Investigation of the significance of population-based breast cancer screening among women aged under 40  years.
Investigation of the significance of population-based breast cancer screening among women aged under 40 years. Breast Cancer. 2020 Jul 08;: Authors: Okazaki M, Bando H, Tohno E, Kujiraoka Y, Iguchi-Manaka A, Ichioka E, Tsushima Y, Watanabe H, Hara H Abstract BACKGROUND: Owing to low incidence rates, population-based breast cancer screening is not recommended by many municipalities in Japan for women aged
Source: Breast Cancer - July 8, 2020 Category: Cancer & Oncology Authors: Okazaki M, Bando H, Tohno E, Kujiraoka Y, Iguchi-Manaka A, Ichioka E, Tsushima Y, Watanabe H, Hara H Tags: Breast Cancer Source Type: research

Current status of MRI-guided vacuum-assisted breast biopsy in Japan.
Abstract In April 2018, the national health insurance coverage of MRI-guided vacuum-assisted breast biopsy (VAB) was instituted with the application of the Japan Breast Cancer Society. Although MRI-guided VAB has been considered as a special procedure for a long time, having an access to this procedure should be recommended for facilities performing breast MRI as in Western countries. From now on, relevant societies should make efforts in data collection and quality control of MRI-guided VAB in Japan. We must avoid the following. To delay the early diagnosis of breast cancer in the judgment of an inaccurate indica...
Source: Breast Cancer - July 6, 2020 Category: Cancer & Oncology Authors: Takahama N, Tozaki M, Ohgiya Y Tags: Breast Cancer Source Type: research

Current status of breast cancer screening in high-risk women in Japan.
Abstract Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the "Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in prognosis using genetic information in Japan" group, as part of the Comprehensive Research Project on the Promotion of Cancer Control, Health and Labour Sciences Research, and have been conducting the study entitled, "Study of the usefulness of MRI surveillance of BRCA1/2 mutation carriers" since 201...
Source: Breast Cancer - July 6, 2020 Category: Cancer & Oncology Authors: Tozaki M, Nakamura S Tags: Breast Cancer Source Type: research

Sedentary behavior and risk of breast cancer: a dose-response meta-analysis from prospective studies.
CONCLUSIONS: Sedentary behavior was validated as a risk factor of breast cancer through dose-response analysis, especially TV viewing. PMID: 32607943 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 30, 2020 Category: Cancer & Oncology Authors: Chong F, Wang Y, Song M, Sun Q, Xie W, Song C Tags: Breast Cancer Source Type: research

The clinical usefulness of the CTS5 in the prediction of late distant recurrence in postmenopausal women with estrogen receptor-positive early breast cancer.
CONCLUSIONS: In postmenopausal women with ER+ breast cancer, low CTS5 was considered to be associated with a very low risk of late DR. Thus, extended endocrine therapy may be unnecessary for patients with low CTS5 scores. Extended endocrine therapy should be offered for patients with intermediate or high CTS5 scores, especially those with high-ER and HER2- breast cancer. PMID: 32601800 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 29, 2020 Category: Cancer & Oncology Authors: Tajiri W, Ijichi H, Takizawa K, Koi Y, Masuda T, Ueo H, Koga C, Nakamura Y, Taguchi K, Okamoto M, Tokunaga E Tags: Breast Cancer Source Type: research

Kounis syndrome after patent blue dye injection for sentinel lymph node biopsy.
CONCLUSION: There are just ten cases of perioperative KS in the literature so far and here we present the first one triggered by patent blue V dye for sentinel node biopsy. PMID: 32601801 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 29, 2020 Category: Cancer & Oncology Authors: Frountzas M, Karathanasis P, Vrakopoulou GZ, Theodoropoulos C, Zografos CG, Schizas D, Zografos GC, Michalopoulos NV Tags: Breast Cancer Source Type: research

Beyond the speed of SOUND.
Abstract Much anticipation awaits the results of the SOUND trial, (Gentilini and Veronesi in Breast 21:678-681, 2012) which may prove the futility of performing sentinel node biopsy (SNB) in low-risk breast cancer patients. However, do we really not know the answer to the questions that the SOUND trial poses already? Consideration must be taken of the very much overlooked trials predating the sentinel node era, which risk stratified patients according to the absence of palpable lymphadenopathy and without dependence upon ultrasound imaging (clinically negative axilla). This automatically selects a low-risk group o...
Source: Breast Cancer - June 27, 2020 Category: Cancer & Oncology Authors: Ahmed M Tags: Breast Cancer Source Type: research

Physician's knowledge, attitudes and practice pattern for breast cancer diagnosed during pregnancy: a survey among breast care specialists in Japan.
CONCLUSIONS: Interest, knowledge, and awareness of the guidelines appear to influence physician attitude, and thus it is urgently important to lay out educational materials and learning opportunities regarding BCP for breast specialists. A regional network of oncologists, obstetricians, and pediatricians to support the BCP patients should be developed. PMID: 32592140 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 26, 2020 Category: Cancer & Oncology Authors: Bando H, Kataoka A, Tamaki K, Kobayashi M, Tamura N, Ozawa M, Kawano J, Fukatsu Y, Kitano A, Shiota K, Yamauchi H Tags: Breast Cancer Source Type: research

Effect of adjuvant chemotherapy in patients with ER  + /HER2- breast cancer, assessed by propensity score matching: significance of nuclear grade and nodal status.
This study investigated the survival benefits of CT for ER + and human epidermal growth factor receptor 2-negative (HER2-) breast cancer (BC) patients by propensity score matching (PSM). METHODS: Patients with stages I-IIIER + /HER2- BC were enrolled in this study. The primary endpoints were 5-year recurrence-free survival (RFS) and overall survival (OS) in the non-CT and CT groups of the selected population matched by PS. The PS was analyzed by a logistic regression model with factors those influence provided indication of chemotherapy [tumor size, nuclear grade (NG), progesterone receptor...
Source: Breast Cancer - June 26, 2020 Category: Cancer & Oncology Authors: Tanaka N, Hirano A, Hattori A, Ogura K, Kamimura M, Inoue H, Yukawa H, Sakaguchi S, Matsuoka A, Kodera A, Shimizu T Tags: Breast Cancer Source Type: research

Fertility under uncertainty: exploring differences in fertility-related concerns and psychosocial aspects between breast cancer survivors and non-cancer infertile women.
Monteiro S Abstract BACKGROUND: The threat to fertility due to anticancer treatments can be distressing to women who wish to complete their family. The current study assessed the fertility-related concerns, psychological distress and health-related quality of life (HRQoL) of breast cancer survivors in comparison to non-cancer women with infertility history and to healthy controls from the general population. METHODS: We surveyed young adult women aged 18 to 40 who wished to have a (or another) biological child. Participants completed self-report measures assessing fertility concerns, anxiety, depression and ...
Source: Breast Cancer - June 24, 2020 Category: Cancer & Oncology Authors: Bártolo A, Neves M, Carvalho B, Reis S, Valério E, Santos IM, Monteiro S Tags: Breast Cancer Source Type: research

Interleukin-34 contributes to poor prognosis in triple-negative breast cancer.
In this study, we evaluated the relationship of IL-34 and prognosis in TNBC using human clinical information and mice model. We found that IL-34 was highly expressed in TNBC, and the survival rate in TNBC was significantly lower in patients with high IL-34 expression. Furthermore, multivariate analysis revealed that IL-34 independently affects prognosis. In murine TNBC model, IL-34 deficiency in tumor cells decreased in vivo tumor growth and increased inflammatory cytokine production from macrophages. These results suggest that tumor-derived IL-34 creates a favorable environment for TNBC cells. Thus, we showed a novel path...
Source: Breast Cancer - June 23, 2020 Category: Cancer & Oncology Authors: Kajihara N, Kitagawa F, Kobayashi T, Wada H, Otsuka R, Seino KI Tags: Breast Cancer Source Type: research

Pure ground glass opacity (GGO) on chest CT: a rare presentation of lung metastasis of Malignant Phyllodes Tumor.
We report here a rare case in which pure ground-glass opacity (GGO) was observed on chest CT about 3 years after the initial treatment of breast PT. After the lung lobectomy, we histologically confirmed that it should be diagnosed as a metastasis of PT. GGO rarely shows on metastatic tumors, and no reports have been made on GGO thus far in connection with metastasis of PT. Thus, in case GGO was found on the CT of patients having a history of PT, we suggest to take possible distant-metastasis into consideration. PMID: 32578005 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 23, 2020 Category: Cancer & Oncology Authors: Nakamura S, Goto T, Nara S, Kawahara Y, Yashiro S, Kano S, Hosokawa Y, Kamada H Tags: Breast Cancer Source Type: research

Retrospective reinterpretation and reclassification of BRCA1/2 variants from Chinese population.
CONCLUSIONS: Our results demonstrated that clinical significance of not only VUS, but also pathogenic/likely pathogenic variants varied from time to time in the Chinese population. Precise reinterpretation of BRCA1/2 variants is of crucial importance to genetic counseling or clinical decision-making for risk individuals or patients. PMID: 32566972 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 22, 2020 Category: Cancer & Oncology Authors: Li D, Shi Y, Li A, Cao D, Su H, Yang H, Zhi Q, Yang Y, Lan Z, Zhou T, You X, Hu G Tags: Breast Cancer Source Type: research

3-Dimensional objective aesthetic evaluation to replace panel assessment after breast-conserving treatment.
CONCLUSION: A six-variable objective aesthetic outcome model for BCT has been described and validated. This can predict and could replace panel assessment, facilitating the independent and unbiased evaluation of aesthetic outcome to communicate and compare results, benchmark practice, and raise standards. PMID: 32562188 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 19, 2020 Category: Cancer & Oncology Authors: Godden AR, O'Connell RL, Barry PA, Krupa KCD, Wolf LM, Mohammed K, Kirby AM, Rusby JE Tags: Breast Cancer Source Type: research

XPC as breast cancer susceptibility gene: evidence from genetic profiling, statistical inferences and protein structural analysis.
CONCLUSION: In conclusion, both XPC polymorphisms confer significant association with increased BC risk. rs2228001 substitution may change the structural and functional preferences of XPC C-terminus, while rs2733532 may have regulatory role thereby leading to potential BC risk. PMID: 32562189 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 19, 2020 Category: Cancer & Oncology Authors: Malik SS, Zia A, Rashid S, Mubarik S, Masood N, Hussain M, Yasmin A, Bano R Tags: Breast Cancer Source Type: research

Comparison between AJCC 8th prognostic stage and UICC anatomical stage in patients with primary breast cancer: a single institutional retrospective study.
CONCLUSION: For the prognostication of primary breast cancer patients, AJCC PS appeared to be able to stratify the cases more appropriately than UICC AS. PMID: 32495291 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 3, 2020 Category: Cancer & Oncology Authors: Tanaka R, Yamagishi Y, Koiwai T, Kono T, Fukumura-Koga M, Einama T, Yamasaki T, Sato K, Ueno H, Kishi Y, Tsuda H Tags: Breast Cancer Source Type: research

Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient's perspective.
CONCLUSION: For patients with previous surgery and radiation who demand a second BCS in the recurrent situation, this surgical technique can be offered in combination with IORT. Our long-term results imply oncological safety, lower complication rate, and good patient satisfaction. PMID: 32488732 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 1, 2020 Category: Cancer & Oncology Authors: Elfgen C, Güth U, Gruber G, Birrer S, Bjelic-Radisic V, Fleisch M, Tausch CJ Tags: Breast Cancer Source Type: research

An investigation into socio-demographic-, health-, and cancer-related factors associated with cortisol and C-reactive protein levels in breast cancer survivors: a longitudinal study.
CONCLUSIONS: Socio-demographic-, health-, and cancer-related factors may help identify BCS at risk of physiological dysregulation who need intervention. Identifying modifiable factors associated with cortisol and CRP will inform cancer care interventions. PMID: 32488733 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 1, 2020 Category: Cancer & Oncology Authors: Lambert M, Sabiston CM, Wrosch C, Brunet J Tags: Breast Cancer Source Type: research

Targeting of antitumor ımmune responses with live-attenuated Leishmania strains in breast cancer model.
CONCLUSION: This promising therapy should be investigated for optimization in further studies with different cancer types and L. tropica may be designed to express antigens to enhance tumor antigen-specific responses, which may further improve efficacy and immune memory development. PMID: 32472473 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 29, 2020 Category: Cancer & Oncology Authors: Caner A, Sadıqova A, Erdoğan A, Namlıses D, Nalbantsoy A, Oltulu F, Toz S, Yiğittürk G, Ozkök E, Gunduz C, Ozbel Y, Haydaroğlu A Tags: Breast Cancer Source Type: research

The comparison of the anatomic stage and pathological prognostic stage according to the AJCC 8th edition for the prognosis in Japanese breast cancer patients: data from a single institution.
CONCLUSION: The ppStage reflects the prognosis of patients with early breast cancer more accurately than the aStage. PMID: 32472474 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 29, 2020 Category: Cancer & Oncology Authors: Tokunaga E, Ijichi H, Tajiri W, Masuda T, Takizawa K, Ueo H, Koga C, Tanaka J, Nakamura Y, Ohno S, Taguchi K, Okamoto M Tags: Breast Cancer Source Type: research

SNORA71B promotes breast cancer cells across blood-brain barrier by inducing epithelial-mesenchymal transition.
CONCLUSIONS: In conclusion, SNORA71B promotes BC cells across the BBB partly via inducing EMT. PMID: 32458152 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 23, 2020 Category: Cancer & Oncology Authors: Duan S, Luo X, Zeng H, Zhan X, Yuan C Tags: Breast Cancer Source Type: research

Multispectral quantitative immunohistochemical analysis of tumor-infiltrating lymphocytes in relation to programmed death-ligand 1 expression in triple-negative breast cancer.
Abstract BACKGROUND: Programmed death-ligand 1 (PD-L1) expression on immune cells (ICs) is a predictive marker for PD-L1 checkpoint blockade in patients with triple-negative breast cancer (TNBC). However, the level of PD-L1 expression and the percentage of cells that are PD-L1+ are continuous variables not dichotomous variables for tumor-infiltrating lymphocytes (TILs) and other cells. METHODS: Multiplexed immunohistochemistry was applied to 31 archived surgical specimens from untreated TNBC patients. TIL levels were visually scored, and CD8+ T cells and PD-L1+ ICs were quantified using an automated multispec...
Source: Breast Cancer - May 23, 2020 Category: Cancer & Oncology Authors: Sugie T, Sato E, Miyashita M, Yamaguchi R, Sakatani T, Kozuka Y, Moritani S, Suzuki E, Kakimi K, Mikami Y, Moriya T Tags: Breast Cancer Source Type: research

Performance analysis of the anti-Ki67 antibody clone 30-9 for immunohistochemical staining of breast cancer.
CONCLUSIONS: The performance of 30-9 is equivalent to that of MIB-1 in Ki67 assessment of breast cancer. The image analysis system can substitute for or support visual counting by a pathologist. PMID: 32440959 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 21, 2020 Category: Cancer & Oncology Authors: Horii R, Tsuda H, Masuda S, Sugita H, Togashi K, Ohno S, Akiyama F Tags: Breast Cancer Source Type: research

Correction to: Histological classification of breast tumors in the General Rules for Clinical and Pathological Recording of Breast Cancer (18th edition).
Abstract In the original publication of the article, the author group and acknowledgements were published incorrectly. PMID: 32430856 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Tsuda H, Tsugawa K, Akiyama F, Horii R, Kurosumi M, Moriya T, Takano T, Takei H, Nakayama T, Miyagi Y, Yamauchi C, Yamashita T, Aogi K, Mukai H, Sugie T, Iwata H, Masuda S Tags: Breast Cancer Source Type: research

Utility of urinary type I collagen cross-linked N-telopeptide as a prognostic indicator in breast cancer patients with bone metastases.
CONCLUSION: We demonstrated that the u-NTX change ratio in denosumab-treated breast cancer patients with bone metastases can be a prognostic marker. PMID: 32415556 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 15, 2020 Category: Cancer & Oncology Authors: Shizuku M, Shibata M, Okumura M, Takeuchi D, Kikumori T, Mizuno Y Tags: Breast Cancer Source Type: research

The efficacy of sequential second-line endocrine therapies (ETs) in postmenopausal estrogen receptor-positive and HER2-negative metastatic breast cancer patients with lower sensitivity to initial ETs.
CONCLUSION: Second-line ET might be a viable treatment option for postmenopausal patients with MBC with low and very low sensitivity to initial ET. Future studies based on larger and independent cohorts are needed to validate these findings. PMID: 32394413 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 11, 2020 Category: Cancer & Oncology Authors: Iwamoto T, Fujisawa T, Shien T, Araki K, Sakamaki K, Sangai T, Kikawa Y, Takao S, Nishimura R, Takahashi M, Aihara T, Mukai H, Taira N Tags: Breast Cancer Source Type: research

Annual report of the Japanese Breast Cancer Society registry for 2016.
This report based on the JBCS registry would support clinical management for breast cancer patients and clinical study in the near future. PMID: 32394414 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 11, 2020 Category: Cancer & Oncology Authors: Kubo M, Kumamaru H, Isozumi U, Miyashita M, Nagahashi M, Kadoya T, Kojima Y, Aogi K, Hayashi N, Tamura K, Asaga S, Niikura N, Ogo E, Iijima K, Tanakura K, Yoshida M, Miyata H, Yamamoto Y, Imoto S, Jinno H Tags: Breast Cancer Source Type: research

Prediction of Oncotype DX recurrence score using deep multi-layer perceptrons in estrogen receptor-positive, HER2-negative breast cancer.
Abstract Oncotype DX (ODX) is a multi-gene expression signature designed for estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer patients to predict the recurrence score (RS) and chemotherapy (CT) benefit. The aim of our study is to develop a prediction tool for the three RS's categories based on deep multi-layer perceptrons (DMLP) and using only the morphoimmunohistological variables. We performed a retrospective cohort of 320 patients who underwent ODX testing from three French hospitals. Clinico-pathological characteristics were recorded. We built a supervi...
Source: Breast Cancer - May 8, 2020 Category: Cancer & Oncology Authors: Baltres A, Al Masry Z, Zemouri R, Valmary-Degano S, Arnould L, Zerhouni N, Devalland C Tags: Breast Cancer Source Type: research

The association between MRI findings and breast cancer subtypes: focused on the combination patterns on diffusion-weighted and T2-weighted images.
Abstract PURPOSE: To assess morphology on diffusion-weighted imaging (DWI) and intratumoral signal intensity (SI) on T2-weighted images (T2WI) of breast carcinomas, and to evaluate the association between the combined DWI and T2WI findings and breast cancer subtypes. METHODS: Two hundred and eighty breast cancer patients who underwent breast MRI prior to therapy were included in this retrospective study. All had invasive carcinomas, which were classified into five subtypes: Luminal A-like (n = 149), Luminal B-like (n = 63), Hormone receptor-positive HER2 (n = 31), Hor...
Source: Breast Cancer - May 6, 2020 Category: Cancer & Oncology Authors: Yuen S, Monzawa S, Yanai S, Matsumoto H, Yata Y, Ichinose Y, Deai T, Hashimoto T, Tashiro T, Yamagami K Tags: Breast Cancer Source Type: research

Integrative review of breast cancer survivors' transition experience and transitional care: dialog with transition theory perspectives.
In conclusion, the BCSITT could provide comprehensive insights for understanding the phenomenon of BCSs' transition from primary treatment completion to self-management and serve as a holistic framework to guide clinical practice and research for BCSs' transitional care. Health care professionals need to assess the readiness of BCSs for transition and provide early interventions for enhancing BCSs' mastering of new skills to manage the challenges of transition. Incorporating stakeholders at each level and providing a comprehensive continuum of care may successfully assist BCSs' patient-to-survivor transition. PMID: 32...
Source: Breast Cancer - May 5, 2020 Category: Cancer & Oncology Authors: Chao YH, Wang SY, Sheu SJ Tags: Breast Cancer Source Type: research

Nipple-sparing mastectomy for breast cancer close to the nipple: a single institution's 11-year experience.
CONCLUSION: Unless clinical and histological evidence of nipple involvement, NSM can be an oncologically safe surgical option for breast cancer, even if the tumor is located close to the nipple. PMID: 32372321 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 5, 2020 Category: Cancer & Oncology Authors: Kim S, Lee S, Bae Y, Lee S Tags: Breast Cancer Source Type: research

Non-invasive quantitative measures of qualitative grading effectiveness as the indices of acute radiation dermatitis in breast cancer patients.
CONCLUSION: Subjectively and objectively measured results of RD were almost similar course and peak points through the study. Therefore, validity of the conventional qualitative scoring for RD is confirmed by the present quantitative assessments. Instrumental evaluations revealed the presence of modest inflammatory changes before radiotherapy and long-lasting skin dryness, suggesting indication of intervention for RD. PMID: 32363524 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - May 3, 2020 Category: Cancer & Oncology Authors: Sekine H, Kijima Y, Kobayashi M, Itami J, Takahashi K, Igaki H, Nakai Y, Mizutani H, Nomoto Y, Kikuchi K, Matsushita H, Nozawa K Tags: Breast Cancer Source Type: research

A case of bilateral methotrexate-associated diffuse large B-cell lymphomas of the breasts with unique clinical presentation and outcome.
Abstract A 54-year-old woman on methotrexate (MTX) treatment developed reddish skin change in her right breast. Mammography and ultrasound showed no masses in the breasts but bilateral mammary glands presented diffuse lower-level echoes. Only 19 days later, the patient developed bilateral breast masses. Histological examination showed that diffuse large B-cell lymphoma cells spread widely and sparsely in the bilateral breasts in addition to the tumor cell conglomerate, leading to the diagnosis of MTX-associated lympho-proliferative disorders (MTX-LPDs). Withdrawal of MTX resulted in complete disappearance of ...
Source: Breast Cancer - May 2, 2020 Category: Cancer & Oncology Authors: Tomita M, Oura S, Nishiguchi H, Makimoto S Tags: Breast Cancer Source Type: research

The era of meta-analyses-based recommendations: how were the Japanese Breast Cancer Society Clinical Practice Guidelines for Systemic Treatment of Breast Cancer established?
PMID: 32342405 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 27, 2020 Category: Cancer & Oncology Authors: Takano T Tags: Breast Cancer Source Type: research

Upregulated cyclins may be novel genes for triple-negative breast cancer based on bioinformatic analysis.
Abstract BACKGROUND: Triple-negative breast cancer (TNBC) is one of the leading causes of death among females around the world. However, the molecular mechanism of the disease among TNBC patients remains to be further studied. METHODS: In our study, four microarray data and two high throughput sequencing data were acquired from the GEO database, and the differentially expressed genes (DEGs) between TNBC and normal tissues had been analyzed. Analysis of functional enrichment and pathway enrichment of DEGs was conducted by the Funrich software, and protein-protein interaction (PPI) network gained from the STRIN...
Source: Breast Cancer - April 27, 2020 Category: Cancer & Oncology Authors: Lu Y, Yang G, Xiao Y, Zhang T, Su F, Chang R, Ling X, Bai Y Tags: Breast Cancer Source Type: research

Enhancing chemosensitivity of wild-type and drug-resistant MDA-MB-231 triple-negative breast cancer cell line to doxorubicin by silencing of STAT 3, Notch-1, and β-catenin genes.
CONCLUSION: Our study showed that the silencing of single and multiple genes involved in drug resistance and tumor progression by siRNA can enhance the chemosensitivity of cancer cells to conventional chemotherapy. PMID: 32328816 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 23, 2020 Category: Cancer & Oncology Authors: Alkaraki A, Alshaer W, Wehaibi S, Gharaibeh L, Abuarqoub D, Alqudah DA, Al-Azzawi H, Zureigat H, Souleiman M, Awidi A Tags: Breast Cancer Source Type: research

Rac1 activation in human breast carcinoma as a prognostic factor associated with therapeutic resistance.
CONCLUSION: These findings suggested Rac1 activation played pivotal roles in the progression and therapeutic resistance of breast cancers and Rac1 might be an important therapeutic target for improvement of the therapy for breast cancer patients. PMID: 32314182 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 20, 2020 Category: Cancer & Oncology Authors: Yamaguchi M, Takagi K, Sato A, Miki Y, Miyashita M, Sasano H, Suzuki T Tags: Breast Cancer Source Type: research

The dynamic change of neutrophil to lymphocyte ratio is predictive of pathological complete response after neoadjuvant chemotherapy in breast cancer patients.
Abstract BACKGROUND: The pre-treatment neutrophil-lymphocyte ratio (NLR) has been reported to be a predictive factor for pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) in breast cancer patients. However, whether the dynamic change of post-treatment neutrophil to lymphocyte ratio (delta-NLR) can better predict the same outcome remains unclear. MATERIALS AND METHODS: We retrospectively analyzed 242 consecutive patients affected by breast cancer and candidates of NACT. The complete blood cell counts before and after NACT were evaluated to calculate NLR. The relationships between delta-N...
Source: Breast Cancer - April 18, 2020 Category: Cancer & Oncology Authors: Dan J, Tan J, Huang J, Zhang X, Guo Y, Huang Y, Yang J Tags: Breast Cancer Source Type: research

Chemotherapy-related cognitive impairment in patients with breast cancer based on MRS and DTI analysis.
Abstract The purpose of this study is to investigate chemotherapy-related cognitive impairment (CRCI) in breast cancer patients, analyze absolute concentration and structural changes of metabolites in different brain regions by multimodal neuroimaging technology, and explore correlation between them. Breast cancer patients with chemotherapy treatment group (Ctx+, N = 24) and control group without treatment (Ctx-, N = 20) underwent neuropsychological tests, multivoxel magnetic resonance spectroscopy (MRS), and diffusion tensor imaging (DTI) before and after chemotherapy. Regions of interest (ROls) in magnetic reson...
Source: Breast Cancer - April 16, 2020 Category: Cancer & Oncology Authors: Tong T, Lu H, Zong J, Lv Q, Chu X Tags: Breast Cancer Source Type: research

Taste alterations in patients with breast cancer following chemotherapy: a cohort study.
CONCLUSIONS: EC chemotherapy induced taste alterations in more than 50% of patients, which decreased to less than 10% immediately before the next chemotherapy cycle. A combination of objective and subjective assessments is essential to evaluate taste alterations induced by EC chemotherapy. These could be used in routine clinical practice. PMID: 32301097 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 16, 2020 Category: Cancer & Oncology Authors: Denda Y, Niikura N, Satoh-Kuriwada S, Yokoyama K, Terao M, Morioka T, Tsuda B, Okamura T, Ota Y, Tokuda Y, Sasano T, Shoji N Tags: Breast Cancer Source Type: research

Gene-to-gene interactions and the association of TP53, XRCC1, TNF α, HMMR, MDM2 and PALB2 with breast cancer in Kyrgyz females.
CONCLUSION: TP53, XRCC1, TNFα, HMMR, MDM2 and PALB2 genes' polymorphic site combinations appear to be candidate markers of genetic predisposition to BC in Kyrgyz population and prompt targeted personalized care. PMID: 32297247 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2020 Category: Cancer & Oncology Authors: Isakova JT, Vinnikov D, Kipen VN, Talaibekova ET, Aldashev AA, Aldasheva NM, Makieva KB, Semetei Kyzy A, Bukuev NM, Tilekov EA, Shaimbetov BO, Kudaibergenova IO Tags: Breast Cancer Source Type: research

Decreased ER dependency after acquired resistance to CDK4/6 inhibitors.
CONCLUSIONS: Dependence on ER signaling appears to decrease after the development of acquired resistance to CDK4/6 inhibitors. Further, CDK4/6 inhibitor-resistant cells acquired cross-resistance to other CDK4/6 inhibitors, PI3K/Akt/mTOR inhibitor therapy and chemotherapeutic drugs might serve as optimal treatment options for such breast cancers. PMID: 32297248 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2020 Category: Cancer & Oncology Authors: Iida M, Toyosawa D, Nakamura M, Tsuboi K, Tokuda E, Niwa T, Ishida T, Hayashi SI Tags: Breast Cancer Source Type: research

Comparative evaluation of nuclear and histological grades as prognostic factors for invasive breast cancer.
CONCLUSIONS: Although not a few patients exhibited discordant results between NG and HG, both NG and HG predict outcomes for breast cancer patients, but the latter might appear to be superior as a three-grade classification scale. PMID: 32297249 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 15, 2020 Category: Cancer & Oncology Authors: Oshiro C, Yamasaki M, Noda Y, Nishimae A, Takahashi H, Inaji H Tags: Breast Cancer Source Type: research

Breast cancer populations may have an increased prevalence of thyroglobulin antibody and thyroid peroxidase antibody: a systematic review and meta-analysis.
Abstract PURPOSE: Thyroid autoimmunity might be in relation to other autoimmune endocrine disease or non-endocrine disorders and there are innate and adaptive immune cells in breast cancer. Because autoimmune factors are common characteristics of both thyroid autoimmunity and breast cancer, these two types of diseases may occur concurrently in certain patients. The chief goal of this meta-analysis is to perform a combined analysis of the raw data from all included studies, and thereby obtain a reliable conclusion concerning whether TgAb or TPOAb positivity and breast cancer are indeed correlated. METHODS...
Source: Breast Cancer - April 11, 2020 Category: Cancer & Oncology Authors: Pan XF, Ma YJ, Tang Y, Yu MM, Wang H, Fan YR Tags: Breast Cancer Source Type: research

Risk factors for breast cancer-related lymphedema: correlation with docetaxel administration.
CONCLUSIONS: Axillary lymph node dissection, radiotherapy and adjuvant chemotherapy, especially docetaxel, were risk factors for breast cancer-related lymphedema, but BMI and neo-adjuvant chemotherapy were not. PMID: 32270417 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 8, 2020 Category: Cancer & Oncology Authors: Aoishi Y, Oura S, Nishiguchi H, Hirai Y, Miyasaka M, Kawaji M, Shima A, Nishimura Y Tags: Breast Cancer Source Type: research

The effect of preoperative depression and anxiety on heart rate variability in women with breast cancer.
Abstract BACKGROUND: Anxiety and depression are prevalent in women with breast cancer. These can affect their autonomic nervous system and hemodynamic stability, which are important factors during operation. We aimed to assess the effect of anxiety and depression on heart rate variability (HRV) in patients with breast cancer. METHODS: Forty-nine women with breast cancer, scheduled for surgery, were asked to complete depression and anxiety questionnaires and categorized into depressed/non-depressed and anxious/non-anxious groups. Their electrocardiography (EKG) were assessed for 150 s on admission, before...
Source: Breast Cancer - April 7, 2020 Category: Cancer & Oncology Authors: Farbood A, Sahmeddini MA, Bayat S, Karami N Tags: Breast Cancer Source Type: research

The Japanese Breast Cancer Society Clinical Practice Guidelines for systemic treatment of breast cancer, 2018 edition.
CONCLUSION: The JBCS updated the Clinical Practice Guidelines for systemic treatment of breast cancer. PMID: 32240526 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - April 2, 2020 Category: Cancer & Oncology Authors: Shimoi T, Nagai SE, Yoshinami T, Takahashi M, Arioka H, Ishihara M, Kikawa Y, Koizumi K, Kondo N, Sagara Y, Takada M, Takano T, Tsurutani J, Naito Y, Nakamura R, Hattori M, Hara F, Hayashi N, Mizuno T, Miyashita M, Yamashita N, Yamanaka T, Saji S, Iwata H Tags: Breast Cancer Source Type: research

Prognostic impact of a tumor-infiltrating lymphocyte subtype in triple negative cancer of the breast.
Abstract BACKGROUND: Tumor-infiltrating lymphocytes (TILs) have recently been reported as an important factor in the tumor microenvironment and influence the growth and progression of cancer. However, the relationship between immune cell subpopulations, such as CD4+, CD8+, and FOXP3+, in breast cancer, especially in triple negative carcinoma (TNC), remains unclear. METHODS: The subjects were 107 patients with TNC that were surgically resected at Dokkyo Medical University Hospital between 2006 and 2018. The expression of CD4+, CD8+, and FOXP3+ was evaluated in TILs and expressed as the numbers of positive cell...
Source: Breast Cancer - March 28, 2020 Category: Cancer & Oncology Authors: Jamiyan T, Kuroda H, Yamaguchi R, Nakazato Y, Noda S, Onozaki M, Abe A, Hayashi M Tags: Breast Cancer Source Type: research

Changes in neutrophil to lymphocyte ratio (NLR) during neoadjuvant treatment correlated with patients' survival.
CONCLUSION: Changes in NLRs after neoadjuvant treatment showed statistically significant correlation with patient survival and could categorize patients into high- and low-risk groups. Larger, prospectively designed clinical trials are required to substantiate findings of this study. PMID: 32221862 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 27, 2020 Category: Cancer & Oncology Authors: Choi H, Noh H, Cho IJ, Lim ST, Han A Tags: Breast Cancer Source Type: research

Body mass index and γ-glutamyl transferase expression in normal and cancerous breast tissue.
CONCLUSIONS: Even if present results provide interesting insights on the still elusive mechanism(s) underlying the association between obesity and epithelial cell proliferation, possibly promoting neoplastic transformation, such relationship deserves further investigation in other independent datasets. PMID: 32198633 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - March 20, 2020 Category: Cancer & Oncology Authors: Coradini D, Gambazza S, Oriana S, Ambrogi F Tags: Breast Cancer Source Type: research