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Drug: Tamoxifen
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Total 2054 results found since Jan 2013.
Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
CONCLUSION: Whole-body AT1R inhibition reduced atherosclerosis equivalently in both male and female mice; however, PTC-specific manipulation of the RAS components had no effects on hypercholesterolemia-induced atherosclerosis.PMID:37655218 | PMC:PMC10466789 | DOI:10.3389/fcvm.2023.1250234
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Masayoshi Kukida Naofumi Amioka Dien Ye Hui Chen Jessica J Moorleghen Ching-Ling Liang Deborah A Howatt Yuriko Katsumata Motoko Yanagita Hisashi Sawada Alan Daugherty Hong S Lu Source Type: research
Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis
CONCLUSION: Our findings suggest an elevated risk of T2D in breast cancer survivors, particularly after tamoxifen therapy. Further research is needed to determine the impact of aromatase inhibitors, and chemotherapy on the incidence of T2D after breast cancer.PMID:37656235 | DOI:10.1007/s10549-023-07043-6
Source: Clinical Genitourinary Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Nanna Jordt Kasper Aalb æk Kjærgaard Reimar W Thomsen Signe Borgquist Deirdre Cronin-Fenton Source Type: research
Manipulation of components of the renin angiotensin system in renal proximal tubules fails to alter atherosclerosis in hypercholesterolemic mice
CONCLUSION: Whole-body AT1R inhibition reduced atherosclerosis equivalently in both male and female mice; however, PTC-specific manipulation of the RAS components had no effects on hypercholesterolemia-induced atherosclerosis.PMID:37655218 | PMC:PMC10466789 | DOI:10.3389/fcvm.2023.1250234
Source: Atherosclerosis - September 1, 2023 Category: Cardiology Authors: Masayoshi Kukida Naofumi Amioka Dien Ye Hui Chen Jessica J Moorleghen Ching-Ling Liang Deborah A Howatt Yuriko Katsumata Motoko Yanagita Hisashi Sawada Alan Daugherty Hong S Lu Source Type: research
Breast cancer and incidence of type 2 diabetes mellitus: a systematic review and meta-analysis
CONCLUSION: Our findings suggest an elevated risk of T2D in breast cancer survivors, particularly after tamoxifen therapy. Further research is needed to determine the impact of aromatase inhibitors, and chemotherapy on the incidence of T2D after breast cancer.PMID:37656235 | DOI:10.1007/s10549-023-07043-6
Source: Clinical Breast Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Nanna Jordt Kasper Aalb æk Kjærgaard Reimar W Thomsen Signe Borgquist Deirdre Cronin-Fenton Source Type: research
Endothelial Cell < em > APOE3 < /em > Regulates Neurovascular, Neuronal, and Behavioral Function
CONCLUSIONS: Our data collectively support the novel concept that endothelial APOE3 plays a critical role in the regulation of the neurovasculature, neural circuit function, and behavior.PMID:37650329 | DOI:10.1161/ATVBAHA.123.319816
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 31, 2023 Category: Cardiology Authors: Felecia M Marottoli Hui Zhang Eden Flores-Barrera Emilce Artur de la Villarmois Frederick C Damen Anabel M M Miguelez Fern ández Hannah V Blesson Rohan Chaudhary Anthony L Nguyen Amanda E Nwokeji Ruju Talati Ashwin S John Kushi Madadakere Sarah E Lutz Ke Source Type: research
Tamoxifen as a modulator of CXCL12-CXCR4-CXCR7 chemokine axis: A breast cancer and glioblastoma view
Cytokine. 2023 Aug 26;170:156344. doi: 10.1016/j.cyto.2023.156344. Online ahead of print.ABSTRACTThe chemokine stromal cell-derived-factor 1 (SDF)-1/CXCL12 acts by binding to its receptors, the CXC-4 chemokine receptor (CXCR4) and the CXC-7 chemokine receptor (CXCR7). The binding of CXCL12 to its receptors results in downstream signaling that leads to cell survival, proliferation and migration of tumor cells. CXCL12 and CXCR4 are highly expressed in breast cancer (BC) and glioblastoma (GBM) compared to normal cells. High expression of this chemokine axis correlates with increased therapy resistance and grade, tumor spread ...
Source: Cytokine - August 28, 2023 Category: Molecular Biology Authors: Thaynan Lopes Gon çalves Luanna Prudencio de Ara újo Val éria Pereira Ferrer Source Type: research
The Breast Surgeon's Role in Risk-Reducing Medication Uptake
Ann Surg Oncol. 2023 Aug 28. doi: 10.1245/s10434-023-14162-3. Online ahead of print.ABSTRACTThe role of the breast surgeon continues to evolve in an era of improved precision pharmacological agents combating breast cancer and de-escalation of locoregional treatments. Surgical breast oncologists should lead the effort to create preventive strategies and help to improve the uptake of risk-reducing medications (RRMEDS) for women at higher risk of developing breast cancer. Helping women to understand their risk of developing breast cancer will help the initiation of RRMEDS. Fear of side effects caused by these RRMEDS remains a...
Source: Ann Oncol - August 28, 2023 Category: Cancer & Oncology Authors: Steven Cai Source Type: research
