Liquid biopsy for breast cancer and other solid tumors: a review of recent advances
Breast Cancer. 2024 Mar 16. doi: 10.1007/s12282-024-01556-8. Online ahead of print.ABSTRACTLiquid biopsy using circulating tumor DNA (ctDNA) has been reported to be less invasive and effective for comprehensive genetic analysis of heterogeneous solid tumors, including decision-making for therapeutic strategies, predicting recurrence, and detecting genetic factors related to treatment resistance in various types of cancers. Breast cancer, colorectal cancer, and lung cancer are among the most prevalent malignancies worldwide, and clinical studies of liquid biopsy for these cancers are ongoing. Liquid biopsy has been used as ...
Source: Breast Cancer - March 16, 2024 Category: Cancer & Oncology Authors: Hirofumi Ohmura Fumiyasu Hanamura Yuta Okumura Yuki Ando Takaaki Masuda Koshi Mimori Koichi Akashi Eishi Baba Source Type: research

The role of the BTLA-HVEM complex in the pathogenesis of breast cancer
In this study, we aim to examine the function of BTLA-HVEM and provide a comprehensive overview of the existing evidence in relation to BC. The obstruction or augmentation of these pathways may potentially enhance the efficacy of BC treatment.PMID:38483699 | DOI:10.1007/s12282-024-01557-7 (Source: Breast Cancer)
Source: Breast Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Xue Hu Source Type: research

The role of the BTLA-HVEM complex in the pathogenesis of breast cancer
In this study, we aim to examine the function of BTLA-HVEM and provide a comprehensive overview of the existing evidence in relation to BC. The obstruction or augmentation of these pathways may potentially enhance the efficacy of BC treatment.PMID:38483699 | DOI:10.1007/s12282-024-01557-7 (Source: Breast Cancer)
Source: Breast Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Xue Hu Source Type: research

The role of the BTLA-HVEM complex in the pathogenesis of breast cancer
In this study, we aim to examine the function of BTLA-HVEM and provide a comprehensive overview of the existing evidence in relation to BC. The obstruction or augmentation of these pathways may potentially enhance the efficacy of BC treatment.PMID:38483699 | DOI:10.1007/s12282-024-01557-7 (Source: Breast Cancer)
Source: Breast Cancer - March 14, 2024 Category: Cancer & Oncology Authors: Xue Hu Source Type: research

Comprehensive Young Age Breast Cancer registry from clinical, genomics, and patient-reported outcomes measured with 15  years follow-up: the CHARM cohort profile
CONCLUSIONS: The SMC YBC cohort serves as a comprehensive registry for YBC to optimize care and improve knowledge regarding the management of YBC.PMID:38472736 | DOI:10.1007/s12282-024-01559-5 (Source: Breast Cancer)
Source: Breast Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Danbee Kang Seri Park Hyo Jung Kim Jiseon Lee Jiyoon Han Seok Won Kim Jeong Eon Lee Jonghan Yu Se Kyung Lee Ji-Yeon Kim Seok Jin Nam Juhee Cho Yeon Hee Park Source Type: research

Enhancing radiosensitivity in triple-negative breast cancer through targeting ELOB
In this study, we investigated the potential of targeting Elongin B (ELOB) to enhance radiotherapy efficacy in TNBC. Analysis of TNBC patient cohorts revealed a significant association between high ELOB expression and poor prognosis in patients who received radiation therapy. Mechanistically, we found that ELOB plays a pivotal role in regulating mitochondrial function via modulating mitochondrial DNA expression and activities of respiratory chain complexes. Targeting ELOB effectively modulated mitochondrial function, leading to enhanced radiosensitivity in TNBC cells. Our findings highlight the importance of ELOB as a pote...
Source: Breast Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Guo Li Xinyue Lin Xinpeng Wang Lvjuan Cai Jianren Liu Yunyun Zhu Zhichao Fu Source Type: research

Comprehensive Young Age Breast Cancer registry from clinical, genomics, and patient-reported outcomes measured with 15  years follow-up: the CHARM cohort profile
CONCLUSIONS: The SMC YBC cohort serves as a comprehensive registry for YBC to optimize care and improve knowledge regarding the management of YBC.PMID:38472736 | DOI:10.1007/s12282-024-01559-5 (Source: Breast Cancer)
Source: Breast Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Danbee Kang Seri Park Hyo Jung Kim Jiseon Lee Jiyoon Han Seok Won Kim Jeong Eon Lee Jonghan Yu Se Kyung Lee Ji-Yeon Kim Seok Jin Nam Juhee Cho Yeon Hee Park Source Type: research

Enhancing radiosensitivity in triple-negative breast cancer through targeting ELOB
In this study, we investigated the potential of targeting Elongin B (ELOB) to enhance radiotherapy efficacy in TNBC. Analysis of TNBC patient cohorts revealed a significant association between high ELOB expression and poor prognosis in patients who received radiation therapy. Mechanistically, we found that ELOB plays a pivotal role in regulating mitochondrial function via modulating mitochondrial DNA expression and activities of respiratory chain complexes. Targeting ELOB effectively modulated mitochondrial function, leading to enhanced radiosensitivity in TNBC cells. Our findings highlight the importance of ELOB as a pote...
Source: Breast Cancer - March 13, 2024 Category: Cancer & Oncology Authors: Guo Li Xinyue Lin Xinpeng Wang Lvjuan Cai Jianren Liu Yunyun Zhu Zhichao Fu Source Type: research

Correlation between postoperative treatment selection and prognosis determined using the Oncotype DX ® test data: a retrospective multicenter study in Japan
CONCLUSIONS: This study presents the largest database-derived prognostic data in Japanese patients, utilizing the Oncotype DX® treatment selection. Further studies are needed to determine the impact on treatment choice, considering the clinical risk, and the need for additional postoperative treatment.PMID:38451415 | DOI:10.1007/s12282-024-01548-8 (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Yasue Tsuchida Naoki Niikura Takashi Chishima Mari Mizuno Takahiko Kawate Hiromi Fuchikami Yasuo Miyoshi Takehiko Sakai Haruru Kotani Naoto Kondo Naoki Hayashi Source Type: research

A prospective comparison study utilizing patient-reported outcomes of taxane-related peripheral neuropathy between nab-paclitaxel and standard paclitaxel in patients with breast cancer
CONCLUSION: Nab-paclitaxel induced sensory PN sooner than paclitaxel, and no difference was observed in the severity and recovery duration between the two agents. Motor PN was more severe, started sooner, and improved over a longer period in the nab-paclitaxel-treated patients than in the paclitaxel-treated patients.PMID:38453739 | DOI:10.1007/s12282-024-01551-z (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Kumiko Kida Akimitsu Yamada Kazuhiro Shimada Kazutaka Narui Sadatoshi Sugae Daisuke Shimizu Takako Doi Mari Oba Itaru Endo Takashi Ishikawa Source Type: research

Correlation between postoperative treatment selection and prognosis determined using the Oncotype DX ® test data: a retrospective multicenter study in Japan
CONCLUSIONS: This study presents the largest database-derived prognostic data in Japanese patients, utilizing the Oncotype DX® treatment selection. Further studies are needed to determine the impact on treatment choice, considering the clinical risk, and the need for additional postoperative treatment.PMID:38451415 | DOI:10.1007/s12282-024-01548-8 (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Yasue Tsuchida Naoki Niikura Takashi Chishima Mari Mizuno Takahiko Kawate Hiromi Fuchikami Yasuo Miyoshi Takehiko Sakai Haruru Kotani Naoto Kondo Naoki Hayashi Source Type: research

A prospective comparison study utilizing patient-reported outcomes of taxane-related peripheral neuropathy between nab-paclitaxel and standard paclitaxel in patients with breast cancer
CONCLUSION: Nab-paclitaxel induced sensory PN sooner than paclitaxel, and no difference was observed in the severity and recovery duration between the two agents. Motor PN was more severe, started sooner, and improved over a longer period in the nab-paclitaxel-treated patients than in the paclitaxel-treated patients.PMID:38453739 | DOI:10.1007/s12282-024-01551-z (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Kumiko Kida Akimitsu Yamada Kazuhiro Shimada Kazutaka Narui Sadatoshi Sugae Daisuke Shimizu Takako Doi Mari Oba Itaru Endo Takashi Ishikawa Source Type: research

Correlation between postoperative treatment selection and prognosis determined using the Oncotype DX ® test data: a retrospective multicenter study in Japan
CONCLUSIONS: This study presents the largest database-derived prognostic data in Japanese patients, utilizing the Oncotype DX® treatment selection. Further studies are needed to determine the impact on treatment choice, considering the clinical risk, and the need for additional postoperative treatment.PMID:38451415 | DOI:10.1007/s12282-024-01548-8 (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Yasue Tsuchida Naoki Niikura Takashi Chishima Mari Mizuno Takahiko Kawate Hiromi Fuchikami Yasuo Miyoshi Takehiko Sakai Haruru Kotani Naoto Kondo Naoki Hayashi Source Type: research

A prospective comparison study utilizing patient-reported outcomes of taxane-related peripheral neuropathy between nab-paclitaxel and standard paclitaxel in patients with breast cancer
CONCLUSION: Nab-paclitaxel induced sensory PN sooner than paclitaxel, and no difference was observed in the severity and recovery duration between the two agents. Motor PN was more severe, started sooner, and improved over a longer period in the nab-paclitaxel-treated patients than in the paclitaxel-treated patients.PMID:38453739 | DOI:10.1007/s12282-024-01551-z (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Kumiko Kida Akimitsu Yamada Kazuhiro Shimada Kazutaka Narui Sadatoshi Sugae Daisuke Shimizu Takako Doi Mari Oba Itaru Endo Takashi Ishikawa Source Type: research

Correlation between postoperative treatment selection and prognosis determined using the Oncotype DX ® test data: a retrospective multicenter study in Japan
CONCLUSIONS: This study presents the largest database-derived prognostic data in Japanese patients, utilizing the Oncotype DX® treatment selection. Further studies are needed to determine the impact on treatment choice, considering the clinical risk, and the need for additional postoperative treatment.PMID:38451415 | DOI:10.1007/s12282-024-01548-8 (Source: Breast Cancer)
Source: Breast Cancer - March 7, 2024 Category: Cancer & Oncology Authors: Yasue Tsuchida Naoki Niikura Takashi Chishima Mari Mizuno Takahiko Kawate Hiromi Fuchikami Yasuo Miyoshi Takehiko Sakai Haruru Kotani Naoto Kondo Naoki Hayashi Source Type: research