Filtered By:
Drug: Tamoxifen
This page shows you your search results in order of date. This is page number 2.
Order by Relevance | Date
Total 2054 results found since Jan 2013.
Confounding Effects of Tamoxifen: Cautionary and Practical Considerations for the Use of Tamoxifen-Inducible Mouse Models in Atherosclerosis Research
CONCLUSIONS: In this study, we establish that tamoxifen administration results in decreased serum cholesterol, decreased plaque formation, and increased hepatic lipid accumulation. These alterations represent significant confounding variables in atherosclerosis research, and we urge future investigators to take these findings into consideration when planning and executing their own atherosclerosis experiments.PMID:37706321 | DOI:10.1161/ATVBAHA.123.319922
Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 14, 2023 Category: Cardiology Authors: Allison M Dubner Sizhao Lu Austin J Jolly Tysen Noble Tyler Hinthorn Raphael A Nemenoff Karen S Moulton Mark W Majesky Mary C M Weiser-Evans Source Type: research
The bHLH Transcription Factor ASCL1 Promotes Differentiation of Endocrine Cells in the Stomach and is Regulated by Notch Signaling
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 12. doi: 10.1152/ajpgi.00043.2023. Online ahead of print.ABSTRACTNotch signaling regulates gastrointestinal stem cell proliferation and differentiation yet Notch-regulated transcriptional effectors of gastric epithelial cell differentiation are poorly understood. Here we tested the role of the bHLH transcription factor achaete-scute homolog 1 (ASCL1) in gastric epithelial cell differentiation, and its regulation by Notch. Newborn Ascl1 null mice showed a loss of expression of markers of neurogenin-3 dependent enteroendocrine cells, with normal expression of enterochromaffin...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Elise S Hibdon Theresa M Keeley Juanita L Merchant Linda C Samuelson Source Type: research
