A diet-wide association study for liver cancer risk: findings from a prospective cohort study in Chinese men
AbstractDietary factors have been extensively investigated as possible risk factors for liver cancer, but the evidence is inconclusive. Our study systematically assessed the association between 142 foods and nutrients and liver cancer risk in a Chinese population using a diet-wide association study. Based on data from 59,844 men in the Shanghai Men ’s Health Study (SMHS), we assessed the diet intake by dietary questionnaires. Cox regression was used to quantify the association between each food and nutrient and liver cancer risk. A false discovery rate (FDR) of 0.05 was used to select the foods and nutrients for validati...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Cohort profile: the China surgery and anesthesia cohort (CSAC)
AbstractThe China Surgery and Anaesthesia Cohort (CSAC) study was launched in July 2020 and is an ongoing prospective cohort study recruiting patients aged 40 –65 years who underwent elective surgeries with general anaesthesia across four medical centres in China. The general objective of the CSAC study is to improve our understanding of the complex interaction between environmental and genetic components as well as to determine their effects on a wide range of interested surgery/anaesthesia-related outcomes. To achieve this goal, we collected enriched phenotypic data, e.g., sociodemographic characteristics, lifestyle fa...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
The pitfalls of focusing on cardiovascular disease mortality to explain differences in life expectancy
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Strong associations of serum selenoprotein P with all-cause mortality and mortality due to cancer, cardiovascular, respiratory and gastrointestinal diseases in older German adults
ConclusionsIn this large cohort study, serum SELENOP concentration was inversely associated with all-cause and cause-specific mortality. Consistent inverse associations with multiple mortality outcomes might be explained by an impaired selenium transport and selenium deficiency in multiple organs. Trials testing the efficacy of selenium supplements in subjects with low baseline SELENOP concentration are needed.Trial registrationRetrospectively registered in the German Clinical Trials Register on Feb 14, 2018 (ID: DRKS00014028). (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Higher-order evidence
AbstractHigher-order evidence is evidenceabout evidence. Epidemiologic examples of higher-order evidence include the settings where the study data constitute first-order evidence and estimates of misclassification comprise the second-order evidence (e.g., sensitivity, specificity) of a binary exposure or outcome collected in the main study. While sampling variability in higher-order evidence is typically acknowledged, higher-order evidence is often assumed to be free of measurement error (e.g., gold standard measures). Here we provide two examples, each with multiple scenarios where second-order evidence is imperfectly mea...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Agricultural activities and risk of Alzheimer ’s disease: the TRACTOR project, a nationwide retrospective cohort study
This study aimed to investigate whether, among the entire French farm manager (FM) workforce, certain agricultural activities are more strongly associated with AD than others, using nationwide data from the TRACTOR (Tracking and monitor ing occupational risks in agriculture) project. Administrative health insurance data (digital electronic health/medical records and insurance claims) for the entire French agricultural workforce, over the period 2002–2016, on the entire mainland France were used to estimate the risk of AD for 26 a gricultural activities with Cox proportional hazards model. For each analysis (one for each ...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
A diet-wide association study for liver cancer risk: findings from a prospective cohort study in Chinese men
AbstractDietary factors have been extensively investigated as possible risk factors for liver cancer, but the evidence is inconclusive. Our study systematically assessed the association between 142 foods and nutrients and liver cancer risk in a Chinese population using a diet-wide association study. Based on data from 59,844 men in the Shanghai Men ’s Health Study (SMHS), we assessed the diet intake by dietary questionnaires. Cox regression was used to quantify the association between each food and nutrient and liver cancer risk. A false discovery rate (FDR) of 0.05 was used to select the foods and nutrients for validati...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Cohort profile: the China surgery and anesthesia cohort (CSAC)
AbstractThe China Surgery and Anaesthesia Cohort (CSAC) study was launched in July 2020 and is an ongoing prospective cohort study recruiting patients aged 40 –65 years who underwent elective surgeries with general anaesthesia across four medical centres in China. The general objective of the CSAC study is to improve our understanding of the complex interaction between environmental and genetic components as well as to determine their effects on a wide range of interested surgery/anaesthesia-related outcomes. To achieve this goal, we collected enriched phenotypic data, e.g., sociodemographic characteristics, lifestyle fa...
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
The pitfalls of focusing on cardiovascular disease mortality to explain differences in life expectancy
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 10, 2024 Category: Epidemiology Source Type: research
Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis
This study showed that both neurodegeneration and cerebral SVD statistically explained almost 30% of the association between diabetes and dementia. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 8, 2024 Category: Epidemiology Source Type: research
Meta-regression of genome-wide association studies to estimate age-varying genetic effects
AbstractFixed-effect meta-analysis has been used to summarize genetic effects on a phenotype across multiple Genome-Wide Association Studies (GWAS) assuming a common underlying genetic effect. Genetic effects may vary with age (or other characteristics), and not allowing for this in a GWAS might lead to bias. Meta-regression models between study heterogeneity and allows effect modification of the genetic effects to be explored. The aim of this study was to explore the use of meta-analysis and meta-regression for estimating age-varying genetic effects on phenotypes. With simulations we compared the performance of meta-regre...
Source: European Journal of Epidemiology - January 6, 2024 Category: Epidemiology Source Type: research
The magnitude and direction of the relationship between risk factor and cognition depends on age: a pooled analysis of 5 community-based studies
AbstractThe mixed evidence of the association between high levels of cardiovascular risk factors (CVRF) and the risk for cognitive impairment may be due to confounding of age across studies. We pooled and harmonized individual-level data (30,967 persons, age range 42 –96 years) from five prospective cohorts to investigate by 1 year age increments to investigate whether or not there is change in slope describing the association of CVRF to a cognitive outcome (Digit Symbol Substitution Test; DSST). The CVRF included: systolic and diastolic blood pressure, tota l cholesterol, fasting glucose and body mass index. Linear an...
Source: European Journal of Epidemiology - January 5, 2024 Category: Epidemiology Source Type: research
The impact of the COVID-19 pandemic on mortality in Sweden —Did it differ across socioeconomic groups?
AbstractThe characterization of the socioeconomic profile of COVID-19 mortality is limited. Likewise, the mapping of potential indirect adverse outcomes of the pandemic, such as suicide and alcohol abuse, along socioeconomic lines is still meagre. The main aim of this paper is to (i) depict SES-differences in COVID-19 mortality, and (ii) to assess the impact of the COVID-19 pandemic on suicide and alcohol mortality across socioeconomic groups. We used Swedish monthly data spanning the period January 2016 –December 2021. We chose education as indicator of socioeconomic status (SES). The following causes of deaths were inc...
Source: European Journal of Epidemiology - January 5, 2024 Category: Epidemiology Source Type: research
