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Drug: Tamoxifen
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Breast cancer survival and incidence of second primary cancers after 30 years in a randomized study of two versus five years of adjuvant tamoxifen therapy
CONCLUSION: Three more years of tamoxifen therapy reduced the risk of breast cancer mortality. The difference was established during the first 15 years after randomization. Moreover, the incidence of contralateral breast cancer gradually decreased for 30 years. The incidence of lung cancer was reduced in the five-year group. In contrast the incidence of endometrial cancer was increased.PMID:37517154 | DOI:10.1016/j.breast.2023.07.010
Source: Breast - July 30, 2023 Category: Cancer & Oncology Authors: Anna Nordenskj öld Helena Fohlin Johan Rosell Nils-Olof Bengtsson Tommy Fornander Thomas Hatschek Henrik Lindman Per Malmstr öm Lisa Ryd én Arne Wallgren Olle St ål Bo Nordenskj öld Source Type: research
Adjuvant Endocrine Therapy in Premenopausal Women With Hormone Receptor-Positive Early-Stage Breast Cancer: Risk Stratification in a Real-World Setting
CONCLUSION: In a real-world setting, treatment options for premenopausal patients who are candidates for HT and OFS should take risk status into account. Therefore, every effort should be made to maintain patient adherence to treatment in order to manage toxicities and improve outcomes.PMID:37507257 | DOI:10.1016/j.clbc.2023.06.013
Source: Clinical Genitourinary Cancer - July 28, 2023 Category: Cancer & Oncology Authors: Raffaella D'Onofrio Claudia Omarini Angela Toss Isabella Sperduti Federico Piacentini Monica Barbolini Laura Cortesi Elena Barbieri Elisa Pettorelli Chiara Chiavelli Massimo Dominici Luca Moscetti Source Type: research
Sex differences in the effects of brown adipocyte CD47 deficiency on age-related weight change and glucose homeostasis
Biochem Biophys Res Commun. 2023 Jul 22;676:78-83. doi: 10.1016/j.bbrc.2023.07.042. Online ahead of print.ABSTRACTOur previous studies demonstrated that mice with global CD47 deficiency are lean and resistant to diet or aging-associated obesity and metabolic complications. This protective effect is partially through modulating brown fat function. To definitively determine the role of brown fat CD47 in age-related metabolic homeostasis, inducible brown adipocyte-specific cd47 deficient mice were generated by crossbreeding cd47 floxed mice with UCP1-CreERT2 mice and characterized in this study. Efficient knockdown of CD47 in...
Source: Biochemical and Biophysical Research communications - July 27, 2023 Category: Biochemistry Authors: Dong Li Taesik Gwag Shuxia Wang Source Type: research
Ethanol changes Nestin-promoter induced neural stem cells to disturb newborn dendritic spine remodeling in the hippocampus of mice
In this study, we applied in vivo fluorescent tracing using NestinCreERT2::Rosa26-tdTomato mice and analyzed the endogenous neurogenesis lineage progression of neural stem cells (NSCs) and dendritic spine formation of newborn neurons in the subgranular zone of the dentate gyrus. We found abnormal orientation of tamoxifen-induced tdTomato+ (tdTom+) NSCs in adult mice 2 months after treatment with EtOH (5.0 g/kg, i.p.) for 7 consecutive days. EtOH markedly inhibited tdTom+ NSCs activation and hippocampal neurogenesis in mouse dentate gyrus from adolescence to adulthood. EtOH (100 mM) also significantly inhibited the prolifer...
Source: Cell Research - July 25, 2023 Category: Cytology Authors: Guixiang Wang Wenjia Wang Ye Zhang Xiaoying Gou Qingqing Zhang Yanmiao Huang Kuo Zhang Haotian Zhang Jingyu Yang Yuting Li Source Type: research
Risk of perioperative hormonal breast cancer therapy for microvascular flap complications in breast reconstruction
CONCLUSION: This article presents one of the largest single-center datasets for the risks of hormone therapy in microsurgical breast reconstruction. Our results show that perioperative hormone therapy does not increase the risk for microsurgical complications. The findings of our study do challenge the common practice of discontinued hormone therapy before microsurgical breast reconstruction.PMID:37487260 | DOI:10.1016/j.bjps.2023.07.004
Source: Hand Surgery - July 24, 2023 Category: Surgery Authors: Maximilian Mahrhofer Raphael Reichert Laura Cosima Siegwart Elisabeth Russe Thomas Schoeller Gottfried Wechselberger Laurenz Weitgasser Source Type: research
Fabrication of versatile and sustainable cellulose nanocrystals from lettuce stalks as potential tamoxifen delivery vehicles for breast cancer treatment: biophysical, cellular and theoretical studies
New J. Chem., 2023, Advance Article DOI: 10.1039/D3NJ02388E, PaperSattar Khashkhashi-Moghadam, Samane Soleimani, Aileen Bazanjani, Saeideh Hoseinpoor, Reza Taheri, Parisa Mokaberi, Mohammad Reza Saberi, Jamshidkhan Chamani The synthesis and characterization of cellulose nanocrystals (CNCs) loaded with Tamoxifen (CNCs/TMX) for evaluating their binding mechanism to serum proteins. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - July 21, 2023 Category: Chemistry Authors: Sattar Khashkhashi-Moghadam Source Type: research
Venous thromboembolism and breast cancer
Bull Cancer. 2023 Jul 18:S0007-4551(23)00296-5. doi: 10.1016/j.bulcan.2023.06.001. Online ahead of print.ABSTRACTBreast cancer is the most common cancer in women. Patients with breast cancer have a 4-fold increased risk of venous thromboembolism (VTE) compared to age- and sex-matched controls without cancer. VTE remains the second leading cause of death in cancer patients and an independent risk factor for mortality. In women with breast cancer, the main risk factors for developing VTE are increasing age, obesity, disease stage, central catheter placement and cancer treatments, including surgery, chemotherapy, hormonothera...
Source: Bulletin du Cancer - July 20, 2023 Category: Cancer & Oncology Authors: Benjamin Crichi Emilie Moati Carlotta Cacciatore Dominique Farge Corinne Frere Source Type: research
Potential risk of tamoxifen: gut microbiota and inflammation in mice with breast cancer
CONCLUSION: Tamoxifen treatment significantly altered gut microbiota and increased inflammation in the breast cancer xenograft mice model. This may be related to tamoxifen-induced intestinal epithelial barrier damage and TLR5 up-regulation.PMID:37469407 | PMC:PMC10353877 | DOI:10.3389/fonc.2023.1121471
Source: Cancer Control - July 20, 2023 Category: Cancer & Oncology Authors: Hailong Li Xiufei Gao Yian Chen Mengqian Wang Chuchu Xu Qinghong Yu Ying Jin Jiaqing Song Qi Zhu Source Type: research
Venous thromboembolism and breast cancer
Bull Cancer. 2023 Jul 18:S0007-4551(23)00296-5. doi: 10.1016/j.bulcan.2023.06.001. Online ahead of print.ABSTRACTBreast cancer is the most common cancer in women. Patients with breast cancer have a 4-fold increased risk of venous thromboembolism (VTE) compared to age- and sex-matched controls without cancer. VTE remains the second leading cause of death in cancer patients and an independent risk factor for mortality. In women with breast cancer, the main risk factors for developing VTE are increasing age, obesity, disease stage, central catheter placement and cancer treatments, including surgery, chemotherapy, hormonothera...
Source: Bulletin du Cancer - July 20, 2023 Category: Cancer & Oncology Authors: Benjamin Crichi Emilie Moati Carlotta Cacciatore Dominique Farge Corinne Frere Source Type: research
