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Drug: Tamoxifen
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Total 2054 results found since Jan 2013.
BRK confers tamoxifen-resistance in breast cancer via regulation of tyrosine phosphorylation of CDK1
Cell Signal. 2023 May 20:110723. doi: 10.1016/j.cellsig.2023.110723. Online ahead of print.ABSTRACTTamoxifen (Tam) has been the first-line therapy for estrogen receptor-positive breast cancer since its FDA-approval in 1998. Tam-resistance, however, presents a challenge and the mechanisms that drive it have yet to be fully elucidated. The non-receptor tyrosine kinase BRK/PTK6 is a promising candidate as previous research has shown that BRK knockdown resensitizes Tam-resistant breast cancer cells to the drug. However, the specific mechanisms that drive its importance to resistance remain to be investigated. Here, we investig...
Source: Cellular Signalling - May 22, 2023 Category: Cytology Authors: Aditya Mandapati Zhibin Ning Akanksha Baharani Kiven Erique Lukong Source Type: research
Celastrol enhances tamoxifen sensitivity in the treatment of triple negative breast cancer via mitochondria mediated apoptosis pathway
CONCLUSION: CEL can promote apoptosis and enhance the TAM sensitivity in TNBC treatment through a mitochondria-mediated pathway.PMID:37193187 | PMC:PMC10182490
Source: Cancer Control - May 16, 2023 Category: Cancer & Oncology Authors: Bingjie Qi Qigao Yan Pei Zhang Yu Ren Huijuan Liu Tingting Liu Lingli Zhu Yu Chen Source Type: research
< em > Nrl:CreERT2 < /em > mouse model to induce mosaic gene expression in rod photoreceptors
Front Mol Neurosci. 2023 Apr 25;16:1161127. doi: 10.3389/fnmol.2023.1161127. eCollection 2023.ABSTRACTPhotoreceptors are sensory neurons that capture light within their outer segment, a narrow cylindrical organelle stacked with disc-shaped membranes housing the visual pigment. Photoreceptors are the most abundant neurons in the retina and are tightly packed to maximize the capture of incoming light. As a result, it is challenging to visualize an individual cell within a crowded photoreceptor population. To address this limitation, we developed a rod-specific mouse model that expresses tamoxifen-inducible cre recombinase un...
Source: Cancer Control - May 14, 2023 Category: Cancer & Oncology Authors: Molly T Thorson Stephanie E Wei Craig Johnson Christopher J Gabriel Vadim Y Arshavsky Jillian N Pearring Source Type: research
Deletion of Smooth Muscle O-GlcNAc Transferase Prevents Development of Atherosclerosis in Western Diet-Fed Hyperglycemic ApoE < sup > -/- < /sup > Mice In Vivo
Int J Mol Sci. 2023 Apr 26;24(9):7899. doi: 10.3390/ijms24097899.ABSTRACTAccumulating evidence highlights protein O-GlcNAcylation as a putative pathogenic contributor of diabetic vascular complications. We previously reported that elevated protein O-GlcNAcylation correlates with increased atherosclerotic lesion formation and VSMC proliferation in response to hyperglycemia. However, the role of O-GlcNAc transferase (OGT), regulator of O-GlcNAc signaling, in the evolution of diabetic atherosclerosis remains elusive. The goal of this study was to determine whether smooth muscle OGT (smOGT) plays a direct role in hyperglycemia...
Source: Atherosclerosis - May 13, 2023 Category: Cardiology Authors: Saugat Khanal Neha Bhavnani Amy Mathias Jason Lallo Shreya Gupta Vahagn Ohanyan Jessica M Ferrell Priya Raman Source Type: research
NAD + Metabolism Generates a Metabolic Vulnerability in Endocrine-Resistant Metastatic Breast Tumors in Females
In this study, we identified NAMPT, an important enzyme in nicotinamide adenine dinucleotide (NAD+) metabolism, to be increased in metastatic breast cancer (MBC) cells treated with Fulv. We tested whether the blockade of NAD+ production via inhibition of nicotinamide phosphoribosyltransferase (NAMPT) synergizes with standard-of-care therapies for ER+ metastatic breast cancer in vitro and in vivo. A synergistic effect was not observed when KPT-9274 was combined with palbociclib or tamoxifen or when Fulv was combined with other metabolic inhibitors. We show that NAMPT inhibitor KPT-9274 and fulvestrant (Fulv) works synergist...
Source: Endocrinology - May 12, 2023 Category: Endocrinology Authors: Ayca Nazli Mogol Qianying Zuo Jin Young Yoo Alanna Zoe Kaminsky Ozan Berk Imir Yosef Landesman Christopher J Walker Zeynep Madak Erdogan Source Type: research
Radiotherapy and targeted therapy for the management of breast cancer: A review
Cancer Radiother. 2023 May 10:S1278-3218(23)00072-0. doi: 10.1016/j.canrad.2023.02.002. Online ahead of print.ABSTRACTThe purpose of this study was to review the current knowledge regarding combinations of the most commonly used targeted therapies or those under development for the management of breast cancer with radiation therapy. Several studies have shown that the combination of radiation therapy and tamoxifen increased the risk of radiation-induced lung toxicity; therefore, the two modalities are generally not given concurrently. The combination of HER2 inhibitors (trastuzumab, pertuzumab) and radiation therapy appear...
Source: Cancer Radiotherapie - May 12, 2023 Category: Cancer & Oncology Authors: A Beddok P Cottu A Fourquet Y Kirova Source Type: research
An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean
In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC.
Source: Frontiers in Pharmacology - May 11, 2023 Category: Drugs & Pharmacology Source Type: research
A Novel Quantitative Electrocardiography Strategy Reveals the Electroinhibitory Effect of Tamoxifen on the Mouse Heart
J Cardiovasc Transl Res. 2023 May 8. doi: 10.1007/s12265-023-10395-5. Online ahead of print.ABSTRACTTamoxifen, a selective estrogen receptor modulator, was initially used to treat cancer in women and more recently to induce conditional gene editing in rodent hearts. However, little is known about the baseline biological effects of tamoxifen on the myocardium. In order to clarify the short-term effects of tamoxifen on cardiac electrophysiology of myocardium, we applied a single-chest-lead quantitative method and analyzed the short-term electrocardiographic phenotypes induced by tamoxifen in the heart of adult female mice. W...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Ming Xie Shuoji Zhu Gang Liu Yijin Wu Wenkai Zhou Dingdang Yu Jinkai Wan Shenghui Xing Siqing Wang Lin Gan Ge Li Dehua Chang Hao Lai Nanbo Liu Ping Zhu Source Type: research
Is venous thromboembolism a time-dependent event in breast cancer patients taking tamoxifen?
Breast Cancer. 2023 May 4. doi: 10.1007/s12282-023-01464-3. Online ahead of print.NO ABSTRACTPMID:37142897 | DOI:10.1007/s12282-023-01464-3
Source: Breast Cancer - May 4, 2023 Category: Cancer & Oncology Authors: Kadri Altundag Source Type: research
