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Cancer: Glioma

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Total 252 results found since Jan 2013.

Colchicine in Neurosurgery.
CONCLUSION: Colchicine is a drug that over the years has shown promising results in certain neurosurgical entities. Its derivatives or potential colchicine-like agents might have a more significant place in neurosurgical practice. PMID: 29336254 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - January 14, 2018 Category: Drugs & Pharmacology Authors: Evangelos D, Dimitrios G, Marios TS Tags: Curr Pharm Des Source Type: research

Direct saturation-corrected chemical exchange saturation transfer MRI of glioma: Simplified decoupling of amide proton transfer and nuclear overhauser effect contrasts.
CONCLUSION: The proposed DISC-CEST method, by correction of nonlinear direct water saturation effect, serves as a promising alternative to both the commonly used MTRasym and the simplistic three-offset analyses. It provides simple yet reliable in vivo CEST quantification such as APT and NOE mapping in brain tumor, which is promising for clinical translation. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine. PMID: 29030880 [PubMed - as supplied by publisher]
Source: Magnetic Resonance in Medicine - October 13, 2017 Category: Radiology Authors: Yuwen Zhou I, Wang E, Cheung JS, Lu D, Ji Y, Zhang X, Fulci G, Sun PZ Tags: Magn Reson Med Source Type: research

Targeting nitric oxide and NMDA receptor-associated pathways in treatment of high grade glial tumors. Hypotheses for nitro-memantine and nitrones
Publication date: Available online 13 October 2017 Source:Nitric Oxide Author(s): Meric A. Altinoz, İlhan Elmaci Glioblastoma multiforme (GBM) is a devastating brain cancer with no curative treatment. Targeting Nitric Oxide (NO) and glutamatergic pathways may help as adjunctive treatments in GBM. NO at low doses promotes tumorigenesis, while at higher levels (above 300 nM) triggers apoptosis. Gliomas actively secrete high amounts of glutamate which activates EGR signaling and mediates degradation of peritumoral tissues via excitotoxic injury. Memantine inhibits NMDA-subtype of glutamate receptors (NMDARs) and induces au...
Source: Nitric Oxide - October 13, 2017 Category: Chemistry Source Type: research

Direct saturation ‐corrected chemical exchange saturation transfer MRI of glioma: Simplified decoupling of amide proton transfer and nuclear overhauser effect contrasts
ConclusionThe proposed DISC‐CEST method, by correction of nonlinear direct water saturation effect, serves as a promising alternative to both the commonly used MTRasym and the simplistic three‐offset analyses. It provides simple yet reliable in vivo CEST quantification such as APT and NOE mapping in brain tumor, which is promising for clinical translation. Magn Reson Med, 2017. © 2017 International Society for Magnetic Resonance in Medicine.
Source: Magnetic Resonance in Medicine - October 13, 2017 Category: Radiology Authors: Iris Yuwen Zhou, Enfeng Wang, Jerry S. Cheung, Dongshuang Lu, Yang Ji, Xiaoan Zhang, Giulia Fulci, Phillip Zhe Sun Tags: Rapid Communication Source Type: research

Researchers hit the brakes on lethal brain cancers in mice
(NIH/National Institute of Neurological Disorders and Stroke) New research conducted in mice provides evidence that highly lethal brain tumors, called high-grade gliomas, stop growing when deprived of a specific molecule naturally produced when brain cells fire. The experiments, led by a group of scientists from Stanford University, Palo Alto, California, suggest that targeting a protein called neuroligin-3 may prove beneficial in patients with these diseases.
Source: EurekAlert! - Cancer - September 20, 2017 Category: Cancer & Oncology Source Type: news

Predicting the higher rate of intracranial hemorrhage in glioma patients receiving therapeutic enoxaparin
Venous thromboembolism occurs in up to one-third of patients with primary brain tumors. Spontaneous intracranial hemorrhage (ICH) is also a frequent occurrence in these patients, but there is limited data on the safety of therapeutic anticoagulation. To determine the rate of ICH in patients treated with enoxaparin, we performed a matched, retrospective cohort study with blinded radiology review for 133 patients with high-grade glioma. After diagnosis of glioma, the cohort that received enoxaparin was 3 times more likely to develop a major ICH than those not treated with anticoagulation (14.7% vs 2.5%; P = .036; hazard rati...
Source: Blood - June 22, 2017 Category: Hematology Authors: Mantia, C., Uhlmann, E. J., Puligandla, M., Weber, G. M., Neuberg, D., Zwicker, J. I. Tags: Free Research Articles, Thrombosis and Hemostasis, Clinical Trials and Observations Source Type: research

Dacrystic seizures--a cry for help
A 69-year-old man with a history of myocardial infarction presented with crying-like spells. MRI demonstrated abnormal signal in the left mesiotemporal lobe, and he was diagnosed with stroke. Over the following 1 year, he developed progressive cognitive decline, slow gait, masked facies, hypophonic voice, and brief facial and upper extremity spasms (8 per hour) often followed by brief crying spells lacking emotion. Spell semiology was consistent with faciobrachial dystonic seizures1 and dacrystic seizures2 (video at Neurology.org/nn). Leucine-rich glioma-inactivated-1 (LGI1) autoantibodies, detected in serum, led to a diag...
Source: Neurology Neuroimmunology and Neuroinflammation - June 16, 2017 Category: Neurology Authors: Gadoth, A., Singh, J., Britton, J. W., Flanagan, E. P., Pittock, S. J. Tags: All Epilepsy/Seizures Clinical/Scientific Notes Source Type: research

Dacrystic seizures: A cry for help
A 69-year-old man with a history of myocardial infarction presented with crying-like spells. MRI demonstrated abnormal signal in the left mesiotemporal lobe, and he was diagnosed with stroke. Over the following 1 year, he developed progressive cognitive decline, slow gait, masked facies, hypophonic voice, and brief facial and upper extremity spasms (8 per hour) often followed by brief crying spells lacking emotion. Spell semiology was consistent with faciobrachial dystonic seizures1 and dacrystic seizures2 (video at Neurology.org/nn). Leucine-rich glioma-inactivated-1 (LGI1) autoantibodies, detected in serum, led to a diag...
Source: Neurology Neuroimmunology and Neuroinflammation - June 16, 2017 Category: Neurology Authors: Gadoth, A., Singh, J., Britton, J. W., Flanagan, E. P., Pittock, S. J. Tags: All Epilepsy/Seizures Clinical/Scientific Notes Source Type: research

Keeping up with Amanda: Life after brain surgery
In most ways, Amanda LePage is just like any other rambunctious fourth grader. She loves school, dance class, playing basketball and keeping up with her twin sister Macy and older brother Nathan. Sometimes it just takes her a little longer to do these everyday things. That’s because Amanda has been through a lot in her short nine years. Amanda was just 5 months old when she was brought by helicopter to Boston Children’s Hospital for a hemorrhage in her brain from an intracranial aneurysm, a type of vascular malformation. Despite long odds, Amanda survived two life-saving brain surgeries and a massive stroke that left ...
Source: Thrive, Children's Hospital Boston - May 22, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Our Patients’ Stories brain aneurysm Dr. Caroline Robson Dr. Craig McClain Dr. Edward Smith Dr. Peter Manley Hydrocephalus low-grade glioma pediatric stroke Source Type: news

Therapeutic dormancy to delay postsurgical glioma recurrence: the past, present and promise of focal hypothermia
AbstractSurgery precedes both radiotherapy and chemotherapy as the first-line therapy for glioma. However, despite multimodal treatment, most glioma patients die from local recurrence in the resection margin. Glioma surgery is inherently lesional, and the response of brain tissue to surgery includes hemostasis, angiogenesis, reactive gliosis and inflammation. Unfortunately, these processes are also associated with tumorigenic side-effects. An increasing amount of evidence indicates that the response to a surgery-related brain injury is hijacked by residual glioma cells and participates in the local regeneration of tumor ti...
Source: Journal of Neuro-Oncology - May 17, 2017 Category: Cancer & Oncology Source Type: research

Recurrent Stroke after Silent Brain Infarction in Patients with Primary Brain Tumors (S51.007)
Conclusions:The short-term risk of recurrent ischemic stroke in patients with PBTs was substantial and the risk was comparable whether the stroke was silent or symptomatic.Study Supported by: Babak Navi was supported by grants from the NINDS (K23NS091395) and the Florence Gould Endowment for Discovery in Stroke. Hooman Kamel was supported by grants from the NINDS (K23NS082367) and the Michael Goldberg Stroke Research Fund.Disclosure: Dr. Parikh has nothing to disclose. Dr. Burch has nothing to disclose. Dr. Kamel has received personal compensation for activities with Genentech as a speaker. Dr. Kamel has received personal ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Parikh, N., Burch, J., Kamel, H., DeAngelis, L., Navi, B. Tags: Cerebrovascular Disease and Interventional Neurology: Stroke Prevention and Translation Source Type: research

Stroke-like migraine attacks in long term survivors of high grade glioma. (P1.174)
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: New, P., Mirza, H. Tags: Neuro-oncology: Gliomas I Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Central positional vertigo (P6.045)
Conclusions:Migraine may be a benign cause of CPV, however, a broad spectrum of diseases including tumors, stroke, infections and neurodegenerative disorders may be responsible. Earlier detection of posterior fossa lesions is critical to improve the outcome. Moreover, central positional vertigo/nystagmus could be the very first manifestation of the underlying disease.Central positional nystagmus is often an unrecognized entity. In this series, 3 patients had isolated positional DBN and truncal ataxia as the initial neurologic abnormality, one of them with a CNS neoplasm. Diagnostic clues for central localization are: prese...
Source: Neurology - April 17, 2017 Category: Neurology Authors: De Schutter, D., Kattah, J. Tags: Neuro-opthalmology/Neuro-otology II Source Type: research

The Application of Nanomaterials in Stem Cell Therapy for some Neurological Diseases.
Abstract Stem cell therapy provides great promising therapeutic benefits for various neurological disorders. Cell transplantation has emerged as cell replacement application for nerve damage. Recently, nanomaterials obtain wide development in various industrial and medical fields, and nanoparticles have been applied to neuro-medical field for tracking and treating nervous system diseases. Combining stem cell with nanotechnology has raised more and more attentions; and it has demonstrated that it has huge effects on clinical diagnosis and therapeutics in multiple central nervous system diseases, meanwhile, improvin...
Source: Current Drug Targets - March 28, 2017 Category: Drugs & Pharmacology Authors: Zhang G, Khan AA, Wu H, Chen L, Gu Y, Gu N Tags: Curr Drug Targets Source Type: research