 and 60 years old, which coincides with menopause, suggesting that certain sex hormones, mainly estrogen, may play a role in disease development. We investigated whether menopausal hormone therapy (MHT) was associated with sarcoidosis risk in women and whether the risk varied by treatment type. We performed a nested case –control study (2007–2020) including incident sarcoidosis cases from the Swedish National Patient Register (n = 2593) and matched (1:10) to general population controls (n = 20,003) on birth year, county, and living in Sweden at the time of ...
Source: European Journal of Epidemiology - January 12, 2024 Category: Epidemiology Source Type: research
Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults
ConclusionsIn this large cohort study, serum SELENOP concentration was inversely associated with all-cause and cause-specific mortality. Consistent inverse associations with multiple mortality outcomes might be explained by an impaired selenium transport and selenium deficiency in multiple organs. Trials testing the efficacy of selenium supplements in subjects with low baseline SELENOP concentration are needed.Trial registrationRetrospectively registered in the German Clinical Trials Register on Feb 14, 2018 (ID: DRKS00014028). (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Higher-order evidence
AbstractHigher-order evidence is evidenceabout evidence. Epidemiologic examples of higher-order evidence include the settings where the study data constitute first-order evidence and estimates of misclassification comprise the second-order evidence (e.g., sensitivity, specificity) of a binary exposure or outcome collected in the main study. While sampling variability in higher-order evidence is typically acknowledged, higher-order evidence is often assumed to be free of measurement error (e.g., gold standard measures). Here we provide two examples, each with multiple scenarios where second-order evidence is imperfectly mea...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Agricultural activities and risk of Alzheimer ’s disease: the TRACTOR project, a nationwide retrospective cohort study
This study aimed to investigate whether, among the entire French farm manager (FM) workforce, certain agricultural activities are more strongly associated with AD than others, using nationwide data from the TRACTOR (Tracking and monitor ing occupational risks in agriculture) project. Administrative health insurance data (digital electronic health/medical records and insurance claims) for the entire French agricultural workforce, over the period 2002–2016, on the entire mainland France were used to estimate the risk of AD for 26 a gricultural activities with Cox proportional hazards model. For each analysis (one for each ...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
A diet-wide association study for liver cancer risk: findings from a prospective cohort study in Chinese men
AbstractDietary factors have been extensively investigated as possible risk factors for liver cancer, but the evidence is inconclusive. Our study systematically assessed the association between 142 foods and nutrients and liver cancer risk in a Chinese population using a diet-wide association study. Based on data from 59,844 men in the Shanghai Men ’s Health Study (SMHS), we assessed the diet intake by dietary questionnaires. Cox regression was used to quantify the association between each food and nutrient and liver cancer risk. A false discovery rate (FDR) of 0.05 was used to select the foods and nutrients for validati...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Cohort profile: the China surgery and anesthesia cohort (CSAC)
AbstractThe China Surgery and Anaesthesia Cohort (CSAC) study was launched in July 2020 and is an ongoing prospective cohort study recruiting patients aged 40 –65 years who underwent elective surgeries with general anaesthesia across four medical centres in China. The general objective of the CSAC study is to improve our understanding of the complex interaction between environmental and genetic components as well as to determine their effects on a wide range of interested surgery/anaesthesia-related outcomes. To achieve this goal, we collected enriched phenotypic data, e.g., sociodemographic characteristics, lifestyle fa...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
The pitfalls of focusing on cardiovascular disease mortality to explain differences in life expectancy
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
