Comparison of the diagnostic performance of synthesized two-dimensional mammography and full-field digital mammography alone or in combination with digital breast tomosynthesis.
Abstract PURPOSE: To investigate whether digital breast tomosynthesis (DBT) and subsequently generated synthesized mammography (SM) images show a better performance than full-field digital mammography (FFDM) images for diagnosing malignant breast lesions. In addition, the radiation doses for SM using different procedures were compared. MATERIALS AND METHODS: This prospective study enrolled 212 women (age ≥ 25 years) with clinically suspicious breast lesions. All participants underwent FFDM and DBT with the same breast compression. Finally, 222 lesions were confirmed by pathological analy...
Source: Breast Cancer - July 13, 2019 Category: Cancer & Oncology Authors: You C, Zhang Y, Gu Y, Xiao Q, Liu G, Shen X, Yang W, Peng W Tags: Breast Cancer Source Type: research

Symptoms and QOL in breast cancer patients receiving hormone therapy in Japan.
CONCLUSION: Breast cancer patients undergoing hormone therapy experience a variety of pains, and some also have serious psychological symptoms. Reassessing support systems to examine screening and self-care support is an issue going forward. PMID: 31297685 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 11, 2019 Category: Cancer & Oncology Authors: Iioka Y, Iwata T, Yamauchi H Tags: Breast Cancer Source Type: research

Breast reconstruction after risk-reducing mastectomy in BRCA mutation carriers.
Abstract BACKGROUND: Breast reconstruction is a favorable option for women with BRCA1 or BRCA2 mutations (BRCA1/2Mut+) who undergo risk-reducing mastectomy (RRM). We assessed characteristics of patients who underwent RRM, with or without breast reconstruction. METHODS: We included 46 patients with BRCA1/2Mut+ who underwent RRM from July 2011 to December 2017. RESULTS: Among the 46 patients who underwent RRM, 3 had not been diagnosed with breast cancer (BC) and 43 had cancer in a single breast; 33 patients (71.7%) underwent breast reconstruction with RRM; and 13 patients (28.3%) did not undergo breast rec...
Source: Breast Cancer - July 10, 2019 Category: Cancer & Oncology Authors: Nagura N, Hayashi N, Takei J, Yoshida A, Ochi T, Iwahira Y, Yamauchi H Tags: Breast Cancer Source Type: research

Prediction of late recurrence in patients with breast cancer: elevated neutrophil to lymphocyte ratio (NLR) at 5  years after diagnosis and late recurrence.
This study aimed to determine whether neutrophil to lymphocyte ratio (NLR) taken after primary treatment can be a feasible prognostic factor for late recurrence. METHODS: Patients who were diagnosed with primary breast cancer and completed planned treatment were enrolled; data were retrospectively collected from the Wonju Severance Hospital database of Yonsei University. RESULTS: 496 patients completed planned treatment for their primary breast cancer. 385 were disease free after 5 years of the primary diagnosis and 330 were enrolled for second-look NLR analysis. NLR analysis performed approximately 5 y...
Source: Breast Cancer - July 6, 2019 Category: Cancer & Oncology Authors: Moon G, Noh H, Cho IJ, Lee JI, Han A Tags: Breast Cancer Source Type: research

Knockdown of FAM64A suppresses proliferation and migration of breast cancer cells.
CONCLUSIONS: Our findings suggest that FAM64A plays an important role in the proliferation and migration of BrC cells, which might serve as a potential target for BrC treatment. PMID: 31264076 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 1, 2019 Category: Cancer & Oncology Authors: Yao Z, Zheng X, Lu S, He Z, Miao Y, Huang H, Chu X, Cai C, Zou F Tags: Breast Cancer Source Type: research

Fatal events during clinical trials: an evaluation of deaths during breast cancer studies.
CONCLUSIONS: Death during study treatment was mainly related to infections, and patients with advanced disease, high BMI, underlying comorbidities, CRFs and concomitant medications. If considered for study participation these patients need careful monitoring due to their higher risk for death on study. PMID: 31254201 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 28, 2019 Category: Cancer & Oncology Authors: Furlanetto J, von Minckwitz G, Lederer B, Möbus V, Schneeweiss A, Huober J, Fasching PA, Gerber B, Bauerfeind I, Nitz U, Lück HJ, Hanusch C, Thomssen C, Untch M, Nekljudova V, Mehta K, Loibl S Tags: Breast Cancer Source Type: research

MicroRNA-138-5p inhibits cell migration, invasion and EMT in breast cancer by directly targeting RHBDD1.
CONCLUSIONS: Our findings revealed the tumor-suppressive role of miR-138-5p in regulating BC migration by targeting RHBDD1, suggesting that miR-138-5p negatively regulating EMT might be a therapeutic target in BC. PMID: 31243644 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 26, 2019 Category: Cancer & Oncology Authors: Zhao C, Ling X, Li X, Hou X, Zhao D Tags: Breast Cancer Source Type: research

Identification of differentially expressed genes between triple and non-triple-negative breast cancer using bioinformatics analysis.
CONCLUSION: Our research provides new insight into the subnetwork of biomarkers connected with TNBC, which could be useful for prognostication and risk stratification of TNBC patients. PMID: 31197620 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Zhai Q, Li H, Sun L, Yuan Y, Wang X Tags: Breast Cancer Source Type: research

A Systematic Review of Electronic Health (eHealth) interventions to improve physical activity in patients with breast cancer.
CONCLUSION: The results show that eHealth interventions can improve the level of PA in breast cancer patients. Although there are numerous eHealth interventions focusing on PA in cancer patients, there is still an essential need for eHealth interventions to be tailored for breast cancer patients specifically. Clinical trials with appropriate methodology, enough intervention time and follow-up are needed to make evidence-based results more generalizable. TRIAL REGISTRATION: PROSPERO CRD42018092422; https://www.crd.york.ac.uk/PROSPERO/ . PMID: 31187411 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 12, 2019 Category: Cancer & Oncology Authors: Dorri S, Asadi F, Olfatbakhsh A, Kazemi A Tags: Breast Cancer Source Type: research

A novel nipple-areola complex involvement predictive index for indicating nipple-sparing mastectomy in breast cancer patients.
Abstract BACKGROUND: Nipple-sparing mastectomy (NSM) is increasingly used in breast cancer patients, as it offers better cosmetic outcomes and improves quality of life. Nipple-areola complex (NAC) involvement must be accurately determined to identify which patients may be candidates for NSM. We aimed to identify the predictors of NAC involvement and develop a clinical predictive model to determine the patients for whom NAC preservation may be considered. PATIENTS AND METHODS: Patients (n = 168) with primary operable breast cancer who underwent subcutaneous mastectomy for breast reconstruction at...
Source: Breast Cancer - June 8, 2019 Category: Cancer & Oncology Authors: Seki H, Sakurai T, Mizuno S, Tokuda T, Kaburagi T, Seki M, Karahashi T, Nakajima K, Shimizu K, Jinno H Tags: Breast Cancer Source Type: research

Pharmacotherapy decision-making among patients with breast cancer in Japan: results of an online survey.
CONCLUSIONS: Our findings suggest that among patients with breast cancer, a shared role in treatment decision-making, longer consultation time at treatment selection, and having multiple treatment options are important for higher patient satisfaction with communication with their physician. PMID: 31177375 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 8, 2019 Category: Cancer & Oncology Authors: Shimizu C, Sakata Y, Sakai R, Ikezawa H, Uetaki Y, Matsuoka T Tags: Breast Cancer Source Type: research

Simultaneous comparison between strain and shear wave elastography of breast masses for the differentiation of benign and malignant lesions by qualitative and quantitative assessments.
CONCLUSION: The addition of both SE and SWE to B-mode ultrasound improved the diagnostic performance with increased AUC, and especially SWE was more useful than SE, and no significant difference was found between qualitative and quantitative assessments. PMID: 31175605 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Fujioka T, Mori M, Kubota K, Kikuchi Y, Katsuta L, Kasahara M, Oda G, Ishiba T, Nakagawa T, Tateishi U Tags: Breast Cancer Source Type: research

Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM.
CONCLUSION: These results revealed that icariin might potentially be useful as an adjuvant agent in cancer chemotherapy to enhance the effect of tamoxifen through suppression of autophagy in vitro and provide insight into the therapeutic potential of icariin for the treatment of chemo-resistant breast cancer. PMID: 31172425 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Cheng X, Tan S, Duan F, Yuan Q, Li Q, Deng G Tags: Breast Cancer Source Type: research

Correction to: Neutropenia management with palbociclib in Japanese patients with advanced breast cancer.
Abstract The correct name of the last author should be "Masakazu Toi", and not ''Masakuzu Toi" as given in the original publication of the article. PMID: 31168692 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 5, 2019 Category: Cancer & Oncology Authors: Masuda N, Mukai H, Inoue K, Rai Y, Ohno S, Mori Y, Hashigaki S, Muramatsu Y, Umeyama Y, Iwata H, Toi M Tags: Breast Cancer Source Type: research

Mean platelet volume may not be an independent prognostic factor in breast cancer patients with type 2 diabetes mellitus.
PMID: 31161368 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 3, 2019 Category: Cancer & Oncology Authors: Beyan C, Beyan E Tags: Breast Cancer Source Type: research

Transgelin-2 expression in breast cancer and its relationships with clinicopathological features and patient outcome.
CONCLUSIONS: Transgelin-2 was expressed significantly higher in breast cancer cells and correlated with some clinicopathological factors. High transgelin-2 expression might predict poor prognosis for ER-negative patients. PMID: 31144206 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 29, 2019 Category: Cancer & Oncology Authors: Hao R, Liu Y, Du Q, Liu L, Chen S, You H, Dong Y Tags: Breast Cancer Source Type: research

Neutropenia management with palbociclib in Japanese patients with advanced breast cancer.
CONCLUSION: Neutropenia was manageable with dose modifications, without affecting palbociclib treatment duration or efficacy. TRIAL REGISTRATION: Pfizer (NCT01740427, NCT01684215, NCT01942135). PMID: 31127500 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 24, 2019 Category: Cancer & Oncology Authors: Masuda N, Mukai H, Inoue K, Rai Y, Ohno S, Mori Y, Hashigaki S, Muramatsu Y, Umeyama Y, Iwata H, Toi M Tags: Breast Cancer Source Type: research

Comparison of central sensitization-related symptoms and health-related quality of life between breast cancer survivors with and without chronic pain and healthy controls.
This study aimed to compare the demographic characteristics, psychological factors, and CS-related symptoms between breast cancer survivors with pain, those without pain, and healthy controls, and to investigate the relationships of these factors with HRQoL. METHODS: We conducted a cross-sectional survey of 218 women, including patients who underwent breast cancer surgery and adjuvant therapy and healthy women. RESULTS: Patients were divided into the pain group (n = 42), without-pain group (n = 51), and healthy group (n = 47); thus, among breast cancer survivors, 45% repo...
Source: Breast Cancer - May 24, 2019 Category: Cancer & Oncology Authors: Manfuku M, Nishigami T, Mibu A, Tanaka K, Kitagaki K, Sumiyoshi K Tags: Breast Cancer Source Type: research

Association between pre-diagnosis BMI, physical activity, pathologic complete response, and chemotherapy completion in women treated with neoadjuvant chemotherapy for breast cancer.
CONCLUSIONS: Pathologic complete response was associated with lower BMI; chemotherapy completion was associated with exercising at CDC-recommended levels prior to breast cancer diagnosis. PMID: 31119682 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 22, 2019 Category: Cancer & Oncology Authors: Usiskin I, Li F, Irwin ML, Cartmel B, Sanft T Tags: Breast Cancer Source Type: research

Tumor microenvironmental growth factors induce long-term estrogen deprivation resistance in breast cancer.
CONCLUSIONS: This study demonstrates the importance of tumor microenvironment-derived factors for the development of AI resistance. These resistant models did not utilize the same resistance mechanism, suggesting that flexible strategies are essential in conquering resistance. PMID: 31119683 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 22, 2019 Category: Cancer & Oncology Authors: Tsuboi K, Uematsu C, Yamaguchi Y, Niwa T, Hayashi SI Tags: Breast Cancer Source Type: research

Prognostic significance of tumor-infiltrating lymphocytes may differ depending on Ki67 expression levels in estrogen receptor-positive/HER2-negative  operated breast cancers.
CONCLUSIONS: In Ki67-high breast cancers, high TILs were associated with favorable DFS, irrespective of subtype, but increasing TIL levels correlated with worse DFS in the Ki67-low group with the ER + /HER2 - subtype. These results highlight variation in TIL prognostic significance between Ki67-high and -low breast cancers, particularly for the ER + /HER2 - subtype. PMID: 31098866 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 16, 2019 Category: Cancer & Oncology Authors: Fujimoto Y, Watanabe T, Hida AI, Higuchi T, Miyagawa Y, Ozawa H, Bun A, Fukui R, Sata A, Imamura M, Hirota S, Miyoshi Y Tags: Breast Cancer Source Type: research

Preoperative mean platelet volume predicts survival in breast cancer patients with type 2 diabetes.
CONCLUSIONS: Our study first established a connection between MPV and BC patients with T2DM, suggesting that MPV was an independent prognostic factor and could be the biomarker for prognosis. PMID: 31087273 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 13, 2019 Category: Cancer & Oncology Authors: Li N, Lv XH, Wang X, Wang RT, Huang YX Tags: Breast Cancer Source Type: research

Cardiorespiratory fitness predicts cardiovascular health in breast cancer survivors, independent of body composition, age and time post-treatment completion.
CONCLUSIONS: This study provides evidence for an association between cardiorespiratory fitness and cardiovascular health in female breast cancer survivors. While fatness may be associated with cardiovascular health, it appears to be more strongly associated with age. PMID: 31087274 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 13, 2019 Category: Cancer & Oncology Authors: Jones LM, Stoner L, Brown C, Baldi JC, McLaren B Tags: Breast Cancer Source Type: research

A meta-analysis of clinical benefit rates for fulvestrant 500  mg vs. alternative endocrine therapies for hormone receptor-positive advanced breast cancer.
CONCLUSIONS: In postmenopausal patients with hormone receptor-positive ABC, fulvestrant 500 mg first-line was associated with significantly greater CBR (more patients benefiting from treatment) vs. comparator endocrine therapy. PMID: 31079343 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 11, 2019 Category: Cancer & Oncology Authors: Robertson JFR, Jiang Z, Di Leo A, Ohno S, Pritchard KI, Ellis M, Bradbury I, Campbell C Tags: Breast Cancer Source Type: research

Reproductive history and breast cancer survival: a prospective patient cohort study in Japan.
CONCLUSION: The results indicate that the timing of menarche and parity have significant effects on patient survival, providing clues for understanding the association between women's life course and breast cancer outcome. PMID: 30993643 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2019 Category: Cancer & Oncology Authors: Minami Y, Nishino Y, Kawai M, Tada H, Kanemura S, Miyashita M, Ishida T, Kakugawa Y Tags: Breast Cancer Source Type: research

PIM1 is responsible for IL-6-induced breast cancer cell EMT and stemness via c-myc activation.
CONCLUSION: This study proposed the upregulation of PIM1 by IL-6 contributed to breast cancer cell aggressiveness and targeting PIM1 or c-myc could be novel approaches for breast cancer treatment. PMID: 30989585 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2019 Category: Cancer & Oncology Authors: Gao X, Liu X, Lu Y, Wang Y, Cao W, Liu X, Hu H, Wang H Tags: Breast Cancer Source Type: research

Five screening-detected breast cancer cases in initially disease-free BRCA1 or BRCA2 mutation carriers.
In conclusion, our results show that some challenges exist in the early detection of breast cancers in BRCA1 or BRCA2 mutation carriers. There are also some difficulties in approaching those individuals in Japanese society. PMID: 30980249 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 12, 2019 Category: Cancer & Oncology Authors: Shimada S, Yoshida R, Nakashima E, Kitagawa D, Gomi N, Horii R, Takeuchi S, Ashihara Y, Kita M, Akiyama F, Ohno S, Saito M, Arai M Tags: Breast Cancer Source Type: research

Clinical application of ceramide in cancer treatment.
Abstract Development of innovative strategies for cancer treatment is a pressing public health issue. Despite recent advances, the mechanisms of cancer progression and the resistance to cancer treatment have not been fully elucidated. Sphingolipids, including ceramide and sphingoshin-1-phosphate, are bioactive mediators that regulate cancer cell death and survival through the dynamic balance of what has been termed the 'sphingolipid rheostat'. Specifically, ceramide, which acts as the central hub of sphingolipid metabolism, is generated via three major pathways by many stressors, including anti-cancer treatments, ...
Source: Breast Cancer - April 8, 2019 Category: Cancer & Oncology Authors: Moro K, Nagahashi M, Gabriel E, Takabe K, Wakai T Tags: Breast Cancer Source Type: research

Paving the way for changing perceptions in breast surgery: a systematic literature review focused on oncological and aesthetic outcomes of oncoplastic surgery for breast cancer.
CONCLUSION: Tumor margins, mastectomy rates, and cosmetic outcomes of OPS have to be further improved by standardizing various aspects of OPS. Research efforts should focus on level I evidence assessing both oncological and aesthetic outcomes of OPS and survival rates. PMID: 30955172 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 6, 2019 Category: Cancer & Oncology Authors: Papanikolaou IG, Dimitrakakis C, Zagouri F, Marinopoulos S, Giannos A, Zografos E, Zografos CG, Kritikou D, Rodolakis A, Zografos GC, Loutradis D Tags: Breast Cancer Source Type: research

Patients' preferences for postmenopausal hormone receptor-positive, human epidermal growth factor receptor 2-negative advanced breast cancer treatments in Japan.
CONCLUSIONS: Japanese postmenopausal patients with HR+ breast cancer preferred treatments that extend PFS despite potential grade 2 diarrhea. However, when diarrhea severity increased to grade 3, patients were more willing to sacrifice PFS to avoid more frequent diarrhea. Prevention or limitation of diarrhea to grade ≤ 2 is important for maintaining patients' motivation for treatment that can extend PFS. Additionally, patient characteristics (age, family context, therapeutic experience) should be considered during treatment choice. PMID: 30949915 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 4, 2019 Category: Cancer & Oncology Authors: Omori Y, Enatsu S, Cai Z, Ishiguro H Tags: Breast Cancer Source Type: research

Predicting metastasis in clinically negative axillary lymph nodes with minimum apparent diffusion coefficient value in luminal A-like breast cancer.
CONCLUSIONS: The minimum ADC value of primary breast lesions predicts axillary LN metastasis in luminal A-like breast cancer with clinically negative nodes, with high sensitivity and high NPV. PMID: 30937834 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 1, 2019 Category: Cancer & Oncology Authors: Kato F, Kudo K, Yamashita H, Baba M, Shimizu A, Oyama-Manabe N, Kinoshita R, Li R, Shirato H Tags: Breast Cancer Source Type: research

Correction to: Breast cancer cell motility is promoted by 14-3-3 γ.
Correction to: Breast cancer cell motility is promoted by 14-3-3γ. Breast Cancer. 2019 Mar 29;: Authors: Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Ito A, Okada M Abstract The correct name of the corresponding author should be ''Takahiro Mimae'', and not ''Emiko Hiraoka'' as given in the original publication of the article. PMID: 30927243 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 29, 2019 Category: Cancer & Oncology Authors: Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Ito A, Okada M Tags: Breast Cancer Source Type: research

Diabetes as a prognostic factor in HER-2 positive breast cancer patients treated with targeted therapy.
CONCLUSIONS: Type 2 diabetes was associated with detrimental effects on survival in postoperative HER-2+ breast cancer patients who were treated with trastuzumab. The poor prognostic effect of diabetes in HER-2+ breast cancer patients could be associated with the high levels of HER-3 and neuregulin 1, thus it should be considered and evaluated more. PMID: 30927244 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 29, 2019 Category: Cancer & Oncology Authors: Lee A, Jo S, Lee C, Shin HH, Kim TH, Ahn KJ, Park SK, Cho H, Yoon HK, Kim WG, Park J, Choi Y Tags: Breast Cancer Source Type: research

Sentinel node mapping and ductal carcinoma in situ.
CONCLUSIONS: In our moderate-sized surgical experience evaluating women with pure DCIS who underwent a sentinel node mapping due to large tumor size or high grade histology, we were unable to confirm that either is predictive of occult node involvement. PMID: 30903404 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 22, 2019 Category: Cancer & Oncology Authors: Pollock SE, Pollock J, Nestor S, Hardin R, Ghaphery D Tags: Breast Cancer Source Type: research

Oncologic outcomes and radiation safety of nipple-sparing mastectomy with intraoperative radiotherapy for breast cancer.
CONCLUSIONS: Our findings indicate that Intrabeam intraoperative radiotherapy during nipple-sparing mastectomy combined with breast reconstruction is safe and feasible. TRIAL REGISTRATION: The current study was approved by the Ethics Committee of the First Affiliated Hospital of Guangzhou Medical University (registering order 201750). All participants gave their written informed consent. PMID: 30888580 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 19, 2019 Category: Cancer & Oncology Authors: Pan L, Ye C, Chen L, Tang W, Zhang X, Gao J, Wu R, Ye X, Tan W, Wan M, Zheng W Tags: Breast Cancer Source Type: research

Discrepancies of current recommendations in breast cancer follow-up: a systematic review.
CONCLUSIONS: Follow-up of patients with early breast cancer needs to become standardized and prospective clinical trials focusing on optimal follow-up are more than mandatory. PMID: 30887287 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 18, 2019 Category: Cancer & Oncology Authors: Kyriazoglou A, Zagouri F, Fotiou D, Dimitrakakis C, Marinopoulos S, Zakopoulou R, Kaparelou M, Zygogianni A, Dimopoulos MA Tags: Breast Cancer Source Type: research

C677T and A1298C methylenetetrahydrofolate reductase polymorphisms and breast cancer susceptibility among Latinos: a meta-analysis.
ia ME Abstract BACKGROUND: Previous meta-analyses have shown an ethnic dependency of the C677T and the A1298C methylenetetrahydrofolate reductase (MTHFR) polymorphisms, with no focus on the Latino population. For Latinos, many studies have examined these polymorphisms and breast cancer susceptibility, yielding no concise result. Therefore, we undertook this meta-analysis to determine the effect these polymorphisms have on breast cancer risk for Latinos. METHODS: PubMed, EBSCO, LILACS, Scopus, and Latin American-specific databases were searched for studies exploring the association between the MTHFR polymorphi...
Source: Breast Cancer - March 15, 2019 Category: Cancer & Oncology Authors: Meneses-Sanchez P, Garcia-Hernandez SC, Porchia LM, Pérez-Fuentes R, Torres-Rasgado E, Del Angel Soto A, Gonzalez-Mejia ME Tags: Breast Cancer Source Type: research

Novel tumor-infiltrating lymphocytes ultrasonography score based on ultrasonic tissue findings predicts tumor-infiltrating lymphocytes in breast cancer.
Abstract BACKGROUND: The presence of tumor-infiltrating lymphocytes (TILs) is a prognostic factor for breast cancer. However, because of tumor tissue heterogeneity, an accurate and simple evaluation method is needed. We determined if preoperative characteristic ultrasonography (US) image findings are predictive of lymphocyte-predominant breast cancer (LPBC). METHODS: We evaluated 191 patients with invasive breast cancer treated by curative surgery between January 2014 and December 2017. Stromal lymphocytes in surgical pathological specimens were evaluated. Fifty-two patients with ≥ 50% stromal TILs ...
Source: Breast Cancer - March 13, 2019 Category: Cancer & Oncology Authors: Fukui K, Masumoto N, Shiroma N, Kanou A, Sasada S, Emi A, Kadoya T, Yokozaki M, Arihiro K, Okada M Tags: Breast Cancer Source Type: research

Lateral thoracoaxillar dermal-fat flap for breast conserving surgery: the changes of the indication and long-term results.
CONCLUSIONS: We reported satisfying long-term outcomes of 487 cases treated by LTDF. LTDF is a suitable oncoplastic technique for BCS. PMID: 30847663 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2019 Category: Cancer & Oncology Authors: Nakagomi H, Inoue M, Nakada H, Ohmori M, Nakayama Y, Furuya K, Watanabe H, Ikegame K, Kobayashi K Tags: Breast Cancer Source Type: research

Breast cancer cell motility is promoted by 14-3-3 γ.
CONCLUSION: The role of 14-3-3γ in breast cancer invasiveness might be to promote cell motility. Inhibition of 14-3-3γ could, therefore, become a novel target of therapy to prevent invasion and metastasis in patients with breast cancers expressing 14-3-3γ. PMID: 30830684 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 4, 2019 Category: Cancer & Oncology Authors: Hiraoka E, Mimae T, Ito M, Kadoya T, Miyata Y, Ito A, Okada M Tags: Breast Cancer Source Type: research

The clinical impact of MRI screening for BRCA mutation carriers: the first report in Japan.
Abstract BACKGROUND: There is no consensus on the appropriate surveillance for high-risk women with breast cancer in Japan. We investigated their imaging features and pathological characteristics to build a proper surveillance system for asymptomatic high-risk individuals in the future. METHODS: We retrospectively reviewed 93 female (median age 43 years) BRCA1 and BRCA2 mutation carriers from our institutional clinical database from 2011 to 2017. The study population was composed of 112 breast cancers. Mammography and MRI were reviewed by examiners blinded to patients' clinical history. Final surgical or...
Source: Breast Cancer - February 28, 2019 Category: Cancer & Oncology Authors: Murakami W, Tozaki M, Nakamura S, Ide Y, Inuzuka M, Hirota Y, Murakami K, Takahama N, Ohgiya Y, Gokan T Tags: Breast Cancer Source Type: research

Impact of germinal center-associated nuclear protein polymorphisms on breast cancer risk and prognosis in a Japanese population.
CONCLUSIONS: The G allele of rs2839178 at the GANP locus was significantly associated with reduced breast cancer risk and longer DFS in breast cancer patients, showing a consistent direction in the association between susceptibility and clinical outcome. GANP is, therefore, important for the occurrence and progression of sporadic breast cancer. PMID: 30810967 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - February 27, 2019 Category: Cancer & Oncology Authors: Kotani H, Ito H, Kuwahara K, Kuzushima K, Iwata H, Tsunoda N, Nagino M, Matsuo K Tags: Breast Cancer Source Type: research

Relationships among personality, coping, and concurrent health-related quality of life in women with breast cancer.
CONCLUSIONS: A high prevalence of sleep disorders for patients with breast cancer has occurred and sleep disorders were negatively associated with PQOL and MQOL. In addition, neuroticism was positively related to sleep disorders and could be relevant to psycho-educational interventions. PMID: 30747373 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - February 12, 2019 Category: Cancer & Oncology Authors: Lai HL, Chen CI, Lu CY, Yao YC, Huang CY Tags: Breast Cancer Source Type: research

Comparison of the efficacy of trastuzumab emtansine between patients with metastatic human epidermal growth factor receptor 2-positive breast cancers previously treated with combination trastuzumab and pertuzumab and with trastuzumab only in Japanese population.
CONCLUSIONS: Patients with HER2-positive MBC who received Tmab and Pmab treatment before T-DM1 have fewer benefits from T-DM1. PMID: 30737616 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - February 8, 2019 Category: Cancer & Oncology Authors: Noda-Narita S, Shimomura A, Kawachi A, Sumiyoshi-Okuma H, Sudo K, Shimoi T, Noguchi E, Yonemori K, Shimizu C, Fujiwara Y, Tamura K Tags: Breast Cancer Source Type: research

Pharmacogenomic-pharmacokinetic study of selective estrogen-receptor modulators with intra-patient dose escalation in breast cancer.
We examined the role of TOR and its dose escalation among poor TAM metabolizers. METHODS: The pharmacokinetics (PK) and pharmacogenomics (PGx) of TAM and TOR were studied. Correlation between PK and CYP2D6 inhibitor use, smoking status, and PGx were examined by regression analysis. For patients showing low endoxifen levels, an intra-patient dose escalation of TOR was conducted, and TOR was increased from 40 to 120 mg for ≥ 24 weeks with PK sampling. Total activity was calculated as the sum of the concentration of each active metabolite adjusted by their respective in vitro activities. RESULTS: Fift...
Source: Breast Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Ishiguro H, Ohno S, Yamamoto Y, Takao S, Sato N, Fujisawa T, Kadoya T, Kuroi K, Bando H, Teramura Y, Iwata H, Tanaka S, Toi M Tags: Breast Cancer Source Type: research

Reinterpretation of BRCA1 and BRCA2 variants of uncertain significance in patients with hereditary breast/ovarian cancer using the ACMG/AMP 2015 guidelines.
CONCLUSIONS: Since the clinical significance of VUS in BRCA1/2 may vary from time to time, reinterpretation of the VUS results could contribute to clinical decision-making. PMID: 30725392 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - February 6, 2019 Category: Cancer & Oncology Authors: So MK, Jeong TD, Lim W, Moon BI, Paik NS, Kim SC, Huh J Tags: Breast Cancer Source Type: research

Oncoplastic breast surgery combining partial mastectomy with immediate breast reshaping using multiple local flaps for a patient with slim body.
We report the results of OBS in a Japanese patient with early breast cancer located on the outer lower quadrant area. We performed OBS combining partial mastectomy with immediate breast reshaping using multiple adipofascial cutaneous flaps and free dermal fat graft because she refused any other OBS. We selected three local flaps to repair the defect. Perioperative and postoperative complications were not seen. The cosmetic findings 3 years after surgery were not excellent, but the patient was satisfied with the results. OBS combining partial mastectomy with immediate breast reshaping using a combination of several fla...
Source: Breast Cancer - January 25, 2019 Category: Cancer & Oncology Authors: Kijima Y, Hirata M, Shinden Y, Utsumi T, Morise Z, Natsugoe S Tags: Breast Cancer Source Type: research

3, 3'-Diindolylmethane-encapsulated chitosan nanoparticles accelerate molecular events during chemical carcinogen-induced mammary cancer in Sprague Dawley rats.
CONCLUSION: Our results clearly provide evidence that DIM@CS-NP exerts chemotherapeutic effect than DIM in DMBA model of mammary cancer by hold back anomalous tumor cell proliferation and inducing apoptosis to intervene through alterations of up-regulated and down-regulated molecules. Taken together, the data provide new evidence for mechanism action of DIM@CS-NP on mammary cancer. PMID: 30684233 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - January 25, 2019 Category: Cancer & Oncology Authors: Isabella S, Mirunalini S Tags: Breast Cancer Source Type: research

URG4 expression in invasive breast carcinoma and its relation to clinicopathological characteristics.
CONCLUSION: The literature data suggest that URG4 overexpression is associated with poor prognosis in many types of cancer. Conversely, our results in breast cancer specimens indicate that URG4 overexpression in breast ductal carcinomas is significantly associated with good prognostic parameters. Nevertheless, these preliminary findings should be confirmed by further studies. PMID: 30680688 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - January 24, 2019 Category: Cancer & Oncology Authors: Aslan F, Avcıkurt AS Tags: Breast Cancer Source Type: research

Association between alcohol consumption and mammographic density: a hospital-based cross-sectional study.
CONCLUSION: MD was positively associated with alcohol consumption in Japanese women. PMID: 30680689 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - January 24, 2019 Category: Cancer & Oncology Authors: Okamoto T, Ito A Tags: Breast Cancer Source Type: research