Drug-induced Lung Disease Associated With Ustekinumab in a Pediatric Patient With Crohn Disease
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Case Report Source Type: research

An Unusual Case of Diverticulitis in a Teenager With a Complicated Clinical Course
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Image of the Month Source Type: research

Hematite Ingestion in Pediatrics: Risk of Iron Poisoning
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Image of the Month Source Type: research

Psychometrics of the Functional Oral Intake Scale for Children With Dysphagia
This study proposed a FOIS for children and investigated the reliability and validity of the scale. Methods: We adapted the original FOIS into a scale for children by removing 2 item levels to generate a 5-point scale. This retrospective study included 194 children ages 1 to 7 years. Their nutrition records were evaluated separately by 2 raters using the FOIS for children. Dysphagia and aspiration severity were evaluated based on the findings from a videofluoroscopic swallowing study. For children partially dependent on tube feeding, medical records were investigated to determine whether full oral feeding was accomplish...
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Assessing Diet Quality in a Racially and Ethnically Diverse Cohort of Low-income Toddlers
Conclusions: Despite scores reflective of DGA recommendations for fruit, dairy and protein foods, toddlers in this diverse sample had low quality diets as measured by the HEI, driven largely by low component scores for whole grains, vegetables, and ratio of unsaturated to saturated fatty acids. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

National Recommendations for Infant and Young Child Feeding in the World Health Organization European Region
Conclusions: National infant feeding recommendations vary widely between studied countries and partly differ from international recommendations. Too early introduction of complementary feeding can reduce duration of exclusive breast-feeding (EBF). Too late introduction of iron-rich complementary foods might increase anemia risk and adversely affect child development. A review and further harmonization of national recommendations appears desirable. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

COVID-19-associated Multisystem Inflammatory Syndrome in Children Presenting as Acute Pancreatitis
We describe a patient who presented with acute pancreatitis before rapidly progressing to multisystem organ dysfunction consistent with multisystem inflammatory syndrome in children due to COVID-19. Clinicians should be aware that in the context of the COVID-19 pandemic, pancreatitis can be an early presentation of multisystem inflammatory syndrome in children. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Short Communication: Pancreatology Source Type: research

Extended Screening for Cystic Fibrosis-related Liver Disease Including Elastography in Children and Adolescents
Conclusions: In total, 8 patients (9.5%) in this pediatric CF population were categorized as having CFLD according to both biochemical and sonographic tests. Consistency was found among the results of FibroScan and SWE. We suggest WUSS and either FibroScan or SWE, combined with GGT as diagnostic markers for CFLD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Article: Pancreatology Source Type: research

Abnormal Bilirubin Metabolism in Patients With Sodium Taurocholate Cotransporting Polypeptide Deficiency
Conclusions: NTCP deficiency is the exclusive or major cause of isolated hypercholanemia in Han Chinese children, with c.800C>T the major contributing genetic variation. The defect may affect bilirubin metabolism and present as transient neonatal cholestasis and/or persistent mild conjugated hyperbilirubinmia, but with no apparent long-term clinical consequences. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Intracranial Hypertension and Papilledema in a Large Cohort of Pediatric Patients With Alagille Syndrome
Conclusions: True ICHT may be underdiagnosed in patients with ALGS. Our findings underscore the need for close ophthalmic follow-up before and after LT in these patients. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Cardiovascular Risk Assessment in Children With Chronic Cholestatic Liver Diseases
Conclusions: Children with BA and AGS may present with increased cardiovascular risk factors but vascular parameters are not directly related to lipid abnormalities. cIMT and BP should be considered for clinical practice in these cholestatic disorders so as to determine individuals with potential CV risk. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Quality of Life in Parents of Children With Biliary Atresia
Objectives: The aim of the study was to determine quality of life (QoL), stress, and anxiety levels in parents of children with biliary atresia (BA), and to assess factors associated with parental QoL. Methods: Parents of children (6–16 years) with BA were included in this cross-sectional study. We used validated questionnaires to assess parental QoL, stress, and anxiety levels. We compared the results with reference data from the general population and determined associated factors using generalized linear mixed model analysis. Results are given as mean ± SD or median [min-max]. Results: We includ...
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

The Role of Cannabinoid Receptor Type 2 in the Bone Loss Associated With Pediatric Celiac Disease
Conclusions: CB2 could be a molecular marker to predict the risk of bone alterations in CD and a pharmacological target to reduce bone mass loss in patients who need a direct intervention on bone metabolism, in addition to the GFD. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Article: Gastroenterology: Celiac Disease Source Type: research

Gut Microenvironment and Bacterial Invasion in Paediatric Inflammatory Bowel Diseases
Conclusions: Alterations in the gut microenvironment in IBD can affect bacterial invasion. Succinate is associated with increased bacterial invasion and can alter bacterial virulence in IBD. This highlights the interaction between specific metabolites and bacteria that could be instrumental in propagating or suppressing inflammation in paediatric IBD patients. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Article: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Factors Associated With 5- and 10-Year Survival After Intestinal Transplantation in Infants and Children
Conclusions: In our experience, outcomes in pediatric intestinal transplantation have improved substantially for anatomic but not functional intestinal failure. Graft survival depends on avoidance of severe infectious and immunological complications including GVHD, whereas inclusion of a liver graft provides no obvious survival benefit. Reduced success with functional intestinal failure may reflect inherently increased susceptibility to complications in this group. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Polyp Progression in Paediatric Patients With Familial Adenomatous Polyposis: A Single-centre Experience
This study aimed to examine the natural history of FAP in children by evaluating adenoma progression and factors influencing timing of colectomy. Method: Patients with FAP younger than 18 years at first surveillance colonoscopy and who had undergone more than 1 colonoscopy were identified. Demographic, endoscopic, genetic, and surgical data were retrieved. Cumulative adenoma (polyp) counts were obtained while accounting for any polypectomies during the study period. The rate of polyp progression and factors influencing the timing of colectomy were evaluated. Results: Eighty-four patients (50% boys; mean age at first co...
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Feasibility Study of a New Magnetic Resonance Imaging Mini-capsule Device to Measure Whole Gut Transit Time in Paediatric Constipation
Objective: In England, 27,500 children are referred annually to hospital with constipation. An objective measure of whole gut transit time (WGTT) could aid management. The current standard WGTT assessment, the x-ray radiopaque marker (ROM) test, gives poor definition of colonic anatomy and the radiation dose required is undesirable in children. Our objective was to develop an alternative magnetic resonance imaging (MRI) WGTT measure to the x-ray ROM test and to demonstrate its initial feasibility in paediatric constipation. Methods: With the Nottingham Young Person's Advisory Group we developed a small (8 × ...
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

Does Combined Multichannel Intraluminal Impedance and pH (MII-pH) Testing Improve Clinical Outcomes in Children With Gastroesophageal Reflux Disease?
Objectives: The aim of the study was to investigate the role of combined multichannel intraluminal impedance and pH (MII-pH) testing in clinical management of children with gastroesophageal reflux disease (GERD) by exploring the impact of treatment changes made based on MII-pH testing results on symptoms and quality of life outcomes. Methods: All patients ( (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology Source Type: research

The Gut Microbiome and the Triple Environmental Hit Concept of Inflammatory Bowel Disease Pathogenesis
The incidence of chronic inflammatory bowel diseases (IBDs), such as Crohn's disease (CD) and ulcerative colitis (UC) have significantly increased in recent decades implicating environmental effects. The developmental origin of disease concept provides a theoretical framework by which the complex interplay between environmental factors and host cells, particularly during vulnerable time periods, ultimately cause disease, such as IBD. Epigenetics has been proposed as the underlying mechanism within this concept, turning environmental triggers into stable changes of cellular function. Adding further to the complexity of IBD ...
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Review Article Source Type: research

The Ethics of Feeding the Aspirating Child in an Age of Increasing Patient Complexity
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Topic of the Month Source Type: research

Pediatric Intestine Transplantation: Are We Ready for the Prime Time?
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Invited Commentaries Source Type: research

Endocannabinoid System and Bone Loss in Celiac Disease: Towards a Demanding Research Agenda
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - October 24, 2020 Category: Gastroenterology Tags: Invited Commentaries Source Type: research

Response to Letter: Effectivity of Pancreatic Enzyme Replacement Therapy in Malnourished Children
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Letter to the Editor Re: Effectivity of Pancreatic Enzyme Replacement Therapy in Malnourished Children
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Response to Letter to the Editor on “Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up”
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Columnar Lined Esophagus/Gastric Metaplasia Requires Careful Follow-up
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

The Refinement of Radiographic Protocols in Assessment of Pediatric Foreign Body Ingestions: Location, Location, Location
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Importance of Supine Abdominal X-rays in Suspected Foreign Body Ingestion
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Response to letter from Mannini et al
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Plant-based Milks: A Possible Therapeutic Tool if Correctly Labeled and Prescribed
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Ruxolitinib Response in an Infant With Very-early-onset Inflammatory Bowel Disease and Gain-of-function STAT1 Mutation
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Letters to the Editor Source Type: research

Novel Percutaneous Image-guided Treatment of Choledocholithiasis in a 30-Day-old Infant
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Case Report Source Type: research

Ingestion of an Entire Vaping Device
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Image of the Month Source Type: research

Abundant Pancreatic Cysts in a Teenager Leading to a Diagnosis of Von Hippel-Lindau
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Image of the Month Source Type: research

Anemia in Children With Inflammatory Bowel Disease: A Position Paper by the IBD Committee of the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition
This article reviews management of anemia in children with IBD, including diagnosis, etiopathogenesis, evaluation of a patient, protocol to screen and monitor patients for early detection and response to therapy, treatment including parenteral iron therapy, and newer approaches in management of anemia of chronic disease. This report has been compiled by a group of pediatric gastroenterologists serving on the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) IBD committee, in collaboration with a pediatric hematologist, pharmacist, and a registered dietician who specializes in pediat...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Society Paper Source Type: research

Outcomes and Safety of Blenderized Tube Feedings in Pediatric Patients: A Single Center's Experience
Conclusions: Our data suggest that BTF is a safe dietary intervention that may improve gastrointestinal symptoms in pediatric patients. Further prospective studies are needed to compare safety and efficacy of BTF and commercial formulas in pediatric patients. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Emotional Wellbeing in Parents of Children on Home Parenteral Nutrition
This study explored the emotional wellbeing and coping styles of parents and children on HPN. Methods: Questionnaire data were collected for parents of children (0–18 years) on HPN. Children 8 years and older completed the revised children's anxiety and depression scale. Parents completed the Hospital Anxiety and Depression Scale, Paediatric Inventory for Parents (PIP) and brief COPE. Results: A total of 14 children were included, 20 parents (13 females) and 4 children completed the survey. Parents had mean PIP difficulty and frequency score of 117.9 and 124, respectively, higher compared to parents of children...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Translation of EU Food Law and Nutrient Reference Values Into Practice: the German Dietary Scheme for the First Year of Life
Conclusions: Taken together, European dietary reference values for energy and nutrients can mostly be met by the modular system of the Dietary Scheme as a total diet concept for infant nutrition in Germany. The different proposed meals generally agree with EU regulations for complementary food. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Adiponectin is Increased in Pediatric Patients With Autoimmune Hepatitis Independent of Body Weight
The objective of this study was to examine the relationship between excess weight and systemic inflammation, adipokines, and ghrelin in adolescents with AIH. Method: This case-controlled study included 27 adolescents with AIH (13 with excess weight and 14 with normal weight) and a control group. Excess weight was defined by a body mass index/age Z score>+1 standard deviation. Adipokines (adiponectin, leptin, tumor necrosis factor alpha, interleukin 6 [IL-6], and IL-10) and ghrelin were measured with Luminex technology. Results: Adiponectin (μg/mL) was higher (P  (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

In the Short-term, Milk Fat Globule Epidermal Growth Factor-8 Causes Site-specific Intestinal Growth in Resected Piglets
Objectives: Short bowel syndrome (SBS) remains the leading cause of neonatal intestinal failure. Milk fat globule epidermal growth factor-8 (MFG-E8), present in human milk, has homology with epidermal growth factor (EGF), known to enhance adaptation in SBS. In this pilot study, the role of oral MFG-E8 treatment in SBS was explored in neonatal piglets. Methods: Neonatal piglets underwent 75% intestinal resection, either distal (jejunal-colonic [JC] anastomosis) or mid-intestinal (jejunal-ileal [JI] anastomosis). Piglets were randomized to intragastric treatment with MFG-E8  (5 mg/kg per day) or saline and were main...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Who's at Risk? A Prognostic Model for Severity Prediction in Pediatric Acute Pancreatitis
Objectives: The aim of the study was to validate and optimize a severity prediction model for acute pancreatitis (AP) and to examine blood urea nitrogen (BUN) level changes from admission as a severity predictor. Study Design: Patients from 2 hospitals were included for the validation model (Children's Hospital of the King's Daughters and Children's National Hospital). Children's Hospital of the King's Daughters and Cincinnati Children's Hospital Medical Center data were used for analysis of BUN at 24 to 48 hours. Results: The validation cohort included 73 patients; 22 (30%) with either severe or moderately sever...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Article: Pancreatology Source Type: research

A Narrow Window: Booming Gluten-free Market and Fostering Healthy Dietary Habits in Children With Celiac Disease
An expanding gluten-free marketplace has left children with celiac disease and their families with a host of new dietary options. The quality of these foods is inconsistent and processed items may be high in caloric content while lacking nutritional value. Assessing the dietary preferences of a cohort of children with celiac disease via cross-sectional survey, we find that these processed food items have become a staple of the gluten-free diet, and in many cases, these foods are consumed to the exclusion of healthy alternatives. Furthermore, children with celiac disease and their families become less interested in dietary ...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Short Communication: Gastroenterology: Celiac Disease Source Type: research

Case Series: Role of Pill Esophagram to Identify Pediatric Patients With Eosinophilic Esophagitis Amenable to Therapeutic Dilation
Eosinophilic esophagitis (EoE) is a chronic disease of the esophagus that leads to esophageal remodeling. Dysphagia is a common symptom that likely results from the inflammatory process or remodeling. Identifying patients that may benefit from dilation can be challenging because of difficulties in detecting subtle narrowing in patients with EoE. Here we report the benefits of a pill esophagram in the detection of esophageal narrowing in EoE. We identified a series of children with EoE and symptoms of dysphagia who underwent barium esophagram with a barium-coated pill to assess symptoms. Three subjects had a normal fluorosc...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Short Communication: Gastroenterology: Eosinophilic GI Disease Source Type: research

High Patient Disease Burden in a Cross-sectional, Multicenter Contact Registry Study of Eosinophilic Gastrointestinal Diseases
Objectives: Clinical features of eosinophilic esophagitis (EoE) have been well-described in the literature, however, characterization of features experienced by patients with other eosinophilic gastrointestinal diseases (EGIDs) is lacking. Using data collected from a patient contact registry, we sought to characterize and contrast patient-reported gastrointestinal and extragastrointestinal symptoms and comorbidities in non-EoE EGIDs, including eosinophilic gastritis, gastroenteritis and colitis, relative to EoE. Methods: We conducted a cross-sectional study of contact registry data collected from 2015 to 2018. Statist...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Article: Gastroenterology: Eosinophilic Gastrointestinal GI Disease Source Type: research

WD Repeat Domain 1 (WDR1) Deficiency Presenting as a Cause of Infantile Inflammatory Bowel Disease
We present a case of an infant boy who presented with hematochezia and thrombocytopenia in the first week of life and developed IBD by the age of 1 month. Additional clues to his diagnosis included lymphopenia and nuclear herniation observed in his neutrophils. Compound heterozygous damaging variants were identified in WD Repeat Domain 1 (WDR1) by whole-exome sequencing (WES) and represents a novel cause of VEOIBD. Our patient's IBD and immunologic phenotype was successfully treated by hematopoietic stem cell transplant (HSCT). (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Short Communications: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Paediatric Patients (Less Than Age of 17 Years) Account for Less Than 1.5% of All Prevalent Inflammatory Bowel Disease Cases
The prevalence of inflammatory bowel disease (IBD) continues to rise globally; however, the true proportion of paediatric IBD patients remains unknown. We conducted an all-age, multiparameter, population-based search using capture-recapture methodology to identify all IBD cases to August 31, 2018 within Lothian, a defined health board and the largest of the 3 within South-East Scotland. Individual case note validation was performed for all 24,601 possible IBD cases according to internationally recognised diagnostic and age criteria. Of 7035 confirmed point-prevalent patients, 560 were classified as A1 age phenotype at diag...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Short Communications: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Therapeutic Drug Monitoring-guided High-dose Infliximab for Infantile-onset Inflammatory Bowel Disease: A Case Series
We present a case series of 4 patients with infantile-onset IBD achieving clinical and biologic remission, after treatment with therapeutic drug monitoring (TDM)-guided accelerated high-dose IFX therapy. All patients were treated with accelerated high-dose IFX induction of up to 22 mg/kg. In 3 of these patients, accelerated high-dose IFX was used following failure of intensified standard dose induction. All patients achieved remission following re-induction. We suggest that children with infantile-onset IBD may require a TDM-guided accelerated high-dose IFX induction and maintenance treatment in order to achieve and mai...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Short Communications: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Genetic Predictors of Long-term Response to Antitumor Necrosis Factor Agents in Pediatric Inflammatory Bowel Disease
Objectives: Inflammatory bowel disease (IBD) is more complex in children and they will have to live with the disease for much longer. For this reason, it is necessary to optimize treatment. The polymorphisms associated with the response to anti-tumor necrosis factor (TNF) drugs in adults with IBD have not been analyzed in children. The aim of the study was to identify genetic variants associated with the long-term response to anti-TNF drugs in children with IBD. Methods: An observational, longitudinal, ambispective cohort's study was conducted. We recruited 209 anti-TNF-treated children diagnosed with IBD and genotype...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

Vedolizumab Trough Levels in Children With Anti-Tumor Necrosis Factor Refractory Inflammatory Bowel Disease
Objectives: Inflammatory bowel disease (IBD) can be successfully treated with vedolizumab. Studies in adult IBD patients have shown that differences in response to vedolizumab may be related to variability in vedolizumab trough levels, but in children with pediatric-onset IBD data regarding vedolizumab trough levels are not available. Thus far, the role of trough levels in pediatric-onset IBD treatment remains unclear. We aimed to investigate predictors of vedolizumab trough levels in pediatric-onset IBD patients. Methods: Data from anti-tumor necrosis factor refractory pediatric-onset IBD patients who received vedoli...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research

A New Domain Structure for the IMPACT-III Health-related Quality of life Tool for Pediatric Inflammatory Bowel Disease
This study developed a new domain structure based on the current IMPACT version. Methods: Baseline data from 3 prospectively collected datasets of children and adolescents with IBD was used. Exploratory, then confirmatory factor analyses were carried out to develop a new domain structure. Internal consistency (Cronbach alpha) and construct validity with PROMIS measures (Pearson correlations, and Independent Mann-Whitney U-tests) were examined. Results: Data from the IBD Partners dataset alone (n = 374; 47% girls, mean age = 13.4 ± 2.5 years, median disease duration = 2.5 years, 75% were in remi...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 22, 2020 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research