Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review
AbstractDiseases diagnosed in adulthood may have antecedents throughout (including prenatal) life. Gaining a better understanding of how exposures at different stages in the lifecourse influence health outcomes is key to elucidating the potential benefits of disease prevention strategies. Mendelian randomisation (MR) is increasingly used to estimate causal effects of exposures across the lifecourse on later life outcomes. This systematic literature review explores MR methods used to perform lifecourse investigations and reviews previous work that has utilised MR to elucidate the effects of factors acting at different stage...
Source: European Journal of Epidemiology - November 8, 2023 Category: Epidemiology Source Type: research
Re: Interpreting epidemiologic studies of colorectal cancer prevention
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - November 8, 2023 Category: Epidemiology Source Type: research
Evidence-based policy-making - epidemiology as a key science for quality of life in society
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - November 8, 2023 Category: Epidemiology Source Type: research
Re: Interpreting epidemiologic studies of colorectal cancer prevention
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - November 8, 2023 Category: Epidemiology Source Type: research
Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review
AbstractDiseases diagnosed in adulthood may have antecedents throughout (including prenatal) life. Gaining a better understanding of how exposures at different stages in the lifecourse influence health outcomes is key to elucidating the potential benefits of disease prevention strategies. Mendelian randomisation (MR) is increasingly used to estimate causal effects of exposures across the lifecourse on later life outcomes. This systematic literature review explores MR methods used to perform lifecourse investigations and reviews previous work that has utilised MR to elucidate the effects of factors acting at different stage...
Source: European Journal of Epidemiology - November 8, 2023 Category: Epidemiology Source Type: research
Measuring mortality arising from the Covid-19 pandemic and the impact of vaccination
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - November 4, 2023 Category: Epidemiology Source Type: research
Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism
AbstractHigher coffee consumption has been associated with reduced dementia risk, yet with inconsistencies across studies. CYP1A2 polymorphisms, which affects caffeine metabolism, may modulate the association between coffee and the risk of dementia and Alzheimer ’s disease (AD). We included 5964 participants of the Three-City Study (mean age 74 years-old), free of dementia at baseline when they reported their daily coffee consumption, with available genome-wide genotyping and followed for dementia over a median of 9.0 (range 0.8–18.7) years. In Cox prop ortional-hazards models, the relationship between coffee consumpti...
Source: European Journal of Epidemiology - October 31, 2023 Category: Epidemiology Source Type: research
Re: A comprehensive analysis of all-cause and cause-specific excess deaths in 30 countries during 2020. Alicandro et al. Eur J Epidemiol 2023
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 31, 2023 Category: Epidemiology Source Type: research
Habitual coffee consumption and risk of dementia in older persons: modulation by CYP1A2 polymorphism
AbstractHigher coffee consumption has been associated with reduced dementia risk, yet with inconsistencies across studies. CYP1A2 polymorphisms, which affects caffeine metabolism, may modulate the association between coffee and the risk of dementia and Alzheimer ’s disease (AD). We included 5964 participants of the Three-City Study (mean age 74 years-old), free of dementia at baseline when they reported their daily coffee consumption, with available genome-wide genotyping and followed for dementia over a median of 9.0 (range 0.8–18.7) years. In Cox prop ortional-hazards models, the relationship between coffee consumpti...
Source: European Journal of Epidemiology - October 31, 2023 Category: Epidemiology Source Type: research
Re: A comprehensive analysis of all-cause and cause-specific excess deaths in 30 countries during 2020. Alicandro et al. Eur J Epidemiol 2023
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 31, 2023 Category: Epidemiology Source Type: research
Lower mental health related quality of life precedes dementia diagnosis: findings from the EPIC-Norfolk prospective population-based study
AbstractLower Health Related Quality of Life (HRQoL) precedes dementia in older adults in the USA. We explore prospective associations between HRQoL and dementia in British adults in mid and late-life, when interventions to optimise cognitive ageing may provide benefit. 7,452 community-dwelling participants (57% women; mean age 69.3 ± 8.3 years) attended the European Prospective Investigation of Cancer-Norfolk study’s third health check (3HC) and reported their HRQoL using Short-Form 36 (SF-36). Cox Proportional Hazard regression models explored associations between standard deviation differences in baseline Physic...
Source: European Journal of Epidemiology - October 30, 2023 Category: Epidemiology Source Type: research
Exposure to different residential indoor characteristics during childhood and asthma in adolescence: a latent class analysis of the Danish National Birth Cohort
ConclusionOur findings suggest that, in a high-income country such as Denmark, groups of adolescents growing up in homes with mold and moisture during mid-childhood might be at increased risk of current asthma at age 18. Adolescents who grew-up in a farmhouse and who were exposed to pets seem less likely to suffer from asthma by age 18. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - October 21, 2023 Category: Epidemiology Source Type: research
