Comparison of subjective, objective and patient-reported cosmetic outcomes between accelerated partial breast irradiation and whole breast radiotherapy: a prospective propensity score-matched pair analysis.
CONCLUSIONS: Overall cosmetic outcomes as well as individual subdomains are significantly better with APBI as compared to WBRT by all methods of assessment of cosmesis when matched for various factors. PMID: 31512161 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 11, 2019 Category: Cancer & Oncology Authors: Wadasadawala T, Sinha S, Parmar V, Verma S, Gaikar M, Kannan S, Mondal M, Pathak R, Jain U, Sarin R Tags: Breast Cancer Source Type: research

Instruments for determining clinically relevant fatigue in breast cancer patients during radiotherapy.
CONCLUSIONS: MFI-20 and FIR scores are highly correlated measures of CRF among breast cancer patients treated with RT. An MFI-20 score of ≥ 43.5 is suggested as a clinically significant score indicating moderate-to-severe fatigue, while an MFI score of ≥ 52.5 is indicative of severe fatigue. PMID: 31493295 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 6, 2019 Category: Cancer & Oncology Authors: Andic F, Miller AH, Brown G, Chu L, Lin J, Liu T, Sertdemir Y, Torres MA Tags: Breast Cancer Source Type: research

Physical symptoms and components of labor tasks associated with upper limb disability among working breast cancer survivors.
io FF Abstract BACKGROUND: Each year, the number of breast cancer (BC) cases increases in Brazil and worldwide. In addition, BC affects women of working age who need to resume their jobs after treatments. This is an observational, cross-sectional study that investigated the association of physical symptoms and work tasks with upper limb disability and return to work in BC survivors. METHODS: Sociodemographic, labor, clinical and surgical aspects, and physical incapacity of the upper limbs of 62 women diagnosed with BC were evaluated through a questionnaire of our own and the disability of the arm, shoulder, a...
Source: Breast Cancer - August 27, 2019 Category: Cancer & Oncology Authors: de Souza Cunha N, Zomkowski K, Fernandes BL, Sacomori C, de Azevedo Guimarães AC, Sperandio FF Tags: Breast Cancer Source Type: research

kOBCS ©: a novel software calculator program of the Objective Breast Cosmesis Scale (OBCS).
kOBCS©: a novel software calculator program of the Objective Breast Cosmesis Scale (OBCS). Breast Cancer. 2019 Aug 26;: Authors: Soror T, Lancellotta V, Kovács G, Lanzotti V, Tagliaferri L, Casà C, Aristei C, Barberini F, Mahmoud M, Badakhshi H Abstract PURPOSE: The Objective Breast Cosmesis Scale (OBCS) is an objective method that documents the aesthetic changes in breast cancer patients. This work evaluates the kOBCS© software ( http://www.kobcs.info ) which simplifies the estimation of the OBCS values. METHODS: Five schematic drawings were photographed and imported into...
Source: Breast Cancer - August 26, 2019 Category: Cancer & Oncology Authors: Soror T, Lancellotta V, Kovács G, Lanzotti V, Tagliaferri L, Casà C, Aristei C, Barberini F, Mahmoud M, Badakhshi H Tags: Breast Cancer Source Type: research

Current conditions and issues of physicians and working conditions at institutions accredited by the Japanese Breast Cancer Society.
CONCLUSIONS: Current systems for treatment of breast cancer should be improved so that all surgeons specializing in the breast can develop their career while maintaining their personal life. PMID: 31440900 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 22, 2019 Category: Cancer & Oncology Authors: Kawase K, Yamashita H, Iwase H, Akashi-Tanaka S, Iijima K, Ishida T, Takeishi Y, Tanaka F, Doihara H, Nakano S, Yamauchi H, Masuda S Tags: Breast Cancer Source Type: research

miR-638 represses the stem cell characteristics of breast cancer cells by targeting E2F2.
CONCLUSION: MiR-638 represses the characteristics and behaviors of BCSCs by targeting E2F2. MiR-638 may be a potential target for breast cancer therapy. PMID: 31410735 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 13, 2019 Category: Cancer & Oncology Authors: Lin QY, Wang JQ, Wu LL, Zheng WE, Chen PR Tags: Breast Cancer Source Type: research

Chemotherapy-induced nausea and vomiting in patients with breast cancer: a prospective cohort study.
CONCLUSIONS: The degree of nausea was worst in the acute phase, although delayed nausea was more in proportion in HEC. Estimation by medical staff is not accurate. PMID: 31407150 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 12, 2019 Category: Cancer & Oncology Authors: Naito Y, Kai Y, Ishikawa T, Fujita T, Uehara K, Doihara H, Tokunaga S, Shimokawa M, Ito Y, Saeki T Tags: Breast Cancer Source Type: research

Usefulness of second-look ultrasonography using anatomical breast structures as indicators for magnetic resonance imaging-detected breast abnormalities.
CONCLUSIONS: Second-look US using anatomical breast structures as indicators and US-guided FNAC are useful for refining the diagnosis of suspicious breast lesions detected using MRI. PMID: 31407151 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 12, 2019 Category: Cancer & Oncology Authors: Izumori A, Kokubu Y, Sato K, Gomi N, Morizono H, Sakai T, Horii R, Akiyama F, Iwase T, Ohno S Tags: Breast Cancer Source Type: research

Assessment of significant procedures in multigene molecular detection for breast cancer in clinical laboratories: from variant detection to targeted therapy.
CONCLUSION: The variant detection capability was satisfactory, but the ability to provide accuracy and comprehensive targeted drug information should be urgently improved. Our study summarized a completed NGS-based multigene molecular detection pipeline, aiming to better inform precision treatment for breast cancer patients. PMID: 31388961 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 6, 2019 Category: Cancer & Oncology Authors: Zhang R, Gao P, Ding J, Li Z, Li J Tags: Breast Cancer Source Type: research

Developing a checksheet for breast cancer patients receiving endocrine therapy-examining reliability and validity.
CONCLUSION: This study verified that the checksheet in its initial development as a scale has high reliability and validity. PMID: 31376075 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 2, 2019 Category: Cancer & Oncology Authors: Iioka Y, Iwata T, Yamauchi H Tags: Breast Cancer Source Type: research

High expression of soluble CD155 in estrogen receptor-negative breast cancer.
CONCLUSIONS: The serum level of sCD155 is correlated with high risk factors in breast cancer. PMID: 31372841 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 1, 2019 Category: Cancer & Oncology Authors: Iguchi-Manaka A, Okumura G, Ichioka E, Kiyomatsu H, Ikeda T, Bando H, Shibuya A, Shibuya K Tags: Breast Cancer Source Type: research

Histological features of skin and subcutaneous tissue in patients with breast cancer who have received neoadjuvant chemotherapy and their relationship to post-treatment edema.
CONCLUSIONS: These pathological findings can help to identify patients who will develop edema and improve their treatment. PMID: 31346921 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 25, 2019 Category: Cancer & Oncology Authors: Nakagawa A, Fujimoto H, Nagashima T, Sangai T, Takada M, Masuda T, Teranaka R, Ota S, Matsushima J, Akita S, Ohtsuka M Tags: Breast Cancer Source Type: research

Taxane-based combinations as adjuvant chemotherapy for node-positive ER-positive breast cancer based on 2004-2009 data from the Breast Cancer Registry of the Japanese Breast Cancer Society.
CONCLUSIONS: In patients with ER-positive, HER2-negative breast cancer, adding taxane to an anthracycline regimen did not improve DFS in patients with metastasis in 1-3 lymph nodes. We considered that the group without the addition of taxane might be present in patients with ER-positive, HER2-negative lymph node metastases. PMID: 31327134 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 20, 2019 Category: Cancer & Oncology Authors: Hojo T, Masuda N, Iwamoto T, Niikura N, Anan K, Aogi K, Ohnishi T, Yamauchi C, Yoshida M, Kinoshita T, Masuoka H, Sagara Y, Sakatani T, Kojima Y, Tsuda H, Kumamaru H, Miyata H, Nakamura S Tags: Breast Cancer Source Type: research

Comparison of the diagnostic performance of synthesized two-dimensional mammography and full-field digital mammography alone or in combination with digital breast tomosynthesis.
Abstract PURPOSE: To investigate whether digital breast tomosynthesis (DBT) and subsequently generated synthesized mammography (SM) images show a better performance than full-field digital mammography (FFDM) images for diagnosing malignant breast lesions. In addition, the radiation doses for SM using different procedures were compared. MATERIALS AND METHODS: This prospective study enrolled 212 women (age ≥ 25 years) with clinically suspicious breast lesions. All participants underwent FFDM and DBT with the same breast compression. Finally, 222 lesions were confirmed by pathological analy...
Source: Breast Cancer - July 13, 2019 Category: Cancer & Oncology Authors: You C, Zhang Y, Gu Y, Xiao Q, Liu G, Shen X, Yang W, Peng W Tags: Breast Cancer Source Type: research

Symptoms and QOL in breast cancer patients receiving hormone therapy in Japan.
CONCLUSION: Breast cancer patients undergoing hormone therapy experience a variety of pains, and some also have serious psychological symptoms. Reassessing support systems to examine screening and self-care support is an issue going forward. PMID: 31297685 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 11, 2019 Category: Cancer & Oncology Authors: Iioka Y, Iwata T, Yamauchi H Tags: Breast Cancer Source Type: research

Breast reconstruction after risk-reducing mastectomy in BRCA mutation carriers.
Abstract BACKGROUND: Breast reconstruction is a favorable option for women with BRCA1 or BRCA2 mutations (BRCA1/2Mut+) who undergo risk-reducing mastectomy (RRM). We assessed characteristics of patients who underwent RRM, with or without breast reconstruction. METHODS: We included 46 patients with BRCA1/2Mut+ who underwent RRM from July 2011 to December 2017. RESULTS: Among the 46 patients who underwent RRM, 3 had not been diagnosed with breast cancer (BC) and 43 had cancer in a single breast; 33 patients (71.7%) underwent breast reconstruction with RRM; and 13 patients (28.3%) did not undergo breast rec...
Source: Breast Cancer - July 10, 2019 Category: Cancer & Oncology Authors: Nagura N, Hayashi N, Takei J, Yoshida A, Ochi T, Iwahira Y, Yamauchi H Tags: Breast Cancer Source Type: research

Prediction of late recurrence in patients with breast cancer: elevated neutrophil to lymphocyte ratio (NLR) at 5  years after diagnosis and late recurrence.
This study aimed to determine whether neutrophil to lymphocyte ratio (NLR) taken after primary treatment can be a feasible prognostic factor for late recurrence. METHODS: Patients who were diagnosed with primary breast cancer and completed planned treatment were enrolled; data were retrospectively collected from the Wonju Severance Hospital database of Yonsei University. RESULTS: 496 patients completed planned treatment for their primary breast cancer. 385 were disease free after 5 years of the primary diagnosis and 330 were enrolled for second-look NLR analysis. NLR analysis performed approximately 5 y...
Source: Breast Cancer - July 6, 2019 Category: Cancer & Oncology Authors: Moon G, Noh H, Cho IJ, Lee JI, Han A Tags: Breast Cancer Source Type: research

Knockdown of FAM64A suppresses proliferation and migration of breast cancer cells.
CONCLUSIONS: Our findings suggest that FAM64A plays an important role in the proliferation and migration of BrC cells, which might serve as a potential target for BrC treatment. PMID: 31264076 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 1, 2019 Category: Cancer & Oncology Authors: Yao Z, Zheng X, Lu S, He Z, Miao Y, Huang H, Chu X, Cai C, Zou F Tags: Breast Cancer Source Type: research

Fatal events during clinical trials: an evaluation of deaths during breast cancer studies.
CONCLUSIONS: Death during study treatment was mainly related to infections, and patients with advanced disease, high BMI, underlying comorbidities, CRFs and concomitant medications. If considered for study participation these patients need careful monitoring due to their higher risk for death on study. PMID: 31254201 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 28, 2019 Category: Cancer & Oncology Authors: Furlanetto J, von Minckwitz G, Lederer B, Möbus V, Schneeweiss A, Huober J, Fasching PA, Gerber B, Bauerfeind I, Nitz U, Lück HJ, Hanusch C, Thomssen C, Untch M, Nekljudova V, Mehta K, Loibl S Tags: Breast Cancer Source Type: research

MicroRNA-138-5p inhibits cell migration, invasion and EMT in breast cancer by directly targeting RHBDD1.
CONCLUSIONS: Our findings revealed the tumor-suppressive role of miR-138-5p in regulating BC migration by targeting RHBDD1, suggesting that miR-138-5p negatively regulating EMT might be a therapeutic target in BC. PMID: 31243644 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 26, 2019 Category: Cancer & Oncology Authors: Zhao C, Ling X, Li X, Hou X, Zhao D Tags: Breast Cancer Source Type: research

Identification of differentially expressed genes between triple and non-triple-negative breast cancer using bioinformatics analysis.
CONCLUSION: Our research provides new insight into the subnetwork of biomarkers connected with TNBC, which could be useful for prognostication and risk stratification of TNBC patients. PMID: 31197620 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhai Q, Li H, Sun L, Yuan Y, Wang X Tags: Breast Cancer Source Type: research

A Systematic Review of Electronic Health (eHealth) interventions to improve physical activity in patients with breast cancer.
CONCLUSION: The results show that eHealth interventions can improve the level of PA in breast cancer patients. Although there are numerous eHealth interventions focusing on PA in cancer patients, there is still an essential need for eHealth interventions to be tailored for breast cancer patients specifically. Clinical trials with appropriate methodology, enough intervention time and follow-up are needed to make evidence-based results more generalizable. TRIAL REGISTRATION: PROSPERO CRD42018092422; https://www.crd.york.ac.uk/PROSPERO/ . PMID: 31187411 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 12, 2019 Category: Cancer & Oncology Authors: Dorri S, Asadi F, Olfatbakhsh A, Kazemi A Tags: Breast Cancer Source Type: research

A novel nipple-areola complex involvement predictive index for indicating nipple-sparing mastectomy in breast cancer patients.
Abstract BACKGROUND: Nipple-sparing mastectomy (NSM) is increasingly used in breast cancer patients, as it offers better cosmetic outcomes and improves quality of life. Nipple-areola complex (NAC) involvement must be accurately determined to identify which patients may be candidates for NSM. We aimed to identify the predictors of NAC involvement and develop a clinical predictive model to determine the patients for whom NAC preservation may be considered. PATIENTS AND METHODS: Patients (n = 168) with primary operable breast cancer who underwent subcutaneous mastectomy for breast reconstruction at...
Source: Breast Cancer - June 8, 2019 Category: Cancer & Oncology Authors: Seki H, Sakurai T, Mizuno S, Tokuda T, Kaburagi T, Seki M, Karahashi T, Nakajima K, Shimizu K, Jinno H Tags: Breast Cancer Source Type: research

Pharmacotherapy decision-making among patients with breast cancer in Japan: results of an online survey.
CONCLUSIONS: Our findings suggest that among patients with breast cancer, a shared role in treatment decision-making, longer consultation time at treatment selection, and having multiple treatment options are important for higher patient satisfaction with communication with their physician. PMID: 31177375 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 8, 2019 Category: Cancer & Oncology Authors: Shimizu C, Sakata Y, Sakai R, Ikezawa H, Uetaki Y, Matsuoka T Tags: Breast Cancer Source Type: research

Simultaneous comparison between strain and shear wave elastography of breast masses for the differentiation of benign and malignant lesions by qualitative and quantitative assessments.
CONCLUSION: The addition of both SE and SWE to B-mode ultrasound improved the diagnostic performance with increased AUC, and especially SWE was more useful than SE, and no significant difference was found between qualitative and quantitative assessments. PMID: 31175605 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Fujioka T, Mori M, Kubota K, Kikuchi Y, Katsuta L, Kasahara M, Oda G, Ishiba T, Nakagawa T, Tateishi U Tags: Breast Cancer Source Type: research

Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM.
CONCLUSION: These results revealed that icariin might potentially be useful as an adjuvant agent in cancer chemotherapy to enhance the effect of tamoxifen through suppression of autophagy in vitro and provide insight into the therapeutic potential of icariin for the treatment of chemo-resistant breast cancer. PMID: 31172425 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Cheng X, Tan S, Duan F, Yuan Q, Li Q, Deng G Tags: Breast Cancer Source Type: research

Correction to: Neutropenia management with palbociclib in Japanese patients with advanced breast cancer.
Abstract The correct name of the last author should be "Masakazu Toi", and not ''Masakuzu Toi" as given in the original publication of the article. PMID: 31168692 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 5, 2019 Category: Cancer & Oncology Authors: Masuda N, Mukai H, Inoue K, Rai Y, Ohno S, Mori Y, Hashigaki S, Muramatsu Y, Umeyama Y, Iwata H, Toi M Tags: Breast Cancer Source Type: research

Mean platelet volume may not be an independent prognostic factor in breast cancer patients with type 2 diabetes mellitus.
PMID: 31161368 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 3, 2019 Category: Cancer & Oncology Authors: Beyan C, Beyan E Tags: Breast Cancer Source Type: research

Transgelin-2 expression in breast cancer and its relationships with clinicopathological features and patient outcome.
CONCLUSIONS: Transgelin-2 was expressed significantly higher in breast cancer cells and correlated with some clinicopathological factors. High transgelin-2 expression might predict poor prognosis for ER-negative patients. PMID: 31144206 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 29, 2019 Category: Cancer & Oncology Authors: Hao R, Liu Y, Du Q, Liu L, Chen S, You H, Dong Y Tags: Breast Cancer Source Type: research

Neutropenia management with palbociclib in Japanese patients with advanced breast cancer.
CONCLUSION: Neutropenia was manageable with dose modifications, without affecting palbociclib treatment duration or efficacy. TRIAL REGISTRATION: Pfizer (NCT01740427, NCT01684215, NCT01942135). PMID: 31127500 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 24, 2019 Category: Cancer & Oncology Authors: Masuda N, Mukai H, Inoue K, Rai Y, Ohno S, Mori Y, Hashigaki S, Muramatsu Y, Umeyama Y, Iwata H, Toi M Tags: Breast Cancer Source Type: research

Comparison of central sensitization-related symptoms and health-related quality of life between breast cancer survivors with and without chronic pain and healthy controls.
This study aimed to compare the demographic characteristics, psychological factors, and CS-related symptoms between breast cancer survivors with pain, those without pain, and healthy controls, and to investigate the relationships of these factors with HRQoL. METHODS: We conducted a cross-sectional survey of 218 women, including patients who underwent breast cancer surgery and adjuvant therapy and healthy women. RESULTS: Patients were divided into the pain group (n = 42), without-pain group (n = 51), and healthy group (n = 47); thus, among breast cancer survivors, 45% repo...
Source: Breast Cancer - May 24, 2019 Category: Cancer & Oncology Authors: Manfuku M, Nishigami T, Mibu A, Tanaka K, Kitagaki K, Sumiyoshi K Tags: Breast Cancer Source Type: research

Association between pre-diagnosis BMI, physical activity, pathologic complete response, and chemotherapy completion in women treated with neoadjuvant chemotherapy for breast cancer.
CONCLUSIONS: Pathologic complete response was associated with lower BMI; chemotherapy completion was associated with exercising at CDC-recommended levels prior to breast cancer diagnosis. PMID: 31119682 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 22, 2019 Category: Cancer & Oncology Authors: Usiskin I, Li F, Irwin ML, Cartmel B, Sanft T Tags: Breast Cancer Source Type: research

Tumor microenvironmental growth factors induce long-term estrogen deprivation resistance in breast cancer.
CONCLUSIONS: This study demonstrates the importance of tumor microenvironment-derived factors for the development of AI resistance. These resistant models did not utilize the same resistance mechanism, suggesting that flexible strategies are essential in conquering resistance. PMID: 31119683 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 22, 2019 Category: Cancer & Oncology Authors: Tsuboi K, Uematsu C, Yamaguchi Y, Niwa T, Hayashi SI Tags: Breast Cancer Source Type: research

Prognostic significance of tumor-infiltrating lymphocytes may differ depending on Ki67 expression levels in estrogen receptor-positive/HER2-negative  operated breast cancers.
CONCLUSIONS: In Ki67-high breast cancers, high TILs were associated with favorable DFS, irrespective of subtype, but increasing TIL levels correlated with worse DFS in the Ki67-low group with the ER + /HER2 - subtype. These results highlight variation in TIL prognostic significance between Ki67-high and -low breast cancers, particularly for the ER + /HER2 - subtype. PMID: 31098866 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 16, 2019 Category: Cancer & Oncology Authors: Fujimoto Y, Watanabe T, Hida AI, Higuchi T, Miyagawa Y, Ozawa H, Bun A, Fukui R, Sata A, Imamura M, Hirota S, Miyoshi Y Tags: Breast Cancer Source Type: research

Preoperative mean platelet volume predicts survival in breast cancer patients with type 2 diabetes.
CONCLUSIONS: Our study first established a connection between MPV and BC patients with T2DM, suggesting that MPV was an independent prognostic factor and could be the biomarker for prognosis. PMID: 31087273 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 13, 2019 Category: Cancer & Oncology Authors: Li N, Lv XH, Wang X, Wang RT, Huang YX Tags: Breast Cancer Source Type: research

Cardiorespiratory fitness predicts cardiovascular health in breast cancer survivors, independent of body composition, age and time post-treatment completion.
CONCLUSIONS: This study provides evidence for an association between cardiorespiratory fitness and cardiovascular health in female breast cancer survivors. While fatness may be associated with cardiovascular health, it appears to be more strongly associated with age. PMID: 31087274 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 13, 2019 Category: Cancer & Oncology Authors: Jones LM, Stoner L, Brown C, Baldi JC, McLaren B Tags: Breast Cancer Source Type: research

A meta-analysis of clinical benefit rates for fulvestrant 500  mg vs. alternative endocrine therapies for hormone receptor-positive advanced breast cancer.
CONCLUSIONS: In postmenopausal patients with hormone receptor-positive ABC, fulvestrant 500 mg first-line was associated with significantly greater CBR (more patients benefiting from treatment) vs. comparator endocrine therapy. PMID: 31079343 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 11, 2019 Category: Cancer & Oncology Authors: Robertson JFR, Jiang Z, Di Leo A, Ohno S, Pritchard KI, Ellis M, Bradbury I, Campbell C Tags: Breast Cancer Source Type: research

Reproductive history and breast cancer survival: a prospective patient cohort study in Japan.
CONCLUSION: The results indicate that the timing of menarche and parity have significant effects on patient survival, providing clues for understanding the association between women's life course and breast cancer outcome. PMID: 30993643 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2019 Category: Cancer & Oncology Authors: Minami Y, Nishino Y, Kawai M, Tada H, Kanemura S, Miyashita M, Ishida T, Kakugawa Y Tags: Breast Cancer Source Type: research

PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation.
CONCLUSION: This study proposed the upregulation of PIM1 by IL-6 contributed to breast cancer cell aggressiveness and targeting PIM1 or c-myc could be novel approaches for breast cancer treatment. PMID: 30989585 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2019 Category: Cancer & Oncology Authors: Gao X, Liu X, Lu Y, Wang Y, Cao W, Liu X, Hu H, Wang H Tags: Breast Cancer Source Type: research

Five screening-detected breast cancer cases in initially disease-free BRCA1 or BRCA2 mutation carriers.
In conclusion, our results show that some challenges exist in the early detection of breast cancers in BRCA1 or BRCA2 mutation carriers. There are also some difficulties in approaching those individuals in Japanese society. PMID: 30980249 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2019 Category: Cancer & Oncology Authors: Shimada S, Yoshida R, Nakashima E, Kitagawa D, Gomi N, Horii R, Takeuchi S, Ashihara Y, Kita M, Akiyama F, Ohno S, Saito M, Arai M Tags: Breast Cancer Source Type: research

Clinical application of ceramide in cancer treatment.
Abstract Development of innovative strategies for cancer treatment is a pressing public health issue. Despite recent advances, the mechanisms of cancer progression and the resistance to cancer treatment have not been fully elucidated. Sphingolipids, including ceramide and sphingoshin-1-phosphate, are bioactive mediators that regulate cancer cell death and survival through the dynamic balance of what has been termed the 'sphingolipid rheostat'. Specifically, ceramide, which acts as the central hub of sphingolipid metabolism, is generated via three major pathways by many stressors, including anti-cancer treatments, ...
Source: Breast Cancer - April 8, 2019 Category: Cancer & Oncology Authors: Moro K, Nagahashi M, Gabriel E, Takabe K, Wakai T Tags: Breast Cancer Source Type: research

Paving the way for changing perceptions in breast surgery: a systematic literature review focused on oncological and aesthetic outcomes of oncoplastic surgery for breast cancer.
CONCLUSION: Tumor margins, mastectomy rates, and cosmetic outcomes of OPS have to be further improved by standardizing various aspects of OPS. Research efforts should focus on level I evidence assessing both oncological and aesthetic outcomes of OPS and survival rates. PMID: 30955172 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 6, 2019 Category: Cancer & Oncology Authors: Papanikolaou IG, Dimitrakakis C, Zagouri F, Marinopoulos S, Giannos A, Zografos E, Zografos CG, Kritikou D, Rodolakis A, Zografos GC, Loutradis D Tags: Breast Cancer Source Type: research

Patients' preferences for postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treatments in Japan.
CONCLUSIONS: Japanese postmenopausal patients with HR+ breast cancer preferred treatments that extend PFS despite potential grade 2 diarrhea. However, when diarrhea severity increased to grade 3, patients were more willing to sacrifice PFS to avoid more frequent diarrhea. Prevention or limitation of diarrhea to grade ≤ 2 is important for maintaining patients' motivation for treatment that can extend PFS. Additionally, patient characteristics (age, family context, therapeutic experience) should be considered during treatment choice. PMID: 30949915 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 4, 2019 Category: Cancer & Oncology Authors: Omori Y, Enatsu S, Cai Z, Ishiguro H Tags: Breast Cancer Source Type: research

Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer.
CONCLUSIONS: The minimum ADC value of primary breast lesions predicts axillary LN metastasis in luminal A-like breast cancer with clinically negative nodes, with high sensitivity and high NPV. PMID: 30937834 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 1, 2019 Category: Cancer & Oncology Authors: Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato H Tags: Breast Cancer Source Type: research

Correction to: Breast cancer cell motility is promoted by 14-3-3 γ.
Correction to: Breast cancer cell motility is promoted by 14-3-3γ. Breast Cancer. 2019 Mar 29;: Authors: Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Ito A, Okada M Abstract The correct name of the corresponding author should be ''Takahiro Mimae'', and not ''Emiko Hiraoka'' as given in the original publication of the article. PMID: 30927243 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 29, 2019 Category: Cancer & Oncology Authors: Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Ito A, Okada M Tags: Breast Cancer Source Type: research

Diabetes as a prognostic factor in HER-2 positive breast cancer patients treated with targeted therapy.
CONCLUSIONS: Type 2 diabetes was associated with detrimental effects on survival in postoperative HER-2+ breast cancer patients who were treated with trastuzumab. The poor prognostic effect of diabetes in HER-2+ breast cancer patients could be associated with the high levels of HER-3 and neuregulin 1, thus it should be considered and evaluated more. PMID: 30927244 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 29, 2019 Category: Cancer & Oncology Authors: Lee A, Jo S, Lee C, Shin HH, Kim TH, Ahn KJ, Park SK, Cho H, Yoon HK, Kim WG, Park J, Choi Y Tags: Breast Cancer Source Type: research

Sentinel node mapping and ductal carcinoma in situ.
CONCLUSIONS: In our moderate-sized surgical experience evaluating women with pure DCIS who underwent a sentinel node mapping due to large tumor size or high grade histology, we were unable to confirm that either is predictive of occult node involvement. PMID: 30903404 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 22, 2019 Category: Cancer & Oncology Authors: Pollock SE, Pollock J, Nestor S, Hardin R, Ghaphery D Tags: Breast Cancer Source Type: research

Oncologic outcomes and radiation safety of nipple-sparing mastectomy with intraoperative radiotherapy for breast cancer.
CONCLUSIONS: Our findings indicate that Intrabeam intraoperative radiotherapy during nipple-sparing mastectomy combined with breast reconstruction is safe and feasible. TRIAL REGISTRATION: The current study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University (registering order 201750). All participants gave their written informed consent. PMID: 30888580 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 19, 2019 Category: Cancer & Oncology Authors: Pan L, Ye C, Chen L, Tang W, Zhang X, Gao J, Wu R, Ye X, Tan W, Wan M, Zheng W Tags: Breast Cancer Source Type: research

Discrepancies of current recommendations in breast cancer follow-up: a systematic review.
CONCLUSIONS: Follow-up of patients with early breast cancer needs to become standardized and prospective clinical trials focusing on optimal follow-up are more than mandatory. PMID: 30887287 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 18, 2019 Category: Cancer & Oncology Authors: Kyriazoglou A, Zagouri F, Fotiou D, Dimitrakakis C, Marinopoulos S, Zakopoulou R, Kaparelou M, Zygogianni A, Dimopoulos MA Tags: Breast Cancer Source Type: research

C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis.
ia ME Abstract BACKGROUND: Previous meta-analyses have shown an ethnic dependency of the C677T and the A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms, with no focus on the Latino population. For Latinos, many studies have examined these polymorphisms and breast cancer susceptibility, yielding no concise result. Therefore, we undertook this meta-analysis to determine the effect these polymorphisms have on breast cancer risk for Latinos. METHODS: PubMed, EBSCO, LILACS, Scopus, and Latin American-specific databases were searched for studies exploring the association between the MTHFR polymorphi...
Source: Breast Cancer - March 15, 2019 Category: Cancer & Oncology Authors: Meneses-Sanchez P, Garcia-Hernandez SC, Porchia LM, Pérez-Fuentes R, Torres-Rasgado E, Del Angel Soto A, Gonzalez-Mejia ME Tags: Breast Cancer Source Type: research