Analysis of subsequent therapy in Japanese patients with hormone receptor ‒positive/human epidermal growth factor receptor 2‒negative advanced breast cancer who received palbociclib plus endocrine therapy in PALOMA-2 and -3.
CONCLUSIONS: The types of first subsequent therapy received by Japanese patients in the palbociclib plus ET and placebo plus ET groups were similar. Further evaluation of subsequent therapy data in the real-world setting is warranted considering the small sample size of this analysis. PMID: 33085032 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - October 21, 2020 Category: Cancer & Oncology Authors: Masuda N, Mukai H, Inoue K, Rai Y, Ohno S, Ohtani S, Shimizu C, Hashigaki S, Muramatsu Y, Umeyama Y, Iwata H, Toi M Tags: Breast Cancer Source Type: research

KRAS expression is a prognostic indicator and associated with immune infiltration in breast cancer.
CONCLUSION: This study suggests that KRAS expression can be used as a prognostic indicator of breast cancer, and it is closely related to tumor immune infiltration. PMID: 33067762 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - October 16, 2020 Category: Cancer & Oncology Authors: Liang H, Zhou G, Lv L, Lu J, Peng J Tags: Breast Cancer Source Type: research

Profilin 2 (PFN2) promotes the proliferation, migration, invasion and epithelial-to-mesenchymal transition of triple negative breast cancer cells.
CONCLUSIONS: Higher PFN2 expression is associated with a worse 10-year overall survival and relapse-free survival in breast cancer patients, as well as worse 10-year relapse-free survival in TNBC patients. PFN2 promotes the proliferation, migration and invasion of TNBC cells by regulating epithelial-to-mesenchymal transition. PMID: 33047272 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - October 12, 2020 Category: Cancer & Oncology Authors: Ling Y, Cao Q, Liu Y, Zhao J, Zhao Y, Li K, Chen Z, Du X, Huo X, Kang H, Chen Z Tags: Breast Cancer Source Type: research

Characteristics and survival of de novo and recurrent metastatic breast cancer in New Zealand.
This study included women diagnosed with dnMBC and women who developed rMBC between 2010 and 2017. The Kaplan-Meier method was used to examine cancer-specific survival. Cox proportional hazards regression was used to estimate the adjusted hazard ratio (HR) of cancer-specific mortality by ethnicity, age, year of diagnosis, socioeconomic deprivation, site of metastases, number of metastatic sites, biomarker subtype and MBC subgroup. RESULTS: We included 2177 MBC patients (667 dnMBC and 1510 rMBC). The median survival of dn MBC patients was 26 months compared to 18 months for rMBC. There were no differences in ...
Source: Breast Cancer - October 12, 2020 Category: Cancer & Oncology Authors: Lao C, Kuper-Hommel M, Elwood M, Campbell I, Edwards M, Lawrenson R Tags: Breast Cancer Source Type: research

Subjective and objective cognitive functioning among patients with breast cancer: effects of chemotherapy and mood symptoms.
CONCLUSION: Our findings suggest cognitive impairments in the domain of executive functioning among patients with BC who received chemotherapy. Providing relevant suggestions or strategies of managements for these negative consequences may help increase the long-term quality of life of patients with BC. PMID: 33030667 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - October 8, 2020 Category: Cancer & Oncology Authors: Hsu YH, Chen VC, Hsieh CC, Weng YP, Hsu YT, Hsiao HP, Wang WK, Chen HM, Weng JC, Wu SI, Gossop M Tags: Breast Cancer Source Type: research

Correction to: 3, 3'-Diindolylmethane-encapsulated chitosan nanoparticles accelerate molecular events during chemical carcinogen-induced mammary cancer in Sprague Dawley rats.
Abstract In the original publication of the article. PMID: 32997276 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 29, 2020 Category: Cancer & Oncology Authors: Isabella S, Mirunalini S Tags: Breast Cancer Source Type: research

EZH2 knockdown in tamoxifen-resistant MCF-7 cells unravels novel targets for regaining sensitivity towards tamoxifen.
CONCLUSION: Overall, we propose that targeting EZH2 or the molecules down the cascade might be helpful in reacquiring sensitivity to tamoxifen in breast cancer. PMID: 32990923 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 28, 2020 Category: Cancer & Oncology Authors: Kumari K, Kumar S, Parida DK, Mishra SK Tags: Breast Cancer Source Type: research

Acknowledgements to reviewers 2020.
Authors: PMID: 32989707 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 27, 2020 Category: Cancer & Oncology Tags: Breast Cancer Source Type: research

Germline variants of Brazilian women with breast cancer and detection of a novel pathogenic ATM deletion in early-onset breast cancer.
CONCLUSIONS: Our findings contribute to the characterization of the genetic background of breast cancer predisposition in the Brazilian population as a useful resource to discriminate between deleterious variants and VUS, thus enabling improvement in the preventive health care and clinical management of carriers. PMID: 32986223 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 27, 2020 Category: Cancer & Oncology Authors: Bandeira G, Rocha K, Lazar M, Ezquina S, Yamamoto G, Varela M, Takahashi V, Aguena M, Gollop T, Zatz M, Passos-Bueno MR, Krepischi A, Okamoto OK Tags: Breast Cancer Source Type: research

Patient and clinician satisfaction and clinical outcomes of Magseed compared with wire-guided localisation for impalpable breast lesions.
CONCLUSIONS: This is the first large study of satisfaction with localisation and showed clinician preference for Magseed and a reduction in patient anxiety. It also demonstrated similar positive margin rates despite smaller specimen weights in the Magseed group. Magnetic seed localisation offers an acceptable clinical alternative to guide wire localisation. The impact on local service provision should also be considered. PMID: 32974810 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 23, 2020 Category: Cancer & Oncology Authors: Micha AE, Sinnett V, Downey K, Allen S, Bishop B, Hector LR, Patrick EP, Edmonds R, Barry PA, Krupa KDC, Rusby JE Tags: Breast Cancer Source Type: research

Breast cancer screening for women at high risk: review of current guidelines from leading specialty societies.
Abstract The purpose of this article is to overview the existing breast cancer screening guidelines for women at high risk from world-leading specialty societies. Accumulation of evidence and development of accessible genetic testing strategies have changed the idea of breast cancer screening for high-risk women. Personalized tailor-made screening adjusted for risk factors has been conducted in accordance with guidelines. The use of imaging modalities other than mammography including contrast-enhanced MRI and other various strategies for improving screening are discussed. The present review also mentions the exist...
Source: Breast Cancer - September 20, 2020 Category: Cancer & Oncology Authors: Onishi N, Kataoka M Tags: Breast Cancer Source Type: research

Analysis of RPL37A, MTSS1, and HTRA1 expression as potential markers for pathologic complete response and survival.
CONCLUSION: RPL37A is a potential biomarker for response to NCT and for prognosis. Additional studies evaluating HTRA1 and MTSS1 prognostic value are needed. PMID: 32951185 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 19, 2020 Category: Cancer & Oncology Authors: Carrara GFA, Evangelista AF, Scapulatempo-Neto C, Abrahão-Machado LF, Morini MA, Kerr LM, Folgueira MAAK, da Costa Vieira RA Tags: Breast Cancer Source Type: research

Correlation between modified Magee equation-2 and Oncotype-Dx recurrence scores using both traditional and TAILORx cutoffs and the clinical application of the Magee Decision Algorithm: a single institutional review.
CONCLUSION: There is a moderate correlation between MME-2 score and ODX-RS. The overall concordance was similar for both traditional and TAILORx cutoffs. The strongest concordance was found in the high-risk category for both cutoffs. The MME-2 can be used to identify patients unlikely to benefit from ODX testing using the MDA. PMID: 32951186 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 19, 2020 Category: Cancer & Oncology Authors: Glasgow A, Sechrist H, Bomeisl P, Gilmore H, Harbhajanka A Tags: Breast Cancer Source Type: research

Optimizing breast cancer surgery during the COVID-19 pandemic.
Abstract The COVID-19 pandemic poses current and future challenges in the maintenance of surgical operating capacity. In the United Kingdom surgery has continued-in a reduced capacity-through the establishment of regional 'cancer hubs' using independent sector facilities to treat public healthcare patients. It is essential that these scarce operating facilities available are optimally utilized and that logistical challenges that result from remote operating away from the surgeon's primary hospital site are considered. These issues are best addressed through the application of currently available medical technology...
Source: Breast Cancer - September 17, 2020 Category: Cancer & Oncology Authors: Ahmed M Tags: Breast Cancer Source Type: research

Prospective observational study of chemotherapy-induced alopecia after sequential FEC  + taxane and the effects of age in breast cancer patients.
CONCLUSIONS: Severe CIA occurred in all 68 patients who received FEC and taxane chemotherapy. The present findings provide the first data demonstrating that age was not associated with the degree or incidence of hair loss, but age affected the recovery from CIA. These results contribute more accurate information provision and insights regarding the proper treatment of CIA. PMID: 32944881 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 16, 2020 Category: Cancer & Oncology Authors: Fujii T, Ichiba K, Honda C, Tokuda S, Nakazawa Y, Ogino M, Kurozumi S, Obayashi S, Yajima R, Shirabe K Tags: Breast Cancer Source Type: research

Prognostic factors for breast cancer patients with T1-2 tumors and 1-3 positive lymph nodes and the role of postmastectomy radiotherapy in these patients.
Abstract PURPOSE: The purpose of this study was to identify independent prognostic factors for breast cancer patients with T1-2 tumors and 1-3 positive lymph nodes, and discuss the role of postmastectomy radiotherapy(PMRT) in these patients. METHODS: Between January 2005 and December 2015, the data on 840 eligible patients with breast cancer were retrospectively reviewed. Of these patients, 368 women received PMRT and 472 did not. The endpoints were locoregional recurrence (LRR) and distant metastasis (DM). RESULTS: With a median follow-up of 62.0 months, multivariate analysis identified the followi...
Source: Breast Cancer - September 16, 2020 Category: Cancer & Oncology Authors: Zhao JM, An Q, Sun CN, Li YB, Qin ZL, Guo H, Zeng X, Zhang YT, Wei LL, Han N, Sun SC, Zhang N Tags: Breast Cancer Source Type: research

Unmet needs in breast cancer survivors are common, and multidisciplinary care is underutilised: the Survivorship Needs Assessment Project.
CONCLUSION: Despite high satisfaction ratings, survivorship issues and unmet needs were relatively common, particularly among younger participants. Use of multidisciplinary care was inconsistent and overall underutilised. IMPLICATIONS FOR CANCER SURVIVORS: Ongoing specific evaluation and optimisation of existing models of multidisciplinary survivorship care are essential in meeting the complex needs of breast cancer survivors. PMID: 32929637 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 13, 2020 Category: Cancer & Oncology Authors: Vuksanovic D, Sanmugarajah J, Lunn D, Sawhney R, Eu K, Liang R Tags: Breast Cancer Source Type: research

The impact of cognitive impairment on survival and medication adherence among older women with breast cancer.
CONCLUSION: The results of this study indicate that older female patients with cognitive impairments and a breast cancer diagnosis have a heightened risk of cancer-specific and non-cancer mortality. Our findings do not indicate that chronic medication adherence plays a role in the association between a history of cognitive impairment and mortality, it is still necessary to further investigate this issue. PMID: 32909167 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 8, 2020 Category: Cancer & Oncology Authors: Alatawi Y, Hansen RA, Chou C, Qian J, Suppiramaniam V, Cao G Tags: Breast Cancer Source Type: research

Correction to: Letter to the Editor: comment on 'Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient's perspective' by Elfgen et al.
Abstract In the original publication of the article, surnames and given names of the authors were interchanged. PMID: 32897486 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 7, 2020 Category: Cancer & Oncology Authors: Akrida I, Argentou MI Tags: Breast Cancer Source Type: research

Development and biological assessment of MMAE-trastuzumab antibody-drug conjugates (ADCs).
CONCLUSION: MMAE-trastuzumab ADCs represent a promising therapeutic strategy to treat HER2-positive breast cancer. PMID: 32889587 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 4, 2020 Category: Cancer & Oncology Authors: Yaghoubi S, Gharibi T, Karimi MH, Sadeqi Nezhad M, Seifalian A, Tavakkol R, Bagheri N, Dezhkam A, Abdollahpour-Alitappeh M Tags: Breast Cancer Source Type: research

Prevalence of germline TP53 variants among early-onset breast cancer patients from Polish population.
CONCLUSION: Germline pathogenic TP53 variants were found in 4% early-onset Polish BC patients. No founder mutations were identified in Polish population. To improve the treatment and surveillance screening, the search for germline TP53 pathogenic variants is recommended for all female BC cases diagnosed ≤ 30 years old. PMID: 32888145 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - September 3, 2020 Category: Cancer & Oncology Authors: Rogoża-Janiszewska E, Malińska K, Górski B, Scott RJ, Cybulski C, Kluźniak W, Lener M, Jakubowska A, Gronwald J, Huzarski T, Lubiński J, Dębniak T Tags: Breast Cancer Source Type: research

miR-484 suppresses endocrine therapy-resistant cells by inhibiting KLF4-induced cancer stem cells in estrogen receptor-positive cancers.
Abstract Endocrine therapy (mainly anti-estrogen therapy) is the mainstay of treatment for estrogen receptor (ER) positive breast cancer (BCa). However, approximately one-third of BCa patients who receive endocrine therapy may develop resistance. The detailed mechanism is still unclear. MCF7 and T-47D cells were treated with ERα antagonist tamoxifen for 2 months until they became tamoxifen-resistant. qPCR was used to detect the stem markers like CD44, OCT4 and SOX2. Flow cytometry and sphere formation were performed to test the stemness. Cell growth and invasiveness were measured by MTS assay, xenograft...
Source: Breast Cancer - August 30, 2020 Category: Cancer & Oncology Authors: Wei Y, Li H, Qu Q Tags: Breast Cancer Source Type: research

Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis.
We present a comprehensive review of HBOC, which will be a useful resource in the clinical setting. Many hereditary tumors, including HBOC, are syndromes characterized by the development of different types of cancer in succession. Taking advantage of knowing predisposition of susceptibility to cancer, it is important to continue and update cancer management protocols, which includes the adoption of preventive measures, countermeasures, and treatments, to accurately assess and prevent the impact of cancer on the quality of life of the next generation of patients. PMID: 32862296 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 28, 2020 Category: Cancer & Oncology Authors: Yoshida R Tags: Breast Cancer Source Type: research

Resistance to cyclin-dependent kinase (CDK) 4/6 inhibitors confers cross-resistance to other CDK inhibitors but not to chemotherapeutic agents in breast cancer cells.
CONCLUSIONS: Our study suggests that acquired resistance to PAL or ABE confers cross-resistance to the other CDK4/6 inhibitor but not to chemotherapeutic agents in HR-positive, HER2-negative breast cancer cells. Down-regulation of basal RB expression and normalized RB phosphorylation reduced by CDK4/6 inhibitors may be responsible for the attenuated anti-cell growth effects of the inhibitors. PMID: 32860163 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 27, 2020 Category: Cancer & Oncology Authors: Ogata R, Kishino E, Saitoh W, Koike Y, Kurebayashi J Tags: Breast Cancer Source Type: research

Resistance training in breast cancer patients undergoing primary treatment: a systematic review and meta-regression of exercise dosage.
CONCLUSION: Low volume resistance training might be a suitable exercise recommendation for breast cancer patients undergoing primary treatment producing superior benefits for muscle strength compared to higher volume training, regardless of the training intensity. Low volume resistance training may provide a conservative and appropriate approach for breast cancer patients, allowing gradual progression and modification throughout the exercise program. PMID: 32815096 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 18, 2020 Category: Cancer & Oncology Authors: Lopez P, Galvão DA, Taaffe DR, Newton RU, Souza G, Trajano GS, Pinto RS Tags: Breast Cancer Source Type: research

The prognosis of invasive ductal carcinoma, lobular carcinoma and mixed ductal and lobular carcinoma according to molecular subtypes of the breast.
CONCLUSIONS: The prognoses of female patients with IDC, ILC or IDLC were associated with the molecular subtypes of breast carcinoma. Management decisions should be based on pathological types and molecular subtypes. PMID: 32812198 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 17, 2020 Category: Cancer & Oncology Authors: Zhao H Tags: Breast Cancer Source Type: research

A survey on the current status of clinical resources for diagnosis and treatment of breast cancer in rural hospitals of the Tohoku region in Japan.
CONCLUSIONS: The surveyed rural hospitals needed practical and knowledge-based support from specialists. Unfortunately, the number of specialists is currently insufficient in Tohoku. Increased number of certified physicians, clinical pathways for sharing patient's information and updated knowledge, and information and communication technology for treatment with specialists' intervention in rural hospitals may solve issues in Tohoku. PMID: 32794129 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 12, 2020 Category: Cancer & Oncology Authors: Ishida K, Ohnuki K, Usami S, Komatsu H, Sasaki A Tags: Breast Cancer Source Type: research

Fibromatosis of the breast: a 10-year multi-institutional experience and review of the literature.
CONCLUSIONS: Breast fibromatosis is rare but affects young patients. Active surveillance is now favoured over surgical resection due to high recurrence rates and extensive morbidity. Dedicated guidelines are required to ensure best outcomes. PMID: 32780320 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Boland MR, Nugent T, Nolan J, O'Mahony J, O'Keeffe S, Gillham CC, Maguire A, Geraghty J, McCartan D, Evoy D, Prichard RS, McDermott EW, Alazawi D, Boyle TJ, Connolly EM Tags: Breast Cancer Source Type: research

Prognostic and predictive value of the combination of TOP2A and HER2 in node-negative tumors 2  cm or smaller (T1N0) breast cancer.
CONCLUSION: Patients with both HER2+ and high expression level of TOP2A protein predicts poor prognosis in T1N0 breast cancer patients. Patients with double positive for TOP2A protein and HER2 may benefit from anthracycline-based regimens. PMID: 32780321 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 10, 2020 Category: Cancer & Oncology Authors: Zhong W, Yang Y, Zhang A, Lin W, Liang G, Ling Y, Zhong J, Yong J, Liu Z, Tian Z, Lin Q, Luo Q, Li Y, Gong C Tags: Breast Cancer Source Type: research

The role of adjuvant radiotherapy in patients with malignant phyllodes tumor of the breast: a propensity-score matching analysis.
CONCLUSIONS: Among MPTB patients, adjuvant RT did not improve OS or DSS. In patients with tumor larger than 50 mm and receiving BCS, a survival benefit trend from adjuvant RT existed. PMID: 32748225 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - August 2, 2020 Category: Cancer & Oncology Authors: Zhao W, Tian Q, Zhao A, Wang B, Yang J, Wang L, Zhang L, Dong D, Chen L, Yang J Tags: Breast Cancer Source Type: research

Letter to the Editor: comment on 'Breast-conserving surgery with intraoperative radiotherapy in recurrent breast cancer: the patient's perspective' by Elfgen et al.
Abstract This is a comment on the article by Elfgen et al. on the use of intraoperative radiotherapy in patients with ipsilateral breast cancer recurrence following breast conserving surgery. The achievement of acceptable breast preservation rates without compromising oncologic safety in breast cancer patients is very important. Therefore, we wish to highlight a significant issue regarding axillary surgery treatment plan of their study group. PMID: 32737702 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 30, 2020 Category: Cancer & Oncology Authors: Ioanna A, Maria-Ioanna A Tags: Breast Cancer Source Type: research

Awake breast cancer surgery: strategy in the beginning of COVID-19 emergency.
CONCLUSION: In the "COVID-19 era", fast track awake breast surgery provides a reduction of ORT, LOS and potentially surgical treatment for a wider number of oncological patients. PMID: 32734327 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 29, 2020 Category: Cancer & Oncology Authors: Vanni G, Pellicciaro M, Materazzo M, Dauri M, D'angelillo RM, Buonomo C, De Majo A, Pistolese C, Portarena I, Mauriello A, Servadei F, Giacobbi E, Chiaravalloti A, Buonomo OC Tags: Breast Cancer Source Type: research

Detection of breast cancer precursor lesions by autofluorescence ductoscopy.
CONCLUSIONS: This study demonstrates for the first time the in vivo feasibility of autofluorescence ductoscopy to detect pathologically confirmed breast cancer precursor lesions in both breast cancer patients and high-risk women that were occult under white light. PMID: 32725533 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 27, 2020 Category: Cancer & Oncology Authors: Waaijer L, Filipe MD, Simons J, van der Pol CC, de Boorder T, van Diest PJ, Witkamp AJ Tags: Breast Cancer Source Type: research

Ipsilateral breast tumor control following hypofractionated and conventional fractionated whole-breast irradiation for early breast cancer: a long-term follow-up.
CONCLUSIONS: There was no difference in IBTC between CF-WBI and HF-WBI in our patients. Positive surgical margin was a risk factor independently associated with IBTC rates after CF-WBI and HF-WBI. Further investigation is required to establish adequate treatment strategies for patients with positive surgical margins. PMID: 32719997 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 26, 2020 Category: Cancer & Oncology Authors: Yoshida-Ichikawa Y, Horimoto Y, Shikama N, Yanagisawa N, Koyanagi A, Arakawa A, Saito M, Karasawa K Tags: Breast Cancer Source Type: research

Circular RNAs serve as miRNA sponges in breast cancer.
Abstract Circular RNAs are a large group of non-coding RNAs with a closed-loop structure. circRNAs play significant roles in many biological processes as miRNA sponges, regulators for gene transcription, combining with RNA-binding proteins and translation of protein. Nowadays, circRNAs have become a research hotspot in the field of cancer and molecular biology. Accumulating evidences have indicated that circRNAs participate in the initiation and development of various cancers such as breast cancer. Breast cancer is a heterogeneous disease, which is the most common malignancy in women. The incidence and mortality r...
Source: Breast Cancer - July 25, 2020 Category: Cancer & Oncology Authors: Misir S, Hepokur C, Aliyazicioglu Y, Enguita FJ Tags: Breast Cancer Source Type: research

Prospective observational study of bevacizumab combined with paclitaxel as first- or second-line chemotherapy for locally advanced or metastatic breast cancer: the JBCRG-C05 (B-SHARE) study.
CONCLUSIONS: In Japanese clinical practice, combined bevacizumab-paclitaxel was as effective as in previous studies. Factors that independently predicted poor prognosis in the present study are consistent with those identified previously. TRIAL REGISTRATION: Trial no. UMIN000009086. PMID: 32715420 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 25, 2020 Category: Cancer & Oncology Authors: Yamamoto Y, Yamashiro H, Toh U, Kondo N, Nakamura R, Kashiwaba M, Takahashi M, Tsugawa K, Ishikawa T, Nakayama T, Ohtani S, Takano T, Fujisawa T, Toyama T, Kawaguchi H, Mashino K, Tanino Y, Morita S, Toi M, Ohno S Tags: Breast Cancer Source Type: research

Mapping the cancer-specific FACT-B onto the generic SF-6Dv2.
CONCLUSION: The best algorithm developed for SF-6Dv2ind-6 enables researchers to convert cancer-specific instruments scores into preference-based scores when the data are gathered using cancer-specific instruments. PMID: 32712768 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 24, 2020 Category: Cancer & Oncology Authors: Nahvijou A, Safari H, Yousefi M, Rajabi M, Arab-Zozani M, Ameri H Tags: Breast Cancer Source Type: research

Annual report of the Japanese Breast Cancer Registry for 2017.
CONCLUSIONS: This analysis of the registry provides new information for effective treatment in clinical practice, cancer prevention, and the conduct of clinical trials. Further development of the registry and progress in collecting prognostic data will greatly enhance its scientific value. PMID: 32710374 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - July 23, 2020 Category: Cancer & Oncology Authors: Hayashi N, Kumamaru H, Isozumi U, Aogi K, Asaga S, Iijima K, Kadoya T, Kojima Y, Kubo M, Miyashita M, Miyata H, Nagahashi M, Niikura N, Ogo E, Tamura K, Tanakura K, Yamamoto Y, Yoshida M, Imoto S, Jinno H Tags: Breast Cancer Source Type: research

Pathophysiology of neratinib-induced diarrhea in male and female rats: microbial alterations a potential determinant.
In this study, we developed a reproducible model for neratinib-induced diarrhea in male and female rats. METHODS: At first, male rats were treated with neratinib at 15, 30 or 50 mg/kg or vehicle control via oral gavage for 28 days (total n = 12). Secondly, we compared outcomes of male (n = 7) and female (n = 8) rats, treated with 50 mg/kg neratinib. RESULTS: Rats treated with a 50 mg/kg daily dose of neratinib had a reproducible and clinically relevant level of diarrhea and therefore was confirmed as an appropriate dose. Male rats treated with neratini...
Source: Breast Cancer - July 17, 2020 Category: Cancer & Oncology Authors: Secombe KR, Ball IA, Shirren J, Wignall AD, Keefe DM, Bowen JM Tags: Breast Cancer Source Type: research

Triple-negative breast cancer incidence in the United States: ecological correlations with area-level sociodemographics, healthcare, and health behaviors.
Abstract PURPOSE: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer, more commonly diagnosed among black women than other subgroups. TNBC varies geographically, but little is known about area-level characteristics associated with elevated incidence. METHODS: We generated 2011-2013 age-adjusted TNBC incidence rates for state economic areas (SEAs) in 43 states using data from North American Association of Central Cancer Registries. For cases missing data on molecular markers, we imputed TNBC status using cross-marginal proportions. We linked these data to SEA covariates from nationa...
Source: Breast Cancer - July 14, 2020 Category: Cancer & Oncology Authors: Moss JL, Tatalovich Z, Zhu L, Morgan C, Cronin KA Tags: Breast Cancer Source Type: research

In vitro anti-breast cancer studies of LED red light therapy through autophagy.
Abstract LED red light has been reported to have many health benefits. The present study was conducted to characterise anti-proliferation properties of four LED red light wavelengths (615, 630, 660 and 730 nm) against non-triple negative (MCF-7) and triple negative (MDA-MB-231) breast cancer-origin cell lines. It has been shown by MTT assay that at 24 h post-exposure time point, only LED red light with wavelength 660 nm possessed anti-proliferative effects against both cell lines with 40% reduction of cell viability. The morphology of LED 660 nm irradiated cells was found flatten with enlarged ...
Source: Breast Cancer - July 10, 2020 Category: Cancer & Oncology Authors: Yang KL, Khoo BY, Ong MT, Yoong ICK, Sreeramanan S Tags: Breast Cancer Source Type: research

Investigation of the significance of population-based breast cancer screening among women aged under 40  years.
Investigation of the significance of population-based breast cancer screening among women aged under 40 years. Breast Cancer. 2020 Jul 08;: Authors: Okazaki M, Bando H, Tohno E, Kujiraoka Y, Iguchi-Manaka A, Ichioka E, Tsushima Y, Watanabe H, Hara H Abstract BACKGROUND: Owing to low incidence rates, population-based breast cancer screening is not recommended by many municipalities in Japan for women aged
Source: Breast Cancer - July 7, 2020 Category: Cancer & Oncology Authors: Okazaki M, Bando H, Tohno E, Kujiraoka Y, Iguchi-Manaka A, Ichioka E, Tsushima Y, Watanabe H, Hara H Tags: Breast Cancer Source Type: research

Current status of MRI-guided vacuum-assisted breast biopsy in Japan.
Abstract In April 2018, the national health insurance coverage of MRI-guided vacuum-assisted breast biopsy (VAB) was instituted with the application of the Japan Breast Cancer Society. Although MRI-guided VAB has been considered as a special procedure for a long time, having an access to this procedure should be recommended for facilities performing breast MRI as in Western countries. From now on, relevant societies should make efforts in data collection and quality control of MRI-guided VAB in Japan. We must avoid the following. To delay the early diagnosis of breast cancer in the judgment of an inaccurate indica...
Source: Breast Cancer - July 5, 2020 Category: Cancer & Oncology Authors: Takahama N, Tozaki M, Ohgiya Y Tags: Breast Cancer Source Type: research

Current status of breast cancer screening in high-risk women in Japan.
Abstract Overseas, the importance for breast MRI screening for high-risk groups has been shown. However, the evidence among Japanese population was lacking. Therefore, we collaborated with the "Study on clinical and genetic characterization of hereditary breast and ovarian cancer and improvement in prognosis using genetic information in Japan" group, as part of the Comprehensive Research Project on the Promotion of Cancer Control, Health and Labour Sciences Research, and have been conducting the study entitled, "Study of the usefulness of MRI surveillance of BRCA1/2 mutation carriers" since 201...
Source: Breast Cancer - July 5, 2020 Category: Cancer & Oncology Authors: Tozaki M, Nakamura S Tags: Breast Cancer Source Type: research

Sedentary behavior and risk of breast cancer: a dose-response meta-analysis from prospective studies.
CONCLUSIONS: Sedentary behavior was validated as a risk factor of breast cancer through dose-response analysis, especially TV viewing. PMID: 32607943 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 29, 2020 Category: Cancer & Oncology Authors: Chong F, Wang Y, Song M, Sun Q, Xie W, Song C Tags: Breast Cancer Source Type: research

The clinical usefulness of the CTS5 in the prediction of late distant recurrence in postmenopausal women with estrogen receptor-positive early breast cancer.
CONCLUSIONS: In postmenopausal women with ER+ breast cancer, low CTS5 was considered to be associated with a very low risk of late DR. Thus, extended endocrine therapy may be unnecessary for patients with low CTS5 scores. Extended endocrine therapy should be offered for patients with intermediate or high CTS5 scores, especially those with high-ER and HER2- breast cancer. PMID: 32601800 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 28, 2020 Category: Cancer & Oncology Authors: Tajiri W, Ijichi H, Takizawa K, Koi Y, Masuda T, Ueo H, Koga C, Nakamura Y, Taguchi K, Okamoto M, Tokunaga E Tags: Breast Cancer Source Type: research

Kounis syndrome after patent blue dye injection for sentinel lymph node biopsy.
CONCLUSION: There are just ten cases of perioperative KS in the literature so far and here we present the first one triggered by patent blue V dye for sentinel node biopsy. PMID: 32601801 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 28, 2020 Category: Cancer & Oncology Authors: Frountzas M, Karathanasis P, Vrakopoulou GZ, Theodoropoulos C, Zografos CG, Schizas D, Zografos GC, Michalopoulos NV Tags: Breast Cancer Source Type: research

Beyond the speed of SOUND.
Abstract Much anticipation awaits the results of the SOUND trial, (Gentilini and Veronesi in Breast 21:678-681, 2012) which may prove the futility of performing sentinel node biopsy (SNB) in low-risk breast cancer patients. However, do we really not know the answer to the questions that the SOUND trial poses already? Consideration must be taken of the very much overlooked trials predating the sentinel node era, which risk stratified patients according to the absence of palpable lymphadenopathy and without dependence upon ultrasound imaging (clinically negative axilla). This automatically selects a low-risk group o...
Source: Breast Cancer - June 26, 2020 Category: Cancer & Oncology Authors: Ahmed M Tags: Breast Cancer Source Type: research

Physician's knowledge, attitudes and practice pattern for breast cancer diagnosed during pregnancy: a survey among breast care specialists in Japan.
CONCLUSIONS: Interest, knowledge, and awareness of the guidelines appear to influence physician attitude, and thus it is urgently important to lay out educational materials and learning opportunities regarding BCP for breast specialists. A regional network of oncologists, obstetricians, and pediatricians to support the BCP patients should be developed. PMID: 32592140 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 25, 2020 Category: Cancer & Oncology Authors: Bando H, Kataoka A, Tamaki K, Kobayashi M, Tamura N, Ozawa M, Kawano J, Fukatsu Y, Kitano A, Shiota K, Yamauchi H Tags: Breast Cancer Source Type: research

Effect of adjuvant chemotherapy in patients with ER  + /HER2- breast cancer, assessed by propensity score matching: significance of nuclear grade and nodal status.
This study investigated the survival benefits of CT for ER + and human epidermal growth factor receptor 2-negative (HER2-) breast cancer (BC) patients by propensity score matching (PSM). METHODS: Patients with stages I-IIIER + /HER2- BC were enrolled in this study. The primary endpoints were 5-year recurrence-free survival (RFS) and overall survival (OS) in the non-CT and CT groups of the selected population matched by PS. The PS was analyzed by a logistic regression model with factors those influence provided indication of chemotherapy [tumor size, nuclear grade (NG), progesterone receptor...
Source: Breast Cancer - June 25, 2020 Category: Cancer & Oncology Authors: Tanaka N, Hirano A, Hattori A, Ogura K, Kamimura M, Inoue H, Yukawa H, Sakaguchi S, Matsuoka A, Kodera A, Shimizu T Tags: Breast Cancer Source Type: research