Re: The pitfalls of focusing on cardiovascular disease mortality to explain differences in life expectancy
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - February 12, 2024 Category: Epidemiology Source Type: research

The Rotterdam Study. Design update and major findings between 2020 and 2024
AbstractThe Rotterdam Study is a population-based cohort study, started in 1990 in the district of Ommoord in the city of Rotterdam, the Netherlands, with the aim to describe the prevalence and incidence, unravel the etiology, and identify targets for prediction, prevention or intervention of multifactorial diseases in mid-life and elderly. The study currently includes 17,931 participants (overall response rate 65%), aged 40 years and over, who are examined in-person every 3 to 5 years in a dedicated research facility, and who are followed-up continuously through automated linkage with health care providers, both regionall...
Source: European Journal of Epidemiology - February 7, 2024 Category: Epidemiology Source Type: research

Does having siblings really protect against childhood atopic diseases? A total population and within-family analysis
AbstractThe association between having older siblings and decreased risk for atopic symptoms is well-established. This has been interpreted as evidence for the microbiota hypothesis, i.e. that increased early-childhood microbial exposure caused by siblings protects from immune hypersensitivities. However, possible confounders of the association have received little attention. We used register data on Finnish cohorts born in 1995 –2004 (N = 559,077) to assess medication purchases for atopic diseases: antihistamines, eczema medication, asthma medication and Epinephrine. We modelled the probability of atopic medication ...
Source: European Journal of Epidemiology - February 6, 2024 Category: Epidemiology Source Type: research

Occupational exposure to diesel exhausts and liver and pancreatic cancers: a systematic review and meta-analysis
ConclusionsOur findings suggest an association between occupational DE exposure and liver and pancreatic cancer. Further studies with detailed exposure assessment, environmental monitoring data, and appropriate control for confounders are warranted. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 30, 2024 Category: Epidemiology Source Type: research

Two sample Mendelian Randomisation using an outcome from a multilevel model of disease progression
AbstractIdentifying factors that are causes of disease progression, especially in neurodegenerative diseases, is of considerable interest. Disease progression can be described as a trajectory of outcome over time —for example, a linear trajectory having both an intercept (severity at time zero) and a slope (rate of change). A technique for identifying causal relationships between one exposure and one outcome in observational data whilst avoiding bias due to confounding is two sample Mendelian Randomisation (2SMR). We consider a multivariate approach to 2SMR using a multilevel model for disease progression to estimate the...
Source: European Journal of Epidemiology - January 28, 2024 Category: Epidemiology Source Type: research

Partial substitution of red meat or processed meat with plant-based foods and the risk of colorectal cancer
ConclusionsEven small, easily implemented substitutions of red or processed meat with whole grains, vegetables or fruits could lower CRC risk in a population with high meat consumption. These findings broaden our insight into dietary modifications that could foster CRC primary prevention. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 23, 2024 Category: Epidemiology Source Type: research

Authors ’ Reply: Interpreting epidemiologic studies of colonoscopy screening for colorectal cancer prevention
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 23, 2024 Category: Epidemiology Source Type: research

Partial substitution of red meat or processed meat with plant-based foods and the risk of colorectal cancer
ConclusionsEven small, easily implemented substitutions of red or processed meat with whole grains, vegetables or fruits could lower CRC risk in a population with high meat consumption. These findings broaden our insight into dietary modifications that could foster CRC primary prevention. (Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 23, 2024 Category: Epidemiology Source Type: research

Authors ’ Reply: Interpreting epidemiologic studies of colonoscopy screening for colorectal cancer prevention
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 23, 2024 Category: Epidemiology Source Type: research

Re: Interpreting epidemiologic studies of colonoscopy screening for colorectal cancer prevention
(Source: European Journal of Epidemiology)
Source: European Journal of Epidemiology - January 22, 2024 Category: Epidemiology Source Type: research