Melatonin attenuates chronic sleep deprivation-induced cognitive deficits and HDAC3-Bmal1/clock interruption

CONCLUSIONS: Our data indicate that melatonin treatment attenuates CRSD-induced cognitive impairment via regulating HDAC3-Bmal1/Clock interaction. These findings explore a broader understanding of the relationship between sleep and cognition and provide a potential new therapeutic target for cognitive impairment.PMID:37721401 | DOI:10.1111/cns.14474

Source: CNS Neuroscience and Therapeutics - September 18, 2023 Category: Neuroscience Authors: Yujie Hu Yefan Lv Xiaoyan Long Guoshuai Yang Jinxia Zhou Source Type: research