A meta-analysis of the relationship between lymphatic microvessel density and clinicopathological parameters in breast cancer.
CONCLUSION: A close relationship was observed between LMVD and lymph node metastases, though no correlation between LMVD and other important clinicopathological parameters was apparent. The current meta-analysis suggests that LMVD may be associated with increased metastatic activity in breast cancer, though the full role of lymphangiogenesis in breast cancer remains uncertain. PMID: 23501839 [PubMed - indexed for MEDLINE] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Chen Y, Yan J, Yuan Z, Yu S, Yang C, Wang Z, Zheng Q Tags: Bull Cancer Source Type: research

[Evaluation of a support group for children of parents with cancer after 4 years of experience].
CONCLUSION: The short-term benefits in relation to initial expectations are described in this study. They are based on a solid and structured organization that has been well accepted by the families. Despite a small cohort, these encouraging results should allow other care providers to take over the model. A longer term evaluation is obviously necessary, according special attention to developmental issues. PMID: 23514784 [PubMed - indexed for MEDLINE] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Adam V, Kitzmann R, Rios M, Pegliasco C, Olivier JB, Raft J Tags: Bull Cancer Source Type: research

[Home-based zoledronic acid infusion therapy in patients with solid tumours: compliance and patient-nurse satisfaction].
CONCLUSION: Home zoledronic acid treatment was well tolerated. There was a very high level of both patient and nurse satisfaction with home therapy. However, better compliance with best practice should be encouraged. PMID: 23518272 [PubMed - indexed for MEDLINE] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Lebret T, Mouysset JL, Lortholary A, Kouri CE, Bastit L, Ktiouet M, Khemaies S, Murraciole X, Guérif S Tags: Bull Cancer Source Type: research

[Optimizing good use and costs of anticancer drugs: A French inter regional study of the Observatory of Cancer].
C, Vidal AM Abstract Optimizing the care management of patients is a major issue for our society. In Brittany-Pays-de-la-Loire (almost 10% of French population), an observatory of cancer has been created in 2003. Its main objective was the follow-up of expensive drugs. The knowledge of the use of these drugs in clinical practice has led to development of a thesaurus of good use. Thus, regular exchanges between clinicians have almost totally reduced not medically justified prescriptions by the thesaurus after and before administration to patient. The thesaurus has given away to national guidelines from 2007. For ex...
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Grudé F, Bessard R, Bourgeois H, Douillard JY, Gamelin E, Metges JP, Riché C, Vidal AM Tags: Bull Cancer Source Type: research

[Management of brain metastases for lung cancer patients].
lus P Abstract Brain metastases from primary lung cancer represent 40% of all brain metastases. On the other hand, 10 to 80% of primary lung cancer patients will present with synchronous or metachronous brain metastases. Management of these patients is therefore a big challenge. The management will depend on the circumstances of diagnosis (symptomatic or not), the cancer history (synchronous or metachronous brain metastases), the histology and the number of lesions. PMID: 23518334 [PubMed - indexed for MEDLINE] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Barlesi F, Khobta N, Tallet A, Goncalves A, Azria D, Spano JP, Carpentier AF, Régis J, Metellus P Tags: Bull Cancer Source Type: research

[The influence of culture in the oral expression of pain: comparative study between French and Syrian cancer patients].
This study examines the role of culture in the perception and the verbal expression of pain among syrian and french blood-related cancer patients. The level of intensity (AVS scale) and the different aspects (Saint-Antoine Pain Questionnaire [SAPQ]) of their pain were studied. The sensory and emotional descriptors chosen by the Syrian possessed a stronger semantic content in comparison to those used by the French. The patient's cultural background, which affect the perception and verbal expression of pain should be a new indicator in the optimization of global medical management. PMID: 23548892 [PubMed - indexed for M...
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Lebreuilly R, Sakkour S, Lebreuilly J Tags: Bull Cancer Source Type: research

[From quality of life to palliative care in cancerology].
PMID: 23671915 [PubMed - indexed for MEDLINE] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - March 1, 2013 Category: Cancer & Oncology Authors: Zittoun R Tags: Bull Cancer Source Type: research

Epidemiology of cancers in Niger, 1992 to 2009.
Epidemiology of cancers in Niger, 1992 to 2009. Bull Cancer. 2013 Feb 18; Authors: Garba SM, Zaki HM, Arfaoui A, Hami H, Soulaymani A, Nouhou H, Quyou A Abstract The present study aims to determine the various epidemiological characteristics of cancers in Niger from 1992 to 2009. It is a retrospective and descriptive study led from the data of the National cancers Register of Niger country between 1992 and 2009. During that period, 7,031 cases of cancers were collected. The number of registered patients suffering from cancers significantly increased, from 186 cases in 1992 to 646 cases in 2009. The as...
Source: Bulletin du Cancer - February 18, 2013 Category: Cancer & Oncology Authors: Garba SM, Zaki HM, Arfaoui A, Hami H, Soulaymani A, Nouhou H, Quyou A Tags: Bull Cancer Source Type: research

Descriptive epidemiology of cancers in Cote d'Ivoire.
This study research aimed at describing the epidemiological features of cancers in Cote d'Ivoire. It is a 26-year retrospective and descriptive study focusing on all cancers confirmed histologically by using the data from the registers of Anatomic Pathology laboratory of Abidjan teaching hospitals. The parameters of the study were frequency, age, sex, site and histological type. We obtained 12,841 cancers within patients aged from 2 months to 107 years old along with 51.26-year median age and 0.9 as sex-ratio. The most important cancer locations are cervix (17.41%) followed by skin (15.81%), prostate (7...
Source: Bulletin du Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Effi AB, Koffi KE, Aman NA, Doukouré B, N'dah KJ, Koffi KD, Kouyaté M, Koui BB, Hondé M, Diomandé MI Tags: Bull Cancer Source Type: research

Twelve years of working of Brazzaville cancer registry.
; Mbalawa C Abstract The Brazzaville cancer registry was created in 1996 with the support of the International Agency Research against Cancer (IARC) which is located in Lyon, France. The Brazzaville cancer registry is a registry which is based on population which records new cancer cases occurring in Brazzaville by using Canreg 4.0 Software. Its aim is to supply useful information to fight against cancer to physicians and to decision makers. We conducted this study whose target was to determine the incidence of cancer in Brazzaville during twelve years, from January 1st, 1998 to December 31, 2009. During that peri...
Source: Bulletin du Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Nsondé Malanda J, Nkoua Mbon JB, Bambara AT, Ibara G, Minga B, Nkoua Epala B, Gombé Mbalawa C Tags: Bull Cancer Source Type: research

Diagnosis and treatment of the epithelial ovarian cancer at the West African Cancer Center of Dakar.
Conclusion. Prognosis of epithelial ovarian cancer is worse in Senegal as like as in the world. To improve the survival of our patients, we must detect the early diagnosis of these tumors and to introduce the neoadjuvant chemotherapy before optimal surgery. PMID: 23407147 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Dem A, Dieng MM, Ka S, Gaye PM, Diouf D, Gaye-Fall MC Tags: Bull Cancer Source Type: research

First year results of "APAAC Infos Services"
Conclusion. Those results raises questions about the necessity to create and to continue this kind of telephone counseling for cancer, but also on the need of communication and extension of listening days and hours. In our country context with a population with weak resources, the necessity of access to free call was also raised. PMID: 23407212 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 14, 2013 Category: Cancer & Oncology Authors: Didi-Kouko Coulibaly J, Aka Dago-Akribi H, Oyoua B, Koffi-Gnagne Y, Adoubi I, Echimane KA Tags: Bull Cancer Source Type: research

Arrival of patients at advanced stage: to tempt to identify responsibility.
Conclusion. The medical vulgarization, large information, specialization training adapted were the way to choose in the resolution of the problem, which impact on therapeutic result was undeniable. PMID: 23392547 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 8, 2013 Category: Cancer & Oncology Authors: Gombé Mbalawa C, Diouf D, Nkoua Mbon JB, Minga B, Makouanzi Nsimba S, Nsondé Malanda J Tags: Bull Cancer Source Type: research

Clinical and outcome characteristics of inflammatory breast cancers in Brazzaville.
awa C Abstract T4 breast cancers are a heterogeneous group. We conducted this study to analyze the differences between inflammatory and non-inflammatory T4 breast cancers. In a cross-sectional descriptive study over a period ranging from 2007 to 2010, we collected patients with T4 breast cancer. These patients were divided into two groups: a group of inflammatory breast cancer (IBC) and a group of breast cancer T4 non inflammatory (NIBC). We compared the epidemiological, clinical and outcome characteristics of the two groups. We identified 129 patients with T4 stage out of 343 pa...
Source: Bulletin du Cancer - February 8, 2013 Category: Cancer & Oncology Authors: N'koua-M'bon JB, Bambara AT, Moukassa D, Gombé-Mbalawa C Tags: Bull Cancer Source Type: research

Retinoblastoma: inventory in Mali and program to develop early diagnosis, treatments and rehabilitation.
esjardins L Abstract Retinoblastoma (RB) is a rare embryonic tumour that represents 1/16,000 births in France. In Mali, a study showed the characteristics of a hospital series of cases seen in Bamako in the Pediatric Oncology Unit of Gabriel Touré Teaching Hospital and in the Tropical Ophthalmology Institute of Africa (IOTA) between January 2005 and June 2007. Median age was 4 years versus 2 years in France for unilateral disease. Near two third of children with RB had extra-ocular extension at diagnosis, which is now exceptional in France. Only 11% were bilateral versus 35% in France. C...
Source: Bulletin du Cancer - February 8, 2013 Category: Cancer & Oncology Authors: Traore F, Togo B, Sylla F, Cheick TB, Diakité AA, Dicko-Traore F, Sylla M, Sidibé T, Doz F, Harif M, Bey P, Desjardins L Tags: Bull Cancer Source Type: research

Place of surgery in brain metastases.
nei P Abstract Surgical excision in brain metastases has been well evaluated in unique metastases. Two randomized phase III trials have shown that combined with adjuvant whole brain radiotherapy, it significantly improves overall survival. However, even in the presence of multiple brain metastases, surgery may be useful in large, symptomatic or life-threatening lesions (posterior fossa tumor with mass effect). Also, even in lesions amenable to radiosurgery, surgical resection is preferred when tumors displayed cystic or necrotic aspect with important edema or when located in highly eloquent areas or cortico-subcor...
Source: Bulletin du Cancer - February 4, 2013 Category: Cancer & Oncology Authors: Métellus P, Faillot T, Guyotat J, Farah W, Bauchet L, Mornex F, Menei P Tags: Bull Cancer Source Type: research

Stereotactic radiosurgery and radiotherapy for brain metastases.
on JJ Abstract Brain metastases management is still controversial even though many trials are trying to define the respective roles of neurosurgery, whole-brain radiotherapy, single-dose stereotactic radiotherapy and fractionated stereotactic radiotherapy. In this article, we review data from trials that examine the role of radiosurgery and fractionated stereotactic radiotherapy in the management of brain metastases. PMID: 23376580 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - February 4, 2013 Category: Cancer & Oncology Authors: Tanguy R, Métellus P, Mornex F, Mazeron JJ Tags: Bull Cancer Source Type: research

Brain metastases of non small cell lung cancers: systemic treatments.
Abstract Chemotherapy, as all systemic treatments, is generally effective in brain metastases because the brain blood barrier (BBB) does not affect treatment's diffusion. Platinum-based chemotherapy provides response rates ranging from 23 to 50% for brain metastases. Anti-EGFR therapies are effective mostly when a somatic EGFR activating mutation is detected, or in selected population (adenocarcinoma, Asian population, never-smokers and women): response rate ranges from 38 to 69.6%. Bevacizumab is now allowed for non-small cell lung cancer (NSCLC) patients with brain metastases and non-squamous histology. The pres...
Source: Bulletin du Cancer - February 4, 2013 Category: Cancer & Oncology Authors: Chaubet-Houdu M, Besse B Tags: Bull Cancer Source Type: research

Editorial.
P, Tallet A PMID: 23360733 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Carpentier A, Gonçalves A, Azria D, Barlesi F, Métellus P, Spano JP, Tallet A Tags: Bull Cancer Source Type: research

Symptomatic management of brain metastasis.
Abstract Indications and choice of antiepileptic drugs (AED), treatments for cerebral edema and prophylactic and curative treatments of thromboembolic complications of brain metastasis are discussed. PMID: 23360760 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - January 29, 2013 Category: Cancer & Oncology Authors: Le Rhun E, Taillandier L, Beauchene P, Bailon O, Dubois F Tags: Bull Cancer Source Type: research

Prognostic factors for patients with brain metastases.
l G Abstract Approximately 20 to 40 % of patients with metastatic cancer will develop brain metastases (BM) during the disease course. Whole-brain radiation therapy (WBRT) is considered the standard treatment for most patients, particularly those with extensive intracranial disease, providing symptom relief and increasing median and overall survival. Despite WBRT, the prognosis for the general population of patients with BM remains poor, with a median survival time of approximately five months. Several studies have examined the relative contribution of patient characteristics to survival and have attempt...
Source: Bulletin du Cancer - January 23, 2013 Category: Cancer & Oncology Authors: Le Scodan R, Massard C, Noël G Tags: Bull Cancer Source Type: research

Brain metastasis: clinical and cognitive assessments.
Abstract The incidence of brain metastases (BM) has increased due to the improvement of therapeutics and diagnostic imaging, but also to an aging population. The initial symptoms may develop suddenly or insidiously over weeks or months. The symptoms depend on the location of the BM and related complications (hydrocephalus, tumor hemorrhage, cerebral herniation). Headaches are the most frequent symptoms (50%); they are related to intracranial hypertension. Cognitive deficits are commonly described at diagnosis (67 to 90.5%). Cognitive assessment is essential because of its impact on patients' prognosis and quality ...
Source: Bulletin du Cancer - January 23, 2013 Category: Cancer & Oncology Authors: Ramirez C, Blonski M, Belin C, Carpentier A, Taillia H Tags: Bull Cancer Source Type: research

Systemic treatment of brain metastases from breast cancer: cytotoxic chemotherapy and targeted therapies.
ves A Abstract Prevalence of brain metastases is increasing in breast cancer. Brain metastases represent a poor-prognosis disease for which local treatments continue to play a major role. In spite of the presence of a physiological blood-brain barrier limiting their activity, some systemic treatments may display a significant antitumor activity at the central nervous system level. In HER2-positive metastatic breast cancer with brain metastases not previously treated with whole brain radiotherapy, capecitabine and lapatinib combination obtains a volumetric reponse in two thirds of patients (LANDSCAPE study). If con...
Source: Bulletin du Cancer - January 11, 2013 Category: Cancer & Oncology Authors: Bachelot T, Le Rhun E, Labidi-Gally I, Heudel P, Gilabert M, Bonneterre J, Pierga JY, Gonçalves A Tags: Bull Cancer Source Type: research

Present role of prophylactic cranial irradiation.
ain F Abstract Prophylactic cranial irradiation (PCI) plays a role in the management of lung cancer patients, especially small cell lung cancer (SCLC) patients. As multimodality treatments are now able to ensure better local control and a lower rate of extracranial metastases, brain relapse has become a major concern in lung cancer. As survival is poor after development of brain metastases (BM) in spite of specific treatment, PCI has been introduced in the 1970's. PCI has been evaluated in randomized trials in both SCLC and non-small cell lung cancer (NSCLC) to reduce the incidence of BM and possibly increase surv...
Source: Bulletin du Cancer - January 11, 2013 Category: Cancer & Oncology Authors: Le Péchoux C, Al Mohkles H, Dhermain F Tags: Bull Cancer Source Type: research

Cognition and radiation therapy for brain metastases: a new paradigm to define.
lus P Abstract Whole-brain radiation therapy is suspected of early and late neurocognitive impairment in long-surviving patients with brain metastases. This putative whole-brain radiation therapy neurotoxicity leads to its postponing in brain metastases management, despite its well-established benefit in the brain control of the illness especially when associated with surgery or stereotactic radiosurgery. The incidence of neurocognitive impairment in patients with brain metastases and their link with tumoral progression or radiation during time are discussed in the light of recent randomized controlled trials. The...
Source: Bulletin du Cancer - January 9, 2013 Category: Cancer & Oncology Authors: Tallet A, Dhermain F, Taillia H, Ricard D, Mornex F, Métellus P Tags: Bull Cancer Source Type: research

The role of whole brain radiation therapy for brain metastases.
x F Abstract Brain metastases are the leading cause of intracranial malignancy and a major cause of mortality and morbidity. From 20 to 40% of cancer patients develop brain metastases. The irradiation of the whole brain remains the most commonly undertaken treatment, but should be discussed in relation to other therapeutic alternatives such as stereotactic radiotherapy or the use of new chemotherapy drugs. Its use according to pathology should be discussed. It can lead to a long-term neurocognitive toxicity that should be evaluated more precisely. This literature review aims to highlight the role of whole-brain ra...
Source: Bulletin du Cancer - January 9, 2013 Category: Cancer & Oncology Authors: Antoni D, Noël G, Mornex F Tags: Bull Cancer Source Type: research

Diagnosis of brain metastases: an update in 2012.
Abstract Diagnosis of brain metastases should aim to identify anatomoclinical entities for which a specific treatment is more accurate. Growing numbers of targeted therapies have shown to be effective against specific cancers. Several studies have reported that targeted therapies are capable of reducing brain metastases in melanoma or non small cell lung cancer (NSCLC), sometimes with a high dramatic response. These results have clearly impacted routine neuropathological practice, leading to multidisciplinary strategy management of brain metastases tissues. In accordance with the recommendations of French National...
Source: Bulletin du Cancer - January 9, 2013 Category: Cancer & Oncology Authors: Lechapt-Zalcman E, Karanian-Philippe M, Rousseau A Tags: Bull Cancer Source Type: research

Brain metastases epidemiology and biology.
Abstract Recent progresses in chemotherapies and targeted therapies have improved survival in cancer patients. In this context of better-controlled systemic disease, brain metastases (BM) are emerging as a new challenge for the oncologist. However, BM epidemiology and biology remain largely unclear. Incidence of BM is increasing. This trend could be explained by improvement in the quality of neuro-imaging (MRI) and increased survival. Primary cancers associated with BM patients are mainly: lung, breast, renal, colorectal cancers and melanoma. Prevalence of BM is estimated at 9% although this figure is probably und...
Source: Bulletin du Cancer - January 9, 2013 Category: Cancer & Oncology Authors: Tabouret E, Bauchet L, Carpentier AF Tags: Bull Cancer Source Type: research

Conventional therapeutic strategies for relapsed chronic lymphocytic leukemia.
ournilhac O Abstract The choice of salvage therapy for patients presenting relapsed chronic lymphocytic leukemia (CLL) has to take into account some factors influencing tumor resistance and comorbidities. Since 2010, new drugs targeting the tumor cells' signaling have been proposed for CLL patients. Waiting the results of various clinical trials evaluating these treatments, there is a need to describe the state-of-the-art concerning approved treatments such as chemotherapy and monoclonal antibodies. PMID: 23249977 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - December 19, 2012 Category: Cancer & Oncology Authors: Guièze R, Ysebaert L, de Guibert S, Dhédin N, Bay JO, Troussard X, Tournilhac O Tags: Bull Cancer Source Type: research

Evolution of prostate cancer brachytherapy.
Abstract Curietherapy, more commonly named brachytherapy, is one of the oldest irradiation techniques used for prostate cancer. Prostate brachytherapy evolved according to the scientific and technological progress. After a historical reminder of the evolution of prostate brachytherapy, different technical aspects are discussed: low-dose rate brachytherapy using permanent or temporary implants, high-dose rate brachytherapy as well as new imaging modalities. Prostate brachytherapy indications are listed regarding to the evidence-based medicine data for low, intermediate and high risks prostate cancers. Potential ind...
Source: Bulletin du Cancer - December 18, 2012 Category: Cancer & Oncology Authors: Hannoun-Levi JM, Chevallier D, Cosset JM, Gerbaulet A Tags: Bull Cancer Source Type: research

The molecular biology of epithelial ovarian cancer.
te; C Abstract Epithelial ovarian cancer frequently presents at an advanced stage where the cornerstone of management remains surgery and platinum-based chemotherapy. Unfortunately, despite sometimes dramatic initial responses, advanced ovarian cancer almost invariably relapses. Little progress has been made in the identification of effective targeted-therapies for ovarian cancer. The majority of clinical trials investigating novel agents have been negative and the only approved targeted-therapy is bevacizumab, for which reliable predictive biomarkers still elude us. Ovarian cancer is treated as a uniform disease....
Source: Bulletin du Cancer - December 14, 2012 Category: Cancer & Oncology Authors: Leary A, Pautier P, Tazi Y, Morice P, Duvillard P, Gouy S, Uzan C, Gauthier H, Balleyguier C, Lhommé C Tags: Bull Cancer Source Type: research

Cancer research program performed by surgeons invade the biology field - from dormancy to metastasis.
Cancer research program performed by surgeons invade the biology field - from dormancy to metastasis. Bull Cancer. 2012 Dec 14; Authors: Pocard M, Eveno C, Allaire E Abstract Cancer research program was analyzed. This research was identified using the "master of science in surgery" performed by the majority of surgical resident and fellow. It was analyzed as three axes studying: (i) how to improve the technical practice; (ii) the contribution of surgical skills in basic research, in particular via orthotopic animal models as microenvironment; and (iii) the research in basic biology, tes...
Source: Bulletin du Cancer - December 14, 2012 Category: Cancer & Oncology Authors: Pocard M, Eveno C, Allaire E Tags: Bull Cancer Source Type: research

Antibody-drug conjugates in oncology: from the concept to trastuzumab emtansine (T-DM1).
Dumontet C Abstract Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate (ADC) which associates the selective intracellular targeting of the cytotoxic agent, DM1 (maytansine derivative) to the antitumor activity of trastuzumab. T-DM1 targets the epidermal growth factor receptor 2 (HER2), highly expressed in the most aggressive forms of breast cancer. Current standard of care in HER2-positive advanced or metastatic breast cancers has its limitations, particularly after progression on HER2-targeted approved therapies. T-DM1 showed a significant antitumor activity in vitro and in vivo, and in experi...
Source: Bulletin du Cancer - December 14, 2012 Category: Cancer & Oncology Authors: Gonçalves A, Trédan O, Villanueva C, Dumontet C Tags: Bull Cancer Source Type: research

Cancer stem cells, cornerstone of radioresistance and perspectives for radiosensitization: glioblastoma as an example.
E, Magné N Abstract Cancer stem cells are a subject of increasing interest in oncology. In particular, several data suggest that cancer stem cells are involved in the mechanisms of tumor radioresistance, and may explain the therapeutic failures after radiotherapy. Because of its poor prognosis and high recurrence rate after irradiation, glioblastoma model is often studied in the search for new radiosensitizers. There are several preclinical data suggesting that cancer stem cells could be a potential therapeutic target for improving the biological effectiveness of radiation therapy. Through the example of gl...
Source: Bulletin du Cancer - December 11, 2012 Category: Cancer & Oncology Authors: Chargari C, Moncharmont C, Lévy A, Guy JB, Bertrand G, Guilbert M, Rousseau C, Védrine L, Alphonse G, Toillon RA, Rodriguez-Lafrasse C, Deutsch E, Magné N Tags: Bull Cancer Source Type: research

Do anti-angiogenic therapies prevent brain metastases in advanced renal cell carcinoma?
Abstract We analyzed renal cell carcinoma (RCC) brain metastasis (BM) risk factors and compared BM occurrence in metastatic RCC (mRCC) treated with or without anti-angiogenic agents (AA). Data from all consecutive metastatic RCC patients (patients) treated in a french cancer center between 1995 and 2008 were reviewed. Patients had histologically confirmed advanced RCC without synchronous BM at the time of metastasis diagnosis. AA were sorafenib, sunitinib and bevacizumab. We also included patients treated with mTor inhibitors, temsirolimus and everolimus, as they also demonstrated anti-angiogenic activit...
Source: Bulletin du Cancer - December 7, 2012 Category: Cancer & Oncology Authors: Vanhuyse M, Penel N, Caty A, Fumagalli I, Alt M, Zini L, Adenis A Tags: Bull Cancer Source Type: research

Chromatin remodeling defects and cancer: the SWI/SNF example.
che I Abstract The SWI/SNF complex is a multiprotein complex essential for chromatin remodelling. As such, it plays a key role in the epigenetic regulation of genome expression. This complex is composed of a dozen of proteins, some of which are constant and ubiquitous, especially SMARCB1 and SMARCA4. Mutations in these genes are now described in an increasing number of tumors. Mutations in SMARCB1 characterize the majority of rhabdoid tumors, an aggressive malignancy that exquisitely depends on this single genetic event. Rare rhabdoid tumors have mutation in SMARCA4, a genetic abnormality also found in s...
Source: Bulletin du Cancer - December 7, 2012 Category: Cancer & Oncology Authors: Bourdeaut F, Bièche I Tags: Bull Cancer Source Type: research

Advances in haploidentical transplantation in hematological malignancies.
Abstract The possibility to use a family donor sharing only one haplotype with recipient affected by hematological malignancy has been searched from many years because it allows having a donor in every case for every patient. At the beginning, this kind of transplantation was considered too toxic, but after the development of specific strategies of conditioning regimens and ex vivo T-cell depletion, its feasibility and efficacy has been proved, mainly for acute leukemia. However, these haploidentical programs with ex vivo T-cell depletion need of sophisticated and dedicated laboratories and are characterized by fr...
Source: Bulletin du Cancer - December 6, 2012 Category: Cancer & Oncology Authors: Castagna L, Blaise D Tags: Bull Cancer Source Type: research

Minutes of the 54(th) meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), Boston (USA), 28-31 October 2012.
Minutes of the 54(th) meeting of the American Society for Therapeutic Radiology and Oncology (ASTRO), Boston (USA), 28-31 October 2012. Bull Cancer. 2012 Nov 29; Authors: Thariat J, Mazeron JJ PMID: 23192678 [PubMed - as supplied by publisher] (Source: Bulletin du Cancer)
Source: Bulletin du Cancer - November 29, 2012 Category: Cancer & Oncology Authors: Thariat J, Mazeron JJ Tags: Bull Cancer Source Type: research