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Cancer: Glioma

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Total 252 results found since Jan 2013.

Verbal and memory deficits caused by aphasic status epilepticus after resection of a left temporal lobe glioma
CONCLUSION: Prolonged ASE can induce verbal and memory deficits. Early intervention with intravenous anesthetics is required to obtain a favorable neurological prognosis.PMID:34992930 | PMC:PMC8720448 | DOI:10.25259/SNI_1120_2021
Source: Surgical Neurology International - January 7, 2022 Category: Neurosurgery Authors: Misaki Kamogawa Naoki Ikegaya Yohei Miyake Takahiro Hayashi Hidetoshi Murata Kensuke Tateishi Tetsuya Yamamoto Source Type: research

'Moderate global aphasia': A generalized decline of language processing caused by glioma surgery but not stroke
Brain Lang. 2021 Dec 6;224:105057. doi: 10.1016/j.bandl.2021.105057. Online ahead of print.ABSTRACTUnlike stroke, neurosurgical removal of left-hemisphere gliomas acts upon a reorganized language network and involves brain areas rarely damaged by stroke. We addressed whether this causes the profiles of neurosurgery- and stroke-induced language impairments to be distinct. K-means clustering of language assessment data (neurosurgery cohort: N = 88, stroke cohort: N = 95) identified similar profiles in both cohorts. But critically, a cluster of individuals with specific phonological deficits was only evident in the stroke but...
Source: Brain and Language - December 9, 2021 Category: Neurology Authors: Andrey Zyryanov Ekaterina Stupina Elizaveta Gordeyeva Olga Buivolova Evdokiia Novozhilova Yulia Akinina Oleg Bronov Natalia Gronskaya Galina Gunenko Ekaterina Iskra Elena Ivanova Anton Kalinovskiy Evgenii Kliuev Dmitry Kopachev Elena Kremneva Oksana Kryuc Source Type: research

Orexin-A alleviates astrocytic apoptosis and inflammation via Inhibiting OX1R-mediated NF- κB and MAPK signaling pathways in cerebral ischemia/reperfusion injury
Biochim Biophys Acta Mol Basis Dis. 2021 Aug 3:166230. doi: 10.1016/j.bbadis.2021.166230. Online ahead of print.ABSTRACTOrexin-A (OXA) is a neuropeptide with neuroprotective effect by reducing cerebral ischemia/reperfusion injury (CIRI). Inflammation and apoptosis mediated by astrocyte activation are the key pathological mechanisms for CIRI. We thus attempted to confirm neuroprotective effects of OXA on astrocytic inflammation and apoptosis in CIRI and clarify the relative mechanisms. A middle cerebral artery occlusion and reperfusion (MCAO/R) rat model and U251 glioma cells model subjected to oxygen glucose deprivation an...
Source: Biochimica et Biophysica Acta - August 6, 2021 Category: Biochemistry Authors: Dandan Xu Tingting Kong Ziqi Shao Minghui Liu Rumin Zhang Shengnan Zhang Qingxia Kong Jing Chen Baohua Cheng Chunmei Wang Source Type: research

Tat-NTS Suppresses the Proliferation, Migration and Invasion of Glioblastoma Cells by Inhibiting Annexin-A1 Nuclear Translocation
Cell Mol Neurobiol. 2021 Aug 3. doi: 10.1007/s10571-021-01134-y. Online ahead of print.ABSTRACTPrevention of the nuclear translocation of ANXA1 with Tat-NTS was recently reported to alleviate neuronal injury and protect against cerebral stroke. However, the role that Tat-NTS plays in the occurrence and development of gliomas still needs to be elucidated. Therefore, human glioblastoma (GB) cells were treated with various concentrations of Tat-NTS for 24 h, and cell proliferation, migration and invasion were assessed with CCK-8 and Transwell assays. The nuclear translocation of ANXA1 was evaluated by subcellular extraction a...
Source: Cellular and Molecular Neurobiology - August 4, 2021 Category: Cytology Authors: Zhenzhao Luo Li Liu Xing Li Weiqun Chen Zhongxin Lu Source Type: research

Safety of apixaban for venous thromboembolic primary prophylaxis in patients with newly diagnosed malignant glioma
In this study, we treated ten patients with newly diagnosed MG with apixaban, 2.5  mg twice daily beginning 2–21 days after craniotomy and continuing for up to 6 months. Unacceptable toxicity was defined by ≥ grade 2 CNS or non-CNS hemorrhage, a thromboembolic event (i.e. stroke) or cardiovascular event requiring anticoagulation or anti-platelet therapy. There were no unacc eptable toxicities to report and no treatment-related adverse events. None of the patients on the study were diagnosed with a VTE while receiving apixaban. We conclude that apixaban can be given safely to patients with primary MG shortly after cra...
Source: Journal of Thrombosis and Thrombolysis - August 4, 2021 Category: Hematology Source Type: research

Unilateral basal ganglia restricted diffusion in anti ‐leucine‐rich glioma‐inactivated 1 encephalitis mimicking cerebral infarction: A report on two cases and literature review
ConclusionOur report adds to the heterogeneity of anti-leucine-rich glioma-inactivated  1 encephalitis and highlights the need to consider this diagnosis in patients who present atypically.
Source: Clinical and Experimental Neuroimmunology - July 23, 2021 Category: Neurology Authors: Mervyn Q. W. Poh, Hui Jin Chiew, Zheyu Xu, Kevin Tan, Tchoyoson C. C. Lim, Tianrong Yeo Tags: CASE REPORT Source Type: research

The PROGRAM study: awake mapping versus asleep mapping versus no mapping for high-grade glioma resections: study protocol for an international multicenter prospective three-arm cohort study
This study is an international, multicenter, prospective three-arm cohort study of observational nature. Consecutive HGG patients will be operated with awake mapping, asleep mapping or no mapping with a 1:1:1 ratio. Primary endpoints are: (1) proportion of patients with National Institute of Health Stroke Scale deterioration at 6 weeks, 3 months and 6 months after surgery and (2) residual tumour volume of the contrast-enhancing and non-contrast-enhancing part as assessed by a neuroradiologist on postoperative contrast MRI scans. Secondary endpoints are: (1) overall survival and (2) progression-free survival at 12 months af...
Source: BMJ Open - July 21, 2021 Category: General Medicine Authors: Gerritsen, J. K. W., Dirven, C. M. F., De Vleeschouwer, S., Schucht, P., Jungk, C., Krieg, S. M., Nahed, B. V., Berger, M. S., Broekman, M. L. D., Vincent, A. J. P. E. Tags: Open access, Neurology Source Type: research

Non–Contrast-Enhancing Glioma Mimicking Acute Ischemic Stroke Within Three Hours of Onset
Publication date: Available online 3 July 2021Source: Annals of Emergency MedicineAuthor(s): Yo-Lin Lin, Sai-Wai Ho, Ling-Jun Liu
Source: Annals of Emergency Medicine - July 4, 2021 Category: Emergency Medicine Source Type: research