Filtered By:
Drug: Tamoxifen
This page shows you your search results in order of date. This is page number 6.
Order by Relevance | Date
Total 2054 results found since Jan 2013.
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
A novel Nlrp3 knock-in mouse model with hyperactive inflammasome in development of lethal inflammation
Clin Exp Immunol. 2023 Aug 18:uxad097. doi: 10.1093/cei/uxad097. Online ahead of print.ABSTRACTNOD-like receptor family, pyrin domain-containing 3 (NLRP3) is a central protein contributing to human inflammatory disorders, including cryopyrin associated periodic syndrome and sepsis. However, the molecular mechanisms and functions of NLRP3 activation in various diseases remain unknow. Here, we generated gain-of-function knock-in mice associated with Muckle-Wells syndromes using the Cre-LoxP system allowing for the constitutive T346M mutation of NLRP3 to be globally expressed in all cells under the control of tamoxifen. The m...
Source: Clinical and Developmental Immunology - August 18, 2023 Category: Allergy & Immunology Authors: Yongting Zhou Xiyue Yang Lei Zhu Source Type: research
High expression of autophagy-related gene < em > EIF4EBP1 < /em > could promote tamoxifen resistance and predict poor prognosis in breast cancer
CONCLUSION: This study indicated that EIF4EBP1 was overexpressed in the BC and TAM-resistant cell line, which increased cell proliferation, invasion, migration and TAM resistance in BC cells.PMID:37583983 | PMC:PMC10424051 | DOI:10.12998/wjcc.v11.i20.4788
Source: Clinical Genitourinary Cancer - August 16, 2023 Category: Cancer & Oncology Authors: Shan Yang Tian-Li Hui Hao-Qi Wang Xi Zhang Yun-Zhe Mi Meng Cheng Wei Gao Cui-Zhi Geng Sai-Nan Li Source Type: research
Resistance to hormone therapy in breast cancer cells promotes autophagy and EGFR signaling pathway
Am J Physiol Cell Physiol. 2023 Aug 14. doi: 10.1152/ajpcell.00199.2023. Online ahead of print.ABSTRACTBreast cancer is the leading cause of cancer deaths for women worldwide. Endocrine therapies represent the cornerstone for hormone-dependent breast cancer treatment. However, in many cases, endocrine resistance is induced with poor prognosis for patients. In the current study, we have developed MCF-7 cell lines resistant to Fulvestrant (MCF-7Fulv) and Tamoxifen (MCF-7Tam) aiming at investigating mechanisms underlying resistance. Both resistant cell lines exerted lower proliferation capacity in 2D cultures but retain ERĪ± ...
Source: American Journal of Physiology. Cell Physiology - August 14, 2023 Category: Cytology Authors: Konstantinos E Siatis Efstathia Giannopoulou Dimitra Manou Panagiotis Sarantis Michalis V Karamouzis Sofia Raftopoulou Konstantinos Fasseas Fatimah Mohammed Alzahrani Haralabos P Kalofonos Achilleas D Theocharis Source Type: research
