Risk of Dementia in Long-Term Benzodiazepine Users: Evidence from a Meta-Analysis of Observational Studies.
CONCLUSIONS: This meta-analysis that pooled ten studies has shown that BDZ significantly increases the risk of dementia in the elderly population. The risk is higher in patients taking BDZ with a longer half-life (>20 hours) and for a longer duration (>3 years). PMID: 30375757 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Intracranial Arterial Calcificationes Can Reflect Cerebral Atherosclerosis Burden.
Authors: Kim JM, Park KY, Bae JH, Han SH, Jeong HB, Jeong D Abstract BACKGROUND AND PURPOSE: We investigated whether the intracranial arterial calcification status reflects the overall cerebral atherosclerosis burden. METHODS: Patients with acute cerebral infarction who were admitted to a single university hospital stroke center and underwent brain computed tomography angiography (CTA) between May 2011 and December 2015 were included. We reviewed their demographic, clinical, and imaging data. Cerebral artery calcification was assessed from the cavernous portion of both internal carotid arteries, and patients we...
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Qualitative Comparison of Semantic Memory Impairment in Patients with Amnestic Mild Cognitive Impairment Based on β-Amyloid Status.
CONCLUSIONS: In spite of similar clinical manifestations, Aβ+ aMCI was more similar to AD than Aβ- aMCI in terms of semantic memory disruption. Semantic memory may serve as an early indicator of brain Aβ pathology. Therefore, semantic memory dysfunction deserves more consideration in clinical practice. Longitudinal research with the follow-up data is needed. PMID: 30375759 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Real-World Effectiveness of Disease-Modifying Therapies in Korean Patients with Relapsing Multiple Sclerosis.
This study assessed the long-term outcomes of disease-modifying therapies (DMTs) in Korean multiple sclerosis (MS) patients treated in real-world clinical settings in Korea. METHODS: We retrospectively evaluated the medical records of 160 patients with an initial diagnosis of clinically isolated syndrome or relapsing-remitting MS who were treated for at least 2 years. A status of 3 for no evidence of disease activity (NEDA3) was defined as no relapse, disability progression, or active lesions in annual magnetic resonance imaging (MRI) evaluations. RESULTS: Patients who were initially treated with interferon β ...
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Adult-Onset Walking-Upstairs Dystonia.
Authors: Portaro S, Naro A, Cacciola A, Marra A, Quartarone A, Milardi D, Calabrò RS PMID: 30375761 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Acquired Hepatocerebral Degeneration in the Absence of Portosystemic Shunting.
Authors: Caranci G, Cordano C, Giannini E, Bandini F PMID: 30375762 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

A Case of Anti-N-Methyl-D-Aspartate Receptor Encephalitis Associated with Glioma of the Pons.
Authors: Beretta F, Aliprandi A, Di Leo C, Salmaggi A PMID: 30375763 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

A Case of Intracranial Hypotension after Horse Riding.
Authors: Karsidag S, Cinar N, Sahin S, Ates MF, Tabak NA PMID: 30375764 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Novel Pathogenic Variant of SPAST (c.1413+4A > G) in a Patient with Hereditary Spastic Paraplegia.
Novel Pathogenic Variant of SPAST (c.1413+4A>G) in a Patient with Hereditary Spastic Paraplegia. J Clin Neurol. 2018 Oct 26; Authors: Yang J, Seo JY, Lee KW, Park HM PMID: 30375765 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Neurological Manifestations of Myeloneuropathy in Patients with Nitrous Oxide Intoxication.
Authors: Kang SW, Hong JM, Namgung DW, Choi YC PMID: 30375766 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Unhappy End of "Happy Balloons": Subacute Combined Degeneration Caused by Nitrous Oxide Gas.
Unhappy End of "Happy Balloons": Subacute Combined Degeneration Caused by Nitrous Oxide Gas. J Clin Neurol. 2018 Oct 26; Authors: Kwon YJ, Rho JH, Hwang J, Baek SH PMID: 30375767 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 31, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Interarm Blood Pressure Difference is Associated with Early Neurological Deterioration, Poor Short-Term Functional Outcome, and Mortality in Noncardioembolic Stroke Patients.
This study included 1,008 consecutive noncardioembolic cerebral infarction patients who were admitted within 24 hours of onset and had automatic measurements of blood pressures in the bilateral arms. END was assessed within 72 hours of stroke onset according to predefined criteria. A poor functional outcome was defined as a score on the modified Rankin Scale ≥3 at 3 months after the index stroke. All-cause mortality was also investigated during a median follow-up of 24 months. The absolute difference of blood pressure measurements in both arms were used to define IASBD and IADBD. RESULTS: END occurred in 15.3% (155/...
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Insufficient Sleep in Tension-Type Headache: A Population Study.
CONCLUSIONS: Our findings suggest that insufficient sleep is prevalent among subjects with TTH and is linked to an exacerbation of TTH. Therefore, the proper evaluation and management of sleep may lead to the better management of TTH. PMID: 30284768 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Hashimoto Encephalopathy Mimicking Acute Ischemic Stroke: Perfusion-Weighted Magnetic Resonance Imaging.
Authors: Cho BH, Cheon K, Lee KY PMID: 30284769 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Cerebral Large-Vessel Vasculitis in Sjogren's Syndrome: Utility of High-Resolution Magnetic Resonance Vessel Wall Imaging.
Authors: Unnikrishnan G, Hiremath N, Chandrasekharan K, Sreedharan SE, Sylaja PN PMID: 30284770 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

A Novel Nonsense Mutation in Leucine-Rich, Glioma-Inactivated-1 Gene as the Underlying Cause of Familial Temporal Lobe Epilepsy.
Authors: Kanwal S, Yoo DH, Tahir S, Lee SJ, Lee MH, Choi BO, Chung KW PMID: 30284771 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Effect of Levetiracetam Monotherapy on Liver Enzymes and Creatine Kinase Concentrations in Children with Epilepsy: A Prospective Study.
Authors: Attilakos A, Dinopoulos A, Paschalidou M, Tsirouda M, Prasouli A, Siafakas N, Garoufi A PMID: 30284772 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

A Novel Heterozygous ANO3 Mutation with Basal Ganglia Dysfunction in a Patient with Adult-Onset Isolated Segmental Dystonia.
Authors: Yoo HS, Lee H, Chung SJ, Lee JS, Hong SK, Lee PH, Kim YJ, Sohn YH, Shin HW PMID: 30284773 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

The Relationship between Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease and the Rubella Virus.
Authors: Choi SJ, Oh DA, Chun W, Kim SM PMID: 30284774 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Mycotic Cerebral Aneurysms Secondary to Scedosporium Prolificans Infection in a Patient with Multiple Sclerosis.
Authors: Guadalajara MCV, Hernández González A, Carrasco García de León S, Rojo MG, Del Real Francia MÁ PMID: 30284775 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - October 5, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Abnormal Oculomotor Functions in Amyotrophic Lateral Sclerosis.
Authors: Kang BH, Kim JI, Lim YM, Kim KK Abstract BACKGROUND AND PURPOSE: Although traditionally regarded as spared, a range of oculomotor dysfunction has been recognized in amyotrophic lateral sclerosis (ALS) patients. ALS is nowadays considered as a neurodegenerative disorder of a third compartment comprising widespread areas of extra-motor brain including cerebellum. Our objective was to perform an observational study to examine for ocular motor dysfunction in patients with ALS and for any differences between bulbar-onset and spinal-onset patients. METHODS: Thirty two ALS patients (bulbar onset: 10, spinal o...
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Region-Based Analysis of Prevalence and Incidence of Parkinson's Disease: Analysis of the National Sample Cohort in South Korea.
CONCLUSIONS: The standardized prevalence of PD increased steadily from 2003 to 2012 in South Korea, while its standardized incidence has remained constant. There were regional differences in the prevalence and incidence of PD based on the degree of urbanization and the area of agricultural land. PMID: 30198219 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Multimodal Assessment of Neural Substrates in Computerized Cognitive Training: A Preliminary Study.
CONCLUSIONS: The anterior cingulate and anterior insula, which are parts of the salience network, may be substrates for the improvements in cognitive function induced by computerized cognitive training. PMID: 30198220 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Paroxysmal Dyskinesia in Children: from Genes to the Clinic.
CONCLUSIONS: This study has summarized the clinical and genetic heterogeneity of paroxysmal dyskinesia in children. We suggest that pediatric paroxysmal dyskinesia should not be diagnosed using clinical features alone, but by combining them with broader genetic testing. PMID: 30198221 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Consolidation of a Learned Skill Correlates with Dopamine SPECT Uptake in Early Parkinson's Disease.
CONCLUSIONS: This study provides evidence of a correlation between procedural memory impairment and striatal dopaminergic dysfunction in early PD. PMID: 30198222 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

A Novel Homozygous Variant of SETX Causes Ataxia with Oculomotor Apraxia Type 2.
CONCLUSIONS: This report extends the allelic heterogeneity of SETX mutations causing AOA2 and also presents an asymptomatic patient with a pathogenic ATM variant. PMID: 30198223 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Changes in the Multiple Sclerosis Treatment Paradigm. What Do We Do Now and What Were We Doing Before?
CONCLUSIONS: We have identified that the tendency for treatment changes has increased following the arrival of new drugs. Efficacy has been the main cause of these changes. PMID: 30198224 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

The Role of Information Processing Speed in Clinical and Social Support Variables of Patients with Multiple Sclerosis.
Authors: Eizaguirre MB, Vanotti S, Merino Á, Yastremiz C, Silva B, Alonso R, Garcea O Abstract BACKGROUND AND PURPOSE: Information processing speed is one of the most impaired cognitive functions in multiple sclerosis (MS). There are two tests widely used for evaluating information processing speed: the Symbol Digit Modalities Test (SDMT) and the Paced Auditory Serial Addition Test (PASAT). To analyze the relationship between processing speed and the clinical and social support variables of patients with MS. METHODS: A group of 47 patients with relapsing-remitting MS was studied, 31 were women and 16, me...
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Therapeutic Interventions in Adult Low-Grade Gliomas.
Authors: Chammas M, Saadeh F, Maaliki M, Assi H Abstract Treating adult low-grade gliomas (LGGs) is particularly challenging due to the highly infiltrative nature of this type of brain cancer. Although surgery, radiotherapy, and chemotherapy are the mainstay treatment modalities for LGGs, the optimal combination management plan for a particular patient based on individual symptoms and the risk of treatment-induced toxicity remains unclear. This review highlights the competency and limitations of standard treatment options while providing an essential therapeutic update regarding current clinical trials aimed at imp...
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Neuromonitoring for Spinal Cord Stimulation Lead Placement Under General Anesthesia.
Authors: Shils JL, Arle JE Abstract Spinal cord stimulation (SCS) is a common therapeutic technique for treating medically refractory neuropathic back and other limb pain syndromes. SCS has historically been performed using a sedative anesthetic technique where the patient is awakened at various times during a surgical procedure to evaluate the location of the stimulator lead. This technique has potential complications, and thus other methods that allow the use of a general anesthetic have been developed. There are two primary methods for placing leads under general anesthesia, based on 1) compound muscle action po...
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Association between Frontal-Executive Dysfunction and Speech-in-Noise Perception Deficits in Mild Cognitive Impairment.
CONCLUSIONS: Our findings suggest that frontal-executive function is strongly related to speech-in-noise perception and that MCI patients with FED have greater deficits in speech-in-noise perception compared to other subgroups of MCI. PMID: 30198228 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Factors Associated with Cheyne-Stokes Respiration in Acute Ischemic Stroke.
CONCLUSIONS: CSR frequently occurs in strokes involving large arteries or due to cardioembolism, regardless of the location and severity of the stroke. Predisposing conditions such as preexisting neurologic disability, low LVEF, and LA enlargement are associated with CSR in acute stroke. PMID: 30198229 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Muscle Thickness and Echo Intensity of the Abdominal and Lower Extremity Muscles in Stroke Survivors.
CONCLUSIONS: Our results indicate that quantitative and qualitative changes on the paretic side in stroke survivors were the most robust in the thigh muscles, whereas such changes might not occur in the abdominal muscles. PMID: 30198230 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Effects of Antiepileptic Drugs on Language Abilities in Benign Epilepsy of Childhood with Centrotemporal Spikes.
This study is to assess the responsiveness of electroencephalography (EEG) abnormalities and their effects on language ability after initiating different types of antiepileptic therapy in children with newly diagnosed benign epilepsy of childhood with centrotemporal spikes (BECTS). METHODS: The records of patients newly diagnosed with BECTS (n=120; 69 males) were reviewed retrospectively. The patients were randomly treated with lamotrigine, oxcarbazepine, or topiramate monotherapy, and underwent at least two EEG and standardized language tests. Effects were compared using Pearson's chi-square tests and paired t-tests. ...
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Characteristics of South Korean Patients with Hereditary Transthyretin Amyloidosis.
CONCLUSIONS: South Korean patients with hereditary TTR amyloidosis exhibited heterogeneous TTR genotypes and clinical phenotypes. The findings of this study suggest that the distribution of TTR amyloidosis in South Korea is due to de novo mutations and/or related to the other countries in East Asia. PMID: 30198232 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Predictors of Excessive Daytime Sleepiness in Patients with Parkinson's Disease.
CONCLUSIONS: Nighttime sleep problems, older age, and levodopa use are significantly associated with EDS in PD. A careful assessment and the management of sleep problems in PD patients might help to improve their quality of life. PMID: 30198233 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Determining the Etiology of Internuclear Ophthalmoplegia in a Patient with a Cardiac Pacemaker and Complex Neurological Presentation.
Authors: Nourbakhsh B, Cordano C, Renthal W PMID: 30198234 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Safe Childbirth after Taking Teriflunomide in a Woman with Multiple Sclerosis.
Authors: Cho BH, Lee SH PMID: 30198235 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

GNE Myopathy with Prominent Axial Muscle Involvement.
Authors: Park JM, Shin JH, Park JS PMID: 30198236 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Giant Cell Arteritis Associated Arteritic Anterior Ischemic Optic Neuropathy: Sudden Vision Loss on the Contralateral Side of Headache.
Authors: Lee EJ, Woo KA, Koo DL PMID: 30198237 [PubMed - as supplied by publisher] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - September 11, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Age-Specific Cutoff Scores on a T1-Weighted Axial Medial Temporal-Lobe Atrophy Visual Rating Scale in Alzheimer's Disease Using Clinical Research Center for Dementia of South Korea Data.
This study aimed to determine the optimal cutoff score on a T1-weighted axial MTA Visual Rating Scale (VRS) for differentiating patients with AD from cognitively normal elderly people. METHODS: The 3,430 recruited subjects comprising 1,427 with no cognitive impairment (NC) and 2003 AD patients were divided into age ranges of 50-59, 60-69, 70-79, and 80-89 years. Of these, 446 participants (218 in the NC group and 228 in the AD group) were chosen by random sampling for inclusion in this study. Each decade age group included 57 individuals, with the exception of 47 subjects being included in the 80- to 89-year NC group. ...
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Adverse Events During Perampanel Adjunctive Therapy in Intractable Epilepsy.
CONCLUSIONS: Slow titration of perampanel may reduce perampanel-related adverse events. PMID: 29971974 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Presentations and Phenotypic Spectrum of Multiple Sclerosis at a University Hospital in Saudi Arabia.
CONCLUSIONS: MS presenting in the hospital setting is more common in KSA than reported previously, and the number of diagnosed cases in increasing. It is therefore an emerging and disabling neurological illness in KSA with clinical characteristics not dissimilar to those in other middle eastern countries. A decrease in the frequency of patients with secondary progressive multiple sclerosis (SPMS) indicates either that more new cases of RRMS are being diagnosed or that adequate treatments of RRMS are preventing the evolution to SPMS. Further larger and population-wide epidemiological and clinical studies with the long-term ...
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Effect of Vitamin D Deficiency on the Frequency of Headaches in Migraine.
Authors: Song TJ, Chu MK, Sohn JH, Ahn HY, Lee SH, Cho SJ Abstract BACKGROUND AND PURPOSE: The risk of vitamin D deficiency varies with the season. The frequency of vitamin D deficiency in migraine patients and its association with migraine are unclear. METHODS: We retrospectively evaluated first-visit migraine patients between January 2016 and May 2017, and investigated the demographics, season, migraine subtypes, frequency, severity, and impact of migraine, psychological and sleep variables, climate factors, and vitamin D levels. The nonfasting serum 25-hydroxyvitamin D concentration was measured to determine...
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

The Etiologies of Chronic Progressive Cerebellar Ataxia in a Korean Population.
CONCLUSIONS: This is the largest epidemiological study to analyze the frequencies of various cerebellar ataxias in a Korean population based on the large database of a tertiary hospital movement-disorders clinic in South Korea. These data would be helpful for clinicians in constructing diagnostic strategies and counseling for patients with cerebellar ataxias. PMID: 29971977 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Hand Tremor Questionnaire: A Useful Screening Tool for Differentiating Patients with Hand Tremor between Parkinson's Disease and Essential Tremor.
CONCLUSIONS: The developed Hand Tremor Questionnaire might be a good screening tool for hand tremors in patients with PD and ET. PMID: 29971978 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Application of 2017 McDonald Diagnostic Criteria for Multiple Sclerosis.
CONCLUSIONS: The new 2017 Multiple Sclerosis criteria may have an important impact in clinical practice with an earlier treatment to avoid the risk of disease dissemination. Their application requires a careful assessment to avoid misdiagnosis and mistreatments. PMID: 29971979 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Postoperative Transient Neurologic Dysfunction: A Proposal for Pathophysiology.
CONCLUSIONS: Transient neurologic dysfunction can occur during the postoperative period of brain surgery. Although this may last more than usual transient ischemic attack or seizure, it eventually resolves regardless of treatment. Based on our observation, we propose that this is the manifestation of the transient cortical depression triggered by mechanical stimulation, analogous to migraine aura associated with cortical spreading depression. PMID: 29971980 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Clinical Heterogeneity of Anti-GM2-Ganglioside-Antibody Syndrome.
CONCLUSIONS: This study has identified that anti-GM2 antibody can be found in various subtypes of GBS and its variants in rare cases. Compared to the clinical heterogeneity of the IgM-positive group, the IgG-positive group can be characterized by cranial-dominant GBS variants presenting mainly with oculomotor and vestibular dysfunctions. PMID: 29971981 [PubMed] (Source: Journal of Clinical Neurology)
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research

Mechanical Thrombectomy in Strokes with Large-Vessel Occlusion Beyond 6 Hours: A Pooled Analysis of Randomized Trials.
This study performed a pooled analysis of data from trials in which mechanical thrombectomy was performed beyond 6 hours from symptom onset. METHODS: We searched for randomized controlled trials that compared mechanical thrombectomy with the best medical treatment beyond 6 hours for ischemic strokes due to ELVO and reported on between 1990 and April 2018. The intervention group comprised patients treated with mechanical thrombectomy. Statistical analysis was conducted while pooling data and analyzing fixed- or random-effects models as appropriate. RESULTS: Four trials involving 518 stroke patients met the eligibili...
Source: Journal of Clinical Neurology - July 6, 2018 Category: Neurology Tags: J Clin Neurol Source Type: research