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Drug: Tamoxifen
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Total 2054 results found since Jan 2013.
The bHLH Transcription Factor ASCL1 Promotes Differentiation of Endocrine Cells in the Stomach and is Regulated by Notch Signaling
Am J Physiol Gastrointest Liver Physiol. 2023 Sep 12. doi: 10.1152/ajpgi.00043.2023. Online ahead of print.ABSTRACTNotch signaling regulates gastrointestinal stem cell proliferation and differentiation yet Notch-regulated transcriptional effectors of gastric epithelial cell differentiation are poorly understood. Here we tested the role of the bHLH transcription factor achaete-scute homolog 1 (ASCL1) in gastric epithelial cell differentiation, and its regulation by Notch. Newborn Ascl1 null mice showed a loss of expression of markers of neurogenin-3 dependent enteroendocrine cells, with normal expression of enterochromaffin...
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - September 12, 2023 Category: Physiology Authors: Elise S Hibdon Theresa M Keeley Juanita L Merchant Linda C Samuelson Source Type: research
Dense and Sparse Labelling of Mitral Cells by Oral and Intraperitoneal Routes of Tamoxifen Administration
Methods Mol Biol. 2023;2710:185-193. doi: 10.1007/978-1-0716-3425-7_14.ABSTRACTCell type-specific labelling and manipulation using Cre-driver lines have become integral to analyses of neuronal circuits in the brain. To study how mitral cells of the olfactory bulb process olfactory information and how they contribute to behavior, an inducible Cre-driver line, Lbhd2-CreERT2, can be used. In this chapter, we describe two methods for administering tamoxifen. The first method achieves a dense recombination pattern using tamoxifen-containing food, while the second method involving an intraperitoneal injection is suited for spars...
Source: Mol Biol Cell - September 9, 2023 Category: Molecular Biology Authors: Xiaochen Fu Yu-Pei Huang Sander Lindeman Adam Mago Izumi Fukunaga Source Type: research
< em > CYP2C19*17 < /em > association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients
This study was conducted to explore the influence of genetic polymorphisms in CYP2C19 gene on Tam's pharmacogenetics and pharmacokinetics in estrogen-positive BC patients. Data from healthy, unrelated individuals (n = 410; control group) and ER-positive BC patients (n = 430) receiving 20 mg of Tam per day were recruited. Steady-state plasma concentrations of Tam and its three metabolites were quantified using the high-performance liquid chromatography in the patients. The CYP2C19 polymorphisms were genotyped using an Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) approach. More than 65% of he...
Source: Cancer Control - September 9, 2023 Category: Cancer & Oncology Authors: Muhammad Usman Tareen Sana Riaz Saima Shakil Malik Sana Zahid Anum Khursheed Fizza Tariq Faiza Abbas Muhammad Nouman Malik Riffat Aysha Anis Mariam Anees Iram Murtaza Aneesa Sultan Source Type: research
Dense and Sparse Labelling of Mitral Cells by Oral and Intraperitoneal Routes of Tamoxifen Administration
Methods Mol Biol. 2023;2710:185-193. doi: 10.1007/978-1-0716-3425-7_14.ABSTRACTCell type-specific labelling and manipulation using Cre-driver lines have become integral to analyses of neuronal circuits in the brain. To study how mitral cells of the olfactory bulb process olfactory information and how they contribute to behavior, an inducible Cre-driver line, Lbhd2-CreERT2, can be used. In this chapter, we describe two methods for administering tamoxifen. The first method achieves a dense recombination pattern using tamoxifen-containing food, while the second method involving an intraperitoneal injection is suited for spars...
Source: Mol Biol Cell - September 9, 2023 Category: Molecular Biology Authors: Xiaochen Fu Yu-Pei Huang Sander Lindeman Adam Mago Izumi Fukunaga Source Type: research
Chemical Synthesis and Biochemical Properties of Cholestane-5 α,6β-diol-3-sulfonate, A Non-hydrolysable Analogue of cholestane-5α,6β-diol-3β-sulfate
J Steroid Biochem Mol Biol. 2023 Sep 6:106396. doi: 10.1016/j.jsbmb.2023.106396. Online ahead of print.ABSTRACTCholestane-3β,5α,6β-triol (CT) is a primary metabolite of 5,6-epoxycholesterols (5,6-EC) that is catalyzed by the cholesterol-5,6-epoxide hydrolase (ChEH). CT is a well-known biomarker for Niemann-Pick disease type C (NP-C), a progressive inherited neurodegenerative disease. On the other hand, CT is known to be metabolized by the 11β-hydroxysteroid-dehydrogenase of type 2 (11β-HSD2) into a tumor promoter named oncosterone that stimulates the growth of breast cancer tumors. Sulfation is a major metabolic trans...
Source: Mol Biol Cell - September 8, 2023 Category: Molecular Biology Authors: Philippe de M édina Silia Ayadi R égis Soulès Bruno Payre Sandrine Rup-Jacques Sandrine Silvente-Poirot Mohammad Samadi Marc Poirot Source Type: research
Oral Health Concerns of Female Breast Cancer Survivors on Adjuvant Endocrine Therapy
CONCLUSIONS: Data analysis showed that female breast cancer survivors taking adjuvant endocrine therapy appear more likely to have oral health issues than those not taking such therapy. Improved awareness of these issues is critical. Assessment and management guidelines to address these oral health issues are needed by health care providers.PMID:37678330 | DOI:10.1097/01.NAJ.0000978924.32557.53
Source: The American Journal of Nursing - September 7, 2023 Category: Nursing Authors: So-Hyun Park Shiela M Strauss Source Type: research
De-escalation of Post-mastectomy Irradiation in Hormone Receptor-Positive Breast Cancer with One to Three Positive Nodes
CONCLUSIONS: In our cohort of patients with one to three positive nodes and a RS ≤ 25, omission of post-mastectomy radiation therapy had no impact on OS. Our results suggest that RS may be utilized in the individualized decision making on PMRT.PMID:37679538 | DOI:10.1245/s10434-023-14155-2
Source: Ann Oncol - September 7, 2023 Category: Cancer & Oncology Authors: Gili G Halfteck Y Efstathia Polychronopoulou Waqar Haque Roi Weiser Sandra S Hatch V Suzanne Klimberg Source Type: research
Oral Health Concerns of Female Breast Cancer Survivors on Adjuvant Endocrine Therapy
CONCLUSIONS: Data analysis showed that female breast cancer survivors taking adjuvant endocrine therapy appear more likely to have oral health issues than those not taking such therapy. Improved awareness of these issues is critical. Assessment and management guidelines to address these oral health issues are needed by health care providers.PMID:37678330 | DOI:10.1097/01.NAJ.0000978924.32557.53
Source: The American Journal of Nursing - September 7, 2023 Category: Nursing Authors: So-Hyun Park Shiela M Strauss Source Type: research
