Distinct Roles of DRP1 in Conventional and Alternative Mitophagy in Obesity Cardiomyopathy

CONCLUSIONS: DRP1 is an essential factor in mitochondrial quality control during obesity cardiomyopathy that controls multiple forms of mitophagy. Although DRP1 regulates conventional mitophagy through a mitochondria-associated membrane-independent mechanism during the acute phase, it acts as a component of the mitophagy machinery at the mitochondria-associated membranes in alternative mitophagy during the chronic phase of HFD consumption.PMID:37232152 | DOI:10.1161/CIRCRESAHA.123.322512

Source: Circulation Research - May 26, 2023 Category: Cardiology Authors: Mingming Tong Risa Mukai Satvik Mareedu Peiyong Zhai Shin-Ichi Oka Chun-Yang Huang Chiao-Po Hsu Fawad A K Yousufzai Luke Fritzky Wataru Mizushima Gopal J Babu Junichi Sadoshima Source Type: research