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Nordic walking increases circulating VEGF more than traditional walking training in postmenopause.
Abstract OBJECTIVES: Nordic walking (NW) is widely practiced by postmenopausal women. Its effects are peculiar owing to the involvement of more muscle groups than in traditional walking training (WT). Since mechanical load promotes secretion of vascular endothelial growth factor (VEGF) from both skeletal muscle and muscle endothelium, the aim of the study was to compare the effect of NW and WT on VEGF levels. METHOD: Thirty postmenopausal women were randomly assigned to NW or WT. Both groups trained 40-50 min/day, three times per week, at a mean intensity of 12 on a 15-category scale of the ratings of ...
Source: Climacteric - September 17, 2017 Category: Geriatrics Authors: Izzicupo P, D'Amico MA, Di Blasio A, Napolitano G, Di Baldassarre A, Ghinassi B Tags: Climacteric Source Type: research

Native tissue repair versus mesh repair in pelvic organ prolapse surgery.
Abstract In pelvic organ prolapse, the anatomical defects develop at the anterior (anterior vaginal wall), the posterior (posterior vaginal wall) and the apical (the uterus/cervix or the apex of the vagina, vaginal vault or cuff scar after hysterectomy) compartments. These defects occur in more than one compartment. Treatment of pelvic organ prolapse is commonly surgical, aiming to restore the anatomy of structures supporting the pelvic organs. The surgical repair techniques are classified as 'native tissue repair (NTR)' when only pelvic organ support tissues are used and 'augmented repair (AR)' when some other ma...
Source: Climacteric - September 5, 2017 Category: Geriatrics Authors: Kalkan U, Yoldemir T, Ozyurek ES, Daniilidis A Tags: Climacteric Source Type: research

Effects of soy isoflavones on the concentration of hyaluronic acid in the vagina of type 1 diabetic rats.
otilde;es M Abstract OBJECTIVE: To assess the effects of isoflavones and 17β-estradiol on the vaginal epithelium extracellular matrix and hyaluronic acid (HA) in the diabetic rat model. METHODS: Sixty adult, virgin, female rats underwent ovariectomy, then randomization into six groups of ten animals each: GI, sham ovariectomized control animals; GII, sham ovariectomized control diabetic animals; GIII, control ovariectomized rats receiving propylene glycol vehicle; GIV, control ovariectomized diabetic animals receiving propylene glycol vehicle; GV, diabetic ovariectomized animals treated with soy isoflavo...
Source: Climacteric - September 2, 2017 Category: Geriatrics Authors: F Carbonel AA, Azevedo Lima PD, Lim JJ, Teixeira Borges F, Rodrigues da Silva Sasso G, Portugal Fuchs LF, S Simões R, Chada Baracat E, Soares JM, J Simões M Tags: Climacteric Source Type: research

Turning the spotlight on lasers.
PMID: 28862053 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 1, 2017 Category: Geriatrics Authors: Hillard TC Tags: Climacteric Source Type: research

Turner syndrome - growing pressure for more multidisciplinary clinics for adults and earlier diagnosis in children.
PMID: 28862878 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 1, 2017 Category: Geriatrics Authors: Conway GS Tags: Climacteric Source Type: research

Correction to: Langer et al., Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.
Authors: PMID: 28853954 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 30, 2017 Category: Geriatrics Tags: Climacteric Source Type: research

Experience of menopause in women with inflammatory bowel disease: pilot study.
CONCLUSION: Women with IBD may experience additional challenges when going through the menopause transition. Our findings support the need for further studies to better inform patients and clinicians on the relationship between IBD and menopause to optimize patient care. PMID: 28817315 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 17, 2017 Category: Geriatrics Authors: Donaldson EK, Huang V, Ross S, Sydora BC Tags: Climacteric Source Type: research

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.
Abstract The US Preventive Services Task Force (USPSTF) Draft Recommendation statement on Menopausal Hormone Therapy: Primary Prevention for Chronic Diseases, released in May 2017, perpetuates a major disconnect between the primary population affected, women within roughly 10 years of menopause, and the data cited. Furthermore, major elements of the evidence relied upon have been misinterpreted or misstated, particularly in regard to coronary heart disease and breast cancer, for which there is no statistically significant evidence of harm. As currently drafted, the recommendations reiterate the USPSTF statements o...
Source: Climacteric - August 14, 2017 Category: Geriatrics Authors: Langer RD, Simon JA, Pines A, Lobo RA, Hodis HN, Pickar JH, Archer DF, Sarrel PM, Utian WH Tags: Climacteric Source Type: research

Age-related differences in left ventricular structure and function between healthy men and women.
RE Abstract OBJECTIVES: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, function and mechanics, and (2) to compare these measures between pre- and postmenopausal women in the middle-aged group. METHODS: Resting echocardiography was performed in a cross-sectional sample of 82 healthy adults (14 young men, 19 middle-aged men, 15 young women, 34 middle-aged women: 15 premenopausal and 19 postmenopausal). Two-way ANOVAs were used to ex...
Source: Climacteric - August 8, 2017 Category: Geriatrics Authors: Nio AQX, Stöhr EJ, Shave RE Tags: Climacteric Source Type: research

Abnormal uterine bleeding in perimenopause.
Abstract Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Once a proper diagnosis has been established, appropriate therapy may be embarked upon. Fortunately, only a minority of such patients will have premalignant or malignant disease. ...
Source: Climacteric - August 7, 2017 Category: Geriatrics Authors: Goldstein SR, Lumsden MA Tags: Climacteric Source Type: research

Dependency of cardiovascular risk on reproductive stages and on age among middle-aged Chinese women.
CONCLUSIONS: CVD risk factors were frequent and more than 10% of the women were at moderate or high risk of developing cardiovascular disease within the next 10 years. To our knowledge, this was demonstrated for the first time in middle-aged Chinese women. Thus, women should maintain a healthy lifestyle and physicians should monitor them to prevent CVD. PMID: 28771097 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 3, 2017 Category: Geriatrics Authors: Sun Y, Ruan X, Mueck AO Tags: Climacteric Source Type: research

The hot flush: symptom of menopause or sign of disease?
PMID: 28699430 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - July 14, 2017 Category: Geriatrics Authors: Baber R Tags: Climacteric Source Type: research

Factors associated with complementary and alternative medicine use among women at midlife.
Abstract Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. To date, several large, population-based studies have focused upon CAM use amongst menopausal women and the factors associated with the adoption of su...
Source: Climacteric - July 8, 2017 Category: Geriatrics Authors: Costanian C, Christensen RAG, Edgell H, Ardern CI, Tamim H Tags: Climacteric Source Type: research

Low bone mineral density is associated with cancer in postmenopausal women: the methodological issue.
PMID: 28682642 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 6, 2017 Category: Geriatrics Authors: Moradpour F, Mansori K Tags: Climacteric Source Type: research

Changing the conversation about hormone therapy.
PMID: 28675703 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 4, 2017 Category: Geriatrics Authors: Pinkerton JV Tags: Climacteric Source Type: research

The UK breast screening program - what you need to know.
Abstract Breast cancer is the most commonly diagnosed cancer in women with a lifetime risk of 1 in 8 in the UK. The disease is associated with considerable morbidity and mortality. The UK breast screening program has been in place for almost 30 years and has evolved with improved diagnostic imaging. The overall benefits of the screening program are subject to continued heated debate with multiple potential harms. The aim of this review is to provide the non-breast specialist health-care professional an overview of the evolution of the breast screening program, a summary of the evidence of the benefits, and a descr...
Source: Climacteric - June 29, 2017 Category: Geriatrics Authors: Godley KC, Gladwell C, Murray PJ, Denton E Tags: Climacteric Source Type: research

Lichen sclerosus in women: a review.
-Baptista P Abstract Female lichen sclerosus is a chronic inflammatory dermatitis, with a predilection for the anogenital area, which in some cases can become seriously distorted (atrophy of the labia minora, phimosis, introital stenosis, etc.). Most cases are diagnosed in postmenopausal women, but it can affect women of any age. Lichen sclerosus is usually a pruriginous condition, although it can also be asymptomatic. It is associated with an increased risk of vulvar cancer, even though it is not a premalignant condition itself. The true precursor of cancer associated with lichen sclerosus is vulvar intraepitheli...
Source: Climacteric - June 29, 2017 Category: Geriatrics Authors: Pérez-López FR, Vieira-Baptista P Tags: Climacteric Source Type: research

Monurelle Biogel( ®) vaginal gel in the treatment of vaginal dryness in postmenopausal women.
Monurelle Biogel(®) vaginal gel in the treatment of vaginal dryness in postmenopausal women. Climacteric. 2017 Jun 28;:1-9 Authors: Nappi RE, Cagnacci A, Becorpi AM, Nappi C, Paoletti AM, Busacca M, Martella S, Bellafronte M, Tredici Z, Di Carlo C, Corda V, Vignali M, Bagolan M, Sardina M Abstract OBJECTIVES: To evaluate efficacy, tolerability and safety of Monurelle Biogel(®) vaginal gel for treatment of vaginal dryness. METHODS: Multicenter, national, randomized, controlled vs. no-treatment, open-label study. Ninety-five postmenopausal women were randomized (48 to Monurelle Biogel(®...
Source: Climacteric - June 28, 2017 Category: Geriatrics Authors: Nappi RE, Cagnacci A, Becorpi AM, Nappi C, Paoletti AM, Busacca M, Martella S, Bellafronte M, Tredici Z, Di Carlo C, Corda V, Vignali M, Bagolan M, Sardina M Tags: Climacteric Source Type: research

Analysis of differential genetic expression in endometrial polyps of postmenopausal women.
CONCLUSION: The study found no evidence that symptomatic endometrial polyps have a similar phenotype to type 1 endometrial cancer; further studies are needed in order to establish whether endometrial polyps are in fact true cancer precursors, or simply raise cancer incidence due to a detection bias. PMID: 28622040 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - June 16, 2017 Category: Geriatrics Authors: Troncon JK, Meola J, Candido-Dos-Reis FJ, Poli-Neto OB, Nogueira AA, Rosa-E-Silva JC Tags: Climacteric Source Type: research

The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review.
CONCLUSIONS: The available evidence (of low and moderate quality) shows that, when administered vaginally, estriol preparations appear to be safe for women who have risk factors related to systemic estrogen therapy. PMID: 28622049 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - June 16, 2017 Category: Geriatrics Authors: Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI Tags: Climacteric Source Type: research

Sleep duration and midlife women's health.
Abstract Sleep is mandatory for life and therefore any sleep deprivation or disruption might carry ill-health outcomes. The optimal night's sleep duration seems to be around 7 h, as too little sleep and too much sleep have been found to be associated with a variety of changes in well-being, physical and psychological parameters. This mini-review enlightens the potential health consequences of sleep disturbance relevant to menopause and midlife women's health. These include cardiovascular and metabolic derangements, cognitive impairment, osteoporosis, and cancer-related perspectives. Still, the current knowl...
Source: Climacteric - June 14, 2017 Category: Geriatrics Authors: Pines A Tags: Climacteric Source Type: research

Association of objectively measured physical activity and physical fitness with menopause symptoms. The Flamenco Project.
riano-Maldonado A Abstract OBJECTIVE: The primary aim was to analyze the association of moderate-to-vigorous physical activity (MVPA) with menopause symptomatology and its overall impact. A secondary/exploratory aim was to assess the association of different components of physical fitness with menopause symptomatology. METHODS: This cross-sectional study comprised 191 perimenopausal women from Southern Spain (age range 45-60 years, mean age 52.6 ± 4.5 years). The Blatt-Kupperman Menopausal Index was used to evaluate menopause symptomatology. Objectively measured MVPA was registered with a...
Source: Climacteric - June 3, 2017 Category: Geriatrics Authors: Aparicio VA, Borges-Cosic M, Ruiz-Cabello P, Coll-Risco I, Acosta-Manzano P, Špacírová Z, Soriano-Maldonado A Tags: Climacteric Source Type: research

The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis.
Abstract OBJECTIVES: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-analysis to estimate the prognostic value of the PLR in ovarian cancer. METHODS: We searched the EMBASE, Medline, PubMed, and Web of Science databases to identify clinical studies that had evaluated the association between the PLR and ovarian cancer prognosis. Outcomes evaluated included overall survival (...
Source: Climacteric - June 1, 2017 Category: Geriatrics Authors: Ma XM, Sun X, Yang GW, Yu MW, Zhang GL, Yu J, Zhang Y, Wang XM Tags: Climacteric Source Type: research

Low bone mineral density is associated with breast cancer in postmenopausal women: a case-control study.
CONCLUSION: Postmenopausal breast cancer survivors had a higher incidence of osteopenia and osteoporosis in the femoral neck than women without breast cancer. A history of chemotherapy was a risk factor for low BMD, whereas regular physical activity and high body mass index reduced the risk among breast cancer survivors. PMID: 28569124 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - June 1, 2017 Category: Geriatrics Authors: Ferreira Poloni P, Vespoli HL, Almeida-Filho BS, Bueloni-Dias F, Nahas-Neto J, Nahas EAP Tags: Climacteric Source Type: research

Custom-compounded bioidentical hormone therapy: why so popular despite potential harm? The case against routine use.
Abstract Wide rejection of conventional hormone therapy (HT) after the initial publication of the Women's Health Initiative (WHI) led to unjustified use of custom-compounded bioidentical hormones. In the USA, it became an unregulated drug manufacturer industry in disguise, without proper control and making false claims and misleading advertisements. Manufacturing quality is not ensured. Unspecific harm from compounding has occurred on a large scale, such as deaths from infected products and end-stage renal failure plus carcinoma due to confusion between different Chinese herbs. Oral estrogens increase venous throm...
Source: Climacteric - May 18, 2017 Category: Geriatrics Authors: L'Hermite M Tags: Climacteric Source Type: research

Impact of risk-reducing salpingo-oophorectomy in premenopausal women.
CONCLUSIONS: The conclusions of this systematic review are limited by the absence of randomized, controlled trials. There is growing evidence from observational studies that RRSO may impact negatively on all-cause non-survival endpoints. PMID: 28509627 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - May 18, 2017 Category: Geriatrics Authors: Vermeulen RFM, Beurden MV, Korse CM, Kenter GG Tags: Climacteric Source Type: research

Fractional CO2 laser therapy: a new challenge for vulvovaginal atrophy in postmenopausal women.
Abstract OBJECTIVE: To evaluate the effects of CO2 laser in the treatment of vulvovaginal atrophy (VVA) in postmenopausal women. METHODS: VVA was assessed in 87 postmenopausal women (mean age 58.6 ± 6.9 years) before and after the treatment. The protocol consisted of three monthly treatments and included the treatment of vulva. Subjective measures included VAS (Visual Analog Scale) both for vaginal dryness and dyspareunia; DIVA (Day-by-day Impact of Vaginal Aging); a questionnaire on treatment satisfaction and one about the degree of pain during the procedure. Objective measures included ...
Source: Climacteric - May 15, 2017 Category: Geriatrics Authors: Siliquini GP, Tuninetti V, Bounous VE, Bert F, Biglia N Tags: Climacteric Source Type: research

What is the right dose of modern medicine?
PMID: 28497704 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - May 12, 2017 Category: Geriatrics Authors: Bell RJ Tags: Climacteric Source Type: research

Tissue-specific effects of estrogen on glycerol channel aquaporin 7 expression in an ovariectomized mouse model of menopause.
CONCLUSIONS: Our results suggest that estrogen has tissue-specific effects on AQP7 expression, and modulation of AQP7 by estrogen alters the balance of adipocyte metabolism between adipose tissue depots. PMID: 28489425 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - May 10, 2017 Category: Geriatrics Authors: Jin B, Chen X, Xing L, Xu W, Fu X, Zhu J, Mou X, Wang Z, Shu J Tags: Climacteric Source Type: research

Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life?
Abstract To date, the world's leading cause of death amongst women is cardiovascular disease. Polycystic ovary syndrome (PCOS) is associated with an unfavorable cardiometabolic profile in early life. Apart from dyslipidemia, obesity and onset of type 2 diabetes mellitus, androgens are thought to influence cardiovascular health. The question rises whether women with PCOS are truly at risk for cardiovascular disease in later life. In this review paper, we aim to reflect on this assumed relation based on studies in different stages of life in women with PCOS. Cardiovascular risk factors (type 2 diabetes mellitus, obe...
Source: Climacteric - April 29, 2017 Category: Geriatrics Authors: Gunning MN, Fauser BCJM Tags: Climacteric Source Type: research

Primary ovarian insufficiency with t(5;13): a case report and literature review on disrupted genes.
CONCLUSIONS: Autosomal translocations are rare in women with POI. We have reported the first case of a de novo reciprocal translocation involving chromosomes 5 and 13 in a POI patient. As one of the breakpoints encompasses the FOXO1 gene, it seems that disruption of this gene can be the cause of POI in this patient. This provides further evidence on the role of autosomal translocations in disrupting POI-associated genes. Therefore, concentrating on the genes at the breakpoints will be helpful to delineate the new biological pathways or genes involved in POI pathogenesis. PMID: 28453298 [PubMed - as supplied by publish...
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Mohamadhashem F, Rafati M, Hoseininasab F, Rostami S, Tabatabaie R, Rezai S, Keramatipour M, Ghaffari SR Tags: Climacteric Source Type: research

-643C   >  T RANKL gene polymorphism is associated with osteoporosis in Tunisian postmenopausal women.
CONCLUSION: We have demonstrated the association of the -643C > T polymorphism with BMD variation and osteoporosis risk in postmenopausal Tunisian women. PMID: 28453307 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Sassi R, Sahli H, Cheour E, Sellami S, El Gaaied ABA Tags: Climacteric Source Type: research

Genitourinary syndrome of menopause in five Asian countries: results from the Pan-Asian REVIVE survey.
CONCLUSION: GSM is underdiagnosed and undertreated in Asia. As discussion of GSM with HCPs appears to be a factor influencing women's awareness and treatment status, a more active role by HCPs to facilitate early discussions on GSM and its treatment options is needed. PMID: 28453308 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Chua Y, Limpaphayom KK, Cheng B, Ho CM, Sumapradja K, Altomare C, Huang K Tags: Climacteric Source Type: research

Vasomotor symptoms in menopause: a biomarker of cardiovascular disease risk and other chronic diseases?
Abstract Menopausal disorders may include shorter-term symptoms, such as hot flushes and night sweats (vasomotor symptoms, VMS) and longer-term chronic conditions such as cardiovascular disease (CVD), osteoporosis, and cognitive impairment. Initially, no clear link between the shorter-term symptoms and longer-term chronic conditions was evident and these disorders seemed to occur independently from each other. However, there is a growing body of evidence demonstrating that VMS may be a biomarker for chronic disease. In this review, the association between VMS and a range of chronic postmenopausal conditions includ...
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Biglia N, Cagnacci A, Gambacciani M, Lello S, Maffei S, Nappi RE Tags: Climacteric Source Type: research

Relationship between delivery modes and genitourinary syndrome among postmenopausal women.
This study aimed to evaluate the relationship between mode of delivery and GSM among postmenopausal women. METHODS: We performed a case-control study of women who had had either vaginal delivery or Cesarean section. Data were collected through a sociodemographic questionnaire and a check list for assessing signs and symptoms of GSM. Subjective symptoms of vaginal atrophy (dryness, dyspareunia, itching, burning and paleness), pH of the vagina and maturation index were assessed and recorded. Data were analyzed using the χ(2) test and independent t-test. RESULTS: A total of 125 postmenopausal women were recruite...
Source: Climacteric - April 25, 2017 Category: Geriatrics Authors: Yaralizadeh M, Abedi P, Salehinejad P Tags: Climacteric Source Type: research

Similarity of female central (hypogonadotropic) hypogonadism and postmenopause.
CONCLUSIONS: Despite the young age of women with central hypogonadism, clinical, hormonal and biochemical abnormalities were similar in many aspects to those in postmenopausal women at middle/old age. These revealed features could be considered as signs of premature aging in young amenorrheic women with low gonadotropin levels. PMID: 28438051 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 24, 2017 Category: Geriatrics Authors: Ilovayskaya I, Zektser V, Lazebnik L Tags: Climacteric Source Type: research

Hormone therapy for premature ovarian insufficiency patients with malignant hematologic diseases.
CONCLUSION: Myeloablative chemotherapy against leukemia may cause POI. HT may relieve perimenopausal symptoms after myeloablative chemotherapy and HSCT. HT was safe and no excessive recurrences or mortality were seen in the hormone-treated group for patients who survived from malignant hematologic diseases and who received HSCT. PMID: 28399661 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 11, 2017 Category: Geriatrics Authors: Yang X, Wang C, He X, Wei J, Wang Y, Li X, Xu LP Tags: Climacteric Source Type: research

Climacteric symptoms and their relation to feminine self-concept.
CONCLUSIONS: Our study confirmed the impact of subjective factors such as satisfaction, self-concept, and quality of life on climacteric symptoms; specifically, we observed the moderating effect of the sexual quality of life on the previously established correlation between depression and aggravation of climacteric symptoms. PMID: 28398825 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 11, 2017 Category: Geriatrics Authors: Quiroga A, Larroy C, González-Castro P Tags: Climacteric Source Type: research

Impact of insomnia on pain in postmenopausal women.
CONCLUSIONS: Insomnia status affected climacteric symptoms and pain interference, but not pain intensity in postmenopausal women. Women with insomnia had higher rates of climacteric symptoms than those without insomnia or those with subthreshold insomnia. No changes in objective sleep pattern were found. PMID: 28391713 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 9, 2017 Category: Geriatrics Authors: Frange C, Naufel MF, Andersen ML, Ribeiro EB, Girão MJ, Tufik S, Hachul H Tags: Climacteric Source Type: research

Determinants of percent mammographic density in women with premature ovarian insufficiency.
Abstract OBJECTIVE: To evaluate the determinants of breast density in women with premature ovarian insufficiency (POI). METHODS: In a cross-sectional study of 163 women with POI undergoing mammography, percent mammographic density (PMD) was evaluated by digitizing the image. PMD was correlated with age, age at menarche, age at POI, time since POI, body mass index (BMI), gestational history and hormone therapy (HT) use (duration, dose, regimen). RESULTS: POI was diagnosed at a mean age of 32.3 ± 5.9 years. The mean age of the women at mammography was 41.3 ± 5.4 ye...
Source: Climacteric - April 9, 2017 Category: Geriatrics Authors: Torelli FR, Brancalion MF, Yela DA, Benetti-Pinto CL Tags: Climacteric Source Type: research

Knowledge and attitudes of health professionals regarding menopausal hormone therapies.
Abstract OBJECTIVE: To evaluate the knowledge and attitudes of Australian health professionals (HPs) including general practitioners (GPs), gynecologists and endocrinologists, to menopausal hormone therapy (MHT). METHODS: Participants were recruited from medical societies/colleges and a national GP conference. An online survey containing devised and previously published questions was used. Data analysis included frequencies, ANOVA, χ(2) and regression analysis. RESULTS: A total of 745/888 responses were analyzed. Fewer HPs (52%) reported being knowledgeable regarding non-hormonal therapies compared w...
Source: Climacteric - April 5, 2017 Category: Geriatrics Authors: Yeganeh L, Boyle J, Teede H, Vincent A Tags: Climacteric Source Type: research

The menopausal hot flush: a review.
Abstract The hot flush is the most characteristic and often the most distressing symptom of the menopause. It is a unique feature and yet the mechanism and health implications are still not fully understood. This review summarizes some of the current thoughts on factors contributing to flushing, the physiological, vascular and neuroendocrine changes associated with flushing and the possible cardiovascular and other health implications for women experiencing hot flushes. Therapy is not discussed. PMID: 28379074 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 5, 2017 Category: Geriatrics Authors: Sturdee DW, Hunter MS, Maki PM, Gupta P, Sassarini J, Stevenson JC, Lumsden MA Tags: Climacteric Source Type: research

A simple anthropometric tool for the assessment of pre-sarcopenia in postmenopausal women.
CONCLUSION: The availability of reliable and simple clinical instruments to identify low muscle mass is of great relevance. Anthropometric methods reported in this paper could represent an innovative resource for muscle mass assessment in daily practice. The contribution of these approaches in the detection and management of sarcopenia should allow the physician to make early interventions and thus prevent or modify its relevant health consequences. PMID: 28379719 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 5, 2017 Category: Geriatrics Authors: Morosano ME, Menoyo IM, Tomat MF, Masoni AM, Pezzotto SM Tags: Climacteric Source Type: research

An International Menopause Society study of vasomotor symptoms in Bangkok and Chiang Mai, Thailand.
CONCLUSION: HFNS reports are prevalent with moderate frequency and problem-ratings in these urban centers in Thailand. The results will be included in the broader International Menopause Society study of Climate, Altitude and Temperature (IMS-CAT) of the impact of climate on HFNS. PMID: 28286984 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Sriprasert I, Pantasri T, Piyamongkol W, Suwan A, Chaikittisilpa S, Sturdee D, Gupta P, Hunter MS Tags: Climacteric Source Type: research

Use of mindfulness, meditation and relaxation to treat vasomotor symptoms.
Abstract Postmenopausal women with bothersome vasomotor symptoms (VMS) often seek alternatives to hormone-based treatment due to medication risks or personal preference. We sought to identify the effects of meditation, mindfulness, hypnosis and relaxation on VMS and health-related quality of life in perimenopausal and postmenopausal women. To do this, we conducted an umbrella review supplemented by new randomized, controlled trials (RCTs) published since the most recent good-quality systematic review for eligible interventions. We searched MEDLINE and the Cochrane Database of Systematic Reviews, PubMed, EMBASE, CI...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Goldstein KM, Shepherd-Banigan M, Coeytaux RR, McDuffie JR, Adam S, Befus D, Goode AP, Kosinski AS, Masilamani V, Williams JW Tags: Climacteric Source Type: research

Age-related prevalence of osteoporosis and fragility fractures: real-world data from an Austrian Menopause and Osteoporosis Clinic.
The objectives of this study were to determine the age-related prevalence of osteopenia and osteoporosis according to WHO criteria and fragility fractures in middle-aged and older women. METHODS: Women ≥40 years, who were referred to a menopause and osteoporosis outpatient clinic for BMD measurements, were assessed for patient characteristics, BMD and previous fragility fractures of the hip, the distal forearm and the vertebrae. Only records of their initial consultations were used for data analysis. RESULTS: Between 1990 and 2012, 99,399 women, mean age 56.1 years, were referred to the clinic for BMD testing....
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Boschitsch EP, Durchschlag E, Dimai HP Tags: Climacteric Source Type: research

Endometriosis after menopause: physiopathology and management of an uncommon condition.
Abstract Endometriosis is a hormone-dependent inflammatory disease that is usually characterized by infertility and pain symptoms. This disease mainly occurs during the reproductive years and is rarely diagnosed after menopause. We discuss the physiopathology of this condition after menopause as well as treatment options and the risk of malignant transformation. Occurrence or progression of postmenopausal endometriosis lesions could be related to extra-ovarian production of estrogen by endometriosis lesions and adipose tissue, which becomes the major estrogen-producing tissue after menopause. Postmenopausal women ...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Streuli I, Gaitzsch H, Wenger JM, Petignat P Tags: Climacteric Source Type: research

Exercise and nutritional approaches to prevent frail bones, falls and fractures: an update.
Abstract Osteoporosis (low bone strength) and sarcopenia (low muscle mass, strength and/or impaired function) often co-exist (hence the term 'sarco-osteoporosis') and have similar health consequences with regard to disability, falls, frailty and fractures. Exercise and adequate nutrition, particularly with regard to vitamin D, calcium and protein, are key lifestyle approaches that can simultaneously optimize bone, muscle and functional outcomes in older people, if they are individually tailored and appropriately prescribed in terms of the type and dose. Not all forms of exercise are equally effective for optimizin...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Daly RM Tags: Climacteric Source Type: research

A Precision Medicine Initiative for Alzheimer's disease: the road ahead to biomarker-guided integrative disease modeling.
Abstract After intense scientific exploration and more than a decade of failed trials, Alzheimer's disease (AD) remains a fatal global epidemic. A traditional research and drug development paradigm continues to target heterogeneous late-stage clinically phenotyped patients with single 'magic bullet' drugs. Here, we propose that it is time for a paradigm shift towards the implementation of precision medicine (PM) for enhanced risk screening, detection, treatment, and prevention of AD. The overarching structure of how PM for AD can be achieved will be provided through the convergence of breakthrough technological ad...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: Hampel H, O'Bryant SE, Durrleman S, Younesi E, Rojkova K, Escott-Price V, Corvol JC, Broich K, Dubois B, Lista S, Alzheimer Precision Medicine Initiative Tags: Climacteric Source Type: research

The quest for new drugs to prevent osteoporosis-related fractures.
Abstract There is a need for the development of new drugs to prevent osteoporosis-related fractures. Fractures are projected to increase and the present drugs have modest efficacy, significant side-effects and poor compliance. To illustrate the difficulties in the development of new drugs, the author reviews the fate of several drugs that have failed to gain regulatory approval. These drugs include arzoxifene, lasofoxifene, MK-5442, roncalceret and odanacatib. Romosozumab and abaloparatide are the only new drugs presently in phase-3 development. It is anticipated that ongoing studies of the mechanisms and signalin...
Source: Climacteric - March 15, 2017 Category: Geriatrics Authors: de Villiers TJ Tags: Climacteric Source Type: research