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Drug: Melatonin
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Total 4647 results found since Jan 2013.
Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice
CONCLUSIONS: Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium-like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium.PMID:37736695 | DOI:10.1111/cns.14436
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xixi Jia Yanan Song Zhengqian Li Ning Yang Taotao Liu Dengyang Han Zhuonan Sun Chengmei Shi Yang Zhou Jie Shi Yajie Liu Xiangyang Guo Source Type: research
Melatonin targets ferroptosis through bimodal alteration of redox environment and cellular pathways in NAFLD model
Biosci Rep. 2023 Sep 20:BSR20230128. doi: 10.1042/BSR20230128. Online ahead of print.ABSTRACTFerroptosis is a non-conventional cellular death caused by lipid peroxide induced iron deposition. Intracellular lipid accumulation followed by generation of lipid peroxides is an Hallmark of Non Alcoholic Fatty Liver Disease (NAFLD). Melatonin (MLT) is an important pineal hormone with tremendous antioxidant and anti-inflammatory properties. Various studies targeted ferroptosis in different diseases using melatonin. However, none of them focused the intrinsic mechanism of MLT's action to counteract ferroptosis in NAFLD. Hence, the ...
Source: Bioscience Reports - September 20, 2023 Category: Biomedical Science Authors: Moumita Saha Sanjib Das Krishnendu Manna Krishna Das Saha Source Type: research
MiR-126 and miR-146a as Melatonin-Responsive Biomarkers for Neonatal Brain Ischemia
AbstractDespite advances in obstetric and neonatal care, challenges remain in early identification of neonates with encephalopathy due to hypoxia-ischemia who are undergoing therapeutic hypothermia. Therefore, there is a deep search for biomarkers that can identify brain injury. The aims of this study were to investigate the serum and brain expressions of two potential biomarkers, miR-126/miR-146a, in a preclinical model of hypoxia-ischemia (HI) –induced brain injury, and to explore their modulation during melatonin treatment. Seven-day-old rats were subjected to permanent ligation of the right carotid artery followed by...
Source: Journal of Molecular Neuroscience - September 19, 2023 Category: Neuroscience Source Type: research
A seasonal switch hypothesis for the neuroendocrine control of aggression
Trends Endocrinol Metab. 2023 Sep 16:S1043-2760(23)00168-6. doi: 10.1016/j.tem.2023.08.015. Online ahead of print.ABSTRACTAggression is a well-studied social behavior that is universally exhibited by animals across a wide range of contexts. Prevailing knowledge suggests gonadal steroids primarily mediate aggression; however, this is based mainly on studies of male-male aggression in laboratory rodents. When males and females of other species, including humans, are examined, a positive relationship between gonadal steroids and aggression is less substantiated. For instance, hamsters housed in short 'winter-like' days show i...
Source: Trends in Endocrinology and Metabolism: TEM - September 18, 2023 Category: Endocrinology Authors: Gregory E Demas Kathleen M Munley Aaron M Jasnow Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Melatonin as a therapeutic agent for alleviating endothelial dysfunction in cardiovascular diseases: Emphasis on oxidative stress
Biomed Pharmacother. 2023 Sep 16;167:115475. doi: 10.1016/j.biopha.2023.115475. Online ahead of print.ABSTRACTThe vascular endothelium is vital in maintaining cardiovascular health by regulating vascular permeability and tone, preventing thrombosis, and controlling vascular inflammation. However, when oxidative stress triggers endothelial dysfunction, it can lead to chronic cardiovascular diseases (CVDs). This happens due to oxidative stress-induced mitochondrial dysfunction, inflammatory responses, and reduced levels of nitric oxide. These factors cause damage to endothelial cells, leading to the acceleration of CVD progr...
Source: Atherosclerosis - September 18, 2023 Category: Cardiology Authors: Xiaolu Zhang Yujia Zheng Ziyu Wang Jiali Gan Bin Yu Bin Lu Xijuan Jiang Source Type: research
Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption
CONCLUSIONS: Our data indicate that melatonin treatment attenuates CRSD-induced cognitive impairment via regulating HDAC3-Bmal1/Clock interaction. These findings explore a broader understanding of the relationship between sleep and cognition and provide a potential new therapeutic target for cognitive impairment.PMID:37721401 | DOI:10.1111/cns.14474
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Yujie Hu Yefan Lv Xiaoyan Long Guoshuai Yang Jinxia Zhou Source Type: research
Monoamines' role in islet cell function and type 2 diabetes risk
Trends Mol Med. 2023 Sep 16:S1471-4914(23)00194-6. doi: 10.1016/j.molmed.2023.08.009. Online ahead of print.ABSTRACTThe two monoamines serotonin and melatonin have recently been highlighted as potent regulators of islet hormone secretion and overall glucose homeostasis in the body. In fact, dysregulated signaling of both amines are implicated in β-cell dysfunction and development of type 2 diabetes mellitus (T2DM). Serotonin is a key player in β-cell physiology and plays a role in expansion of β-cell mass. Melatonin regulates circadian rhythm and nutrient metabolism and reduces insulin release in human and rodent islets...
Source: Trends in Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Fiona Louise Roberts Luis Rodrigo Cataldo Malin Fex Source Type: research
Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption
CONCLUSIONS: Our data indicate that melatonin treatment attenuates CRSD-induced cognitive impairment via regulating HDAC3-Bmal1/Clock interaction. These findings explore a broader understanding of the relationship between sleep and cognition and provide a potential new therapeutic target for cognitive impairment.PMID:37721401 | DOI:10.1111/cns.14474
Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Yujie Hu Yefan Lv Xiaoyan Long Guoshuai Yang Jinxia Zhou Source Type: research
Melatonin as preemptive analgesic for intraoperative pain
This study evaluates the efficacy of using melatonin and ketorolac for pain prevention during open-flap debridement surgery. This prospective randomized controlled trial was performed in patients who presented with chronic periodontitis after non-surgical periodontal therapy, requiring flap surgery. Group 1: Flap surgery following non-surgical periodontal therapy after one month with no oral administration of analgesic. Group 2: Flap surgery following non-surgical periodontal therapy after one month with oral administration of Ketorolac 400mg one hour prior to the surgery. Group 3: Flap surgery following non-surgical perio...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Chanchal Katariya Sankari Malaiappan Source Type: research
