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Cancer: Glioma

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Total 252 results found since Jan 2013.

Arterial Spin Labeling Imaging Characteristics of Anti-leucine-rich Glioma-Inactivated 1 Encephalitis: A Qualitative and Quantitative Analysis
DiscussionIn this preliminary study of six patients, we demonstrate an ASL hyperperfusion pattern, with a possible predilection for the right mesial temporal lobe on both qualitative and quantitative assessments in patients with seropositive LGI1. Larger scale studies are necessary to further characterize the strength of these associations.
Source: Frontiers in Neurology - July 28, 2022 Category: Neurology Source Type: research

< mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" > < mml:mrow > < mml:msubsup > < mml:mi > T < /mml:mi > < mml:mn > 2 < /mml:mn > < mml:mo > ' < /mml:mo > < /mml:msubsup > < /mml:mrow > < /mml:math > mapping of the brain from water-unsuppressed < sup > 1 < /sup > H-MRSI  and turbo spin-echo data
CONCLUSIONS: High-quality T 2 ' $$ {\mathrm{T}}_2^{\prime } $$ maps can be obtained from water-unsuppressed 1 H-MRSI and TSE data using the proposed method. With further development, this method may lay a foundation for simultaneously imaging oxygenation and neurometabolic alterations of brain disorders.PMID:35844075 | DOI:10.1002/mrm.29386
Source: Magnetic Resonance in Medicine - July 18, 2022 Category: Radiology Authors: Tianxiao Zhang Rong Guo Yudu Li Yibo Zhao Yao Li Zhi-Pei Liang Source Type: research

Awake Mapping With Transopercular Approach in Right Insular–Centered Low-Grade Gliomas Improves Neurological Outcomes and Return to Work
CONCLUSION: This is the first study comparing asleep vs awake surgery for right insula–centered LGG. Despite similar extent of resection, functional outcomes were significantly better in awake patients by avoiding permanent neurological impairment and by increasing RTW. These results support the mapping of higher-order functions during awake procedure.
Source: Neurosurgery - June 22, 2022 Category: Neurosurgery Tags: Research—Human—Clinical Studies: Tumor Source Type: research

The Effect of Right Temporal Lobe Gliomas on Left and Right Hemisphere Neural Processing During Speech Perception and Production Tasks
Using fMRI, we investigated how right temporal lobe gliomas affecting the posterior superior temporal sulcus alter neural processing observed during speech perception and production tasks. Behavioural language testing showed that three pre-operative neurosurgical patients with grade 2, grade 3 or grade 4 tumours had the same pattern of mild language impairment in the domains of object naming and written word comprehension. When matching heard words for semantic relatedness (a speech perception task), these patients showed under-activation in the tumour infiltrated right superior temporal lobe compared to 61 neurotypical pa...
Source: Frontiers in Human Neuroscience - May 16, 2022 Category: Neuroscience Source Type: research

Assessment of structural disconnections in gliomas: comparison of indirect and direct approaches
Brain Struct Funct. 2022 May 3. doi: 10.1007/s00429-022-02494-x. Online ahead of print.ABSTRACTGliomas are amongst the most common primary brain tumours in adults and are often associated with poor prognosis. Understanding the extent of white matter (WM) which is affected outside the tumoral lesion may be of paramount importance to explain cognitive deficits and the clinical progression of the disease. To this end, we explored both direct (i.e., tractography based) and indirect (i.e., atlas-based) approaches to quantifying WM structural disconnections in a cohort of 44 high- and low-grade glioma patients. While these metho...
Source: Brain Structure and Function - May 3, 2022 Category: Neuroscience Authors: Erica Silvestri Umberto Villani Manuela Moretto Maria Colpo Alessandro Salvalaggio Mariagiulia Anglani Marco Castellaro Silvia Facchini Elena Monai Domenico D'Avella Alessandro Della Puppa Diego Cecchin Maurizio Corbetta Alessandra Bertoldo Source Type: research

Long Non Coding RNA Based Regulation of Cerebrovascular Endothelium
The rapid and high throughput discovery of long non coding RNAs (lncRNAs) has far outstripped the functional annotation of these novel transcripts in their respective cellular contexts. The cells of the blood brain barrier (BBB), especially the cerebrovascular endothelial cells (CVECs), are strictly regulated to maintain a controlled state of homeostasis for undisrupted brain function. Several key pathways are understood in CVEC function that lead to the development and maintenance of their barrier properties, the dysregulation of which leads to BBB breakdown and neuronal injury. Endothelial lncRNAs have been discovered an...
Source: Frontiers in Genetics - April 13, 2022 Category: Genetics & Stem Cells Source Type: research

Eloquent Lower Grade Gliomas, a Highly Vulnerable Cohort: Assessment of Patients ’ Functional Outcome After Surgery Based on the LoG-Glio Registry
Majority of lower grade glioma (LGG) are located eloquently rendering surgical resection challenging. Aim of our study was to assess rate of permanent deficits and its predisposing risk factors. We retrieved 83 patients harboring an eloquently located LGGs from the prospective LoG-Glio Database. Patients without surgery or incomplete postoperative data were excluded. Sign rank test, explorative correlations by Spearman ρ and multivariable regression for new postoperative deficits were calculated. Eloquent region involved predominantly motor (45%) and language (40%). At first follow up after 3 months permanent neuro-logica...
Source: Frontiers in Oncology - March 3, 2022 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 14, Pages 1207: Intercellular Communication in the Brain through Tunneling Nanotubes
Vignais Intercellular communication is essential for tissue homeostasis and function. Understanding how cells interact with each other is paramount, as crosstalk between cells is often dysregulated in diseases and can contribute to their progression. Cells communicate with each other through several modalities, including paracrine secretion and specialized structures ensuring physical contact between them. Among these intercellular specialized structures, tunneling nanotubes (TNTs) are now recognized as a means of cell-to-cell communication through the exchange of cellular cargo, controlled by a variety of biological t...
Source: Cancers - February 25, 2022 Category: Cancer & Oncology Authors: Khattar E. Khattar Janice Safi Anne-Marie Rodriguez Marie-Luce Vignais Tags: Review Source Type: research

Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma
CONCLUSION: Prolonged ASE can induce verbal and memory deficits. Early intervention with intravenous anesthetics is required to obtain a favorable neurological prognosis.PMID:34992930 | PMC:PMC8720448 | DOI:10.25259/SNI_1120_2021
Source: Surgical Neurology International - January 7, 2022 Category: Neurosurgery Authors: Misaki Kamogawa Naoki Ikegaya Yohei Miyake Takahiro Hayashi Hidetoshi Murata Kensuke Tateishi Tetsuya Yamamoto Source Type: research