[Management of CAR-T cell-related encephalopathy syndrome in adult and pediatric patients: Recommendations of the French Society of Bone Marrow transplantation and cellular Therapy (SFGM-TC)].
gha I Abstract CAR-T cell-related encephalopathy syndrome (CRES) reflects the potential neurotoxicity of this therapeutic approach and must be considered in the presence of any neurological symptom after the infusion of the CAR-T. This is the second most common adverse event under this therapy and its incidence varies between 12 and 55%. The median time of the onset of the first neurologic symptoms is 4days after CAR-T infusion. The duration of CRES symptoms is generally between 2 and 4days, but late CRES may occur. Monitoring and diagnosis of CERS includes clinical exam, magnetic resonance imaging and electroence...
Source: Bulletin du Cancer - June 12, 2019 Category: Cancer & Oncology Authors: Cornillon J, Hadhoum N, Roth-Guepin G, Quessar A, Platon L, Ouachée-Chardin M, Nicolas-Virelizier E, Naudin J, Moreau AS, Masouridi-Levrat S, Borel C, Ahmad I, Beauvais D, Baruchel A, Yakoub-Agha I Tags: Bull Cancer Source Type: research

Is chemotherapy rechallenge feasible in advanced-stage non-small-cell lung cancer?
CONCLUSION: Patients eligible for chemotherapy rechallenge were those with good prognostic factors. Chemotherapy rechallenge may provide a well-tolerated additional line of treatment, with decreased efficacy compared to its first application. PMID: 31202557 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - June 12, 2019 Category: Cancer & Oncology Authors: Mignard X, Ruppert AM, Lavolé A, Vieira T, Rozensztajn N, Cadranel J, Wislez M Tags: Bull Cancer Source Type: research

[Dose reassessment: An answer to the high cost of drugs used in oncology?]
ue D PMID: 31202558 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - June 12, 2019 Category: Cancer & Oncology Authors: Levêque D Tags: Bull Cancer Source Type: research

[Drug management of cancer-related peripheral neuropathic pain: A systematic review of the literature].
The objective of the present systematic literature review was to provide an update on medical treatment of neuropathic pain in cancer patients. The number of cancer patients is steadily increasing. Pain is frequent in cancer patients. Few studies have focused on medical treatment of pain, and especially of neuropathic pain, in current or former cancer patients. The present systematic review of all studies published between December 2012 and August 2018 was intended to estimate the scale of this lack. In all, 27 articles were identified on a systematic PubMed search and from the authors' personal knowledge, confirming that ...
Source: Bulletin du Cancer - June 12, 2019 Category: Cancer & Oncology Authors: Medioni J, Pickering G, Delorme C, Lansaman T, Lanteri-Minet M, Legras A, Navez M, Prudhomme M, Serrie A, Viel É, Perrot S Tags: Bull Cancer Source Type: research

The medical treatment of radioiodine-refractory differentiated thyroid cancers in 2019. A TUTHYREF ® network review.
The medical treatment of radioiodine-refractory differentiated thyroid cancers in 2019. A TUTHYREF® network review. Bull Cancer. 2019 Jun 11;: Authors: de la Fouchardiere C, Alghuzlan A, Bardet S, Borget I, Borson Chazot F, Do Cao C, Godbert Y, Leenhardt L, Zerdoud S, Leboulleux S Abstract Patients with radioiodine-refractory (RAIR) differentiated thyroid carcinoma (DTC) represent a challenging subgroup of DTC because they are at higher risk of cancer-related death. Multidisciplinary discussions can assess the role and the nature of local treatments, but also determine the optimal timing for first...
Source: Bulletin du Cancer - June 11, 2019 Category: Cancer & Oncology Authors: de la Fouchardiere C, Alghuzlan A, Bardet S, Borget I, Borson Chazot F, Do Cao C, Godbert Y, Leenhardt L, Zerdoud S, Leboulleux S Tags: Bull Cancer Source Type: research

[Understanding lower gynaecological cancer consultation delay and help-seeking behavior in patients over 65].
CONCLUSION: Our findings are similar to those of other cancers. The peculiarity for this population appears to be the different representations of age-related changes in the reproductive system, and the taboo associated with this issue when facing friends and family. PMID: 31182221 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Vidal EA, Dubuc M, Bouati N, Bourrel G, Marchal F Tags: Bull Cancer Source Type: research

[Treatment of mucositis pain: News and prospects].
Abstract Mucositis, an acute inflammation of the digestive mucosa, is one of the main toxicities secondary to oncological treatments. Among its consequences, mucositis-related pain is an important complication due to its intensity and repercussion, especially on quality of life. Treatment of pain plays a central role in management of mucositis. It must be multimodal, combining local and general opioid or non-opioid treatments, adapted to pain intensity and based on international recommendations updated in 2014. A systemic analgesic treatment with morphine with a patient-controlled analgesia device is often necessa...
Source: Bulletin du Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Guerrini-Rousseau L, Marec-Berard P, Bolle S, Laurent S Tags: Bull Cancer Source Type: research

[Early palliative care in oncology].
Abstract Early palliative care is now recommended in international guidelines. A meta-analyze combining seven randomized studies has been published in 2007. It confirms that early palliative care improves patient's quality of life and reduces symptom burden. There is also a trend for the reduction of depressive disorder and the increase of overall survival. Other studies show that early palliative care improves quality of life of patient's relatives and reduces end of life care aggressiveness. Most of the time, early palliative care is introduced as soon as the diagnosis of advanced cancer is made, and the precise...
Source: Bulletin du Cancer - June 4, 2019 Category: Cancer & Oncology Authors: Bouleuc C, Burnod A, Angellier E, Massiani MA, Robin ML, Copel L, Chvetzoff G, Frasie V, Fogliarini A, Vinant P Tags: Bull Cancer Source Type: research

[Side effects of chemotherapy for testicular cancers and post-cancer follow-up].
Abstract Testicular cancers are the most frequent and the most curable cancers in young men. Treatments of these cancers represent a great success with cure rate over to 95 %. However, chemotherapy side effects may occur during or after several years post-treatment. This review aimed to highlight complications and physical and psychological side effects occurring mainly after chemotherapy treatment for testicular cancer, and to propose a personalized post-cancer plan specific for patients treated for testicular cancer. Treatments of these cancers can cause short-term complications (asthenia, nausea, vomiting,...
Source: Bulletin du Cancer - June 3, 2019 Category: Cancer & Oncology Authors: Joly F, Ahmed-Lecheheb D, Thiery-Vuillemin A, Orillard E, Coquan E Tags: Bull Cancer Source Type: research

[Impact of a coordinated regional organization to secure the management of patients on oral anticancer drugs: CHIMORAL, a comparative trial].
DISCUSSION: This model does not show any difference on the primary endpoint. The lack of randomization, patient selection, power loss, and local initiatives to monitor these patients may have biased the analysis. A large number of uses of the healthcare system were observed. These results confirm the need for a dedicated care pathway for the patient with oral anticancer drugs. PMID: 31130274 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 23, 2019 Category: Cancer & Oncology Authors: Maritaz C, Gault N, Roy C, Tubach F, Burnel S, Lotz JP, CHIMORAL Tags: Bull Cancer Source Type: research

[Social representation of chemotherapy and cancer among intern trainee doctor in Ouagadougou].
DISCUSSION: Knowing these representations makes it possible to understand the stakes of the doctor-patient relationship in order to improve the training of future doctors, as well as the care of patients. PMID: 31130275 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 23, 2019 Category: Cancer & Oncology Authors: Tozoula Bambara A, Akanni F, Zerbo R Tags: Bull Cancer Source Type: research

[Sexual dysfunctions of patients treated with orchidectmoy, chemotherapy and retroperitoneal lymphadenectomy, need for systematic andrological care?]
DISCUSSION: These patients have shown multicomponent sexual dysfunction. They could benefit from a new healthcare pathway implying early involvement of andrologist network. PMID: 31126677 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 21, 2019 Category: Cancer & Oncology Authors: Barkatz J, Kleinclauss F, Rigaud J, Bouchot O, Orillard É, Thiery-Vuillemin A, Mouillet G, Kalbacher E, Madec FX Tags: Bull Cancer Source Type: research

[Securing patients pathways treated by oral antitumoral: Guidelines for better organization of departments and management of incoming calls].
oly F Abstract The emergence of oral cancer treatment in oncology has shifted patient follow-up from the hospital to the home. This trend has resulted in an increase in phone and e-mail interactions initiated by patients, but also by pharmacists, by liberal nurses, by general practitioners, and an increase in calls to the emergency response services (SAMU) both for real or perceived emergencies. This increased volume of patient and pharmacist communication has caused significant disruption in the daily activity of affected oncology departments and in particular of the secretariats. The procedures for formulating a...
Source: Bulletin du Cancer - May 21, 2019 Category: Cancer & Oncology Authors: Fléchon A, Villeminey C, Despiau F, Bertrand C, Lecarpentier E, Joly F Tags: Bull Cancer Source Type: research

[HIPEC in ovarian cancer: What should we expect?]
Abstract The results of PRODIGE 7 study demonstrate that the use of HIPEC is not beneficial for patients in the treatment of colorectal carcinomatosis. Nevertheless, a recent study published in NewEnglandJournalofMedicine showed that hyperthermic intraperitoneal chemotherapy (HIPEC) increased overall survival for patients with ovarian peritoneal carcinomatosis. Although, the emergence of targeted therapies (anti-angiogenic agents, PARP-inhibitors, anti-PDL1) results in new standards of treatment in first line or recurrence disease. In this general context, what is the potential interest of HIPEC for the treatment ...
Source: Bulletin du Cancer - May 21, 2019 Category: Cancer & Oncology Authors: Picard L, Bourgin C, Penault-Llorca F, Beguinot M, Cornou C, Le Bouedec G, Mouret-Reynier MA, Selle F, Pomel C Tags: Bull Cancer Source Type: research

Effects of combined supervised intermittent aerobic, muscle strength and home-based walking training programs on cardiorespiratory responses in women with breast cancer.
Abstract BACKGROUND: The aim of this investigation was to study the effects of supervised combined intermittent aerobic, muscle strength and home-based walking training programs on cardiorespiratory fitness in women with breast cancer during adjuvant chemotherapy treatment. METHODS: Thirty-two women with breast cancer undertaking adjuvant chemotherapy participated in the study (trained group n=20 and control group n=12). The trained group carried out 6weeks of supervised intermittent cycling aerobic, muscle strength and home-based walking training programs. The self-selected walking speed (WS), walking distan...
Source: Bulletin du Cancer - May 20, 2019 Category: Cancer & Oncology Authors: Hiraoui M, Al-Hadabi B, Gmada N, Doutrellot PL, Mezlini A, Ahmaidi S Tags: Bull Cancer Source Type: research

[Reprint of: New guidelines for stage III melanoma (the French Cutaneous Oncology Group)].
Abstract Improved knowledge of sentinel node procedures coupled with the results of adjuvant clinical trials in stage III melanoma have prompted the French Cutaneous Oncology Group to propose new guidelines for the management of stage III melanoma. These guidelines comply with the principles of the evidence-based medicine. PMID: 31122657 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 20, 2019 Category: Cancer & Oncology Authors: Guillot B, Dupuy A, Pracht M, Jeudy G, Hindie E, Desmedt E, Jouary T, Leccia MT Tags: Bull Cancer Source Type: research

[Evolutionary biology and cancers: What are the novel directions?]
PMID: 31122658 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 20, 2019 Category: Cancer & Oncology Authors: Thomas F Tags: Bull Cancer Source Type: research

[Challenges of breast radiologists in Lebanon].
PMID: 31104757 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 16, 2019 Category: Cancer & Oncology Authors: Moussa T, Assi T Tags: Bull Cancer Source Type: research

[Minimum activity threshold for digestive cancer surgery in France: What are the issues?]
PMID: 31103199 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 15, 2019 Category: Cancer & Oncology Authors: El Amrani M, Turpin A, Pruvot FR Tags: Bull Cancer Source Type: research

[Stage 1 germ-cell tumour].
Abstract Stage I germ-cell tumors are rare and highly curable diseases. As such, management of these tumours should carefully follow guidelines. Initial management is based on orchiectomy and several options as adjuvant therapy. Pro's and con's should be discussed with the patient for a personalized management. Patients with stage 1 germ-cell tumours should be addressed to expert centers. PMID: 31088678 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 12, 2019 Category: Cancer & Oncology Authors: Faouzi S, Ouguellit S, Loriot Y Tags: Bull Cancer Source Type: research

[Testicular tumors: A diagnostic challenge of imaging].
CONCLUSION: The era of total orchiectomy for any uncertain testicular lesion is over. We try the challenge of characterization, and define management's algorithms based on clinical biological data and suspected nature of the tumor at imaging. PMID: 31088679 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 12, 2019 Category: Cancer & Oncology Authors: Rocher L, Ksouri A, Maxwell F, Bresson B, Hindawi G, Balasa C, Bellin MF, Albiges L Tags: Bull Cancer Source Type: research

[Pre-therapeutic and evolutive characteristics of patients suffering from chronic myeloid leukemia, in Abidjan, Ivory Coast].
G, Sanogo I Abstract INTRODUCTION: The diagnosis of chronic myeloid leukemia is based on the presence of translocation t(9,22). Additional cytogenetic abnormalities may exist at diagnosis and have prognostic value. The authors evaluated the relationship between these additional chromosomal abnormalities, clinical presentation, and therapeutic response. METHOD: In a retrospective and comparative study from 2005 to 2015, at Yopougon university hospital, 51 cases of myeloid leukemia were selected, including 22 cases with additional chromosomal abnormalities. RESULTS: Thirteen types of additional Ph1 abnorma...
Source: Bulletin du Cancer - May 11, 2019 Category: Cancer & Oncology Authors: Silué DA, Kouakou B, Nanho CD, Kamara I, Djoko S, Sowhe T, Meité N, Ayemou R, Emeuraude N, Tolo A, Koffi G, Sanogo I Tags: Bull Cancer Source Type: research

[Brachytherapy: When needs overtake care offer].
te; N Abstract Brachytherapy has the unique characteristic of being able to deliver high doses to a very localized volume, and remains one of the radiotherapy techniques that has an unparalleled therapeutic index. However, its use has been declining in the past years. Globally, only 55 to 88 % of patients with locally advanced cervical cancer benefit from utero-vaginal brachytherapy, despite the fact that it is proven to enhance both progression-free and overall survival. A decline in the use of low dose rate brachytherapy has likewise been described in the treatment of low-risk and favorable intermediate-ris...
Source: Bulletin du Cancer - May 10, 2019 Category: Cancer & Oncology Authors: Espenel S, Limkin E, Garcia MA, Langrand-Escure J, Vallard A, Chargari C, Magné N Tags: Bull Cancer Source Type: research

Patient characteristics and treatments one year after diagnosis of renal cancer in 2015 according to the presence or absence of metastasis and a history of another tumour: A national observational study.
CONCLUSION: This study highlights the high rate of a history of another tumour and adaptation of treatment according to a history of cancer and the presence of metastases. PMID: 31072597 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 6, 2019 Category: Cancer & Oncology Authors: Tuppin P, Paita M, Gastaldi-Menager C, Le Bihan-Benjamin C, Jean Bousquet P, Fagot Campagna A Tags: Bull Cancer Source Type: research

Paraneoplastic syndromes in cancers of unknown primary: An unknown field for oncologists.
Abstract Paraneoplastic syndromes are signs or symptoms that result from tissue damage at locations remote from tumour sites. Paraneoplastic syndromes associated with cancer of unknown primary (CUP) are not well recognized as they are rarely reported. These syndromes can impair various organ functions and include endocrine, neurologic, dermatologic, rheumatologic, hematologic and several other system alterations. To our knowledge, the association between the histological CUP type and the paraneoplastic syndrome has never been assessed. In some instances, paraneoplastic syndromes can become the major clinical probl...
Source: Bulletin du Cancer - May 6, 2019 Category: Cancer & Oncology Authors: El Rassy E, Assi T, Kattan J, Pavlidis N Tags: Bull Cancer Source Type: research

[Graft failure after allogeneic hematopoietic stem cell transplantation: Definition and risk factors].
let H Abstract Allogeneic hematopoietic stem cell transplantation is the only curative therapy for numerous malignant and non-malignant haematological diseases. A sustained engraftment of the donor stem cells is essential for transplant success and overall outcome. Graft failure is a rare but severe event after allogeneic hematopoietic stem cell transplantation. While different risk factors such as underlying disease, graft source or HLA matching have been found to be consistently associated with graft failure, other factors such as ABO mismatch graft-versus-host disease prophylaxis or infections, particularly vir...
Source: Bulletin du Cancer - May 3, 2019 Category: Cancer & Oncology Authors: Alcazer V, Peffault de Latour R, Ader F, Labussière-Wallet H Tags: Bull Cancer Source Type: research

[French program of breast cancer screening: Radiologist viewpoint].
Abstract French program of breast cancer screening is implemented since15 years and results are in adequation with international guidelines except for participation. To answer to recurrent controversies about breast cancer screening, publications from National Institute of French cancer registry confirm the positive impact of screening on decreasing mortality for participating women. The harms of mammography (and not from screening) need to be communicated to the invited women to help them to make decision about participation but also the risk of worse prognosis in case of symptomatic cancer. The future of screeni...
Source: Bulletin du Cancer - April 29, 2019 Category: Cancer & Oncology Authors: Ceugnart L, Rocourt N, Ben Haj-Amor M, Bachelle F, Boulanger T, Chaveron C, Pouliquen G, Renaud A, Taieb S Tags: Bull Cancer Source Type: research

[Complementary and alternative medicines in cancer patients].
This article aims at establishing a picture of the CAMs admitted by the French Medical Board as well as those which are new or in common medical practices in France. We start with a brief reminder of their origin, their status and how they are used. Then, we review the literature about some of the best clinical trials using CAMs in cancer patients. To finish, we try to understand what makes CAMs so thrilling, but also why they create controversy and which common points they may have with conventional medicine. PMID: 31023481 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 22, 2019 Category: Cancer & Oncology Authors: Bosacki C, Vallard A, Gras M, Daguenet E, Morisson S, Méry B, Jmour O, Guy JB, Magné N Tags: Bull Cancer Source Type: research

[Time perspective and quality of life in rectal cancer patients: An exploratory study].
Abstract The impact of rectal cancer on patient quality of life has been investigated but no research has yet examined the impact of time perspective in the assessment of quality of life of rectal cancer patients. Our goal is to explore the links between quality of life and time perspective and the role of time perspective as a determinant of quality of life. Data were collected from 69 patients who completed a questionnaire comprising a specific measure of quality of life (FACT-C), a measure of time perspective (ZTPI), a measure of emotional distress (HADS) and a collection of socio-demographic and medical data. ...
Source: Bulletin du Cancer - April 19, 2019 Category: Cancer & Oncology Authors: Faury S, Zenad D, Laguette V, Rullier E, Denost Q, Quintard B Tags: Bull Cancer Source Type: research

[Related donors follow-up: Guidelines from the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Abstract Since 2010 there has been an exponential increase of the number of transplants performed from related donors. The development of haploidentical transplants increases the resort to related-donation, which presents two main advantages: a less important financial cost and a faster availability of the graft. Standards for mandatory accreditation exist, but the adherence to these recommendations is not optimal: currently, different practices regarding the organizational modalities of care, recruitment criteria, qualification and follow-up of related donors have been observed among French transplant centers. Th...
Source: Bulletin du Cancer - April 18, 2019 Category: Cancer & Oncology Authors: Polomeni A, Culat-Farhat M, Desbrosses Y, Andrianne C, Ainaoui M, Baillie E, Bancillon N, de Bentzmann N, Bouya S, Duteil E, Fraysse C, Issarni D, Ruscassie A, Sauze S, Thibert JB, Yakoub-Agha I, Faucher C Tags: Bull Cancer Source Type: research

[Osteopathy for chronic pain after breast cancer surgery: A monocentric randomised study].
DISCUSSION: Patients are strongly seeking complementary therapies. Few studies exist. Our study has encountered major recruitment difficulties therefore limiting the interpretation of the results. Despite the absence of difference in the main objective, some other scores (QOL, depression) are noteworthy in favor of osteopathy. Further multicentric studies are needed. PMID: 31005246 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 17, 2019 Category: Cancer & Oncology Authors: Chvetzoff G, Berthier A, Blanc E, Bourne Branchu V, Millaret A, Cropet C, Pérol D Tags: Bull Cancer Source Type: research

[Cancer screening words].
nel N Abstract Screening (secondary prevention) is a public health action aimed at identifying diseases at their earliest stages, before the onset of signs and symptoms and, thus, avoiding or mitigating their negative consequences. The abnormality can be a genetic defect, an infection or the preclinical phase of a chronic disease such as cancer. We discuss elements common to the cancer screening debate: vocabulary about screening, overdiagnosis, and program indication criteria. Finally, we present some significant evolutions on the programs since their implementation in France. PMID: 31003632 [PubMed - as sup...
Source: Bulletin du Cancer - April 16, 2019 Category: Cancer & Oncology Authors: Mathoulin-Pélissier S, Penel N Tags: Bull Cancer Source Type: research

[Children and adolescents discharge guidelines after allogeneic stem cell transplantation for healthcare professionals: Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC)].
Abstract Recommendations for visits or environment restrictions, and sometimes for food are usually well described for inpatient within HSCT unit procedures where those measures are less precise and detailed for outpatient from the discharge to the immune reconstitution achievement. The present paper main objective is to define risk patient groups depending on time, immune-suppressive drugs as well as graft-versus-host disease and immune reconstitution. We define here 3 risk patient groups and propose measures about house cleaning, pets, schools, social activities, hygiene, foods, sexual life and siblings. PM...
Source: Bulletin du Cancer - April 15, 2019 Category: Cancer & Oncology Authors: Sirvent A, Delorme J, Godin S, Grain A, Jubert C, Pertuisel S, Pochon C, Tardieu L, Yakoub-Agha I, Dalle JH Tags: Bull Cancer Source Type: research

[A GERCOR-AERIO national survey of oncology residents in France: Current setting and expectations regarding post-internship and research].
DISCUSSION: This national survey provided useful information about the residents' perspective to academic research. It may serve as a basis for proposing measures adapted to their expectations. PMID: 30987751 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 12, 2019 Category: Cancer & Oncology Authors: Hilmi M, Rousseau B, Cohen R, Vienot A, Vernerey D, Bartholin L, Blanc-Durand F, Louvet C, Turpin A, Neuzillet C Tags: Bull Cancer Source Type: research

[Immunotherapy-induced endocrinopathies: Insights from the 2018 French Endocrine Society Guidelines].
Abstract The management of cancer patients has changed due to the considerably more frequent use of immune checkpoint inhibitors (ICPI). However, the use of ICPI has a risk of side-effects, particularly endocrine toxicity. Since the indications for ICPI are constantly expanding due to their efficacy, it is important that endocrinologists and oncologists know how to look for this type of toxicity and how to treat it when it arises. In view of this, the French Endocrine Society initiated the formulation of a guidance document on ICPI-related endocrine toxicity. In this paper, we summarize the main insights of expert...
Source: Bulletin du Cancer - April 10, 2019 Category: Cancer & Oncology Authors: Castinetti F, Borson-Chazot F Tags: Bull Cancer Source Type: research

[Care of advanced or metastatic bladder cancer in second line: A specific place for vinflunine].
N, Milano G Abstract Urothelial carcinoma of the bladder are rare but aggressive tumors with a high metastatic potential. The prognosis of these tumors has not drastically changed over the past 30 years, with an overall survival of less than two years in advanced or metastatic situations. Even though immune checkpoints inhibitors have changed this picture, it is beneficial for less than 30% of patients and there is no reliable biomarkers to identify this specific population of responders. Vinflunine is a vinca-alkaloid that was specifically developed as second line treatment post-platinum. As of today, it is the s...
Source: Bulletin du Cancer - April 10, 2019 Category: Cancer & Oncology Authors: Houédé N, Milano G Tags: Bull Cancer Source Type: research

[How to reconcile therapeutic patient education and care pathology in oncology: Application in head and neck neoplams].
Abstract Therapeutic education is an educational approach that allows the patient and his entourage to acquire or maintain the skills necessary to manage their daily lives. It requires a global care of patients and caregivers and is much broader than a learning of technical gesture. While their development is encouraged in the plan cancer 2014-2018, few programs exist in cancer surgery because the process is very cumbersome to implement due to a very strict administrative framework. In the absence of permission from the Regional health agency, "therapeutic education" term should not be used under penalty...
Source: Bulletin du Cancer - April 10, 2019 Category: Cancer & Oncology Authors: Buiret G, Chidiac F, Pujo K, Combe C Tags: Bull Cancer Source Type: research

[The impact of the patient's age on the delay of the lung cancer treatment].
CONCLUSION: In patients with>70 years old, the delay of treatment is longer than in other groups, secondary to an extended time for the preoperative assessment. An improvement in therapeutic management is necessary in our care system to shorten this delay. PMID: 30981465 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 10, 2019 Category: Cancer & Oncology Authors: Knoepfli A, Vaillant P, Billon Y, Zysman M, Menard O, Tiotiu A Tags: Bull Cancer Source Type: research

[Hepatobiliary complications following allogeneic hematopoietic cell transplantation: Recommendations of the Francophone Society of Bone Marrow transplantation and cellular Therapy (SFGM-TC)].
Guillaume T Abstract Hepatobiliary complications are frequent in the context of allogeneic hematopoietic cell transplantation (allo-HCT) and contribute largely to the morbidity and mortality after transplantation. Within the framework of the ninth workshops of practice harmonization of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) held in Lille in September 2018, diagnostic approaches and treatments of hepatobiliary dysfunctions prior to and following transplantation were reviewed according to the analysis of published studies. PMID: 30952358 [PubMed - as supplied by pu...
Source: Bulletin du Cancer - April 2, 2019 Category: Cancer & Oncology Authors: Detrait M, de Berranger E, Dulery R, Ménard AL, Thépot S, Toprak SK, Turlure P, Yakoub-Agha I, Guillaume T Tags: Bull Cancer Source Type: research

[Antineoplastic drug induced nausea and vomiting: What is the clinical practice in 2018? An update of AFSOS clinical guidelines].
missements induits par les traitements anti-cancéreux Abstract Antineoplastic drug induced nausea and vomiting (ANDINV) (previously named: Chemotherapy-induced nausea and vomiting [CINV]) are one of the most feared adverse effect for patients who begin treatment with anti-cancer treatments and their bad control have a negative impact in the management of these patients. In this review article, it is proposed an update of French-speaking Association for oncologic supportive care (AFSOS) clinical practice of CINV guidelines. This update became necessary for several reasons: newly available anti-emetic drugs; ...
Source: Bulletin du Cancer - March 25, 2019 Category: Cancer & Oncology Authors: Jovenin N, Eche-Gass A, Chèze S, Launay-Vacher V, Mayeur D, Rey JB, Joly F, Krakowski I, Scotté F, Groupe de travail du référentiel Association francophone pour les soins oncologiques de support (AFSOS) sur les nausées-vomissements induits par les tr Tags: Bull Cancer Source Type: research

[Atypical genital development and tumor risk].
Abstract Atypical genital development (AGD), also called disorders of sex development are a set of miscellaneous pathologies who have in common a morphological and/or functional abnormality of the internal and/or external genital organs. The Chicago classification identifies 3 major groups based on karyotype, hormone balance and genetic studies. Some AGD predispose to the occurrence of tumors, mainly malignant germ cell tumors. The tumor risk depends on many factors: the type of AGD, the position of the gonad, the age of the patient, the phenotype, the function of the gonad and the presence of germ cells in t...
Source: Bulletin du Cancer - March 22, 2019 Category: Cancer & Oncology Authors: Conter CF, Gorduza DB, Mure PY, Pracros JP, Mouriquand P, Bouvattier C, Siffroi JP, Plotton I, Gay CL, Cools M, Dijoud F Tags: Bull Cancer Source Type: research

[Cardiac complications of breast radiation therapy].
This article aims to make an inventory of the IMC irradiations, as well as a review of the mechanisms of radiation-induced cardiac toxicity and ways to diagnose it early. Cooperation between medical oncologists, radiotherapy oncologists and cardiologists is needed to better support patients. PMID: 30905377 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 21, 2019 Category: Cancer & Oncology Authors: Kammerer E, Le Guévelou J, Jacob S, Geffrelot J, Danhier S, Saloux E, Sichel F, Laurent C, Levy C, Thariat J Tags: Bull Cancer Source Type: research

[Testicular germ cell tumors: Histopathological and molecular features].
Abstract In 2016, the WHO classification of testicular germ cell tumors was revised considering advances in the understanding of their tumorigenesis and molecular features. This restructuring led to a division into two major groups with, on one hand, prepubertal-type tumors, not derived from germ cell neoplasia in situ (GCNIS), and on the other hand, postpubertal-type tumors, GCNIS-derived, which occur in youg men (seminoma and non seminomatous germ cell tumors - embryonal carcinoma, yolk sac tumor, teratoma and choriocarcinoma essentially). The term germ cell neoplasia in situ is consensually accepted as a new te...
Source: Bulletin du Cancer - March 21, 2019 Category: Cancer & Oncology Authors: Tourne M, Radulescu C, Allory Y Tags: Bull Cancer Source Type: research

[Update regarding the management of vulvar cancer: The guidelines of the Assistance Publique-H ôpitaux de Paris].
[Update regarding the management of vulvar cancer: The guidelines of the Assistance Publique-Hôpitaux de Paris]. Bull Cancer. 2019 Mar 18;: Authors: Azaïs H, Pauphilet V, Belghiti J, Nikpayam M, Gonthier C, Maingon P, Conforti R, Uzan C, Canlorbe G, Groupe transversal sein-gynécologie AP–HP Abstract Vulvar cancer is a rare disease, which represents 4% of gynecological tumors with an incidence of 0.5 to 1.5 per 100,000 women per year in France. Vulvar cancers are induced in 30 to 69% of cases by the presence of papillomavirus (HPV), in particular HPV 16 and 18, and can also occu...
Source: Bulletin du Cancer - March 18, 2019 Category: Cancer & Oncology Authors: Azaïs H, Pauphilet V, Belghiti J, Nikpayam M, Gonthier C, Maingon P, Conforti R, Uzan C, Canlorbe G, Groupe transversal sein-gynécologie AP–HP Tags: Bull Cancer Source Type: research

[Evolution of the regulatory framework in clinical research].
Abstract The regulatory framework of clinical research is necessary to ensure the protection of participants and to define the actors and their responsibilities. Although main principles have been set up in 1947 with the Nuremberg Code, this regulatory framework is relatively recent in Europe: development of national regulations in the years 1980-1990, first European Directive regarding clinical trials in 2001. In France, as 2006 was marked by the implementation of this first "Clinical trials Directive", the end of the year 2016 and the following months were marked by the enforcement of the Jardé ...
Source: Bulletin du Cancer - March 15, 2019 Category: Cancer & Oncology Authors: Vanseymortier M, Thery J, Penel N Tags: Bull Cancer Source Type: research

[Systematic second opinion review of outside imaging in breast cancer diagnosis: An added value].
DISCUSSION: The systematic second opinion at cancer center allows the detection of new malignancies lesions and significant modifications in the therapeutic plan. A systematic evaluation of axillary ultrasound in cancer center could be considered. PMID: 30885367 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 15, 2019 Category: Cancer & Oncology Authors: Boudier J, Oldrini G, Henrot P, Salleron J, Lesur A Tags: Bull Cancer Source Type: research

[Diagnostic and treatment pitfalls and guidelines for variants of squamous cell carcinomas of the head and neck].
Abstract Among the 20,000 new cases of head and neck neoplasms in France each year, squamous cell carcinomas (HNSCC) represent about 90 % of the cases. Among these, variants of conventional squamous cell carcinomas represent between 5% and 10% of cases. Patient history and risk factors are often similar from those of conventional HSNCC. Variants may, however, be misdiagnosed, which can lead to therapeutic mismanagement due to confusion with sarcomas, glandular tumors or even benign tumors. Diagnostic workup needs to be more cautionary or to include additional exams not to omit their most aggressive component ...
Source: Bulletin du Cancer - March 13, 2019 Category: Cancer & Oncology Authors: Thariat J, Hourseau M, Baglin AC, Digue L, Vulquin N, Badoual C, Baujat B, Janot F, Ferrand FR, Barry B Tags: Bull Cancer Source Type: research

[The practice of management in onco-hematology in Lebanon in 202X: An international model to follow].
PMID: 30878135 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 13, 2019 Category: Cancer & Oncology Authors: Kerbage F, Massoud M Tags: Bull Cancer Source Type: research

[LHRH analogs in adjuvant endocrine therapy for pre-menopausal localized breast cancers: Ending the controversy for novel guidelines?]
né N Abstract Endocrine treatment represents the cornerstone of endocrine-sensitive pre-menopausal early breast cancer. The estrogen blockade plays a leading role in the therapeutic management with surgery, radiotherapy and selective antiestrogen treatment. For several years, selective estrogen receptor modulators, such as tamoxifen, have revolutionized medical care of hormone receptors-positive breast cancer and have conquered the therapeutic arsenal while becoming the gold standard of treatment. Other combinations associating the ovarian function suppression using LHRH agonists with tamoxifen or aromatase...
Source: Bulletin du Cancer - March 7, 2019 Category: Cancer & Oncology Authors: Daguenet E, Jmour O, Vallard A, Guy JB, Jacquin JP, Méry B, Magné N Tags: Bull Cancer Source Type: research

[Management of epithelial ovarian cancer. Short text drafted from the French joint recommendations of FRANCOGYN, CNGOF, SFOG, GINECO-ARCAGY and endorsed by INCa].
r F, Gouy S, Guyon F, Lambaudie E, Leary A, Lecuru F, Lefrere-Belda MA, Leblanc E, Lemoine A, Narducci F, Ouldamer L, Pautier P, Planchamp F, Pouget N, Ray-Coquard I, Rousset-Jablonski C, Senechal-Davin C, Touboul C, Thomassin-Naggara I, Uzan C, You B, Daraï E Abstract Faced to an undetermined ovarian mass on ultrasound, an MRI is recommended and the ROMA score (combining CA125 and HE4) can be proposed (grade A). In case of suspected early stage ovarian or fallopian tube cancer, omentectomy (at least infracolonic), appendectomy, multiple peritoneal biopsies, peritoneal cytology (grade C) and pelvic and para-a...
Source: Bulletin du Cancer - March 5, 2019 Category: Cancer & Oncology Authors: Lavoue V, Huchon C, Akladios C, Alfonsi P, Bakrin N, Ballester M, Bendifallah S, Bolze PA, Bonnet F, Bourgin C, Chabbert-Buffet N, Collinet P, Courbiere B, De la Motte Rouge T, Devouassoux-Shisheboran M, Falandry C, Ferron G, Fournier L, Gladieff L, Golfi Tags: Bull Cancer Source Type: research