[New European approvals: Durvalumab - In first line metastatic small-cell lung cancer].
PMID: 33187682 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - November 10, 2020 Category: Cancer & Oncology Authors: El Kaddissi A, Basse C Tags: Bull Cancer Source Type: research

[Quality assessment of CAR T-cell activity: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
tin N Abstract CAR T-cells are anti-cancer immunocellular therapy drugs that involve reprogramming the patient's T-cells using a transgene encoding a chimeric antigen receptor (CAR). Although CAR T-cells are cellular therapies, the organization for manufacturing and delivering these medicinal products is in many ways different from the one for hematopoietic cell grafts or donor lymphocyte infusions. The implementation of this innovative therapy is recent and requires close coordination between clinical teams, the therapeutic apheresis unit, the cell therapy unit, the pharmaceutical laboratory, and pharmacy. Apart ...
Source: Bulletin du Cancer - November 10, 2020 Category: Cancer & Oncology Authors: Duléry R, Lacassagne MN, Giraud C, Ader V, Beaumont JL, Carnoy S, Carpentier A, Fegueux N, Gibault-Joffe C, Guerout-Verite MA, Huynh TNP, Lewalle P, Perrin A, Plaza-Milhe S, Bonnin A, Yakoub-Agha I, Contentin N Tags: Bull Cancer Source Type: research

[Genomic instability, the engine of oncogenesis].
PMID: 33187684 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - November 10, 2020 Category: Cancer & Oncology Authors: Robert J Tags: Bull Cancer Source Type: research

Optimizing the treatment of liver metastases from uveal melanomas with transarterial chemoembolization using melphalan and calibrated microspheres.
CONCLUSION: For patients with liver metastases from uveal melanoma ineligible for local treatments, TACE using melphalan may be performed as first line therapy in metastatic miliary disease from uveal melanomas with careful supportive care. PMID: 33183739 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - November 9, 2020 Category: Cancer & Oncology Authors: Carle X, Gastaud L, Salleron J, Tardy MP, Caujolle JP, Thyss A, Thariat J, Chevallier P Tags: Bull Cancer Source Type: research

[What's new in the management of meningeal solitary fibrous tumor/hemangiopericytoma?]
Abstract Meningeal fibrous solitary tumors/hemangiopericytoma are rare and aggressive mesenchymal neoplasms considered as sarcomas. They represent less than 1% of intracranial tumors and derive from the pericytes of Zimmerman which permit capillary contraction. They tend to occur more often in males in the fifth decade. They are often revealed by intracranial hypertension. Some scannographic and MRI characteristics permit to distinguish meningeal fibrous solitary tumor/hemangiopericytoma from other meningeal tumors. Meningeal hemangiopericytoma and fibrous solitary tumors were considered as different entities unti...
Source: Bulletin du Cancer - November 4, 2020 Category: Cancer & Oncology Authors: Lottin M, Escande A, Peyre M, Sevestre H, Maurage CA, Chauffert B, Penel N Tags: Bull Cancer Source Type: research

[Drug approval : entrectinib and larotrectinib - cancers with NTRK fusion].
PMID: 33169692 [PubMed - in process] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - November 1, 2020 Category: Cancer & Oncology Authors: Delaye M, Rodrigues M Tags: Bull Cancer Source Type: research

Standard of care for adult Wilms tumor? From adult urologist to pediatric oncologist. A retrospective review.
uur A Abstract Nephroblastoma or Wilms tumor, a common embryonal tumor in children, can occasionally occur in adults. The survival of patients older than 18 years is reported to be significantly inferior to that of pediatric patients. Establishing a diagnosis for these rare tumors can be challenging for both clinicians and pathologists, who are not accustomed to considering Wilms tumor as a potential differential in adults. This leads to misdiagnosis and a subsequent delay in the initiation of appropriate therapy. The standard of care is not well established for Wilms tumors in adults. We provide here a comprehens...
Source: Bulletin du Cancer - October 28, 2020 Category: Cancer & Oncology Authors: Sudour-Bonnange H, Coulomb-Lherminé A, Fantoni JC, Escande A, Brisse HJ, Thebaud E, Verschuur A Tags: Bull Cancer Source Type: research

[3rd colloquium on fundamental research in paediatric oncology].
Grosset CF PMID: 33097208 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 20, 2020 Category: Cancer & Oncology Authors: Trézéguet V, Lesjean S, Veschambre P, Auguste P, Turcq B, Ducassou S, Merched A, Grosset CF Tags: Bull Cancer Source Type: research

[Oncologic supportive care for a personalized support of all patients].
che L Abstract Ever since the officialization of oncologic supportive care by the DHOS circular in February 22nd, 2005 and measure 42 of the 2003-2007 Cancer Plan, their content has been enriched for inpatients and outpatients. A guaranteed care package was determined in February 2017 following a study lead by AFSOS and INCa. It adds adapted physical activity and sexual health support to basic supportive care such as pain relief, nutrition, psychology, social support. Supportive cares in pediatric oncology were defined in March 2004. They always were part of holistic pediatric care. The offer in supportive care fo...
Source: Bulletin du Cancer - October 20, 2020 Category: Cancer & Oncology Authors: Lervat C, Vanlemmens L, Bondil P, Jacquot J, Scotté F, Gofti-Laroche L Tags: Bull Cancer Source Type: research

[Patients on oral anticancer drugs and coordinated pathway: CHIMORAL, feedback from care providers].
DISCUSSION: This intervention has strengthened the networks' links with primary care providers. The use of the community-based care system for adverse events was more frequent, with improved detection and patient awareness, with no observed impact on compliance. A proposed evolution is to maintain an in-home assessment for all patients and to define a frequency and duration of follow-up according to the patient's profile. PMID: 33097210 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 20, 2020 Category: Cancer & Oncology Authors: Maritaz C, Napoly L, Burnel S, Lotz JP Tags: Bull Cancer Source Type: research

[Study of representations of end-of-life platelet transfusion by its protagonists: Patients, nurses and hematologic oncologists].
This study aims to describe these representations of platelet transfusion in a context of a severe and advanced hematologic malignancy through the social representation of its protagonists. METHODS: A qualitative study, using the associative network method and including three groups of 15 participants (patients with an advanced hematologic malignancy, regularly transfused in platelet concentrates; nurses and hematologic oncologists) from four hematology centers was conducted between February and April 2019. Analysis was carried out using IraMuTeQ software. RESULTS: Patients expect platelet transfusion to have a d...
Source: Bulletin du Cancer - October 19, 2020 Category: Cancer & Oncology Authors: Moracchini J, Godard-Marceau A, Aubry R Tags: Bull Cancer Source Type: research

[New European approvals: Glasdegib for Acute myeloid leukemia].
aud L PMID: 33070952 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 15, 2020 Category: Cancer & Oncology Authors: Barrière S, Gastaud L Tags: Bull Cancer Source Type: research

[Genetic instability, a factor limiting the efficiency of targeted therapies in solid oncology].
Abstract Genomic instability is one of the main properties of tumour development, promoting first the acquisition of genetic alterations and thus carcinogenesis. Then, the chronic and anarchic proliferation of cancer cells also supports and contributes to this instability allowing a continuous evolution of the tumour. The accumulation of mutations resulting from that instability contributes to tumour heterogeneity that occurs in a specific environment. The resulting diversity of oncogenic drivers further complicates the characterization of the origin of cancer cells dysfunction and consequently therapeutic decisio...
Source: Bulletin du Cancer - October 15, 2020 Category: Cancer & Oncology Authors: Billaud A, Chevalier LM, Campone M, Morel A, Bigot F Tags: Bull Cancer Source Type: research

[Perceptions and attitudes of nurses on emotional and sexual lives of cancer patients].
CONCLUSION: Nurses must acknowledge the existence of sexual health issues in cancer patients by rectifying their perceptions of sexuality, improving their knowledge and management of care, by addressing the issue of sexual health early enough. PMID: 33069338 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 14, 2020 Category: Cancer & Oncology Authors: Mbalè E, D'Hondt L, Vastrade C, Coppieters Y Tags: Bull Cancer Source Type: research

[Crohn's disease and autologous hemapoietic cell transplantation: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
rge D Abstract Crohn's Disease (CD) is an auto-inflammatory disease, which may involve the entire gastro-intestinal tract. CD is diagnosed on several clinical, biological, endoscopic and histological criteria. First line therapy is based on oral or iv steroids. In case of steroids dependence or resistance, several types of immunosuppressive or immunomodulating therapies are available: classical antimetabolites (thiopurines or methotrexate) or monoclonal antibodies against TNFα, against interleukin 12/23 or against integrin. Nonetheless, Crohn's disease may remain active despite the use of several lines of th...
Source: Bulletin du Cancer - October 13, 2020 Category: Cancer & Oncology Authors: Puyade M, Treton X, Alric L, Badoglio M, Castilla Llorente C, Fotsing G, Marjanovic Z, Rovira M, Terriou L, Torregrosa Díaz Jose M, Tran-Minh ML, Allez M, Pugnet G, Laharie D, Yakoub-Agha I, Farge D Tags: Bull Cancer Source Type: research

[Palliative care medical consultation in a hematology department. Feedback and critical reflection on a year of practice].
We describe the benefits that can be anticipated when collaboration increases between hematology and palliative care, including early on in the course of disease. It is now up to policy-makers to establish priorities regarding the allocation of health resources, in particular regarding end-of-life. This requires identifying patient needs, optimizing patient access to specialized palliative care, and improving the pertinence of palliative care interventions as they cannot be generalized. PMID: 33059871 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 12, 2020 Category: Cancer & Oncology Authors: Prod'homme C Tags: Bull Cancer Source Type: research

[Tumors affecting the temporomandibular joint  - a literature review].
[Tumors affecting the temporomandibular joint - a literature review]. Bull Cancer. 2020 Oct 12;: Authors: Schlund M, Roland-Billecart T, Aubert S, Nicot R Abstract Benign and malign tumors can affect the temporomandibular joint (TMJ) as any other articulation. Nevertheless, TMJ tumors are rare and mostly benign. Their clinical expression is varied including symptomatology similar to TMJ dysfunctional disorders, otologic or neurologic pathologies. In some cases, they remain totally asymptomatic. Hence, diagnosis is difficult since the symptomatology can be misleading with TMJ dysfunctional di...
Source: Bulletin du Cancer - October 12, 2020 Category: Cancer & Oncology Authors: Schlund M, Roland-Billecart T, Aubert S, Nicot R Tags: Bull Cancer Source Type: research

[Influence of age on indications and modalities of radiation therapy: What to keep in mind for adolescents and young adults?]
This article highlights the key points of AYA care with radiation therapy. PMID: 33051053 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 10, 2020 Category: Cancer & Oncology Authors: Jouglar E, Escande A, Martin V, Demoor-Goldschmidt C, Carrie C, Claude L, Bernier-Chastagner V Tags: Bull Cancer Source Type: research

[New drug approval: Encorafenib-metastatic colorectal cancers with BRAF V600E mutation after systemic chemotherapy].
lin E PMID: 33046237 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 9, 2020 Category: Cancer & Oncology Authors: Boilève A, Samalin E Tags: Bull Cancer Source Type: research

[Fundamental aspects of oncogenesis].
Abstract Tumorigenesis has traditionally been considered as a multi-step process involving the activation of oncogenes as well as the inactivation of tumor suppressor genes. However, the mechanisms driving cancer initiation and progression are not restricted to molecular alterations and instead should be viewed as a complex process that interfaces with the entire organism. This didactic review provides an integrated and global view of the key fundamental principles of cancer development. PMID: 33039132 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 7, 2020 Category: Cancer & Oncology Authors: Lemaire J, Larrue R, Perrais M, Cauffiez C, Pottier N Tags: Bull Cancer Source Type: research

[CD34+ cell selection methods, quality controls and expected results: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
gha I, Baudoux É Abstract CD34+ immunomagnetic positive selection allows for CD34+ hematopoietic progenitors separation from CD3+ lymphocytes subsets, usually from an apheresis product collected from a previously mobilized donor. This T-cell depleted stem cell graft is primarily intended for rare cases (around 2% of allotransplanted patients in France) of severe, persistent, symptomatic bi- or tri-cytopenia post-allotransplantation, in order to allow for hematologic reconstitution without increasing the risk of GvHD occurrence. Although semi-manual and complex, the process is of sufficient robustness to con...
Source: Bulletin du Cancer - October 7, 2020 Category: Cancer & Oncology Authors: Calmels B, Gautier É, Magnani A, Magrin É, Mamez AC, Vaissié A, Yakoub-Agha I, Baudoux É Tags: Bull Cancer Source Type: research

[Complementary and alternative medicine in cancer patients and randomized controlled trials].
Abstract More and more cancer patients around the world are using complementary and alternative medicine. They are mostly used as a complement to conventional care in decreasing the side effects of treatment and improving their quality of life. However, patients often use them without reporting it to their oncologists; the main reasons being the short duration of consultation and the fact that their oncologists do not support them due to a lack of scientific evidence. There are hundreds of them, some of which are now being used in French healthcare institutions as supportive care. The randomized controlled trial i...
Source: Bulletin du Cancer - October 7, 2020 Category: Cancer & Oncology Authors: Murat-Ringot A, Preau M, Piriou V Tags: Bull Cancer Source Type: research

[Musculoskeletal tumour surgery for adolescent and young-adult population: Collaboration between adult and pediatric surgeons is necessary].
Abstract Orthopaedic surgery I has a key role on the medical pathway of adolescent and young-adult (AYA) patients with musculo-skeletal tumor from diagnosis, tumor resection, musculo-skeletal immediate or delayed reconstruction, to dealing with late complications and sequelae following reconstruction during childhood. Administrative authorizations, organization by health authorities as well as training courses are quite different for adult and pediatric surgery. However, surgery for musculo-skeletal tumors in AYA patients have neither adult nor pediatric specifities; resection-reconstruction rules and technics are...
Source: Bulletin du Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Gouin F, Laurence V, Hamel A, Mascard E Tags: Bull Cancer Source Type: research

[Attachment and caregivers' life course facing cancer].
DISCUSSION: Detached-type insecure caregiver tend to minimize their signs of distress in the first time of disease. By contrast, preoccupied-type insecure adults tend to maximize distress signals. It's important to consider the specificity of each step of the process to better support caregivers. PMID: 33036740 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Bonnet M, Vadam F, Belot RA, Quibel C, Pozet A, Nerich V Tags: Bull Cancer Source Type: research

[Non endometroid endometrial cancer guidelines evaluation: A multicentric retrospective study].
DISCUSSION: Non endometrioid endometrial cancer guidelines applicability is difficult. This explicated by high age and comorbidity when surgical lymph node stadification is necessary. Using new staging technic will allow target management and better select lymph node staging indication. PMID: 33036741 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Scattarelli A, Poteau A, Aziz M, Lae M, Courville P, Arnaud M, Marpeau L, Resch B Tags: Bull Cancer Source Type: research

[Nomadism of patients treated by radiotherapy in Île-de-France: Does our health system have as much money to waste?]
CONCLUSION: Our results are similar to a report from the General Inspectorate of Social Affairs published in July 2011, which then pointed to an additional cost of between 4 and 6 million euros annually. The long-term care of cancer patients from their homes contributes to a deterioration in the quality of life linked to travel times, a delay in the care of potential treatment complications, and the spread of infectious diseases, such as COVID-19, and bacteria resistant to antibiotics. PMID: 33036742 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Paix A, Popotte H, Lévy C, Perez A, Bouillet T, Zelek L, Duchemann B Tags: Bull Cancer Source Type: research

[Let us also take into account the TRALI-associated cell transplant risks].
PMID: 33036743 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 6, 2020 Category: Cancer & Oncology Authors: Lafarge X Tags: Bull Cancer Source Type: research

Literature meta-analysis about the efficacy of re-challenge with PD-1 and PD-L1 inhibitors in cancer patients.
DISCUSSION: Anti-PD-1/anti-PD-L1 re-challenge showed interesting clinical activity in selected patients, mainly in those achieving a long-term response upon the first ICPi course, that do not discontinue therapy because of disease progression, or that are able to keep a treatment-free period. PMID: 33032816 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - October 5, 2020 Category: Cancer & Oncology Authors: Gobbini E, Charles J, Toffart AC, Leccia MT, Moro-Sibilot D, Levra MG Tags: Bull Cancer Source Type: research

[Evaluation of drug interactions in patients treated for a lung or digestive cancer].
Abstract INTRODUCTION: Cancer patients are particularly at risk for drug interactions. However, in oncology, this risk has not been studied in depth in France. The main objective of this study was to describe the proportion of drug interactions in patients with lung or digestive cancer. METHODS: The drug prescriptions of 93 patients were analyzed from may 27th, 2019 to July 07th, 2019 using two software programs (Thériaque™ and DDI Predictor™) in oncology patients hospitalized in our comprehensive cancer center. RESULTS: Of the 88 patients included in the study, 544 drug interactions w...
Source: Bulletin du Cancer - September 30, 2020 Category: Cancer & Oncology Authors: Ghysel V, Tresch E, Marliot G, Nicot R, Lambert M, Carbonnelle G, Lartigau E, Lefebvre G Tags: Bull Cancer Source Type: research

[The cost of the therapeutic education program "Eat better, move more through nutrition education" in patients with breast cancer].
CONCLUSION: This cost study, an accurate estimate of the production costs, allows to inform the decision-maker in term of pricing of such a program and to make the necessary adjustments in order to optimize the organization of this activity. PMID: 33012504 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 30, 2020 Category: Cancer & Oncology Authors: El Khal M, Perrier L, Carretier J, Touillaud M, Hureau M, Pérol D, Fervers B Tags: Bull Cancer Source Type: research

[PARP inhibitors in breast cancer: Current clinical development and perspectives].
dil;alves A Abstract The association of a germline mutation in the BRCA1/2 genes in breast cancer leads to a higher genomic instability and, thus, a potential higher sensitivity to poly(ADP-ribose) polymerase (PARP) inhibitors. In this review, we will summarize the different DNA-repair pathways including PARP-dependent mechanisms that support the use of PARP inhibitors. We will present clinical trials evaluating PARP inhibitors alone or in combination in early or advanced stage breast cancer. We will then discuss the different mechanisms involved in the resistance to PARP inhibitors. We will also introduce th...
Source: Bulletin du Cancer - September 27, 2020 Category: Cancer & Oncology Authors: Robbe J, Moretta J, Vicier C, Sabatier R, Noguès C, Gonçalves A Tags: Bull Cancer Source Type: research

[Hot flushes and breast cancer with positive hormone receptors: Mechanisms and management].
uet D Abstract Breast cancer is the most frequently diagnosed cancer in women and the first cause of cancer death in France. Among the different subtypes of breast cancer, the predominant form is characterized by positive hormone receptors (more than 70% of breast cancers). Hormone therapy thus plays a key role in the strategy of management of these cancers both in adjuvant and metastatic situations. The two types of adjuvant hormone therapy used are selective estrogen receptor modulators and aromatase inhibitors. Fulvestrant, an anti-estrogen, is used alone or in combination with other molecules in metastatic sit...
Source: Bulletin du Cancer - September 24, 2020 Category: Cancer & Oncology Authors: Cavadias I, Rouzier R, Lerebours F, Héquet D Tags: Bull Cancer Source Type: research

[ALL in adult patients: Contribution and limits of pediatric management].
The objective of this review is to discuss the benefit and the limits of pediatric therapeutic strategies in adults and the perspectives offered by new approaches including immunotherapies. PMID: 32981690 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 23, 2020 Category: Cancer & Oncology Authors: Rabian F, Boissel N Tags: Bull Cancer Source Type: research

Sensitivity and polymorphism of Bethesda panel markers in Chinese population.
CONCLUSION: MSI-H cases showed earlier onset and higher proportion of mucinous carcinomas. Mononucleotide BAT26 and BAT25 exhibited higher sensitivity than dinucleotides D2S123, D17S250 and D5S346 in the Chinese population. The dinucleotide markers were highly polymorphic with high percent of heterozygosity, great variation in repeat length and non-normal distribution in Chinese population from Jiangsu Province. PMID: 32980144 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 22, 2020 Category: Cancer & Oncology Authors: Zheng Y, Chen J, Zhang X, Xie L, Zhang Y, Sun Y Tags: Bull Cancer Source Type: research

[New European approvals: Alpelisib for HRpos/HER2neg metastatic breast cancer with PIK3CA mutation].
PMID: 32977934 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 21, 2020 Category: Cancer & Oncology Authors: Corbaux P, Sabatier R Tags: Bull Cancer Source Type: research

[Dosimetric factors related to postoperative pulmonary complications in locally advanced esophageal cancers treated with preoperative chemoradiotherapy: Literature review].
DISCUSSION: The most frequently identified dosimetric predictors for postoperative pulmonary complications are the V20 and the mean lung dose. Results of prospective studies would lead us to specify which of these parameters is most relevant for predicting the risk of postoperative pulmonary complications. PMID: 32977935 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 21, 2020 Category: Cancer & Oncology Authors: Dworczak M, Le Deley MC, Adenis A, Piessen G, Lartigau É, Mirabel X, Lacornerie T, Pasquier D Tags: Bull Cancer Source Type: research

[First results of a breast cancer risk assessment and management consultation].
CONCLUSION: This RBC evaluation consultation satisfies women and for a majority of them, modifies their methods of breast cancer screening. PMID: 32977936 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 21, 2020 Category: Cancer & Oncology Authors: Uzan C, Ndiaye-Guèye D, Nikpayam M, Oueld Es Cheikh E, Lebègue G, Canlorbe G, Azais H, Gonthier C, Belghiti J, Benusiglio PR, Séroussi B, Gligorov J, Uzan S Tags: Bull Cancer Source Type: research

[Physical activity after breast cancer diagnosis and survival: A systematic review].
CONCLUSION: Post-diagnosis PA reduces overall mortality and appears to impact specific breast cancer mortality and risk of recurrence. However, these results need to be confirmed by larger randomized trials. PMID: 32977937 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 21, 2020 Category: Cancer & Oncology Authors: Maumy L, Salakos E, Rocher G, Al Mamari T, Bonneau C, Elies A, Neuzillet C, Rouzier R Tags: Bull Cancer Source Type: research

[Predictable toxicities with futures immunotherapies or combinations].
Abstract Immunotherapy by immune check-points inhibitors (ICIs) recently improved many solid tumors survival data. ICIs target and inhibit down-regulation signals between T cells and tumor cells involved in carcinogenesis, in order to enhance anti-tumor immunity. With few years' hindsight of ICIs utilization in daily practice, we learned about their safety profile. By releasing the brakes of the host immune-system, ICIs exposure leads to on-target off-tumor immune related adverse events (IRAEs). Compared to standard chemotherapiy regimens, IRAEs remain rare, but sometimes serious and compromising treatment continu...
Source: Bulletin du Cancer - September 21, 2020 Category: Cancer & Oncology Authors: Mogenet A, Tomasini P, Greillier L, Barlesi F Tags: Bull Cancer Source Type: research

[Lebanese physicians' attitude towards prostate cancer screening].
emr E PMID: 32977939 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 21, 2020 Category: Cancer & Oncology Authors: Ghayad T, Mekhael M, Gebara N, Eid R, Kourié HR, Haddad F, Nemr E Tags: Bull Cancer Source Type: research

[Multidisciplinary team meeting in supportive care: 12  years of experience in a French comprehensive cancer center].
[Multidisciplinary team meeting in supportive care: 12 years of experience in a French comprehensive cancer center]. Bull Cancer. 2020 Sep 21;: Authors: Favier L, Bremaud N, Tharin Z, Blanc J, Bertaut A, Alavoine V, Dubief A, Truc G, Dorlean C, Coudert B Abstract In 2006, in response to DHOS Circular 2005/101, we have created a multidisciplinary supportive care meeting. As available literature covering this subject is rare, we report here our own experience. For this purpose, available files from the six initial months of 2006, 2008, 2010, 2012, 2014, 2016 and 2018 were analyzed, repres...
Source: Bulletin du Cancer - September 20, 2020 Category: Cancer & Oncology Authors: Favier L, Bremaud N, Tharin Z, Blanc J, Bertaut A, Alavoine V, Dubief A, Truc G, Dorlean C, Coudert B Tags: Bull Cancer Source Type: research

[Gastrointestinal symptoms revealing COVID-19  in Malian breast cancer patient undergoing chemotherapy].
[Gastrointestinal symptoms revealing COVID-19 in Malian breast cancer patient undergoing chemotherapy]. Bull Cancer. 2020 Sep 21;: Authors: Sidibe FM, Bathily M, Diarra B, Kone AS, Diabate K, Konate M, Cisse HL, Guindo I, Kone AA, Kone J, Berthe D, Ouattara BZ, Fofana Y, Sidibe A, Akpa AA, Dembele JP, Toure BA, Diakite A, Diarra IM, Kone AC, Soumare MD, Minta D, Dao S, Toloba Y, Diallo DA, Sidibe S Abstract In this review, we report a case of a bone's metastatic breast cancer in Malian patient treated by chemotherapy in whom SRAS-COV-2's diagnosis was made 9days after the onset gastrointestinal s...
Source: Bulletin du Cancer - September 20, 2020 Category: Cancer & Oncology Authors: Sidibe FM, Bathily M, Diarra B, Kone AS, Diabate K, Konate M, Cisse HL, Guindo I, Kone AA, Kone J, Berthe D, Ouattara BZ, Fofana Y, Sidibe A, Akpa AA, Dembele JP, Toure BA, Diakite A, Diarra IM, Kone AC, Soumare MD, Minta D, Dao S, Toloba Y, Diallo DA, Si Tags: Bull Cancer Source Type: research

[Nice-Saint-Paul de Vence 2020  recommendations for clinical practice: Management of metastatic and/or relapsing endometrial cancer].
[Nice-Saint-Paul de Vence 2020 recommendations for clinical practice: Management of metastatic and/or relapsing endometrial cancer]. Bull Cancer. 2020 Sep 18;: Authors: Alexandre J, Le Frere-Belda MA, Prulhiere K, Treilleux I, Leary A, Pomel C, Chargari C, Ducassou A, Joly F, groupe ARCAGY-GINECO Abstract Endometrial cancer is a common cancer in older women and is often associated with comorbidities. Management of metastatic disease and/or relapse requires a multidisciplinary approach. Recent advances in the understanding of oncogenesis and molecular classification of endometrial cancers offer ne...
Source: Bulletin du Cancer - September 17, 2020 Category: Cancer & Oncology Authors: Alexandre J, Le Frere-Belda MA, Prulhiere K, Treilleux I, Leary A, Pomel C, Chargari C, Ducassou A, Joly F, groupe ARCAGY-GINECO Tags: Bull Cancer Source Type: research

[Management of immune checkpoint inhibitors-induced liver toxicity in cancer].
rle P Abstract Pharmacological immune checkpoint inhibitors (ICI) restore the anti-tumor properties of T-lymphocytes, but unfortunately can engender auto-immune-like disorders. Those, frequent and of variable severity, sometimes target the liver parenchyma. Liver toxicity of ICI firstly leads to alteration of liver function tests (ALFT) with a risk of clinical decompensation. The appearance of ALFT should lead the clinician to exclude a non-immunological injury or a tumoral invasion of the liver parenchyma. In case of high grade ALFT, liver biopsy is necessary for diagnosis purpose. In ICI-induced hepatoxicity, hi...
Source: Bulletin du Cancer - September 16, 2020 Category: Cancer & Oncology Authors: Lebossé F, Bancel B, Levrero M, Merle P Tags: Bull Cancer Source Type: research

How to improve clinical research in a department of radiation oncology.
This study overviewed the landscape of clinical research at our radiotherapy department. METHODS: We surveyed our institutional database of clinical trials to collect information for completed or ongoing radiation therapy clinical trials, from 2005 to December 2017 at the Lucien Neuwirth cancer institute. RESULTS: A total of 31 clinical trials were undertaken during the study period, of which 4 studies (12.9%) were industry-sponsored and 3 studies (9.7%) were launched by our radiotherapy unit. The vast majority of clinical trials (83.9%) were dedicated to unique organ localization, especially urological cancer (p...
Source: Bulletin du Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Gessen S, Daguenet E, Gras M, Louati S, Bouleftour W, Sotton S, Bosacki C, Magné N Tags: Bull Cancer Source Type: research

[Diagnostic strategy in pediatrics soft tissue sarcomas].
Abstract Soft tissue sarcomas in children are rare tumor, representing around 6 to 7% of children cancer. They spread mostly sporadically (90%) and therefore are rarely associated to an underlying constitutional genetic disease (10%). About half of those sarcomas are rhabdomyosarcomas and the others are a very heterogenous histologic group with various bio-pathologies and prognosis. Clinical presentation is mainly a soft tissue lump often difficult to distinguish from more frequent benign causes (malformative, infectious, benign, or pseudotumor). Inappropriate initial diagnosis work-up has a strong impact on soft ...
Source: Bulletin du Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Collignon C, Brisse HJ, Lemelle L, Cardoen L, Gauthier A, Pierron G, Roussel A, Dumont B, Alimi A, Cordero C, Rouffiange L, Orbach D Tags: Bull Cancer Source Type: research

[Leiomyosarcoma and angiomyomatous hamartoma: An hasardous association?]
PMID: 32950243 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 15, 2020 Category: Cancer & Oncology Authors: Petitjean M, Kashi-Dakhil M, Hachemane S, Dakhil B, Zaimi R, Bagan P Tags: Bull Cancer Source Type: research

[New drug approval: Olaparib  - pancreatic cancer with BRCA germline mutation].
[New drug approval: Olaparib - pancreatic cancer with BRCA germline mutation]. Bull Cancer. 2020 Sep 14;: Authors: Hilmi M, Neuzillet C PMID: 32943226 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 13, 2020 Category: Cancer & Oncology Authors: Hilmi M, Neuzillet C Tags: Bull Cancer Source Type: research

[Allogeneic hematopoietic stem cell transplant in children and adults with sickle cell disease: Indications and modalities].
Pondarre C Abstract Sickle cell disease is associated with severe complications and early mortality in adults. In children, hematopoietic stem cell transplant from HLA-identical sibling can stop the progression of the disease and leads to more than 95% long-term free survival without sickle cell disease. The aim of this workshop was to define indications and modalities of allogeneic hematopoietic stem cell transplant in children and adults with sickle cell disease. Patient and sibling HLA typing should be proposed, early in the course of the disease, when intensification therapies are required. Indications of tra...
Source: Bulletin du Cancer - September 9, 2020 Category: Cancer & Oncology Authors: Dhédin N, Paillard C, Dalle JH, Ouachée M, Buchbinder N, Brissot E, Beguin Y, Masouridi-Levrat S, Yakoub-Agha I, Bernit E, Pondarre C Tags: Bull Cancer Source Type: research

[Long-term occupational situation after cancer: A French registry-based study].
DISCUSSION: Although the employment status of the cases was comparable to that of the controls, efforts should be intensified to make it easier for patients diagnosed with cancer to return to work. PMID: 32919610 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - September 8, 2020 Category: Cancer & Oncology Authors: Saim A, Gernier F, Licaj I, Rod J, Velten M, Klein D, Mercier M, Joly F Tags: Bull Cancer Source Type: research