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Drug: Tamoxifen
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Total 2054 results found since Jan 2013.
Tamoxifen as a modulator of CXCL12-CXCR4-CXCR7 chemokine axis: A breast cancer and glioblastoma view
Cytokine. 2023 Aug 26;170:156344. doi: 10.1016/j.cyto.2023.156344. Online ahead of print.ABSTRACTThe chemokine stromal cell-derived-factor 1 (SDF)-1/CXCL12 acts by binding to its receptors, the CXC-4 chemokine receptor (CXCR4) and the CXC-7 chemokine receptor (CXCR7). The binding of CXCL12 to its receptors results in downstream signaling that leads to cell survival, proliferation and migration of tumor cells. CXCL12 and CXCR4 are highly expressed in breast cancer (BC) and glioblastoma (GBM) compared to normal cells. High expression of this chemokine axis correlates with increased therapy resistance and grade, tumor spread ...
Source: Cytokine - August 28, 2023 Category: Molecular Biology Authors: Thaynan Lopes Gon çalves Luanna Prudencio de Ara újo Val éria Pereira Ferrer Source Type: research
Ataxia Telangiectasia in a Patient with Breast Cancer: A Case Report
We report the case of a woman who had AT in childhood and developed breast cancer in her 20s; the disease was successfully managed by the decision-making of multidisciplinary physicians professionals with ethics support. She was immunocompromised, ataxic, and mentally impaired. The patient's mother noticed a tumor in her right breast and subsequently brought her to our department. Although preoperative testing and surgical procedures were limited as AT is extremely radiosensitive, the patient was diagnosed with cT2N0M0 breast cancer and underwent right mastectomy and axillary lymph node sampling. The final diagnosis was pT...
Source: Clinical Genitourinary Cancer - August 27, 2023 Category: Cancer & Oncology Authors: Mari Mizuno Yuko Ohnuki Ai Unzaki Mizuho Suzuki Kei Takeshita Saori Takahashi Hikaru Kiyohara Saeko Nakagawa Rie Ishida Kozue Yokoyama Mayako Terao Takuho Okamura Toru Hanamura Naoki Niikura Source Type: research
Anti-MUC1 nanobody can synergize the Tamoxifen and Herceptin effects on breast cancer cells by inducing ER, PR and HER2 overexpression
CONCLUSION: The ER, PR, and HER2 overexpression after MUC1 blocking could signal drug hypersensitization and facilitate drug resistance management.PMID:37633239 | DOI:10.1016/j.intimp.2023.110792
Source: International Immunopharmacology - August 26, 2023 Category: Allergy & Immunology Authors: Mahdieh Shokrollahi Barough Neda Jalili Soodabe Shafiee Malihe Salehi Nazanin Naseri Mohammad Amin Javidi Aysooda Hosseinzadeh Leila Farahmand Source Type: research
Genetic inactivation of β-catenin is salubrious whereas its activation is deleterious in desmoplakin cardiomyopathy
CONCLUSION: The cWNT/β-catenin was markedly dysregulated in the cardiac myocytes in a mouse model of desmoplakin cardiomyopathy. Inactivation of β-catenin attenuated whereas its activation aggravated the phenotype, through multiple molecular pathways, independent of the cWNT transcriptional activity. Thus, suppression but not activation of β-catenin might be beneficial in desmoplakin cardiomyopathy.PMID:37625794 | DOI:10.1093/cvr/cvad137
Source: Cell Research - August 25, 2023 Category: Cytology Authors: Melis Olcum Siyang Fan Leila Rouhi Sirisha Cheedipudi Benjamin Cathcart Hyun-Hwan Jeong Zhongming Zhao Priyatansh Gurha Ali J Marian Source Type: research
Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor-Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial
CONCLUSION: Adding OFS for 2 years to adjuvant TAM with a longer follow-up resulted in consistent DFS benefits, suggesting that adding OFS to TAM should be considered for patients who remain in a premenopausal state or resume ovarian function after chemotherapy.PMID:37607321 | DOI:10.1200/JCO.23.00557
Source: Clinical Breast Cancer - August 22, 2023 Category: Cancer & Oncology Authors: Soo Yeon Baek Woo Chul Noh Sei-Hyun Ahn Hyun-Ah Kim Jai Min Ryu Seung Il Kim Eun-Gyeong Lee Seock-Ah Im Yongsik Jung Min Ho Park Kyong Hwa Park Su Hwan Kang Joon Jeong Eunhwa Park Sung Yong Kim Min Hyuk Lee Lee Su Kim Woosung Lim Seonok Kim Hee Jeong Kim Source Type: research
Reply to "Is venous thromboembolism a time-dependent event in breast cancer patients taking tamoxifen?"
Breast Cancer. 2023 Aug 21. doi: 10.1007/s12282-023-01495-w. Online ahead of print.NO ABSTRACTPMID:37603254 | DOI:10.1007/s12282-023-01495-w
Source: Breast Cancer - August 21, 2023 Category: Cancer & Oncology Authors: Shozo Ohsumi Source Type: research
Global, but not chondrocyte-specific, MT1-MMP deficiency in adult mice causes inflammatory arthritis
Matrix Biol. 2023 Aug 18:S0945-053X(23)00090-2. doi: 10.1016/j.matbio.2023.08.003. Online ahead of print.ABSTRACTMembrane-type I metalloproteinase (MT1-MMP/MMP14) plays a key role in various pathophysiological processes, indicating an unaddressed need for a targeted therapeutic approach. However, mice genetically deficient in Mmp14 show severe defects in development and growth. To investigate the possibility of MT1-MMP inhibition as a safe treatment in adults, we generated global Mmp14 tamoxifen-induced conditional knockout (Mmp14kd) mice and found that MT1-MMP deficiency in adult mice resulted in severe inflammatory arthr...
Source: Matrix Biology - August 20, 2023 Category: Molecular Biology Authors: Xiao-Dan Xia Govind Gill Haiming Lin Daniela M Roth Hong-Mei Gu Xiang-Jiang Wang Feng-Yi Su Adekunle Alabi Maria Alexiou Ziyang Zhang Gui-Qing Wang Daniel Graf Da-Wei Zhang Source Type: research
