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Drug: Tamoxifen
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Pharmacogenetics and Pharmacokinetics of Tamoxifen in a Zimbabwean breast cancer cohort
This study aimed to determine the association between the CYP2D6 polymorphisms and endoxifen plasma concentrations in a cohort of Zimbabwean breast cancer patients (n = 40). TaqMan genotyping and copy number assays were done to determine CYP2D6 genotypes. Tamoxifen and metabolites were quantitated using LC-MS/MS. The population had high frequencies of the CYP2D6 reduced function alleles, *17 (15%) and *29 (18%). The median endoxifen concentration was 4.78 ng/ml and 55% of the patients, mostly intermediate metabolizers were below the endoxifen therapeutic threshold 5.97 ng/ml. The CYP2D6 phenotypes and activity scores were ...
Source: Clinical Genitourinary Cancer - June 20, 2023 Category: Cancer & Oncology Authors: Bianza Tinotenda Mbavha Roslyn Stella Thelingwani Zedias Chikwambi Anna Mary Nyakabau Collen Masimirembwa Consortium for Genomics and Therapeutics in Africa Source Type: research
Corrigendum to "Circular RNA circMET contributes to tamoxifen resistance of breast cancer cells by targeting miR-204/AHR signaling" Biochem. Biophys. Res. Commun. 627(2022) 200-206
Biochem Biophys Res Commun. 2023 Jun 15:S0006-291X(23)00690-3. doi: 10.1016/j.bbrc.2023.05.102. Online ahead of print.NO ABSTRACTPMID:37330314 | DOI:10.1016/j.bbrc.2023.05.102
Source: Biochemical and Biophysical Research communications - June 17, 2023 Category: Biochemistry Authors: Junbiao Liu Zhijian Dai Minmin Li Bicheng Wang Xiao Zhang Feng Li Meng Zhang Wenqian Zhang Source Type: research
Molecular docking analysis of phytochemicals with estrogen receptor alpha
Bioinformation. 2022 Aug 31;18(8):697-702. doi: 10.6026/97320630018697. eCollection 2022.ABSTRACTBreast cancer (BC) is linked to estrogen receptor alpha (ER-α) positive. Tamoxifen and other estrogen selective modulators have proven to be beneficial in slowing the progression of ER-α BC. However, tamoxifen resistance emerges as a result of long-term treatment and cancer development. Therefore, it is of interest to document data on the molecular docking analysis of phytochemicals targeting with Estrogen Receptor-alpha. The screening of the phytochemicals from the ZINC database (a total of 87133 compounds) against ER-α pro...
Source: Bioinformation - June 16, 2023 Category: Bioinformatics Authors: Misbahuddin M Rafeeq Source Type: research
