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Drug: Tamoxifen
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Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies
Nutr Cancer. 2023 May 31:1-21. doi: 10.1080/01635581.2023.2219027. Online ahead of print.ABSTRACTAmong luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening found pelargonidin (PG) can inhibit ER-signaling with potent bioactivity and satisfactory toxicological features. The present study explored the anti-tumoral prospect of PG against DMBA-induced ER + murine mammary carcinogenesis. The female BALB/c mice were divided into control...
Source: Nutrition and Cancer - May 31, 2023 Category: Cancer & Oncology Authors: Yahyea Baktiar Laskar Kasturi Bhattacharjee Moumita Nath Yashmin Choudhury Pranab Behari Mazumder Anupam Das Talukdar Source Type: research
Casein kinase 1 controls the shuttling of epidermal growth factor receptor and estrogen receptor in endometrial carcinoma induced by breast cancer hormonal therapy: Relevance of GPER1/Src
This study was performed to elucidate whether specific inhibition of casein kinase 1 (CK1) controls 4-OHT-mediated Ishikawa cell carcinogenesis. 4-OHT significantly stimulated the activity of estrogen receptor alpha (ERα) and nuclear translocation and expression of epidermal growth factor receptor (EGFR) from the plasma membrane to perinuclear or nuclear regions, as well as the activities of G-protein-coupled estrogen receptor 1 (GPER1) and Src in Ishikawa cells. However, inhibition of EGFR by Gefitinib blocked all these events, and inhibition of GPER1 or Src produced a partial block. GPER1 and Src controlled Ishikawa cel...
Source: Cellular Signalling - May 31, 2023 Category: Cytology Authors: Long Ngo Hoang Sook-Jeong Lee Source Type: research
Protective Effects of Pelargonidin against DMBA-Induced Mammary Tumorigenesis in BALB/c Mice through Reduced Oxidative Stress and Lipid Anomalies
Nutr Cancer. 2023 May 31:1-21. doi: 10.1080/01635581.2023.2219027. Online ahead of print.ABSTRACTAmong luminal types of breast cancers, ER + breast cancer is the most frequently diagnosed cancer globally. ER + breast cancer is commonly treated with SERM drugs that block ER to prevent ER-mediated cancerous growth. Our previous computational screening found pelargonidin (PG) can inhibit ER-signaling with potent bioactivity and satisfactory toxicological features. The present study explored the anti-tumoral prospect of PG against DMBA-induced ER + murine mammary carcinogenesis. The female BALB/c mice were divided into control...
Source: Nutrition and Cancer - May 31, 2023 Category: Cancer & Oncology Authors: Yahyea Baktiar Laskar Kasturi Bhattacharjee Moumita Nath Yashmin Choudhury Pranab Behari Mazumder Anupam Das Talukdar Source Type: research
An updated examination of the perception of barriers for pharmacogenomics implementation and the usefulness of drug/gene pairs in Latin America and the Caribbean
In conclusion, although the global contribution of LAC countries remains low in the PGx field, a relevant improvement has been observed in the region. The perception of the usefulness of PGx tests in biomedical community has drastically changed, raising awareness among physicians, which suggests a promising future in the clinical applications of PGx in LAC.PMID:37251329 | PMC:PMC10213898 | DOI:10.3389/fphar.2023.1175737
Source: Cancer Control - May 30, 2023 Category: Cancer & Oncology Authors: Aime é Salas-Hernández Macarena Galleguillos Mat ías Carrasco Andr és López-Cortés Mar ía Ana Redal Dora Fonseca-Mendoza Patricia Esper ón Farith Gonz ález-Martínez Ismael Lares-Asseff Alberto Lazarowski Ver ónica Loera-Castañeda Diadelis Rem Source Type: research
Innovative Thiosemicarbazones that Induce Multi-Modal Mechanisms to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer
Pharmacol Res. 2023 May 25:106806. doi: 10.1016/j.phrs.2023.106806. Online ahead of print.ABSTRACTThe estrogen receptor-α (ER-α) is a key driver of breast cancer (BC) and the ER-antagonist, tamoxifen, is a central pillar of BC treatment. However, cross-talk between ER-α, other hormone and growth factor receptors enables development of de novo resistance to tamoxifen. Herein, we mechanistically dissect the activity of a new class of anti-cancer agents that inhibit multiple growth factor receptors and down-stream signaling for the treatment of ER-positive BC. Using RNA sequencing and comprehensive protein expression analy...
Source: Cell Research - May 27, 2023 Category: Cytology Authors: Faten Shehadeh-Tout Heloisa H Milioli Suraya Roslan Patric J Jansson Mahendiran Dharmasivam Dinny Graham Robin Anderson Tharushi Wijesinghe Mahan Gholam Azad Des R Richardson Zaklina Kovacevic Source Type: research
Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy
CONCLUSIONS: DRP1 is an essential factor in mitochondrial quality control during obesity cardiomyopathy that controls multiple forms of mitophagy. Although DRP1 regulates conventional mitophagy through a mitochondria-associated membrane-independent mechanism during the acute phase, it acts as a component of the mitophagy machinery at the mitochondria-associated membranes in alternative mitophagy during the chronic phase of HFD consumption.PMID:37232152 | DOI:10.1161/CIRCRESAHA.123.322512
Source: Circulation Research - May 26, 2023 Category: Cardiology Authors: Mingming Tong Risa Mukai Satvik Mareedu Peiyong Zhai Shin-Ichi Oka Chun-Yang Huang Chiao-Po Hsu Fawad A K Yousufzai Luke Fritzky Wataru Mizushima Gopal J Babu Junichi Sadoshima Source Type: research
Hypothesizing the Green Synthesis of Tamoxifen Loaded Magnetic Nanoparticles for the Treatment of Breast Cancer
The objective of this hypothesis is to prepare tamoxifen-loaded PEGylated NiO nanoparticles using green chemistry, tumbling the toxic effects of the conventional method of synthesis for targeted delivery to breast cancer cells. Significance of the research work: The significance of the work is to hypothesize a green method for the synthesis of NiO nanoparticles that are eco-friendly, cost-effective, decrease multidrug resistance, and can be used for targeted therapy. Garlic extract contains an organosulfur compound (Allicin) which has drug-metabolizing, anti-oxidant, and tumour growth inhibition effects. In breast cancer, ...
Source: Current Molecular Medicine - May 26, 2023 Category: Molecular Biology Authors: Neha Tyagi Tanya Ralli Asgar Ali Kanchan Kohli Source Type: research
Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy
CONCLUSIONS: DRP1 is an essential factor in mitochondrial quality control during obesity cardiomyopathy that controls multiple forms of mitophagy. Although DRP1 regulates conventional mitophagy through a mitochondria-associated membrane-independent mechanism during the acute phase, it acts as a component of the mitophagy machinery at the mitochondria-associated membranes in alternative mitophagy during the chronic phase of HFD consumption.PMID:37232152 | DOI:10.1161/CIRCRESAHA.123.322512
Source: Circulation Research - May 26, 2023 Category: Cardiology Authors: Mingming Tong Risa Mukai Satvik Mareedu Peiyong Zhai Shin-Ichi Oka Chun-Yang Huang Chiao-Po Hsu Fawad A K Yousufzai Luke Fritzky Wataru Mizushima Gopal J Babu Junichi Sadoshima Source Type: research
The Incident Ocular Diseases Related to Chemotherapy in Cancer Patients are Associated with Increasing Risk of Incident Stroke
CONCLUSIONS: Incident ocular diseases related to chemotherapy were associated with a significantly higher risk of stroke.PMID:37229341 | PMC:PMC10203719 | DOI:10.6515/ACS.202305_39(3).20221005A
Source: Cancer Control - May 25, 2023 Category: Cancer & Oncology Authors: Kai-Chun Cheng Hung-Pin Tu Tsung-Hsien Lin Kai-Hung Cheng Source Type: research
Tamoxifen Effects on Cognition and Language in Women with Breast Cancer
Semin Speech Lang. 2023 Jun;44(3):189-202. doi: 10.1055/s-0043-1768135. Epub 2023 May 23.ABSTRACTCognitive changes following adjuvant treatment for breast cancer (BC) are well documented following chemotherapy. However, limited studies have examined cognitive and/or language functions in chemotherapy-naive women with BC taking tamoxifen (TAM). Using ambulatory cognitive assessment, we investigated the trajectory of cognitive and language changes during early period of adjuvant endocrine treatment (TAM) in women with BC at two time periods (pretreatment and 2 months after treatment began). Four women with BC and 18 cognitiv...
Source: Seminars in Speech and Language - May 23, 2023 Category: Speech-Language Pathology Authors: Saryu Sharma Heather Harris Wright Source Type: research
