Predictors of the Response to an Epidural Blood Patch in Patients with Spinal Leakage of Cerebrospinal Fluid.
Authors: Kanno H, Yoshizumi T, Nakazato N, Shinonaga M Abstract BACKGROUND AND PURPOSE: An epidural blood patch (EBP) is a highly effective therapy for spinal cerebrospinal fluid (CSF) leakage. However, the factors predicting the response to an EBP have not been fully elucidated. The aim of this study was to elucidate factors predicting the response to an EBP. METHODS: We retrospectively examined the relationship between the response to an EBP and clinical variables of 118 patients with spinal CSF leakage, such as patient age, sex, etiology, interval from the onset to EBP application, CSF opening pressure (OP),...
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Effect of Repetitive Transcranial Magnetic Stimulation on Seizure Frequency and Epileptiform Discharges in Drug-Resistant Epilepsy: A Meta-Analysis.
Authors: Mishra A, Maiti R, Mishra BR, Jena M, Srinivasan A Abstract BACKGROUND AND PURPOSE: The role of low-frequency repetitive transcranial stimulation (rTMS) in drug-resistant epilepsy (DRE) has been conflicting and inconclusive in previous clinical trials. This meta-analysis evaluated the efficacy of rTMS on seizure frequency and epileptiform discharges in DRE. METHODS: A standard meta-analysis protocol was registered in the International Prospective Register of Ongoing Systematic Reviews (PROSPERO: CRD42018088544). After performing a comprehensive literature search using specific keywords in MEDLINE, the ...
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Association between Retinal Vascular Geometric Changes and Cognitive Impairment: A Systematic Review and Meta-Analysis.
CONCLUSIONS: A smaller retinal microvascular FD might be associated with cognitive impairment. Further large-sample and well-controlled original studies are required to confirm the present findings. PMID: 31942754 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Plasma Fibroblast Growth Factor 23 Concentration Is Associated with Intracranial Cerebral Atherosclerosis in Acute Ischemic Stroke Patients.
This study aimed to determine the association of the plasma FGF23 concentration with intracranial cerebral atherosclerosis (ICAS) and extracranial cerebral atherosclerosis (ECAS). METHODS: We prospectively enrolled 262 first-ever ischemic stroke patients in whom brain magnetic resonance was performed and a blood sample acquired within 24 h after admission. Plasma FGF23 concentrations were measured using an enzyme-linked immunosorbent assay. The presence of ICAS or ECAS was defined as a ≥50% decrease in arterial diameter in magnetic resonance angiography. The burden of cerebral atherosclerosis was calculated by addin...
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

A Cortical Substrate for Square-Wave Jerks in Progressive Supranuclear Palsy.
CONCLUSIONS: SWJs in PSP are not mediated by midbrain atrophy. Instead, supratentorial cortical structures located mainly in the temporal lobe appear to be deeply involved in the generation of abnormally high SWJ rates in these patients. Known anatomical connections of the temporal lobe to the superior colliculus and the cerebellum might play a role in SWJ genesis. PMID: 31942756 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Effects of Lamotrigine on Problem-Solving Abilities in Newly Diagnosed Pediatric Patients with Epilepsy.
This study aimed to determine the effects of lamotrigine (LTG) on language unction, including problem-solving abilities, in newly diagnosed pediatric epileptic patients. METHODS: This study included 112 newly diagnosed epileptic patients treated with LTG [69 males and 43 females aged 9.6±2.7 years (mean±SD)]. Repeated neurologic examinations, electroencephalography, neuroimaging studies, and standard language tests including the Test of Problem Solving (TOPS), mean length of utterance in words (MLU-w), Receptive and Expressive Vocabulary Test (REVT), and Urimal Test of Articulation and Phonology were perf...
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Real-Life Effectiveness and Tolerability of Perampanel in Pediatric Patients Aged 4 Years or Older with Epilepsy: A Korean National Multicenter Study.
CONCLUSIONS: Adjunctive treatment with perampanel was efficacious and tolerated in pediatric patients aged 4 years or older with epilepsy. Early perampanel treatment may help to reduce the burden of their seizures and improve their quality of life. PMID: 31942758 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Effects of Gamma-Glutamyl Transferase on Stroke Occurrence Mediated by Atrial Fibrillation.
CONCLUSIONS: The GGT level was significantly associated with cardioembolic stroke via AF. The results obtained in the present study may explain why GGT is associated with stroke. PMID: 31942759 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2.
CONCLUSIONS: K-PDSS-2 showed good clinimetric attributes in accordance with previous studies that employed the original version of the PDSS-2, therefore confirming the cross-cultural usefulness of the scale. This study has further documented the first application of an LCA approach for identifying subtypes of sleep disturbance in patients with PD. PMID: 31942760 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical and Genetic Spectrum of ATP1A3-Related Disorders in a Korean Pediatric Population.
CONCLUSIONS: Our study is the first case series of ATP1A3-related disorders to be described in Korea and which further expands the understanding of its genotype-phenotype spectrum. A ketogenic diet showed no clear benefit for the patients with AHC. PMID: 31942761 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Coexistence of Cerebral Microbleeds and Amyloid Pathology in Patients with Cognitive Complaints.
CONCLUSIONS: The prevalence of CMBs was higher in patients with cognitive decline than in the general population. CMBs play distinctive roles in affecting clinical parameters and neuropsychological profiles according to the coexistence of amyloid pathology. PMID: 31942762 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Effective Continuous Positive Airway Pressure Changes Related to Sleep Stage and Body Position in Obstructive Sleep Apnea during Upward and Downward Titration: An Experimental Study.
This study applied successful manual titration of continuous positive airway pressure over 3 hours [including at least 15 min in supine rapid eye movement (REM) sleep] followed by consecutive downward titration for at least 1 hour to 22 patients with moderate-to-severe obstructive sleep apnea. We analyzed baseline polysomnography variables and compared the effective pressures (Peff1upward and Peff2downward) between non-REM and REM sleep and between supine and lateral positions using the paired t-test or Wilcoxon signed-rank test. RESULTS: During upward titration, Peff1 increased during REM sleep compared to non-REM sle...
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Implications of Ketosis in Children with Benign Convulsions with Mild Gastroenteritis.
Authors: Lee JY, Ryu JM, Lee JS, Ko TS, Yum MS Abstract BACKGROUND AND PURPOSE: The pathophysiologic mechanisms underlying benign convulsions with mild gastroenteritis (CwG) in children remain unclear. We investigated the incidence of ketosis in CwG and whether this is related to seizures. METHODS: This retrospective study included children aged from 6 months to 6 years who visited our emergency department and were diagnosed as CwG between June 2015 and December 2018. The clinical and laboratory data were analyzed for these cases. Ketosis and severe ketosis were defined as blood β-hydroxybutyrate levels of...
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Intraoperative Motor Evoked Potential Improvement in Cervical Spondylotic Myelopathy: Comparison of Cortical Stimulation Parameters.
CONCLUSIONS: MEPI is observed in a much larger proportion of cervical decompression surgery cases than previously thought. Intraoperative MEPI with longer-train cortical stimulation may reflect adequacy of decompression and provide additional guidance for the surgical procedure. PMID: 31942765 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Insomnia Symptoms and Mood Disturbances in Shift Workers with Different Chronotypes and Working Schedules.
CONCLUSIONS: Sleep disturbances are more frequent in shift workers than DW. Depressive mood and anxiety symptoms were frequently reported in 3S, then EOD. Different shift schedules cab be a determinant of depressive mood and anxiety symptom. PMID: 31942766 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Individual-Level Lesion-Network Mapping to Visualize the Effects of a Stroke Lesion on the Brain Network: Connectograms in Stroke Syndromes.
CONCLUSIONS: This pilot study has visualized the effects of stroke lesions on the functional brain networks of individual patients. Consideration of the neurobiologic mechanisms underlying the differences between their connectograms has yielded new hypotheses about differences in the effects of stroke lesions. PMID: 31942767 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Comparison of Neuropathic Pain in Neuromyelitis Optica Spectrum Disorder and Multiple Sclerosis.
CONCLUSIONS: The severity of neuropathic pain and the pain-related interference in daily life were greater in NMOSD patients than in MS patients. Individualized analgesic management should be considered based on a comprehensive understanding of neuropathic pain in these patients. PMID: 31942768 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Usefulness of 18F-FC119S Positron-Emission Tomography as an Auxiliary Diagnostic Method for Dementia: An Open-Label, Single-Dose, Evaluator-Blind Clinical Trial.
CONCLUSIONS: ¹⁸F-FC119S PET provides high sensitivity and specificity in detecting AD and therefore may be considered a useful diagnostic tool for AD. PMID: 31942769 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Antiphospholipid and Antinuclear Antibodies in Children with Idiopathic Epilepsy: A 2-Year Prospective Study.
CONCLUSIONS: The increased prevalence of autoantibodies in children with idiopathic epilepsy is strongly associated with the disease itself. PMID: 31942770 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Reliability and Validity of a Short Form of the Korean Dementia Screening Questionnaire-Cognition.
CONCLUSIONS: A short form of the patient- and informant-rated versions of the KDSQ-C (KDSQ-C-II) is as capable as the 15-item KDSQ-C in screening for dementia. PMID: 31942771 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Delayed Diagnosis of Chromosome 22q11.2 Deletion Syndrome Due to Late-Onset Generalized Epilepsy.
Authors: Lee SK, Lee EJ, Kwun KH, Kim TJ, Lee SK PMID: 31942772 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Dementia and the Risk of Hip Fracture.
Authors: Lai SW PMID: 31942773 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

"Self-Neuroenhancement": The Last Frontier of Noninvasive Brain Stimulation?
"Self-Neuroenhancement": The Last Frontier of Noninvasive Brain Stimulation? J Clin Neurol. 2020 Jan;16(1):158-159 Authors: Fisicaro F, Lanza G, Bella R, Pennisi M PMID: 31942774 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Refractory Digital Ulcers Treated by Botulinum Toxin and Endothelin Receptor-1 Antagonist in Anti-MDA5-Antibody-Positive Dermatomyositis.
Authors: Min HK, Kim HR, Lee SH, Park SH, Oh J, Choi K PMID: 31942775 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Acute Vertical Pendular Nystagmus and Delayed Oculopalatal Tremor in a Patient with Bilateral Horizontal Gaze Palsy.
Authors: Lee H, Kim HA PMID: 31942776 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Immune-Mediated Peripheral Neuropathy in Patients with Diffuse Panbronchiolitis.
Authors: Kang YR, Nam TS, Lee KH, Kim S, Park HJ, Lee SJ, Lee SH, Kim BC PMID: 31942777 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Cortical Deafness and Tinnitus Following Sequential Bilateral Putaminal Hemorrhage.
Authors: Yang S, Chen S, Zhu J, Han X PMID: 31942778 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Eye Movements and Vestibulo-Ocular Reflex in Periventricular Leukomalacia.
Authors: Kim SH, Kim JS PMID: 31942779 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

The Rise of Cerebellar Ataxia in South Korea: 2002-2016.
Authors: Park Y, Park KW PMID: 31942780 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Ulnar Neuropathy at the Upper Arm after Parallel-Bars Swinging Exercise.
Authors: Kim YK, Park IW, Ro S, Jeong YH, Suh BC PMID: 31942781 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Erratum to: A Multicenter, Randomized Clinical Trial to Assess the Efficacy of a Therapeutic Intervention Program for Caregivers of People with Dementia.
Authors: Yoo R, Yeom J, Kim GH, Park HK, Kang Y, Hwang J, Choi SH, Na HR, Cho SJ, Yu KH, Kim DH, Lee JH, Jeong JH Abstract This corrects the article on p. 235 in vol. 15, PMID: 30938110. PMID: 31942782 [PubMed - in process] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Erratum to: High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis.
Authors: Kim SH, Kim Y, Jung JY, Park NY, Jang H, Hyun JW, Kim HJ Abstract This corrects the article on p. 454 in vol. 15, PMID: 31591832. PMID: 31942783 [PubMed - in process] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Erratum to: Elevated Serum Uric Acid in Benign Convulsions with Mild Gastroenteritis in Children.
Authors: Yoo IH, Kim W, Cho J, Kim H, Lim BC, Hwang H, Chae JH, Choi J, Kim KJ Abstract This corrects the article on p. 496 in vol. 15, PMID: 31591838. PMID: 31942784 [PubMed - in process] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - January 17, 2020 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical and Radiographic Characteristics of Neuro-Beh çet's Disease in South Korea.
CONCLUSIONS: Approximately 1% of the patients with suspected BD exhibited NBD. Neurologists must understand the clinical characteristics of NBD in order to perform the differential diagnosis and management of these patients. PMID: 31591829 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Altered Regional Cerebral Blood Flow Associated with Mood and Sleep in Shift Workers: Cerebral Perfusion Magnetic Resonance Imaging Study.
CONCLUSIONS: SW experience considerably more insomnia and mood disturbances than do DW, and this is significantly related to perfusion changes in multiple brain areas. PMID: 31591830 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Subcortical Volume Changes in Migraine with Aura.
Authors: Petrusic I, Dakovic M, Zidverc-Trajkovic J Abstract BACKGROUND AND PURPOSE: Various features of the cerebral cortex and white matter have been extensively investigated in migraine with aura (MwA), but the morphological characteristics of subcortical structures have been largely neglected. The aim of this study was to identify possible differences in subcortical structures between MwA patients and healthy subjects (HS), and also to determine the correlations between the characteristics of migraine aura and the volumes of subcortical structures. METHODS: Thirty-two MwA patients and 32 HS matched by sex a...
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

High Seroprevalence and Index of Anti-John-Cunningham Virus Antibodies in Korean Patients with Multiple Sclerosis.
CONCLUSIONS: The seroprevalence and index of anti-JCV antibodies in Korean patients with MS may be higher than those in Western countries. PMID: 31591832 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

The Effect of Repetitive Transcranial Magnetic Stimulation on Spasticity in Patients with Multiple Sclerosis.
This study included 16 patients with a history of MS and spasticity in the adductor hip muscles according to the Modified Ashworth Scale (MAS). The participants were randomized into the active group (n=10) and control group (n=6), in which active rTMS and sham rTMS were applied in 10 sessions, respectively. A physical therapy and rehabilitation program was applied along with rTMS sessions in both groups. The evaluation parameters were assessed at baseline and then 1 week and 1 month after applying rTMS. RESULTS: Statistical analyses with post-hoc correction revealed statistically significant improvements in the active ...
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Efficacy and Safety of Injectable Levetiracetam Versus Phenytoin as Second-Line Therapy in the Management of Generalized Convulsive Status Epilepticus in Children: An Open-Label Randomized Controlled Trial.
CONCLUSIONS: Levetiracetam is significantly more effective than phenytoin for the treatment of convulsive status epilepticus in children who have failed to respond to benzodiazepines. PMID: 31591834 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Backward Gait is Associated with Motor Symptoms and Fear of Falling in Patients with De Novo Parkinson's Disease.
CONCLUSIONS: The BG dynamics were more impaired and more closely related to motor symptoms and fear of falling than were the FG or DG dynamics in patients with de novo PD, indicating that BG parameters are potential biomarkers for the progression of PD. PMID: 31591835 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

'Sirim' (Cold) Pain as a Common Symptom in Korean Patients with Clinically Suspected Small-Fiber Neuropathy.
CONCLUSIONS: 'Sirim' pain, similar to cold pain, should be considered a major neuropathic pain in SFN. Among pain characteristics, stabbing pain of a spontaneous paroxysmal nature may be more pronounced in the setting of dysfunctional Aδ fibers with functional autonomic C fibers. PMID: 31591836 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Combined Assessment of Serum Alpha-Synuclein and Rab35 is a Better Biomarker for Parkinson's Disease.
CONCLUSIONS: Combined assessment of serum αSyn and Rab35 is a better biomarker for discriminating PD patients from NC or atypical parkinsonian patients, and is a useful predictive biomarker for younger sporadic PD patients. PMID: 31591837 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Elevated Serum Uric Acid in Benign Convulsions with Mild Gastroenteritis in Children.
This study included 154 CwG patients (age range 0.73-3.19 years), 2,938 patients with acute gastroenteritis, and 154 patients with febrile seizure. The serum uric acid level was significantly higher in CwG patients than in patients with acute gastroenteritis [9.79±2.16 mg/dL vs. 6.04±2.3 mg/dL (mean±SD), p
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Language-Related White-Matter-Tract Deficits in Children with Benign Epilepsy with Centrotemporal Spikes: A Retrospective Study.
This study assessed language-delivery deficits in BECTS patients using diffusion-tensor magnetic resonance imaging (DTI). METHODS: T1-weighted MRI, DTI, and language tests were conducted in 16 BECTS patients and 16 age-matched controls. DTI data were analyzed using the TRActs Constrained by Underlying Anatomy tool in FreeSurfer 5.3, and 18 major white-matter tracts were extracted, which included 4 language-related tracts: the inferior longitudinal fasciculus, superior longitudinal fasciculus-parietal terminations, superior longitudinal fasciculus-temporal terminations, and uncinate fasciculus (UNC). Language tests incl...
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Prediction of Chemotherapy-Induced Peripheral Neuropathy in Patients with Lymphoma and Myeloma: the Roles of Brain-Derived Neurotropic Factor Protein Levels and A Gene Polymorphism.
CONCLUSIONS: Determining the BDNF protein levels before initiating chemotherapy might be a useful tool for CIPN risk assessment and preemptive dose modification. The present data should be validated in larger studies that include other neurotoxic agents. PMID: 31591840 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease.
CONCLUSIONS: We have demonstrated that a higher-than-normal BMI at the time of a PD diagnosis has a protective effect against the deterioration of cognitive function and the conversion to dementia. PMID: 31591841 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Relationships between [ ¹⁸F]-THK5351 Retention and Language Functions in Primary Progressive Aphasia.
CONCLUSIONS: The pattern of [¹⁸F]-THK5351 retention was well matched with clinical and radiological findings for each PPA subtype, in agreement with the anatomical and functional location of each language domain. PMID: 31591842 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Tissue-Clearing Technique and Cutaneous Nerve Biopsies: Quantification of the Intraepidermal Nerve-Fiber Density Using Active Clarity Technique-Pressure Related Efficient and Stable Transfer of Macromolecules Into Organs.
CONCLUSIONS: This study has shown that a tissue-clearing method provided not only rapid and highly reproducible three-dimensional images of cutaneous nerve fibers but also yielded reliable quantitative IENFD data. Quantification of the IENFD using a tissue-clearing and labeling technique is a promising way to improve conventional cutaneous nerve biopsies. PMID: 31591843 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Long-Term Outcomes of Real-World Korean Patients with Atrial-Fibrillation-Related Stroke and Severely Decreased Ejection Fraction.
Authors: Jung JM, Kim YH, Yu S, O K, Kim CK, Song TJ, Kim YJ, Kim BJ, Heo SH, Park KY, Kim JM, Park JH, Choi JC, Park MS, Kim JT, Choi KH, Hwang YH, Chung JW, Bang OY, Kim GM, Seo WK Abstract BACKGROUND AND PURPOSE: The clinical implications of echocardiography findings for long-term outcomes in atrial fibrillation (AF)-related stroke patients are unknown. METHODS: This was a substudy of the Korean ATrial fibrillaTion EvaluatioN regisTry in Ischemic strOke patieNts (K-ATTENTION), which is a multicenter-based cohort comprising prospective stroke registries from 11 tertiary centers. Stroke survivors who underwent...
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research

Association Analysis of Interleukin-1 β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus.
Association Analysis of Interleukin-1β, Interleukin-6, and HMGB1 Variants with Postictal Serum Cytokine Levels in Children with Febrile Seizure and Generalized Epilepsy with Febrile Seizure Plus. J Clin Neurol. 2019 Oct;15(4):555-563 Authors: Choi J, Choi SA, Kim SY, Kim H, Lim BC, Hwang H, Chae JH, Kim KJ, Oh S, Kim EY, Shin JS Abstract BACKGROUND AND PURPOSE: Febrile seizure (FS) is a unique type of seizure that only occurs during childhood. Genelized epilepsy with febrile seizure plus (GEFS+) is a familial epilepsy syndrome associated with FS and afebrile seizure (AFS). Both seizure types are r...
Source: Journal of Clinical Neurology - October 10, 2019 Category: Neurology Tags: J Clin Neurol Source Type: research