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Cancer: Glioma
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Total 252 results found since Jan 2013.
Neurological Adverse Effects Associated With Anti-tumor Necrosis Factor Alpha Antibodies in Pediatric Inflammatory Bowel Diseases
Conclusions:
NAE associated with anti-TNFα antibodies in pediatric IBD are rare. In severe NAE, we recommend to discontinue anti-TNFα therapy and to consider alternative treatment.
Source: Journal of Pediatric Gastroenterology and Nutrition - May 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
A glioma presenting as a posterior circulation stroke.
PMID: 32329427 [PubMed - as supplied by publisher]
Source: The Canadian Journal of Neurological Sciences - April 23, 2020 Category: Neurology Authors: Lu F, Fowler A, Tam K, Camara-Lemarroy CR Tags: Can J Neurol Sci Source Type: research
The impact of high functional connectivity network hub resection on language task performance in adult low- and high-grade glioma.
CONCLUSIONS: Imaginary coherence measures of functional connectivity using MEG are able to identify HFC network sites within and around low- and high-grade gliomas. Removal of IES-negative HFC sites results in early transient postoperative decline in AN and SYN, which resolved by 3 months in all patients without stroke or early tumor progression. Measures of functional connectivity may therefore be a useful means of counseling patients about postoperative risk and assist with preoperative surgical planning.
PMID: 32244221 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - April 2, 2020 Category: Neurosurgery Authors: Lee AT, Faltermeier C, Morshed RA, Young JS, Kakaizada S, Valdivia C, Findlay AM, Tarapore PE, Nagarajan SS, Hervey-Jumper SL, Berger MS Tags: J Neurosurg Source Type: research
The pivotal role of micro-environmental cells in a human blood –brain barrier in vitro model of cerebral ischemia: functional and transcriptomic analysis
ConclusionsThe co-cultivation with micro-environmental cells is necessary to achieve a functional breakdown of the BBB in the cerebral ischemia model within an in vivo relevant time window. Comprehensive studies by qPCR revealed that distinct expression clusters of barrier markers exist and that these are regulated by different treatments (even by growth medium change) indicating that controls for single cell culture manipulation steps are crucial to understand the observed effects properly.
Source: Fluids and Barriers of the CNS - March 4, 2020 Category: Neuroscience Source Type: research
MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF- κB Signaling Pathway.
MiR-1202 Exerts Neuroprotective Effects on OGD/R Induced Inflammation in HM Cell by Negatively Regulating Rab1a Involved in TLR4/NF-κB Signaling Pathway.
Neurochem Res. 2020 Mar 02;:
Authors: Song S, Pan Y, Li H, Zhen H
Abstract
Recent studies have shown that the level of miR-1202 in peripheral blood is closely related to brain activity and cognitive function in patients with depression, and it is involved in glioma pathological progress. However, the correlation between miR-1202 and neuroinflammation has not been reported. The expressions of miR-1202 and small GTP-ase Rab1a at mRNA level were detect...
Source: Neurochemical Research - March 1, 2020 Category: Neuroscience Authors: Song S, Pan Y, Li H, Zhen H Tags: Neurochem Res Source Type: research
Social Cognition and White Matter: Connectivity and Cooperation
Humans are highly social animals whose survival and well-being depend on their capacity to cooperate in complex social settings. Advances in anthropology and psychology have demonstrated the importance of cooperation for enhancing social cohesion and minimizing conflict. The understanding of social behavior is informed by the notion of social cognition, a set of mental operations including emotion perception, mentalizing, and empathy. The social brain hypothesis posits that the mammalian brain has enlarged over evolution to meet the challenges of social life, culminating in a large human brain well adapted for social cogni...
Source: Cognitive and Behavioral Neurology - March 1, 2020 Category: Neurology Tags: Analysis Source Type: research
Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats.
Authors: Oshita J, Okazaki T, Mitsuhara T, Imura T, Nakagawa K, Otsuka T, Kurose T, Tamura T, Abiko M, Takeda M, Kawahara Y, Yuge L, Kurisu K
Abstract
We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with human iliac bone-derived mesenchymal stem cells (hiMSCs). The expressions of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF ) as neurotrophic factors were analyzed in both MSCs. hiMSCs or hcMSCs were intravenously administered into ischemic st...
Source: Neurologia Medico-Chirurgica - January 22, 2020 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research
New Mom With Brain Tumor Turns To Boston Hospital For Keyhole Brain Surgery
BOSTON (CBS) — Imagine giving birth to a premature baby and then being told you have a brain tumor. That’s what happened to a woman from Holden. But thanks to a new approach at Brigham and Women’s Hospital, this new mom was able to have brain surgery and quickly return to her newborn son.
At 27 weeks pregnant, Bethany Shea was diagnosed with preeclampsia and had an emergency C-section. Then she went blind.
“It was a pregnancy complication due to my high blood pressure,” Bethany explained.
Bethany regained her vision, but worried she had had a stroke, doctors ordered an MRI. But instead of a stroke, it reveale...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 30, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Boston News Health Healthwatch Seen On WBZ-TV Syndicated CBSN Boston Syndicated Local Brigham and Women's Hospital Dr. Mallika Marshall Source Type: news
Incidence and impact of stroke following surgery for low-grade gliomas.
CONCLUSIONS: Recurrent surgeries and insular tumor locations are risk factors for intraoperative strokes. Although they do not affect survival, these strokes negatively affect patient activity and performance status, mainly during the first 3 postoperative months, with gradual functional improvement over 1 year. Several intraoperative parameters may suggest the impending development of an infarct.
PMID: 31881532 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - December 26, 2019 Category: Neurosurgery Authors: Berger A, Tzarfati G, Costa M, Serafimova M, Korn A, Vendrov I, Alfasi T, Krill D, Aviram D, Ben Moshe S, Kashanian A, Ram Z, Grossman R Tags: J Neurosurg Source Type: research
Astrocyte-specific NDRG2 gene: functions in the brain and neurological diseases.
Abstract
In recent years, the roles of astrocytes of the central nervous system in brain function and neurological disease have drawn increasing attention. As a member of the N-myc downstream-regulated gene (NDRG) family, NDRG2 is principally expressed in astrocytes of the central nervous system. NDRG2, which is involved in cell proliferation and differentiation, is commonly regarded as a tumor suppressor. In astrocytes, NDRG2 affects the regulation of apoptosis, astrogliosis, blood-brain barrier integrity, and glutamate clearance. Several preclinical studies have revealed that NDRG2 is implicated in the pathogene...
Source: Cellular and Molecular Life Sciences : CMLS - December 12, 2019 Category: Cytology Authors: Li X, Wu X, Luo P, Xiong L Tags: Cell Mol Life Sci Source Type: research
Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation
AbstractBrain adenosine concentrations can reach micromolar concentrations in stressful situations such as stroke, neurodegenerative diseases or hypoxic regions of brain tumours. Adenosine can act by receptor ‐independent mechanism by reversing the reaction catalysed by S‐adenosylhomocysteine (SAH) hydrolase, leading to SAH accumulation and inhibition of S‐adenosylmethionine (SAM)‐dependent methyltransferases. Astrocytes are essential in maintaining brain homeostasis but their pathological activa tion and uncontrolled proliferation plays a role in neurodegeneration and glioma. Adenosine can affect cell proliferatio...
Source: Journal of Neurochemistry - December 6, 2019 Category: Neuroscience Authors: Helena Marcelino,
Vanda C. Nogueira,
Cec ília R.A. Santos,
Patrícia Quelhas,
Tiago M.A. Carvalho,
João Fonseca‐Gomes,
Joana Tomás,
Maria J. Diógenes,
Ana M. Sebastião,
José F. Cascalheira Tags: ORIGINAL ARTICLE Source Type: research
Predictors of Class I epilepsy surgery outcome in tumour-related chronic temporal lobe epilepsy in adults.
CONCLUSION: The most appropriate management of tumour-related chronic temporal lobe epilepsy in adults appears to be tai-lored temporal lobe resection including tumour and hippocampal complex removal. Surgical treatment of tumoural temporal lobe epilepsy demonstrates excellent results in terms of seizure improvement, especially in patients with glioneuronal tumours.
PMID: 31793658 [PubMed - as supplied by publisher]
Source: Neurologia i Neurochirurgia Polska - December 2, 2019 Category: Neurology Authors: Nowak A, Rysz A, Dziedzic T, Czernicki T, Kunert P, Maj E, Marchel A Tags: Neurol Neurochir Pol Source Type: research
Active targeting towards and inside the brain based on nanoparticles: A Review.
Abstract
Treatment of neurological diseases using systemic and non-surgical techniques presents a significant challenge in medicine. This challenge is chiefly associated with the condensation and coherence of the brain tissue. The coherence structure of the brain is due to the presence of the blood brain barrier (BBB), which consists of a continuous layer of capillary endothelial cells. The BBB prevents most drugs from entering the brain tissue and is highly selective, permitting only metabolic substances and nutrients to pass through. Although this challenge has caused difficulties for the treatment of neurologic...
Source: Current Pharmaceutical Biotechnology - December 1, 2019 Category: Biotechnology Authors: Rabiei M, Kashanian S, Samavati SS, Jamasb S, McInnes SJP Tags: Curr Pharm Biotechnol Source Type: research
Multicentric Registry Study on Epidemiological and Biological Disease Profile as Well as Clinical Outcome in Patients with Low-Grade Gliomas: The LoG-Glio Project
Conclusion The LoG-Glio registry has been successfully implemented. Applied selection criteria result in an appropriately balanced patient cohort. Short-term outcome data on epidemiology as well as the influence of current surgical techniques and adjuvant treatment on patient outcomes are expected. In the long run, the aim of the registry is to validate the new molecular-based WHO classification and the influence of the extent of resection on progression-free survival and OS. The registry provides an open platform for future research projects benefiting patients with LGG.
Trial registration NCT02686229 Clinical tria...
Source: Journal of Neurological Surgery Part A: Central European Neurosurgery - September 23, 2019 Category: Neurosurgery Authors: Pala, Andrej Nadji-Ohl, Minou Faust, Katharina R ückriegel, Stefan Roder, Constantin von der Brelie, Christian Forster, Marie-Therese L öbel, Franziska Schommer, Stefan L öhr, Mario Gr übel, Nadja Rothenbacher, Dietrich K önig, Ralph Engelke, Jens Sc Tags: Original Article Source Type: research
Intractable Central Pain in a Patient With Diffuse Glioma
Central neuropathic pain can be difficult to treat and, subsequently, cause a great amount of disability and distress to patients, which limits quality of life. Common etiologies include the following: stroke, spinal cord injury, multiple sclerosis, infection, vasculitis, and malignancy. This case is a description of an 18-yr-old male patient diagnosed with a grade IV diffuse glioma who experienced severe neuropathic pain refractory to first-line treatment options including the following: gabapentinoids, tricyclic antidepressants, and selective serotonin and norepinephrine reuptake inhibitors. The patient remained on high-...
Source: American Journal of Physical Medicine and Rehabilitation - August 17, 2019 Category: Rehabilitation Tags: Case Report Source Type: research
