Pediatric Hematochezia Caused by Intestinal Ganglioneuromatous Polyposis
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Image of the Month Source Type: research

Neonatal Hemorrhoids: Getting to the Bottom of an Uncommon Finding
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Image of the Month Source Type: research

Nutritional and Safety Concerns of Infant Feeding Trends: Erratum
No abstract available (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Erratum Source Type: research

Acute Hepatitis of Unknown Etiology Among Young Children: Research Agenda by the ESPGHAN Hepatology Committee
In April 2022, an increased incidence of acute hepatitis cases of unknown etiology among previously healthy children across the United Kingdom was described. Since, more than 270 cases from the United Kingdom and hundreds more from all across the world have been reported. The majority of affected children were younger than 6 years of age. The clinical presentation was nonspecific with diarrhea and vomiting usually preceding the appearance of jaundice, abdominal pain, nausea, and malaise. Approximately 5% have required liver transplantation. An infectious etiology has been considered likely given the epidemiological and cli...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Societal Paper Source Type: research

Preterm Infant Fecal Microbiota and Metabolite Profiles Are Modulated in a Probiotic Specific Manner
Objectives: To compare the impact of two probiotic supplements on fecal microbiota and metabolites, as well as on gut inflammation in human milk-fed preterm infants. Methods: In this single-center observational cohort study, we assessed the effects of Bifidobacterium longum subsp. infantis or Lactobacillus reuteri supplementation on the infant gut microbiota by 16S rRNA gene sequencing and fecal metabolome by 1H nuclear magnetic resonance spectroscopy. Fecal calprotectin was measured as a marker of enteric inflammation. Aliquots of human or donor milk provided to each infant were also assessed to determine human...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Impact of COVID-19 Pandemic on Young Children With Feeding and Eating Problems and Disorders and Their Families
Objectives: The incidence of feeding and eating problems and disorders (FEPD) in children increased during the coronavirus disease 2019 (COVID-19) pandemic. The aim of this study was to assess the impact of the COVID-19 pandemic on young children with FEPD and their parents. Methods: Cross-sectional survey: parents of children with FEPD (0–11 years) in the Netherlands completed an online questionnaire (January–April 2021). This questionnaire included 4 demographic questions (including criteria of pediatric feeding disorder [PFD] and/or avoidant/restrictive food intake disorder [ARFID]) and 11 questions relat...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Zinc Kinetics Correlate With Length-for-Age z Scores in Bangladeshi Infants
Conclusions: Zinc kinetics in Bangladeshi infants correlate with LAZ and show that malabsorption of supplemental sources of zinc may occur in stunted infants. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Effects of a Novel High-Quality Protein Infant Formula on Energetic Efficiency and Tolerance: A Randomized Trial
Conclusions: The SF resulted in improved parent-reported gastrointestinal tolerance and more efficient growth with less daily formula and protein intake supporting that this novel formula may potentially reduce the metabolic burden of protein overfeeding associated with infant formula. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Nutrition Source Type: research

Endoscopy in Infants With Gastrointestinal Bleeding Has Limited Diagnostic or Therapeutic Benefit
Objectives: Pediatric gastroenterologists are often consulted to perform diagnostic and therapeutic endoscopy in infants with gastrointestinal bleeding (GIB). The value of endoscopy and risk of complications in this population are not well characterized. We aimed to describe findings and outcomes of infants with GIB who undergo endoscopy. Methods: Retrospective, single-center, cohort study of hospitalized infants ≤12 months who underwent esophagogastroduodenoscopy (EGD) and/or colonoscopy/flexible sigmoidoscopy (COL) for GIB. Current procedural technology codes, international classification of diseases codes, ...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Article: Endoscopy and Procedures Source Type: research

Characterization of Biomarkers of Hemostasis and Bleeding-Related Outcomes in Children With Cirrhosis
Conclusions: Children with cirrhosis had defects in fibrinogen and platelets compared to children without cirrhosis at time of LT; however, these abnormalities did not translate into higher rates of bleeding in the former. Adults with cirrhosis had more defects in clotting factors compared to children with cirrhosis. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Transient Elastography Measures of Hepatic Steatosis and Fibrosis Are Associated With Body Composition Among US Adolescents
We examined transient elastography assessed hepatic steatosis and fibrosis distributions and relationships with body composition and lifestyle factors in a United States national adolescent population sample. Methods: Liver stiffness and controlled attenuation parameter (CAP) were assessed on 1080 non-Hispanic white, non-Hispanic black, non-Hispanic Asian, and Hispanic boys and girls aged 12–19 years in the National Health and Nutrition Examination Survey (NHANES) 2017–2018. Participants underwent anthropometry and dual-energy x-ray absorptiometry (DXA). Results: Compared with girls, boys had higher mean ...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Long-Term Urinary Copper Excretion and Exchangeable Copper in Children With Wilson Disease Under Chelation Therapy
Objectives: Determining 24-hour urinary copper excretion (UCE) levels is useful for diagnosing Wilson’s disease (WD) and for treatment monitoring. Exchangeable copper (ExC) is a novel potential marker, but its long-term changes have never been described in patients under chelation therapy. Our aim was to describe the long-term changes in ExC levels compared to UCE levels in symptomatic WD pediatric patients under chelation therapy. Methods: A retrospective, descriptive, and analytical study including all patients under 18 years of age, diagnosed between 2006 and 2020, and treated with chelation therapy was con...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Efficacy and Safety of Endoscopic Primary Prophylaxis of Bleeding in Children With High-Risk Gastroesophageal Varices
Conclusions: Endoscopic primary prophylaxis of variceal bleeding is reasonably effective and safe in children with high-risk gastroesophageal varices. Worse results are observed in children with more advanced endoscopic features. This pleads for endoscopic screening in children with portal hypertension and early detection of varices warranting primary prophylaxis. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research

Subtyping of Eosinophilic Esophagitis Based on Disease Presentation in a pediatric Cohort
Objective: Eosinophilic esophagitis (EoE) is an immune-mediated inflammatory disease characterized by eosinophilic infiltration of esophageal tissue. Subtyping of EoE patients could be useful in predicting therapeutic response. We propose clinical subtypes, apply them to our pediatric EoE population retrospectively, and assess therapy choices and remission at one year. Methods: A retrospective chart review of pediatric patients diagnosed with EoE was conducted. Patients were grouped into proposed subtypes (severe, allergic, fibrostenotic, inflammatory, unclassified) based on presenting characteristics. The prima...
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Eosinophilic Gastrointestinal Disorders Source Type: research

Comparing Eosinophilic Esophagitis in a Black and Non-Black Pediatric Cohort
Conclusions: This is the largest study to date comparing a black versus non-black pediatric EoE population. The black population had more atopic comorbidities and FTT at presentation and had significantly more issues with nonadherence. This new knowledge describing EoE in a minority population will hopefully improve awareness, diagnosis, and management of EoE in this population. (Source: Journal of Pediatric Gastroenterology and Nutrition)
Source: Journal of Pediatric Gastroenterology and Nutrition - September 23, 2022 Category: Gastroenterology Tags: Original Articles: Gastroenterology: Eosinophilic Gastrointestinal Disorders Source Type: research