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The futile case of the aging ovary: is it mission impossible? A focused review.
Abstract Despite immense and impressive progress in the field of reproductive medicine, little has been achieved in terms of replenishing aged ovaries and improving their reproductive outcome. Age causes irreversible damage to human eggs in terms of quantity as well as quality. Nature probably designed women to reproduce best in their twenties and thirties. However, due to social, personal, career, educational and financial pressures, women delay pregnancies until their late thirties, by which time the chance of becoming pregnant is compromised by low fecundity rates and an increased risk of miscarriage. Age, unfo...
Source: Climacteric - December 8, 2017 Category: Geriatrics Authors: Rasool S, Shah D Tags: Climacteric Source Type: research

Predictors of malignancy in endometrial polyps: study of 421 women with postmenopausal bleeding.
CONCLUSION: The prevalence of hyperplasia and cancer in benign-looking polyps is high. The independent predictors are body mass index and endometrial thickness. Removal of polyps may be warranted until hysteroscopic morphological criteria that can reliably predict the outcome are established in future research. PMID: 29219004 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - December 8, 2017 Category: Geriatrics Authors: Ghoubara A, Sundar S, Ewies AAA Tags: Climacteric Source Type: research

Efficacy and safety evaluation of Cimicifuga foetida extract in menopausal women.
CONCLUSIONS: C. foetida extract is safe and effective for the treatment of menopausal symptoms in postmenopausal women. PMID: 29198157 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - December 4, 2017 Category: Geriatrics Authors: Gao L, Zheng T, Xue W, Wang Y, Deng Y, Zuo H, Sun A Tags: Climacteric Source Type: research

Teaching the teachers.
PMID: 29105537 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 8, 2017 Category: Geriatrics Authors: Baber R Tags: Climacteric Source Type: research

Prediction of age at menopause in women with polycystic ovary syndrome.
Abstract OBJECTIVE: Considering the role of anti-Müllerian hormone (AMH) in female fertility and its high levels in women with polycystic ovary syndrome (PCOS), the longer reproductive span of these women is in doubt. In the present study, we aimed to improve earlier predictions using a non-linear model to substantiate the question as to whether PCOS women reach menopause later. METHODS: In total, 1162 women aged 20-50 years, comprising 378 PCOS cases and 784 eumenorrheic non-hirsute women, met the eligibility criteria. A scatterplot matrix was drawn to detect the association between age and AMH; this as...
Source: Climacteric - November 6, 2017 Category: Geriatrics Authors: Minooee S, Ramezani Tehrani F, Rahmati M, Mansournia MA, Azizi F Tags: Climacteric Source Type: research

Menopause, lung function and obstructive lung disease outcomes: a systematic review.
CONCLUSIONS: As the global burden associated with respiratory conditions continues to rise, the need to understand the associations between menopause and respiratory health is essential to identify potentially modifiable risk factors for respiratory disease in adult women. More studies are needed to clarify the impact of menopause on obstructive lung disease. PMID: 29106307 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - November 6, 2017 Category: Geriatrics Authors: Campbell B, Davis SR, Abramson MJ, Mishra G, Handelsman DJ, Perret JL, Dharmage SC Tags: Climacteric Source Type: research

Screening for general anxiety disorders in postmenopausal women with symptomatic pelvic organ prolapse.
This study aimed to investigate the prevalence of general anxiety disorder (GAD) among postmenopausal women with symptomatic pelvic organ prolapse (POP) and to identify its associated factors. METHODS: A cross-sectional study was conducted among postmenopausal women with symptomatic POP. Sociodemographic data and medical histories were obtained. Participants completed the POP Quantification (POP-Q), the Pelvic Floor Impact Questionnaire-7 (PFIQ-7), and the Pelvic Floor Distress Inventory (PFDI-20) measures. Measures of GAD were obtained using the Generalized Anxiety Disorder-7 (GAD-7). The data were analyzed using ind...
Source: Climacteric - November 2, 2017 Category: Geriatrics Authors: Ai F, Deng M, Mao M, Xu T, Zhu L Tags: Climacteric Source Type: research

Metabolic syndrome in menopause and associated factors: a meta-analysis.
CONCLUSIONS: Menopause nearly adversely affects all components of MetS, and surgical menopause may lead to a higher incidence of MetS compared to natural menopause. HT with various preparations may have different effects on MetS components. These results may clarify the management of menopause-related MetS in clinical practice. PMID: 29064321 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - October 24, 2017 Category: Geriatrics Authors: Pu D, Tan R, Yu Q, Wu J Tags: Climacteric Source Type: research

No increased death toll for long-term menopausal hormone therapy.
Abstract It took many years since the initial publication of data from the Women's Health Initiative (WHI) study until further analyses and additional accumulated clinical information allowed realization of the full scope of its results. At first, the focus was on morbidity, mainly the slightly higher incidence of cardiovascular events and breast cancer cases among postmenopausal hormone users. Then, the age factor became evident, and the good safety profile of hormone therapy in healthy women initiating treatment near menopause and using it for up to 10 years eased the previous concerns. Now, 15 years after the f...
Source: Climacteric - October 23, 2017 Category: Geriatrics Authors: Pines A Tags: Climacteric Source Type: research

Neurokinin 3 receptor antagonism - the magic bullet for hot flushes?
Abstract Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes. Most recently, a randomized, placebo-controlled trial of an NK3R antagonist in symptomatic m...
Source: Climacteric - October 17, 2017 Category: Geriatrics Authors: Prague JK, Dhillo WS Tags: Climacteric Source Type: research

Effects of omega-3 fatty acids on bone turnover markers in postmenopausal women: systematic review and meta-analysis.
CONCLUSION: Omega-3 fatty acids reduced postmenopausal women's serum osteocalcin. Further well-designed studies are needed to verify the effects of omega-3 fatty acids on bone mass density and other bone turnover markers in postmenopausal women. CLINICAL TRIAL REGISTRATION NUMBER: CRD42016053219 ( https://www.crd.york.ac.uk/PROSPERO/ ). PMID: 29034731 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - October 16, 2017 Category: Geriatrics Authors: Shen D, Zhang X, Li Z, Bai H, Chen L Tags: Climacteric Source Type: research

FSH to estradiol ratio can be used as screening method for mild cognitive impairment in postmenopausal women.
CONCLUSIONS: The ratio of FSH to estradiol (>1.94) can be used as a screening method for the occurrence of MCI in postmenopausal women. PMID: 28980489 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - October 5, 2017 Category: Geriatrics Authors: Hestiantoro A, Wiwie M, Shadrina A, Ibrahim N, Purba JS Tags: Climacteric Source Type: research

The association of hyperuricemia and metabolic syndrome in Thai postmenopausal women.
Abstract OBJECTIVE: The purpose of this study was to evaluate the association of hyperuricemia and metabolic syndrome (MS) in Thai postmenopausal women. METHODS: A total of 740 consecutive Thai postmenopausal women were reviewed who were not receiving uric acid or lipid-lowering agents at the Menopause Clinic, Faculty of Medicine Siriraj Hospital, Bangkok, from January 2004 to January 2016. Hyperuricemia was defined as serum uric acid level>5.7 mg/dl. The revised National Cholesterol Education Program (rNCEP) 2004 criteria were used for diagnosis of MS. The association of hyperuricemia and MS was ev...
Source: Climacteric - September 22, 2017 Category: Geriatrics Authors: Techatraisak K, Kongkaew T Tags: Climacteric Source Type: research

17 β-Estradiol induces proliferation of endometrial NK cells (CD56+) in postmenopausal women.
CONCLUSION: 17β-Estradiol induced the proliferation of endometrial uterine natural killer cells (CD56+) in postmenopausal women. PMID: 28933961 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 21, 2017 Category: Geriatrics Authors: Sho T, Hachisuga T, Koi C, Kurita T, Kagami S, Kawagoe T, Matsuura Y, Yoshimura K, Hisaoka M Tags: Climacteric Source Type: research

Influence of menopausal symptoms on perceived work ability among women in a Nigerian University.
This study investigated the menopausal symptoms experienced by women of menopausal age in Ekiti State, Nigeria and the influence on their perceived work ability. METHOD: A descriptive cross-sectional research design was employed and the study was conducted among 200 working-class women aged 45 years and above who had experienced at least 12 continuous months of amenorrhea in Ekiti State University, Ado Ekiti. A semi-structured questionnaire adapted from the Greene Climacteric Scale and the work ability index was used to assess menopausal symptoms and work ability, respectively. RESULT: The prevalence of menopausa...
Source: Climacteric - September 21, 2017 Category: Geriatrics Authors: Olajubu AO, Olowokere AE, Amujo DO, Olajubu TO Tags: Climacteric Source Type: research

The influence of unilateral oophorectomy on the age of menopause.
CONCLUSIONS: Premenopausal unilateral oophorectomy significantly reduces the age of menopause by 1.8 years. Younger age at UO leads to significantly younger age at menopause. PMID: 28933974 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 21, 2017 Category: Geriatrics Authors: Rosendahl M, Simonsen MK, Kjer JJ Tags: Climacteric Source Type: research

Foot problems in older women.
Abstract Between 20 and 45% of women aged over 65 years of age will develop one or more foot problems, which, although not specific to older women, are more common in that age group than in younger women. These include structural defects of the toes including hallux valgus, hammer, mallet or claw toes, skin disorders, fungal infection of the toes and toe nails, thickened toe nails, ulcers, fissures or cracks between the toes, corns and calluses, flat or high-arched feet. Foot pain is common and may be associated with other co-morbid diseases of the foot. Inappropriate footwear has an unfortunate role in the etiolo...
Source: Climacteric - September 21, 2017 Category: Geriatrics Authors: Guidozzi F Tags: Climacteric Source Type: research

Nordic walking increases circulating VEGF more than traditional walking training in postmenopause.
Abstract OBJECTIVES: Nordic walking (NW) is widely practiced by postmenopausal women. Its effects are peculiar owing to the involvement of more muscle groups than in traditional walking training (WT). Since mechanical load promotes secretion of vascular endothelial growth factor (VEGF) from both skeletal muscle and muscle endothelium, the aim of the study was to compare the effect of NW and WT on VEGF levels. METHOD: Thirty postmenopausal women were randomly assigned to NW or WT. Both groups trained 40-50 min/day, three times per week, at a mean intensity of 12 on a 15-category scale of the ratings of ...
Source: Climacteric - September 17, 2017 Category: Geriatrics Authors: Izzicupo P, D'Amico MA, Di Blasio A, Napolitano G, Di Baldassarre A, Ghinassi B Tags: Climacteric Source Type: research

Native tissue repair versus mesh repair in pelvic organ prolapse surgery.
Abstract In pelvic organ prolapse, the anatomical defects develop at the anterior (anterior vaginal wall), the posterior (posterior vaginal wall) and the apical (the uterus/cervix or the apex of the vagina, vaginal vault or cuff scar after hysterectomy) compartments. These defects occur in more than one compartment. Treatment of pelvic organ prolapse is commonly surgical, aiming to restore the anatomy of structures supporting the pelvic organs. The surgical repair techniques are classified as 'native tissue repair (NTR)' when only pelvic organ support tissues are used and 'augmented repair (AR)' when some other ma...
Source: Climacteric - September 5, 2017 Category: Geriatrics Authors: Kalkan U, Yoldemir T, Ozyurek ES, Daniilidis A Tags: Climacteric Source Type: research

Effects of soy isoflavones on the concentration of hyaluronic acid in the vagina of type 1 diabetic rats.
otilde;es M Abstract OBJECTIVE: To assess the effects of isoflavones and 17β-estradiol on the vaginal epithelium extracellular matrix and hyaluronic acid (HA) in the diabetic rat model. METHODS: Sixty adult, virgin, female rats underwent ovariectomy, then randomization into six groups of ten animals each: GI, sham ovariectomized control animals; GII, sham ovariectomized control diabetic animals; GIII, control ovariectomized rats receiving propylene glycol vehicle; GIV, control ovariectomized diabetic animals receiving propylene glycol vehicle; GV, diabetic ovariectomized animals treated with soy isoflavo...
Source: Climacteric - September 2, 2017 Category: Geriatrics Authors: F Carbonel AA, Azevedo Lima PD, Lim JJ, Teixeira Borges F, Rodrigues da Silva Sasso G, Portugal Fuchs LF, S Simões R, Chada Baracat E, Soares JM, J Simões M Tags: Climacteric Source Type: research

Turning the spotlight on lasers.
PMID: 28862053 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 1, 2017 Category: Geriatrics Authors: Hillard TC Tags: Climacteric Source Type: research

Turner syndrome - growing pressure for more multidisciplinary clinics for adults and earlier diagnosis in children.
PMID: 28862878 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 1, 2017 Category: Geriatrics Authors: Conway GS Tags: Climacteric Source Type: research

Correction to: Langer et al., Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.
Authors: PMID: 28853954 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 30, 2017 Category: Geriatrics Tags: Climacteric Source Type: research

Experience of menopause in women with inflammatory bowel disease: pilot study.
CONCLUSION: Women with IBD may experience additional challenges when going through the menopause transition. Our findings support the need for further studies to better inform patients and clinicians on the relationship between IBD and menopause to optimize patient care. PMID: 28817315 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 17, 2017 Category: Geriatrics Authors: Donaldson EK, Huang V, Ross S, Sydora BC Tags: Climacteric Source Type: research

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.
Abstract The US Preventive Services Task Force (USPSTF) Draft Recommendation statement on Menopausal Hormone Therapy: Primary Prevention for Chronic Diseases, released in May 2017, perpetuates a major disconnect between the primary population affected, women within roughly 10 years of menopause, and the data cited. Furthermore, major elements of the evidence relied upon have been misinterpreted or misstated, particularly in regard to coronary heart disease and breast cancer, for which there is no statistically significant evidence of harm. As currently drafted, the recommendations reiterate the USPSTF statements o...
Source: Climacteric - August 14, 2017 Category: Geriatrics Authors: Langer RD, Simon JA, Pines A, Lobo RA, Hodis HN, Pickar JH, Archer DF, Sarrel PM, Utian WH Tags: Climacteric Source Type: research

Age-related differences in left ventricular structure and function between healthy men and women.
RE Abstract OBJECTIVES: Cardiovascular function generally decreases with age, but whether this decrease differs between men and women is unclear. Our aims were twofold: (1) to investigate age-related sex differences in left ventricular (LV) structure, function and mechanics, and (2) to compare these measures between pre- and postmenopausal women in the middle-aged group. METHODS: Resting echocardiography was performed in a cross-sectional sample of 82 healthy adults (14 young men, 19 middle-aged men, 15 young women, 34 middle-aged women: 15 premenopausal and 19 postmenopausal). Two-way ANOVAs were used to ex...
Source: Climacteric - August 8, 2017 Category: Geriatrics Authors: Nio AQX, Stöhr EJ, Shave RE Tags: Climacteric Source Type: research

Abnormal uterine bleeding in perimenopause.
Abstract Abnormal uterine bleeding is one of the commonest presenting complaints encountered in a gynecologist's office or primary-care setting. The wider availability of diagnostic tools has allowed prompt diagnosis and treatment of an increasing number of menstrual disorders in an office setting. This White Paper reviews the advantages and disadvantages of transvaginal ultrasound, blind endometrial sampling and diagnostic hysteroscopy. Once a proper diagnosis has been established, appropriate therapy may be embarked upon. Fortunately, only a minority of such patients will have premalignant or malignant disease. ...
Source: Climacteric - August 7, 2017 Category: Geriatrics Authors: Goldstein SR, Lumsden MA Tags: Climacteric Source Type: research

Dependency of cardiovascular risk on reproductive stages and on age among middle-aged Chinese women.
CONCLUSIONS: CVD risk factors were frequent and more than 10% of the women were at moderate or high risk of developing cardiovascular disease within the next 10 years. To our knowledge, this was demonstrated for the first time in middle-aged Chinese women. Thus, women should maintain a healthy lifestyle and physicians should monitor them to prevent CVD. PMID: 28771097 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 3, 2017 Category: Geriatrics Authors: Sun Y, Ruan X, Mueck AO Tags: Climacteric Source Type: research

The hot flush: symptom of menopause or sign of disease?
PMID: 28699430 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - July 14, 2017 Category: Geriatrics Authors: Baber R Tags: Climacteric Source Type: research

Factors associated with complementary and alternative medicine use among women at midlife.
Abstract Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. To date, several large, population-based studies have focused upon CAM use amongst menopausal women and the factors associated with the adoption of su...
Source: Climacteric - July 8, 2017 Category: Geriatrics Authors: Costanian C, Christensen RAG, Edgell H, Ardern CI, Tamim H Tags: Climacteric Source Type: research

Low bone mineral density is associated with cancer in postmenopausal women: the methodological issue.
PMID: 28682642 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 6, 2017 Category: Geriatrics Authors: Moradpour F, Mansori K Tags: Climacteric Source Type: research

Changing the conversation about hormone therapy.
PMID: 28675703 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 4, 2017 Category: Geriatrics Authors: Pinkerton JV Tags: Climacteric Source Type: research

The UK breast screening program - what you need to know.
Abstract Breast cancer is the most commonly diagnosed cancer in women with a lifetime risk of 1 in 8 in the UK. The disease is associated with considerable morbidity and mortality. The UK breast screening program has been in place for almost 30 years and has evolved with improved diagnostic imaging. The overall benefits of the screening program are subject to continued heated debate with multiple potential harms. The aim of this review is to provide the non-breast specialist health-care professional an overview of the evolution of the breast screening program, a summary of the evidence of the benefits, and a descr...
Source: Climacteric - June 29, 2017 Category: Geriatrics Authors: Godley KC, Gladwell C, Murray PJ, Denton E Tags: Climacteric Source Type: research

Lichen sclerosus in women: a review.
-Baptista P Abstract Female lichen sclerosus is a chronic inflammatory dermatitis, with a predilection for the anogenital area, which in some cases can become seriously distorted (atrophy of the labia minora, phimosis, introital stenosis, etc.). Most cases are diagnosed in postmenopausal women, but it can affect women of any age. Lichen sclerosus is usually a pruriginous condition, although it can also be asymptomatic. It is associated with an increased risk of vulvar cancer, even though it is not a premalignant condition itself. The true precursor of cancer associated with lichen sclerosus is vulvar intraepitheli...
Source: Climacteric - June 29, 2017 Category: Geriatrics Authors: Pérez-López FR, Vieira-Baptista P Tags: Climacteric Source Type: research

Monurelle Biogel( ®) vaginal gel in the treatment of vaginal dryness in postmenopausal women.
Monurelle Biogel(®) vaginal gel in the treatment of vaginal dryness in postmenopausal women. Climacteric. 2017 Jun 28;:1-9 Authors: Nappi RE, Cagnacci A, Becorpi AM, Nappi C, Paoletti AM, Busacca M, Martella S, Bellafronte M, Tredici Z, Di Carlo C, Corda V, Vignali M, Bagolan M, Sardina M Abstract OBJECTIVES: To evaluate efficacy, tolerability and safety of Monurelle Biogel(®) vaginal gel for treatment of vaginal dryness. METHODS: Multicenter, national, randomized, controlled vs. no-treatment, open-label study. Ninety-five postmenopausal women were randomized (48 to Monurelle Biogel(®...
Source: Climacteric - June 28, 2017 Category: Geriatrics Authors: Nappi RE, Cagnacci A, Becorpi AM, Nappi C, Paoletti AM, Busacca M, Martella S, Bellafronte M, Tredici Z, Di Carlo C, Corda V, Vignali M, Bagolan M, Sardina M Tags: Climacteric Source Type: research

Analysis of differential genetic expression in endometrial polyps of postmenopausal women.
CONCLUSION: The study found no evidence that symptomatic endometrial polyps have a similar phenotype to type 1 endometrial cancer; further studies are needed in order to establish whether endometrial polyps are in fact true cancer precursors, or simply raise cancer incidence due to a detection bias. PMID: 28622040 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - June 16, 2017 Category: Geriatrics Authors: Troncon JK, Meola J, Candido-Dos-Reis FJ, Poli-Neto OB, Nogueira AA, Rosa-E-Silva JC Tags: Climacteric Source Type: research

The efficacy and safety of estriol to treat vulvovaginal atrophy in postmenopausal women: a systematic literature review.
CONCLUSIONS: The available evidence (of low and moderate quality) shows that, when administered vaginally, estriol preparations appear to be safe for women who have risk factors related to systemic estrogen therapy. PMID: 28622049 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - June 16, 2017 Category: Geriatrics Authors: Rueda C, Osorio AM, Avellaneda AC, Pinzón CE, Restrepo OI Tags: Climacteric Source Type: research

Sleep duration and midlife women's health.
Abstract Sleep is mandatory for life and therefore any sleep deprivation or disruption might carry ill-health outcomes. The optimal night's sleep duration seems to be around 7 h, as too little sleep and too much sleep have been found to be associated with a variety of changes in well-being, physical and psychological parameters. This mini-review enlightens the potential health consequences of sleep disturbance relevant to menopause and midlife women's health. These include cardiovascular and metabolic derangements, cognitive impairment, osteoporosis, and cancer-related perspectives. Still, the current knowl...
Source: Climacteric - June 14, 2017 Category: Geriatrics Authors: Pines A Tags: Climacteric Source Type: research

Association of objectively measured physical activity and physical fitness with menopause symptoms. The Flamenco Project.
riano-Maldonado A Abstract OBJECTIVE: The primary aim was to analyze the association of moderate-to-vigorous physical activity (MVPA) with menopause symptomatology and its overall impact. A secondary/exploratory aim was to assess the association of different components of physical fitness with menopause symptomatology. METHODS: This cross-sectional study comprised 191 perimenopausal women from Southern Spain (age range 45-60 years, mean age 52.6 ± 4.5 years). The Blatt-Kupperman Menopausal Index was used to evaluate menopause symptomatology. Objectively measured MVPA was registered with a...
Source: Climacteric - June 3, 2017 Category: Geriatrics Authors: Aparicio VA, Borges-Cosic M, Ruiz-Cabello P, Coll-Risco I, Acosta-Manzano P, Špacírová Z, Soriano-Maldonado A Tags: Climacteric Source Type: research

The platelet-to-lymphocyte ratio as a predictor of patient outcomes in ovarian cancer: a meta-analysis.
Abstract OBJECTIVES: The platelet-to-lymphocyte ratio (PLR) is a predictive clinical biomarker for different cancers. However, the results of several studies investigating the association between the PLR and the prognosis of ovarian cancer have been inconclusive. Therefore, there is a need to conduct a meta-analysis to estimate the prognostic value of the PLR in ovarian cancer. METHODS: We searched the EMBASE, Medline, PubMed, and Web of Science databases to identify clinical studies that had evaluated the association between the PLR and ovarian cancer prognosis. Outcomes evaluated included overall survival (...
Source: Climacteric - June 1, 2017 Category: Geriatrics Authors: Ma XM, Sun X, Yang GW, Yu MW, Zhang GL, Yu J, Zhang Y, Wang XM Tags: Climacteric Source Type: research

Low bone mineral density is associated with breast cancer in postmenopausal women: a case-control study.
CONCLUSION: Postmenopausal breast cancer survivors had a higher incidence of osteopenia and osteoporosis in the femoral neck than women without breast cancer. A history of chemotherapy was a risk factor for low BMD, whereas regular physical activity and high body mass index reduced the risk among breast cancer survivors. PMID: 28569124 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - June 1, 2017 Category: Geriatrics Authors: Ferreira Poloni P, Vespoli HL, Almeida-Filho BS, Bueloni-Dias F, Nahas-Neto J, Nahas EAP Tags: Climacteric Source Type: research

Custom-compounded bioidentical hormone therapy: why so popular despite potential harm? The case against routine use.
Abstract Wide rejection of conventional hormone therapy (HT) after the initial publication of the Women's Health Initiative (WHI) led to unjustified use of custom-compounded bioidentical hormones. In the USA, it became an unregulated drug manufacturer industry in disguise, without proper control and making false claims and misleading advertisements. Manufacturing quality is not ensured. Unspecific harm from compounding has occurred on a large scale, such as deaths from infected products and end-stage renal failure plus carcinoma due to confusion between different Chinese herbs. Oral estrogens increase venous throm...
Source: Climacteric - May 18, 2017 Category: Geriatrics Authors: L'Hermite M Tags: Climacteric Source Type: research

Impact of risk-reducing salpingo-oophorectomy in premenopausal women.
CONCLUSIONS: The conclusions of this systematic review are limited by the absence of randomized, controlled trials. There is growing evidence from observational studies that RRSO may impact negatively on all-cause non-survival endpoints. PMID: 28509627 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - May 18, 2017 Category: Geriatrics Authors: Vermeulen RFM, Beurden MV, Korse CM, Kenter GG Tags: Climacteric Source Type: research

Fractional CO2 laser therapy: a new challenge for vulvovaginal atrophy in postmenopausal women.
Abstract OBJECTIVE: To evaluate the effects of CO2 laser in the treatment of vulvovaginal atrophy (VVA) in postmenopausal women. METHODS: VVA was assessed in 87 postmenopausal women (mean age 58.6 ± 6.9 years) before and after the treatment. The protocol consisted of three monthly treatments and included the treatment of vulva. Subjective measures included VAS (Visual Analog Scale) both for vaginal dryness and dyspareunia; DIVA (Day-by-day Impact of Vaginal Aging); a questionnaire on treatment satisfaction and one about the degree of pain during the procedure. Objective measures included ...
Source: Climacteric - May 15, 2017 Category: Geriatrics Authors: Siliquini GP, Tuninetti V, Bounous VE, Bert F, Biglia N Tags: Climacteric Source Type: research

What is the right dose of modern medicine?
PMID: 28497704 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - May 12, 2017 Category: Geriatrics Authors: Bell RJ Tags: Climacteric Source Type: research

Tissue-specific effects of estrogen on glycerol channel aquaporin 7 expression in an ovariectomized mouse model of menopause.
CONCLUSIONS: Our results suggest that estrogen has tissue-specific effects on AQP7 expression, and modulation of AQP7 by estrogen alters the balance of adipocyte metabolism between adipose tissue depots. PMID: 28489425 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - May 10, 2017 Category: Geriatrics Authors: Jin B, Chen X, Xing L, Xu W, Fu X, Zhu J, Mou X, Wang Z, Shu J Tags: Climacteric Source Type: research

Are women with polycystic ovary syndrome at increased cardiovascular disease risk later in life?
Abstract To date, the world's leading cause of death amongst women is cardiovascular disease. Polycystic ovary syndrome (PCOS) is associated with an unfavorable cardiometabolic profile in early life. Apart from dyslipidemia, obesity and onset of type 2 diabetes mellitus, androgens are thought to influence cardiovascular health. The question rises whether women with PCOS are truly at risk for cardiovascular disease in later life. In this review paper, we aim to reflect on this assumed relation based on studies in different stages of life in women with PCOS. Cardiovascular risk factors (type 2 diabetes mellitus, obe...
Source: Climacteric - April 29, 2017 Category: Geriatrics Authors: Gunning MN, Fauser BCJM Tags: Climacteric Source Type: research

Primary ovarian insufficiency with t(5;13): a case report and literature review on disrupted genes.
CONCLUSIONS: Autosomal translocations are rare in women with POI. We have reported the first case of a de novo reciprocal translocation involving chromosomes 5 and 13 in a POI patient. As one of the breakpoints encompasses the FOXO1 gene, it seems that disruption of this gene can be the cause of POI in this patient. This provides further evidence on the role of autosomal translocations in disrupting POI-associated genes. Therefore, concentrating on the genes at the breakpoints will be helpful to delineate the new biological pathways or genes involved in POI pathogenesis. PMID: 28453298 [PubMed - as supplied by publish...
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Mohamadhashem F, Rafati M, Hoseininasab F, Rostami S, Tabatabaie R, Rezai S, Keramatipour M, Ghaffari SR Tags: Climacteric Source Type: research

-643C   >  T RANKL gene polymorphism is associated with osteoporosis in Tunisian postmenopausal women.
CONCLUSION: We have demonstrated the association of the -643C > T polymorphism with BMD variation and osteoporosis risk in postmenopausal Tunisian women. PMID: 28453307 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Sassi R, Sahli H, Cheour E, Sellami S, El Gaaied ABA Tags: Climacteric Source Type: research

Genitourinary syndrome of menopause in five Asian countries: results from the Pan-Asian REVIVE survey.
CONCLUSION: GSM is underdiagnosed and undertreated in Asia. As discussion of GSM with HCPs appears to be a factor influencing women's awareness and treatment status, a more active role by HCPs to facilitate early discussions on GSM and its treatment options is needed. PMID: 28453308 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 28, 2017 Category: Geriatrics Authors: Chua Y, Limpaphayom KK, Cheng B, Ho CM, Sumapradja K, Altomare C, Huang K Tags: Climacteric Source Type: research