[Mechanisms of radiation-induced lymphopenia and therapeutic impact].
Abstract Radiation induced lymphopenia is frequent and can be severe and durable. Although lymphocytes have long been known as highly radiosensitive cells, it is poorly characterized. Radiation-induced lymphopenia seems to affect lymphocyte subpopulations differently and seems to be influenced by radiation modalities. The depth and duration of lymphopenia depend on the location of the irradiation and the volumes of treatment. Importantly, radiation-induced lymphopenia has been associated with poorer prognosis in several tumor types. The knowledge about radiation-induced lymphopenia might lead to a rethinking of th...
Source: Bulletin du Cancer - May 22, 2020 Category: Cancer & Oncology Authors: Cesaire M, Le Mauff B, Rambeau A, Toutirais O, Thariat J Tags: Bull Cancer Source Type: research

[COVID-19 impact on the cancer care structuration: example of the multidisciplinary team meeting dedicated to oncology in Occitanie].
Abstract This work examines the impact of the SARS-CoV2 epidemic and the organizational recommendations that have been issued since March 16 on tumor boards (TB) activity. The tumor board activity was measured from tumor board sheets extracted from the oncologic electronic file between January 7, 2019 and April 24, 2020. The pre-containment activity was compared to the activity of the containment periods but also to the equivalent periods in 2019. The number of meetings held, the average number of files reviewed per meeting including first presentations and the average number of physicians' attendance were the eva...
Source: Bulletin du Cancer - May 18, 2020 Category: Cancer & Oncology Authors: Grosclaude P, Azria D, Guimbaud R, Thibault S, Daubisse L, Cartron G, Renaudie MJ, Dalbies PA, Delord JP, Bauvin E Tags: Bull Cancer Source Type: research

[Prevention and treatment of antineoplastic drug-induced nausea and vomiting in pediatric onco-hematology: An update].
Abstract Antineoplastic drug induced nausea and vomiting are common adverse events in cancer care of paediatric patients ; therefore, prevention and management of these adverse events is a major concern for healthcare professionals. There are common features between paediatric and adult patients in terms of the emetogenic level depending on antineoplastic agents or about available medicines. However, there are also specificities for paediatric population including individual risk factors of emesis or nausea assessment for example. Knowledge relative to available medicines is also limited in the paediatric pop...
Source: Bulletin du Cancer - May 14, 2020 Category: Cancer & Oncology Authors: Delmotte M, Mouffak S, Mongaret C, Michelet-Huot E, Roques G, Slimano F Tags: Bull Cancer Source Type: research

[Effect of activities profile variations on health-related quality of life among breast cancer patients: Secondary exploratory analysis from PASAPAS study data].
The objective of this study was to explore the impact of the daily activity profile evolution on the quality of life among this public. METHODS: Sixty patients (18 to 75 years) with non-metastatic breast cancer were randomized to a 2:1 ratio (physical activity intervention; control) in the PASAPAS randomized clinical trial. Multiple linear regression analyzes were computed to explain quality of life scores 6 months after the start of adjuvant therapy. Variables retained were the baseline quality of life scores, the anxiety trait, the randomization arm, the variations of time spent in different physical activity classe...
Source: Bulletin du Cancer - May 13, 2020 Category: Cancer & Oncology Authors: Reynes E, Berthouze SE, Foucaut AM, Morelle M, Bachmann P, Kempf-Lépine AS, Meyrand R, Baudinet C, Carretier J, Trédan O, Fervers B, Touillaud M Tags: Bull Cancer Source Type: research

[Development of a grid for characterizing structures offering adapted physical activity programs for people who have had cancer].
This article presents the methodological development and validation process of a tool used to characterize the different structures offering physical activity programs for people who have had cancer, and seeks to define the quality criteria that a structure should meet in the current state of knowledge. Ten of these criteria were selected according to a qualitative methodology and the final tool therefore facilitates the identification of quality programs in post-cancer PA, and could be used systematically by both users and professionals as part of the post-cancer care pathway, as well as by the sport-health platforms them...
Source: Bulletin du Cancer - May 12, 2020 Category: Cancer & Oncology Authors: Terrier A, Lion A, Orezzoli A, Labrosse H, Fervers B, Berthouze S, Carretier J Tags: Bull Cancer Source Type: research

[Clinical trials during pandemic crisis: How to ensure safety and maintain access to innovation].
PMID: 32414537 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 7, 2020 Category: Cancer & Oncology Authors: Vignot S, Le Blaye O, Fluckiger L, Errard S, Marin B, Chapel E Tags: Bull Cancer Source Type: research

[Breast cancer screening and diagnosis at the end of the COVID-19 confinement period, practical aspects and prioritization rules: recommendations of 6 French health professionals societies].
PMID: 32416925 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - May 7, 2020 Category: Cancer & Oncology Authors: Ceugnart L, Delaloge S, Balleyguier C, Deghaye M, Veron L, Kaufmanis A, Mailliez A, Poncelet E, Lenczner G, Verzaux L, Gligorov J, Thomassin-Naggara I Tags: Bull Cancer Source Type: research

[Access to fertility preservation for adolescents and young adults aged 15 to 24 years with cancers in Auvergne, France].
The objective of the study was to describe the access to fertility preservation of these patients at the University Hospital of Clermont-Ferrand over a period of 3 years. METHODS: During this retrospective descriptive study, various socio-demographic and clinical data were collected. RESULTS: One hundred and fifty new cases of cancers were diagnosed in patients aged 15 to 24 years. Forty-four percent received at least one fertility consultation, 29 % for girls and 58 % for boys (P
Source: Bulletin du Cancer - May 6, 2020 Category: Cancer & Oncology Authors: Grèze V, Mechdoud S, Vorilhon S, Isfan F, Rouel N, Chaput L, Brugnon F, Kanold J Tags: Bull Cancer Source Type: research

[Awareness on the law of bioethics].
PMID: 32386707 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 30, 2020 Category: Cancer & Oncology Authors: Bay JO, Dalle JH, Dulery R, Magro L, Nguyen-Quoc S, Robin M, Rubio MT, Huynh A Tags: Bull Cancer Source Type: research

COVID-19 and acute lymphoblastic leukemias of children and adolescents: First recommendations of the Leukemia committee of the French Society for the fight against Cancers and Leukemias in children and adolescents (SFCE).
Abstract Since the emergence of the SARS-CoV-2 infection, many recommendations have been made. However, the very nature of acute lymphoblastic leukemias and their treatment in children and adolescents led the Leukemia Committee of the French Society for the fight against cancers and leukemias in children and adolescents (SFCE) to propose more specific recommendations, even if data for this population are still scarce. They may have to evolve according to the rapid evolution of knowledge on COVID-19. PMID: 32387061 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 30, 2020 Category: Cancer & Oncology Authors: Baruchel A, Bertrand Y, Boissel N, Brethon B, Ducassou S, Gandemer V, Halfon-Domenech C, Leblanc T, Leverger G, Michel G, Petit A, Ray-Lunven AF, Rohrlich PS, Schneider P, Sirvent N, Strullu M, SFCE Leukemia Committee Tags: Bull Cancer Source Type: research

[MUTYH-associated polyposis: Review and update of the French recommendations established in 2012 under the auspices of the National Cancer Institute (INCa)].
We report here the revised version of this work which successively considers the phenotype and the tumor risks associated with this genotype, the differential diagnoses, the indication criteria and the strategy of the molecular analysis and the recommendations for the management of affected individuals. We also discuss the phenotype and the tumor risks associated with mono-allelic pathogenic variants of MUTYH gene. PMID: 32362383 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 30, 2020 Category: Cancer & Oncology Authors: Buisine MP, Bonadona V, Baert-Desurmont S, Bonnet D, Coulet F, Dhooge M, Saurin JC, Remenieras A, Bignon YJ, Caron O, De Pauw A, Colas C, Buecher B Tags: Bull Cancer Source Type: research

Reducing the seroma volume by quilting suture after breast reconstruction with a latissimus dorsi flap: Single institutional experience.
CONCLUSION: This study shows the efficacy of quilting suture in reducing postoperative seroma formation in BR using LDF. Efficacy was greater when overedge stitches were used. Obese patients benefited more from quilting suture than patients with BMI
Source: Bulletin du Cancer - April 28, 2020 Category: Cancer & Oncology Authors: Debry L, Luu J, Boulanger L, Le Deley MC, Régis C Tags: Bull Cancer Source Type: research

[COVID 19 and cancer: What are the consequences of the cancer care reorganization?]
PMID: 32359766 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 23, 2020 Category: Cancer & Oncology Authors: El Amrani M, Truant S, Turpin A Tags: Bull Cancer Source Type: research

[Diagnosis, prognosis and treatment of sinonasal carcinomas (excluding melanomas, sarcomas and lymphomas)].
bres REFCOR Abstract Sinonasal carcinomas account for 3% of ENT cancers. They are subdivided into squamous cell carcinomas (50%), adenocarcinomas [20%, mostly of intestinal type (ITAC)], and more rarely, adenoid cystic carcinomas, olfactory neuroblastomas (=esthesioneuroblastomas), neuroendocrine carcinomas or undifferentiated sinonasal carcinomas (SNUC). The 5-year survival rates are, in descending order, 72% for neuroblastomas, 63% for adenocarcinomas, 50-60% for large-cell neuroendocrine carcinomas, 53% for squamous cell carcinomas, 25-50% for adenoid cystic, 35% for small-cell neuroendocrine carcinomas and 35%...
Source: Bulletin du Cancer - April 15, 2020 Category: Cancer & Oncology Authors: Thariat J, Moya Plana A, Vérillaud B, Vergez S, Régis-Ferrand F, Digue L, Even C, Costes V, Baujat B, de Gabory L, Baglin AC, Janot F, membres REFCOR Tags: Bull Cancer Source Type: research

[Retroperitoneal lymph node assessment in pediatric paratesticular rhabdomyosarcoma].
lli H Abstract Paratesticular Rhabdomyosarcoma accounts for 7 to 11% of pediatric rhabdomyosarcomas. Children older than 10 years have a worse event-free survival (69 to 80% vs. 87 to 92%) than children younger than 10 years. In this location, the relapses are essentially in the retroperitoneal lymph nodes and are often fatal. In European protocols, the assessment of the retroperitoneal lymph nodes at diagnosis is made by imaging whereas it is performed by retroperitoneal lymph node dissection in the American protocols. This method has been proved to improve event-free survival in the group of patient older than 1...
Source: Bulletin du Cancer - April 14, 2020 Category: Cancer & Oncology Authors: Guérin F, Martelli H Tags: Bull Cancer Source Type: research

[Intratumoral B cells and tertiary lymphoid structures are biomarkers of survival and immunotherapy responses].
PMID: 32284150 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - April 10, 2020 Category: Cancer & Oncology Authors: Fridman WH, Petitprez F, Sautes-Fridman C Tags: Bull Cancer Source Type: research

[The role of direct oral anticoagulants in the management of cancer-associated thrombosis in 2020].
ron N Abstract Direct oral anticoagulants, anti-IIa or anti-Xa, are widely used in the treatment and prevention of venous thromboembolic disease as well as in nonvalvular atrial fibrillation. Direct oral anticoagulants are characterized by a rapid onset of activity, a predictable response and a relatively wide therapeutic window. Nevertheless, theoretical drug interactions exist since direct oral anticoagulants are substrates of the transport protein P-glycoprotein and/or of isoforms of cytochromes P450 pathway. Direct oral anticoagulants do not have a marketing authorization for the treatment of cancer-associated...
Source: Bulletin du Cancer - April 3, 2020 Category: Cancer & Oncology Authors: Auditeau C, Talbot A, Blandinières A, Smadja DM, Gendron N Tags: Bull Cancer Source Type: research

[Adaptive radiotherapy for nasopharyngeal carcinomas: Where are we?]
We present here an update on the state of the art of adaptive radiotherapy for nasopharyngeal cancer. PMID: 32245602 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 31, 2020 Category: Cancer & Oncology Authors: Hend D, Mnejja W, Fourati N, Kallel M, Siala W, Sahnoun T, Farhat L, Daoud J Tags: Bull Cancer Source Type: research

[Comparative effectiveness of proton therapy versus photon therapy as part of concurrent chemo-radiotherapy for locally advanced cancer].
PMID: 32245604 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 31, 2020 Category: Cancer & Oncology Authors: Larnaudie A, Le Guevelou J, Thariat J Tags: Bull Cancer Source Type: research

[High fidelity simulation training for medical oncology announcement consultation].
Abstract INTRODUCTION: Medical oncology bad news consultation is a particularly stressful situation for both the patient and the physician. High-fidelity simulation is a learning option that has never been evaluated in France in this field. MATERIALS AND METHODS: This is a feedback from simulated announcement consultations carried out from January 2018 to May 2019. Residents from the medical oncology and radiotherapy departments performed high-fidelity simulations at the announcement consultation with an announcement nurse, a psychologist, a certified coach and an oncologist. A competency assessment was compl...
Source: Bulletin du Cancer - March 31, 2020 Category: Cancer & Oncology Authors: Deluche E, Salle H, Facchini-Joguet T, Leobon S, Troussel A, Tubiana-Mathieu N, Caire F, Fourcade L Tags: Bull Cancer Source Type: research

[Carbon footprint and cancer: Time for green oncology?]
PMID: 32245606 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 31, 2020 Category: Cancer & Oncology Authors: Guillon S, Nguyen Ba E, Oufkir N, Hequet D, Rouzier R Tags: Bull Cancer Source Type: research

[Impact of the LACC study. A SFOG survey].
CONCLUSION: The results of the LACC study led to a change in surgical practices with an increase in open surgery and a stop in the use of the uterine manipulator and the laparoscopic/robotic intracorporeal colpotomy in the surgical management of early stage of cervical cancer. PMID: 32245607 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 31, 2020 Category: Cancer & Oncology Authors: Gauthier T, Lacorre A, Sallee C, Tardieu A, Guyon F, Margueritte F, Gouy S Tags: Bull Cancer Source Type: research

[Therapeutic options for genitourinary cancers during the epidemic period of COVID-19].
ute;nitales PMID: 32245603 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 27, 2020 Category: Cancer & Oncology Authors: Fizazi K, pour les membres du bureau du Groupe d'étude des tumeurs uro-génitales Tags: Bull Cancer Source Type: research

[SARS-CoV-2/COVID 19  Infection and Solid Cancers: Synthesis of Recommendations for Health Professionals].
[SARS-CoV-2/COVID 19 Infection and Solid Cancers: Synthesis of Recommendations for Health Professionals]. Bull Cancer. 2020 Mar 27;: Authors: Grellety T, Ravaud A, Canivet A, Ganem G, Guimbaud R, Kaluzinski L, Krakowski I, Mayeur D, Lotz JP, You B PMID: 32229048 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 27, 2020 Category: Cancer & Oncology Authors: Grellety T, Ravaud A, Canivet A, Ganem G, Guimbaud R, Kaluzinski L, Krakowski I, Mayeur D, Lotz JP, You B Tags: Bull Cancer Source Type: research

Cancer prevalence, incidence and mortality rates in Pakistan in 2018.
PMID: 32223970 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 26, 2020 Category: Cancer & Oncology Authors: Abbas G, Shah S, Hanif M, Asghar A, Shafique M, Ashraf K Tags: Bull Cancer Source Type: research

[Better screening for work-related cancers: The experience of Brest University Hospital Occupational Disease Center inpatient service].
We present here data after two years of existence. METHODS: All cases of cancers or malignant hematological diseases (ICD-10 codes C00 to C97 and D37 to D48) seen between March 1, 2016, and March 1, 2018, have been identified. We present sociodemographic data, occupational exposures, occupation, business sector, and tobacco consumption. The causation level between the disease and each of the occupational exposures has been rated as strong, intermediate, weak or null by the occupational medicine specialist of the Occupational Diseases Center. RESULTS: Among the 196 patients encountered, there are 127 work-related ...
Source: Bulletin du Cancer - March 20, 2020 Category: Cancer & Oncology Authors: Grignoux J, Loddé B, Dewitte JD, Larabi L, Durand-Moreau Q Tags: Bull Cancer Source Type: research

[Checkpoint inhibitors-induced hypophysitis].
Abstract Checkpoint inhibitors immunotherapy is more and more prescribed in oncology, causing new immune related endocrine adverse events. Hypophysitis occurs in approximately 10 % of patients treated with anti-CTLA4. It occurs two to three months after initiation of the immunotherapy. The initial presentation is characterized, in typical forms, by the association of headache, asthenia and hyponatremia. Hormonal exploration usually shows ACTH, gonadotropic and thyrotropic deficiencies. ACTH deficiency may be life-threatening and requires urgent supplementation, without awaiting for biological results. MRI is ...
Source: Bulletin du Cancer - March 19, 2020 Category: Cancer & Oncology Authors: du Payrat JA, Cugnet-Anceau C, Maillet D, Levy M, Raverot G, Disse E, Borson-Chazot F Tags: Bull Cancer Source Type: research

[Proteinuria in multiple myeloma: Be careful to iatrogeny].
PMID: 32178835 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 13, 2020 Category: Cancer & Oncology Authors: Sapet M, Fouillet L, Daguenet E, Laurent B, Guyotat D, Le Jeune C Tags: Bull Cancer Source Type: research

[Androgen receptor-positive triple negative breast cancer: From biology to therapy].
Abstract A subgroup of androgen receptor-expressing tumors represents approximately 30 % of all triple negative tumors. The androgen receptor and its signaling pathways have a central biological role in this tumor entity. These triple negative androgen receptor-positive tumors occur in older patients and do not appear to have a better prognosis compared to other triple negative tumors. In addition to androgen receptor-expression, these tumors are genomically characterized by a high frequency of PIK3CA activating mutation. Three clinical trials reported efficacy data for anti-androgens (bicalutamide, abiratero...
Source: Bulletin du Cancer - March 4, 2020 Category: Cancer & Oncology Authors: Grellety T Tags: Bull Cancer Source Type: research

Comprehensive tumor profiling-guided therapy in rare or refractory solid cancer: A feasibility study in daily clinical practice.
Abstract Tumor profiling has been shown to benefit patients with rare or refractory metastatic cancer, but several limitations hamper its use in daily clinical practice. We aim to assess the added benefit of a comprehensive tumor profiling, including factors predictive of response to targeted and cytotoxic therapy, in the treatment of refractory or rare solid tumors outside of a formal clinical trial. Patients were included between 2013 and 2017. Multiplatform comprehensive tumor profiling (CTP) was performed on FFPE specimens. Tumor response was evaluated by imaging using the RECIST criteria version 1.1. The PFS ...
Source: Bulletin du Cancer - March 4, 2020 Category: Cancer & Oncology Authors: Ibrahim T, Ahmadie A, Rassy E, Karak FE, Hanna C, Farhat F, Kattan J, Ghosn M Tags: Bull Cancer Source Type: research

[Preoperative breast imaging review: Interests and limits of specialized validation in oncology].
Barranger E Abstract OBJECTIVES: To evaluate the impact of systematic radiological review by breast specialist radiologist of malignant breast lesion imaging on the therapeutic management of patients. MATERIALS AND METHODS: Data collection was performed for patients with histopathologically proved breast cancer or suspicious breast lesion on imaging realized out of our institution. Patients underwent systematic mammary and axillary ultrasound, imaging review and if necessary complementary mammographic images. We analyzed the number of additional breast biopsies and axillary lymph node fine needle aspiration (...
Source: Bulletin du Cancer - February 27, 2020 Category: Cancer & Oncology Authors: Flory V, Lévy G, Viotti J, Schiappa R, Elkind L, Ghez C, Pellegrin A, Occelli A, Dejode M, Delpech Y, Fouché Y, Figl A, Machiavello JC, Haudebourg J, Peyrottes I, Chapellier C, Barranger E Tags: Bull Cancer Source Type: research

[When epitranscriptomics meets the ribosome: A new avenue in oncology].
PMID: 32115179 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 27, 2020 Category: Cancer & Oncology Authors: Marcel V, Diaz JJ Tags: Bull Cancer Source Type: research

Detailed overview on rare malignant ovarian tumors.
y-Coquard I Abstract The group of rare malignant ovarian tumors includes the group of germ cell tumors, sex cords stromal ovarian tumors, small cell carcinoma, malignant Brenner tumors, rare epithelial tumors such as mucinous carcinoma, clear cell carcinoma, or low-grade serous carcinoma, as well as ovarian carcinosarcoma. Together they comprise about 10% of all ovarian tumors. Due to their low prevalence and their heterogeneity, data and treatment recommendations are limited. Even though all ovarian tumors are staged according to the FIGO staging of epithelial ovarian tumors, treatment differs especially in germ ...
Source: Bulletin du Cancer - February 27, 2020 Category: Cancer & Oncology Authors: Aust S, Eberst L, Tredan O, Rousset-Jablonski C, Treilleux I, Méeus P, Chopin N, Beurrier F, Charreton A, Véronique D, Hallouz A, Coulon A, Ricoeur A, Mastier C, Bouhamama A, Racadot S, Devouassoux-Shisheboran M, Haddad V, Ray-Coquard I Tags: Bull Cancer Source Type: research

[Radiochemotherapy of HPV-positive oropharyngeal carcinomas: Cisplatin is still to be prioritized].
PMID: 32113612 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 26, 2020 Category: Cancer & Oncology Authors: Clement-Colmou K Tags: Bull Cancer Source Type: research

[Current advances in immunotherapy in ovarian cancer].
ard I Abstract Ovarian cancers express highly immunogenic tissue-specific antigens. The resulting immune infiltration is a major prognostic factor. There is therefore a strong biological rationale for the development of immunotherapy in ovarian cancer. However, based on Phase I and II clinical trials data, the efficacy of anti-PD-1 and anti-PD-L1 immune checkpoint inhibitors (ICPIs) remains limited in monotherapy in heavily pre-treated patients. Currently, the identification of predictive biomarkers of response and resistance is one of the major areas of research. Identifying effective combination of anti-PD-1 or ...
Source: Bulletin du Cancer - February 20, 2020 Category: Cancer & Oncology Authors: Le Saux O, Dubois B, Stern MH, Terme M, Tartour E, Classe JM, Chopin N, Trédan O, Caux C, Ray-Coquard I Tags: Bull Cancer Source Type: research

[NTRK Fusions: A new way of treatment for gastro-intestinal tumor?]
te; T Abstract The advent of molecular biology resulted in the discovery of new oncogenes that have led to the development of targeted therapies for the management of cancer patients. The development of these therapies has improved the prognosis of patients in various tumour localizations. The TRK receptor (tropomyosin receptor kinase) is a transmembrane receptor with a tyrosine kinase activity that plays a role in both cell proliferation and the physiology of the nervous system. Fusions involving the NTRK gene, which codes for this receptor, have been found in different types of solid tumours and lead to its cons...
Source: Bulletin du Cancer - February 14, 2020 Category: Cancer & Oncology Authors: Ouali K, Pellat A, Cohen R, Svrcek M, Penault-Llorca F, André T Tags: Bull Cancer Source Type: research

[Wild-type gastroinestinal stromal tumors].
Abstract Gastrointestinal stromal tumors (GIST) are the most common non-epithelial tumors of the gastrointestinal tract. Wild-type GISTs (WT-GIST) consist of a rare heterogeneous group characterized by the lack of activating mutations in the tyrosine kinase receptor (Kit) and/or platelet derived growth factor receptor A (PDGFRA). However, WT-GIST is characterized by other genomic alterations, including dehydrogenase succinate (SDH) deficiency or mutations in the Ras pathway. Recent studies have reported many mutations in others genes that may be incriminated in the development of WT-GISTs. Moreover, WT-GIST is fre...
Source: Bulletin du Cancer - February 13, 2020 Category: Cancer & Oncology Authors: Djerouni M, Dumont SN Tags: Bull Cancer Source Type: research

[How can we improve cervical cancer screening: What can we learn from mistakes?]
The objective of this paper was to review situation of the screening program and to identify gaps and needs in the system and to bring or suggest solution. PMID: 32061377 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 12, 2020 Category: Cancer & Oncology Authors: Grigore M, Nandrean A, Gafitanu D Tags: Bull Cancer Source Type: research

[Exercise and cancer: Evidence of efficacy during and after treatments].
Abstract After a brief semantic and historical presentation, the article presents the main trials and systematic reviews on the tertiary prevention and care of cancers through physical activity. It gives the keys to understanding how, in forty years of research, interventions dedicated to prevent physical inactivity to reduce the risk of cancer have become as indispensable as adapted physical activity (APA) programs for care pathways. If the public health message "move more" with or without cancer remains true, the research encourages practitioners to implement personalized programs in primary prevention...
Source: Bulletin du Cancer - February 12, 2020 Category: Cancer & Oncology Authors: Ninot G, Flori N, Huteau ME, Stoebner-Delbarre A, Senesse P Tags: Bull Cancer Source Type: research

Darier and Ferrand's dermatofibrosarcoma: A carcinologic and cosmetologic challenge in a low-income country.
CONCLUSION: DFS is a common cancer with a good outcome if managed earliest. Delayed diagnoses and inadequate first-time surgery led to tumor extension and recurrences. Locally advanced tumors management needs extensive resections and reconstructive surgery. In addition to surgery, Imatinib and radiotherapy improve outcomes, but are not available in our context. PMID: 32059813 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 11, 2020 Category: Cancer & Oncology Authors: Somé OR, Diallo M, Konkobo D, Belemlilga GLH, Yabré N, Konségré V, Zaré C Tags: Bull Cancer Source Type: research

[Proton pump inhibitors and cancers: A hazardous association?]
Abstract Proton pump inhibitors, a major progress in gastro-enterology, are globally among the most widely prescribed drugs. But, due to their strong gastric acid inhibition, they can be responsible for side effects, particularly in cancer patients. They are involved in renal function impairment, bone fractures, digestive bacterial overgrowth, particularlyclostridium difficile infections, anemia and hypomagnesemia. Long term use can increase the risks of gastric, pancreatic and liver cancers. They decrease absorption of weak bases drugs, particularly tyrosine kinase inhibitors and capecitabine and are responsible ...
Source: Bulletin du Cancer - February 10, 2020 Category: Cancer & Oncology Authors: Raoul JL, Edeline J, Gilabert M, Senellart H, Frenel JS Tags: Bull Cancer Source Type: research

[2019 international oncology news: A compendium].
Bouleuc C, Bay JO Abstract Over the past years, planet oncology has kept changing and moving forward. Recent results of important clinical trials are challenging our daily practices. With modesty, the Editorial Board of BulletinduCancer has selected some clinical trials they consider as "must-know about" even if they go beyond our medical fields. PMID: 32057466 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 10, 2020 Category: Cancer & Oncology Authors: Magné N, Sabatier R, Wislez M, André T, Rodrigues M, Hervé L, Thiery-Vuillemin A, Penel N, Bouleuc C, Bay JO Tags: Bull Cancer Source Type: research

[Localized MSI/dMMR gastric cancer patients, perioperative immunotherapy instead of chemotherapy: The GERCOR NEONIPIGA phase II study is opened to recruitment].
CONCLUSION: This study is planned to include 32 patients to evaluate the pCR-R with the combination of nivolumab and ipilimumab in neoadjuvant setting for MSI/dMMR localized GOA. The MSI/MMR status should be systematically assessed on diagnostic biopsies of all GOA. If it meets its primary endpoint, the GERCOR NEONIPIGA study might mark a turning point in the management of localized MSI/dMMR GOA patients. PMID: 32057467 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 10, 2020 Category: Cancer & Oncology Authors: Cohen R, Pudlarz T, Garcia-Larnicol ML, Vernerey D, Dray X, Clavel L, Jary M, Piessen G, Zaanan A, Aparicio T, Louvet C, Tournigand C, Chibaudel B, Tougeron D, Guimbaud R, Benouna J, Adenis A, Sokol H, Borg C, Duval A, Svrcek M, André T Tags: Bull Cancer Source Type: research

[MiT family translocation renal cell carcinomas: Natural history, molecular features and multidisciplinary management].
cq N, Lang H, Malouf GG Abstract MiT family translocation renal cell carcinomas (tRCC) represent a rare subtype of renal cell carcinomas. These tumors have been introduced for the first time in the World Health Classification (WHO) classification of kidney cancers in 2004. tRCC are characterized by reccurent translocations involving members of the MiT family transcription factors, mainly TFE3 and TFEB. The estimated incidence of these tumors is ∼1-5 % among all renal cell carcinomas, with female prodominance. tRCC were initially described in children, and the spectrum has been expanded over time to encomp...
Source: Bulletin du Cancer - February 7, 2020 Category: Cancer & Oncology Authors: Herrscher H, Boilève A, Lindner V, Barthélémy P, Hutt É, Pierard L, Kurtz JE, Rioux-Leclercq N, Lang H, Malouf GG Tags: Bull Cancer Source Type: research

[Citizens who volunteer as participants for cancer research-results of the Seintinelles Barometer 2018].
DISCUSSION: The Seintinelles Barometer participants manifest a strong wish to be involved in cancer related research. Therefore, this platform seems to be a promising tool for the development of community-based research in the field of cancer. PMID: 32037013 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 6, 2020 Category: Cancer & Oncology Authors: Pannard M, Bauquier C, Bassoleil L, Sablone L, Jacob G, Reyal F, Préau M Tags: Bull Cancer Source Type: research

[Pathological process for sentinel lymph node].
Abstract Sentinel node is defined as the first node to receive drainage from a primary tumor and seems to reflect the nodal status in the lymphatic drainage of the tumor. Sentinel node technique has modified the pathological examination of lymph nodes, with intraoperative evaluation of sentinel node, allowing immediate lymph node dissection in case of positive sentinel node, and histological ultrastratification to detect occult metastases. This is a literature review of different histological protocols of sentinel node according to different organs. Except for sentinel node in breast cancer and melanoma, intraoper...
Source: Bulletin du Cancer - February 6, 2020 Category: Cancer & Oncology Authors: Alsadoun N, Devouassoux-Shisheboran M Tags: Bull Cancer Source Type: research

Intensity of care, expenditure, place and cause of death people with lung cancer in the year before their death: A French population based study.
This study indicates high rates of intensive care unit admissions and chemotherapy during the last month of life and a SSH hospital-centered management with intensive use of HPC mainly during the end-of-life stay. PMID: 32035648 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Tanguy-Melac A, Denis P, Pestel L, Fagot-Campagna A, Gastaldi-Ménager C, Tuppin P Tags: Bull Cancer Source Type: research

[Recourse of patients to their general practitioner in unplanned hospitalization in oncology management: A prospective study in an oncology institute].
DISCUSSION: GP's are not yet integrated into the active management of cancer for study patients. The symptoms that GP's say they can easily manage are the most frequent reasons for hospitalization. PMID: 32035649 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Tomasso D, Salleron J, Lamouille C, Baumard F, Conroy T, Henry A Tags: Bull Cancer Source Type: research

[Stereotaxic ablative radiotherapy in stage 1 non-small-cell lung cancer: Results of the phase 3 randomized trial "CHISEL"].
[Stereotaxic ablative radiotherapy in stage 1 non-small-cell lung cancer: Results of the phase 3 randomized trial "CHISEL"]. Bull Cancer. 2020 Feb 05;: Authors: Gerard M, Lerouge D, Le Guevelou J, Thariat J PMID: 32035650 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Gerard M, Lerouge D, Le Guevelou J, Thariat J Tags: Bull Cancer Source Type: research

[CAR-T cells in acute lymphoblastic leukemias: What's new?]
Abstract The approval of tisagenlecleucel in B-lineage acute lymphoblastic leukemias in 2017 in the USA and in 2018 in Europe not only opened new hopes but forced to rethink the hospital organizations around this innovation. Indeed, if these treatments are very effective in the short term, the complex logistics required imply high quality inter-center and intra-center collaboration. Hematology, intensive care unit, apheresis, neurology, cell therapy and biology laboratories, and radiology services must therefore act in a coordinated manner. A specialized monitoring for the mid and long term must also be implemente...
Source: Bulletin du Cancer - February 5, 2020 Category: Cancer & Oncology Authors: Grain A, Dourthe ME, Baruchel A Tags: Bull Cancer Source Type: research