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Drug: Tamoxifen
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Total 2054 results found since Jan 2013.
Molecular docking analysis of phytochemicals with estrogen receptor alpha
Bioinformation. 2022 Aug 31;18(8):697-702. doi: 10.6026/97320630018697. eCollection 2022.ABSTRACTBreast cancer (BC) is linked to estrogen receptor alpha (ER-α) positive. Tamoxifen and other estrogen selective modulators have proven to be beneficial in slowing the progression of ER-α BC. However, tamoxifen resistance emerges as a result of long-term treatment and cancer development. Therefore, it is of interest to document data on the molecular docking analysis of phytochemicals targeting with Estrogen Receptor-alpha. The screening of the phytochemicals from the ZINC database (a total of 87133 compounds) against ER-α pro...
Source: Bioinformation - June 16, 2023 Category: Bioinformatics Authors: Misbahuddin M Rafeeq Source Type: research
CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer
BMC Res Notes. 2023 Jun 15;16(1):105. doi: 10.1186/s13104-023-06376-1.ABSTRACTOBJECTIVE: To investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role in mediating estrogen-dependant transcription. The study is a continuation of earlier work establishing the role of CITED1 in mammary gland development.RESULTS: CITED1 mRNA is associated with estrogen-receptor positivity and selectively expressed in the GOBO dataset of cell lines and tumours representing the luminal-molecular subtype. In patients treated with tamoxifen, higher CITED1 correlated wi...
Source: Cell Research - June 15, 2023 Category: Cytology Authors: Malin Dahlgren Barbara Lettiero Hina Dalal Kira M årtensson Alexander Gaber Bj örn Nodin Sofia K Gruvberger-Saal Lao H Saal Jillian Howlin Source Type: research
Cardioprotective effect of tamoxifen and raloxifene: Preventing proteoglycan synthesis by modulating non-canonical TGF- β signalling through NADPH oxidase and ERK phosphorylation
This study sought to investigate the impact of tamoxifen and raloxifene on TGF-β-induced CHSY1 expression and Smad2 linker region phosphorylation in VSMCs and to elucidate the role of reactive oxygen species (ROS), NADPH oxidase (NOX), and kinase pathways in mediating these effects. Employing a comprehensive experimental strategy, VSMCs were treated with TGF-β in the presence or absence of tamoxifen, raloxifene, and various pharmacological inhibitors. Subsequently, CHSY1 mRNA expression, Smad2C and Smad2L phosphorylation, ROS production, p47phox and ERK 1/2 phosphorylation were assessed. Our results revealed that tamoxif...
Source: Atherosclerosis - June 12, 2023 Category: Cardiology Authors: Vahid Zarezade Narges Mohammadtaghvaei Mojtaba Rashidi Hossein Babaahmadi-Rezaei Source Type: research
High Expression of TIMM17B Is a Potential Diagnostic and Prognostic Marker of Breast Cancer
In conclusion, the expression of TIMM17B in BC was significantly increased, and it was related to immune infiltration, drug resistance and ferroptosis in BC. Our research shows that TIMM17B can be used as a diagnostic index of BC and one of the targets of immunotherapy.PMID:37300670 | DOI:10.14715/cmb/2023.69.3.25
Source: Mol Biol Cell - June 10, 2023 Category: Molecular Biology Authors: None Mingting Duan None Yun Ren None Jiwen Zhang None Tingting Zhang None Yanhong Wang None Hongyan Jia Source Type: research
Pharmacokinetics, safety and preliminary pharmacodynamic evaluation of DARE-VVA1: a soft gelatin capsule containing tamoxifen for the treatment of vulvovaginal atrophy
CONCLUSIONS: DARE-VVA1 is safe and results in minimal systemic exposure to tamoxifen. Preliminary efficacy data support further development of this product.PMID:37288962 | DOI:10.1080/13697137.2023.2211763
Source: Climacteric - June 8, 2023 Category: Geriatrics Authors: A Thurman L Hull B Stuckey J Hatheway C Mauck N Zack D Friend Source Type: research
