Managing overactive bladder.
This article will review the initial clinical assessment and management of women complaining of OAB including conservative measures and drug therapy, and will also focus on the role of estrogen. In addition, the management of refractory OAB will also be discussed including more invasive strategies such as neuromodulation, Botulinum Toxin, and reconstructive surgery. PMID: 31034265 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - May 1, 2019 Category: Geriatrics Authors: Robinson D, Cardozo L Tags: Climacteric Source Type: research

Pelvic floor function around the menopause and how to improve it.
PMID: 31034266 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - May 1, 2019 Category: Geriatrics Authors: Hillard TC Tags: Climacteric Source Type: research

The metabolic syndrome and diabetes are not synonymous.
cute;pez FR PMID: 31030574 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 29, 2019 Category: Geriatrics Authors: Chedraui P, Pérez-López FR Tags: Climacteric Source Type: research

Recurrent disease after treatment for cervical pre-cancer: determining whether prophylactic HPV vaccination could play a role in prevention of secondary lesions.
Abstract Existing modalities can effectively treat high-grade cervical intraepithelial neoplasia (CIN) but around 7% of treated women will develop recurrence of CIN grade 2 or above within 2 years of treatment. Post-treatment surveillance is therefore required to detect residual or recurrent disease. Since the implementation of human papillomavirus (HPV) vaccination programs in high-income countries, significant reductions in high-grade CIN have been recorded in vaccinated cohorts who were predominantly HPV-naïve at vaccination. There is still debate as to the extent of potential benefit from vaccinati...
Source: Climacteric - April 29, 2019 Category: Geriatrics Authors: Velentzis LS, Brotherton JML, Canfell K Tags: Climacteric Source Type: research

No vaginal estrogen therapy arm in an RCT trial on genitourinary syndrome of menopause is a concern.
PMID: 31017495 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 24, 2019 Category: Geriatrics Authors: Maher CF, Biuttini M Tags: Climacteric Source Type: research

Longitudinal impact of the Women's Health Initiative study on hormone therapy use in Australia.
CONCLUSIONS: MHT use remained low after 2002 despite evidence favoring its use in women younger than 60 years or within 10 years postmenopause. Continued low use could relate to the WHI 2002 media coverage, therapy objectives, key stakeholder uncertainty, health policies, and medicine availability. PMID: 31010331 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 23, 2019 Category: Geriatrics Authors: Natari RB, McGuire TM, Baker PJ, Clavarino AM, Dingle KD, Hollingworth SA Tags: Climacteric Source Type: research

Vitamin D restriction enhances periovarian adipose tissue inflammation in a model of menopause.
CONCLUSION: The results demonstrate that ovariectomy and dietary restriction of VD are inducers of adverse effects on mouse visceral adipose tissue. When combined, these insults might enhance PAT inflammation. PMID: 31010350 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - April 23, 2019 Category: Geriatrics Authors: Borges CC, Bringhenti I, Aguila MB, Mandarim-de-Lacerda CA Tags: Climacteric Source Type: research

Publishing in Climacteric.
PMID: 30895899 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - March 23, 2019 Category: Geriatrics Authors: Pickar JH Tags: Climacteric Source Type: research

Beyond estrogen: advances in tissue selective estrogen complexes and selective estrogen receptor modulators.
Abstract Selective estrogen receptor modulators (SERMs) are synthetic non-steroidal agents which have variable estrogen agonist and antagonist activities in different target tissues. Tamoxifen is an anti-estrogen in the breast used for treatment and prevention of breast cancer, with estrogen agonist activity in the uterus. Raloxifene prevents and treats osteoporosis and prevents breast cancer, and can be safely combined with vaginal but not systemic estrogen. The tissue selective estrogen complex combines conjugated equine estrogens (CEE) with the SERM bazedoxifene (BZA). The five Selective Estrogen Menopause and ...
Source: Climacteric - March 23, 2019 Category: Geriatrics Authors: Pinkerton JV, Conner EA Tags: Climacteric Source Type: research

Sexuality in premature ovarian insufficiency.
Abstract Sexuality in women with spontaneous premature ovarian insufficiency (POI) deserves attention because of the young age and the distressing impact of such a life-changing diagnosis. Biomedical and psychosocial factors work in concert to determine significant changes of sexual function. Early hormonal deprivation gives origin to symptomatic vulvovaginal atrophy and contributes to hypoactive sexual desire disorder modulating central and peripheral circuitries, which regulate sexual response. Emotional and cognitive adjustment to the short-term and long-term consequences of POI may further determine negative a...
Source: Climacteric - March 22, 2019 Category: Geriatrics Authors: Nappi RE, Cucinella L, Martini E, Rossi M, Tiranini L, Martella S, Bosoni D, Cassani C Tags: Climacteric Source Type: research

Bone health in women with breast cancer.
Abstract Women with early, estrogen receptor-positive breast cancer are treated with adjuvant endocrine therapy, using aromatase inhibitors or selective estradiol receptor modulators such as tamoxifen, to deprive breast tissue from the deleterious effects of estradiol action, hence improving long-term prognosis. Aromatase inhibitors and, in premenopausal women, tamoxifen accelerate bone loss and increase fracture risk. Therefore, all women commencing endocrine therapy need a targeted work-up to assess the baseline fracture risk, and monitoring of bone health during endocrine therapy should be individualized based ...
Source: Climacteric - March 21, 2019 Category: Geriatrics Authors: Ramchand SK, Cheung YM, Grossmann M Tags: Climacteric Source Type: research

Factors associated with long-term pessary use in women with symptomatic pelvic organ prolapse.
This study aimed to evaluate the continuation rate and identify the factors associated with long-term pessary use, which are essential for counseling women with symptomatic pelvic organ prolapse (POP) seeking long-term pessary treatment. METHODS: This prospective observational study included 277 patients who had successful pessary fittings between April 2015 and November 2016. All patients were followed until April 2018. Data analysis was performed with independent-samples t-tests, non-parametric tests, chi-square tests, and logistic regression. RESULTS: The median (range) follow-up time was 26 (17-36) months; 76...
Source: Climacteric - March 21, 2019 Category: Geriatrics Authors: Mao M, Xu T, Kang J, Zhang Y, Ai F, Zhou Y, Zhu L Tags: Climacteric Source Type: research

The association between sexual dysfunction and metabolic syndrome among Turkish postmenopausal women.
Abstract OBJECTIVE: The aim of this study is to determine the association between sexual dysfunction and metabolic syndrome (MS) among Turkish postmenopausal women Methods: In total, 290 postmenopausal women between the ages of 50 and 70 years and 265 premenopausal women between the ages of 30 and 49 years who applied to Menopause and Gynecology Clinics at Marmara University-affiliated Pendik Education and Research Hospital, Istanbul, Turkey were included in this prospective survey. Sexual function was assessed using the Female Sexual Function Index (FSFI). A FSFI total score of
Source: Climacteric - March 20, 2019 Category: Geriatrics Authors: Yoldemir T, Garibova N, Atasayan K Tags: Climacteric Source Type: research

Identification of functional estrogen response elements in glycerol channel Aquaporin-7 gene.
CONCLUSIONS: Estrogen induces AQP7 expression by binding EREs in the promoter of the Aqp7 gene, resulting in fat catabolism of adipocyte. These results provide new insights into the molecular mechanisms underpinning the anti-adipogenic effect of estrogen. PMID: 30888885 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - March 19, 2019 Category: Geriatrics Authors: Xing L, Jin B, Fu X, Zhu J, Guo X, Xu W, Mou X, Wang Z, Jiang F, Zhou Y, Chen X, Shu J Tags: Climacteric Source Type: research

TX-004HR clinically improves symptoms of vulvar and vaginal atrophy in postmenopausal women.
CONCLUSION: TX-004HR provided clinically meaningful improvements in dyspareunia and vaginal dryness associated with dyspareunia in postmenopausal women with VVA. Clinicians may be able to use this information when discussing patients' expectations regarding symptom improvement with the estradiol vaginal insert. PMID: 30862193 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - March 12, 2019 Category: Geriatrics Authors: Simon JA, Kagan R, Archer DF, Constantine GD, Bernick B, Graham S, Mirkin S Tags: Climacteric Source Type: research

PGRMC1 can trigger estrogen-dependent proliferation of breast cancer cells: estradiol vs. equilin vs. ethinylestradiol.
CONCLUSIONS: PGRMC1 increases strongly the estrogen-dependent breast cell proliferation. The proliferating effects of EE may be lower compared to E2 and EQ. This could have importance in comparing hormone therapy and contraception. Thus, PGRMC1 not only could predict the risk using progestogens but also of different estrogens. PMID: 30862292 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - March 12, 2019 Category: Geriatrics Authors: Li X, Ruan X, Gu M, Mueck AO Tags: Climacteric Source Type: research

Pelvic floor dysfunction in midlife women.
Abstract Pelvic floor dysfunction in women includes urinary incontinence and pelvic organ prolapse. In midlife, genitourinary atrophy is commonly associated with these conditions and can practically be considered part of the overall condition. The pelvic floor tissues share a common hormone responsiveness and as such respond collectively to midlife estrogen loss. This review article summarizes the expected consequences of menopause and aging on pelvic floor function and discusses how estrogen deprivation might lead to structural and/or functional failure. A framework for the initial evaluation of pelvic function i...
Source: Climacteric - March 11, 2019 Category: Geriatrics Authors: Johnston SL Tags: Climacteric Source Type: research

What can we learn from the vaginal mesh story?
Abstract The use of vaginal mesh in prolapse surgery has created enormous controversy and unprecedented media interest; it has become the most emotive topic in urogynecology today. The US Food and Drug Administration 510(k) system allowed the proliferation of mesh products which were rapidly adopted by surgeons internationally. The importance of a firm understanding of the biomechanical properties of tissue and implants, surgical skill, patient selection, communication skills, informed consent, and high-quality research are all important lessons we can learn from the mesh story. These lessons need to be applied to...
Source: Climacteric - March 4, 2019 Category: Geriatrics Authors: Karmakar D, Hayward L Tags: Climacteric Source Type: research

The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis.
CONCLUSION: The prevalence of POI and EM in women is considerable. The results of this study could contribute to consciousness-raising of health policy-makers toward the necessity of prioritizing, planning, and allocating health resources as preventive and treatment interventions for these women. PMID: 30829083 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - March 4, 2019 Category: Geriatrics Authors: Golezar S, Ramezani Tehrani F, Khazaei S, Ebadi A, Keshavarz Z Tags: Climacteric Source Type: research

Efficacy of oral estrogen plus testosterone gel to improve sexual function in postmenopausal women.
CONCLUSION: The addition of low-dose testosterone gel to daily estrogen may improve sexual function in postmenopausal women, but further evaluation and safety data are needed. PMID: 30810382 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - February 27, 2019 Category: Geriatrics Authors: Chaikittisilpa S, Soimongkol K, Jaisamrarn U Tags: Climacteric Source Type: research

Women's rights in Asia and elsewhere - a fact or an illusion?
Abstract More than one-third of the world's population resides in Asia. China and India have the largest population densities and the focus of this article is on these two countries. In the seventeenth century, women were globally treated as inferior and subordinate to men. Women had to listen to their fathers, husbands, and sons, and they could not inherit business or wealth. Starting in the eighteenth century and continuing in the nineteenth century, women's rights became central to political debates in Europe which demanded human rights, leading to the Women's Rights Movement. The Feminist movement began in the...
Source: Climacteric - February 27, 2019 Category: Geriatrics Authors: Shah D Tags: Climacteric Source Type: research

Construct validity of the Menopause Rating Scale in Indonesia.
CONCLUSION: Results indicated that the brief questionnaire of the MRS possesses acceptable construct validity for evaluating menopause symptoms in Indonesian women. PMID: 30810401 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - February 27, 2019 Category: Geriatrics Authors: Dwi Susanti H, Chang PC, Chung MH Tags: Climacteric Source Type: research

SCD1 methylation in subcutaneous adipose tissue associated with menopausal age.
This study was designed to investigate associations between menopausal age and the DNA methylation levels of stearoyl-coenzyme A desaturase 1 (SCD1, selected by the Illumina Human Methylation 450 K Bead Chip) and explore the changes in mRNA levels of SCD1 and DNA methyltransferases (DNMTs) in response to estrogen replacement therapy (ERT). METHODS: In the human experiment, we performed subcutaneous adipose tissue DNA extraction on 85 menopausal women. Methylation of SCD1 was measured by MethyLight polymerase chain reaction. In the rat experiment, we established models of menopause (ovariectomy group) and ERT (o...
Source: Climacteric - February 19, 2019 Category: Geriatrics Authors: Lu S, Xu F, Hu W, Niu Z, Cai H, Chen Y, Tu Q, Zhang Y, Chen W, Liu W, Tang S, Zhang Z Tags: Climacteric Source Type: research

Current treatments for female primary stress urinary incontinence.
Abstract Stress urinary incontinence (SUI) affects millions of women worldwide. Pelvic floor muscle training is the first-line treatment for SUI, and if this fails, midurethral sling surgery has become the gold-standard treatment. More recently, complications from midurethral mesh slings, particularly chronic pain and dyspareunia, have become a major concern. Although traditional SUI treatments, such as colposuspension and fascia slings, are used, the future of SUI treatment likely will rely on less invasive alternatives. Modern bulking agents could have the potential to become a first-line treatment for SUI, but ...
Source: Climacteric - February 18, 2019 Category: Geriatrics Authors: Itkonen Freitas AM, Rahkola-Soisalo P, Mikkola TS, Mentula M Tags: Climacteric Source Type: research

Do we have new preventive strategies for optimizing cardiovascular health in women?
Abstract Over the past decades, progress in efforts to reduce cardiovascular morbidity and mortality has been achieved, although a disturbing trend for stagnation of cardiovascular mortality rates among younger women compared with those in younger men has been identified. While the menopause transition has traditionally offered an unequivocal opportunity to assess cardiovascular risk and counsel women to adopt preventive strategies, the veritable 'window of opportunity', usually applied to the concept of timing the initiation of menopausal hormone therapy, must be opened much wider to encompass younger women inclu...
Source: Climacteric - February 4, 2019 Category: Geriatrics Authors: Stuenkel CA Tags: Climacteric Source Type: research

Esmirtazapine treatment of postmenopausal vasomotor symptoms: two randomized controlled trials.
CONCLUSIONS: Esmirtazapine reduced the frequency and severity of moderate to severe VMS associated with menopause and was generally well tolerated in the study population. PMID: 30712391 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - February 4, 2019 Category: Geriatrics Authors: Birkhaeuser M, Bitzer J, Braat S, Ramos Y Tags: Climacteric Source Type: research

The evolution of the human menopause.
Abstract The females of most species die soon after ceasing to reproduce, their purpose in life being to ensure survival of their kin. Human females may live more than one-third of their lives after they cease to reproduce, a property shared by few species, one of which is Orca whales. Orcas have been extensively studied because families live together in stable units or pods and individual whales have distinctive markings, enabling them to be identified. The females survive long after the menopause, one possible reason for this being that the older females provide a survival advantage since they are seen to lead t...
Source: Climacteric - February 4, 2019 Category: Geriatrics Authors: Lumsden MA, Sassarini J Tags: Climacteric Source Type: research

Metabolic syndrome during female midlife: what are the risks?
cute;pez FR Abstract The metabolic syndrome (METS) is an entity diagnosed by three or more of the following factors: abdominal obesity, low high-density lipoprotein cholesterol, and high serum triglycerides, fasting glucose, and/or blood pressure levels. Abdominal obesity is the most prevalent component of the syndrome that favors insulin resistance and a proinflammatory and prothrombotic status, and the risk of developing diabetes, hypertension, and other chronic conditions. During the menopausal transition, women tend to gain weight and this has been related to an increase in the prevalence of the METS. Rates ha...
Source: Climacteric - February 4, 2019 Category: Geriatrics Authors: Chedraui P, Pérez-López FR Tags: Climacteric Source Type: research

Hierarchical measurement structure in the Women's Health Questionnaire: a confirmatory factor analysis.
This study conducted confirmatory factor analysis (CFA) to examine the measurement structure of the Women's Health Questionnaire (WHQ) and how its components were organized. METHODS: Participants were 448 postmenopausal women, with a mean age of 63.3 years. CFA was conducted to test how well several proposed measurement models fit the data. RESULTS: The single-factor model performed poorly, indicating the presence of multiple factors. The model with seven correlated factors fit the data well, although the varying degrees of inter-factor correlations suggested grouping of similar factors. The hierarchical m...
Source: Climacteric - February 4, 2019 Category: Geriatrics Authors: Shen BJ, Fan Q, Shiqi Huang J, Moon-Ho Ho R, Mack WJ, Hodis HN Tags: Climacteric Source Type: research

Uterine transplantation.
Abstract Successful human uterine transplantation followed by subsequent pregnancy and live birth in a woman for whom this would otherwise have been impossible is a laudable goal. Research programs have been developed in several countries aimed at achieving this goal. The pioneering Swedish program has reported live births in six women, two of whom had a second pregnancy and birth. Five other live births have been reported from other countries. Most transplants were from a live donor, although recently a live birth has been reported following transplant from a deceased donor. The surgical procedure on a live donor...
Source: Climacteric - February 4, 2019 Category: Geriatrics Authors: Gomel V Tags: Climacteric Source Type: research

Advances in surgical strategies for prolapse.
Abstract Pelvic floor dysfunctions are a complex condition in elderly women; pelvic organ prolapse, urinary or fecal incontinence, constipation, pelvic pain, and sexual dysfunction are common problems. The goal of surgical treatment is functional reconstruction with symptom management and repair of anatomic defects. The recent advancements in surgical treatment of pelvic floor dysfunction allow several good options for choosing the best surgery for each patient. The vaginal procedure is traditionally the gold standard approach for elderly patients, but abdominal surgery is increasing as a mini-invasive approach an...
Source: Climacteric - February 1, 2019 Category: Geriatrics Authors: Giannini A, Caretto M, Russo E, Mannella P, Simoncini T Tags: Climacteric Source Type: research

On the human condition.
PMID: 30721639 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - February 1, 2019 Category: Geriatrics Authors: Baber R Tags: Climacteric Source Type: research

Ovarian tissue cryopreservation for patients with premature ovary insufficiency caused by cancer treatment: optimal protocol.
CONCLUSIONS: OT cryopreserved and thawed in medium supplemented with 5 mM NAC shows the highest antioxidant and lowest ROS capability, good apoptotic parameters, and follicle viability. Our results need to be confirmed in larger patient cohorts prior to being accepted as a standard protocol. PMID: 30676094 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 24, 2019 Category: Geriatrics Authors: Li Y, Ruan X, Liebenthron J, Montag M, Zhou Q, Kong W, Du J, Jin F, Li S, Cheng J, Wang H, Mueck AO Tags: Climacteric Source Type: research

Rationale and design for fractional microablative CO2 laser versus photothermal non-ablative erbium:YAG laser for the management of genitourinary syndrome of menopause: a non-inferiority, single-blind randomized controlled trial.
We present a study protocol for a multicenter, prospective, non-inferiority, single-blinded, randomized controlled trial comparing the fractional microablative CO2 laser versus the photothermal non-ablative erbium:YAG laser for the management of GSM. We will recruit 88 postmenopausal women across two sites who will be randomized to one of the two laser groups. Participants will all have GSM symptoms and a Vaginal Health Index Score
Source: Climacteric - January 24, 2019 Category: Geriatrics Authors: Flint R, Cardozo L, Grigoriadis T, Rantell A, Pitsouni E, Athanasiou S Tags: Climacteric Source Type: research

Cerebrovascular reactivity after cessation of menopausal hormone treatment.
CONCLUSION: MHT has a marginal sustained effect on cerebrovascular reactivity when measured 3 years after cessation of hormone treatment. PMID: 30661405 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 21, 2019 Category: Geriatrics Authors: Barnes JN, Harvey RE, Eisenmann NA, Miller KB, Johnson MC, Kruse SM, Lahr BD, Joyner MJ, Miller VM Tags: Climacteric Source Type: research

Mediterranean diet is associated with bone mineral density and muscle mass in postmenopausal women.
CONCLUSION: Bone mineral density at the lumbar spine and ALMI were positively associated with the MDS in a sample of postmenopausal women from a non-Mediterranean region. PMID: 30661407 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 21, 2019 Category: Geriatrics Authors: Silva TRD, Martins CC, Ferreira LL, Spritzer PM Tags: Climacteric Source Type: research

Association of mindfulness and stress with menopausal symptoms in midlife women.
CONCLUSION: Among midlife women, higher mindfulness and lower stress correlated with lower menopausal symptom scores independently. Among women experiencing more stress, the magnitude of association between mindfulness and lower menopausal symptom scores was greater, largely driven by psychological subdomain scores. Mindfulness may mitigate menopausal symptoms among midlife women. PMID: 30652511 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 17, 2019 Category: Geriatrics Authors: Sood R, Kuhle CL, Kapoor E, Thielen JM, Frohmader KS, Mara KC, Faubion SS Tags: Climacteric Source Type: research

Factors related to muscle strength in postmenopausal women aged younger than 65 years with normal vitamin D status.
z-López FR Abstract OBJECTIVE: The study aimed to determine the impact of age, age at menopause, body mass index (BMI), and lumbar and hip bone mineral density (BMD) on muscle strength in young postmenopausal women with normal vitamin D levels. METHODS: This was a cross-sectional study performed in 392 postmenopausal women aged
Source: Climacteric - January 17, 2019 Category: Geriatrics Authors: Garcia-Alfaro P, Garcia S, Rodríguez I, Tresserra F, Pérez-López FR Tags: Climacteric Source Type: research

Keeping the pelvic floor healthy.
This article aims to define the pelvic floor muscles and functions and to summarize the direct and indirect changes to women's pelvic floor muscles during and after menopause and through aging. A particular focus is also given to the evidence-based literature on how to keep pelvic floor muscles healthy during menopause and in postmenopause using conservative management therapy. PMID: 30653374 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 17, 2019 Category: Geriatrics Authors: Dumoulin C, Pazzoto Cacciari L, Mercier J Tags: Climacteric Source Type: research

Benefit-risk profile of black cohosh (isopropanolic Cimicifuga racemosa extract) with and without St John's wort in breast cancer patients.
In conclusion, with its positive benefit-risk profile, iCR/iCR + HP may offer a safe non-hormonal therapeutic option for breast cancer survivors receiving endocrine therapy. PMID: 30626212 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 10, 2019 Category: Geriatrics Authors: Ruan X, Mueck AO, Beer AM, Naser B, Pickartz S Tags: Climacteric Source Type: research

Hormone replacement therapy and prevention of chronic conditions.
Abstract Nowadays, postmenopausal women are largely undertreated. Analysis of conflicting results among different studies suggests that hormone replacement therapy (HRT) can prevent osteoporosis and cardiovascular disease in symptomatic, early postmenopausal women. In fact, climacteric symptoms are related to an increased risk of chronic conditions, including hypertension and cardiovascular disease. Different scientific societies have pointed out that patient selection, timing of initiation, and the choice of the type and dose of HRT used are the major determinants of the ultimate effect of HRT on women's health a...
Source: Climacteric - January 10, 2019 Category: Geriatrics Authors: Gambacciani M, Cagnacci A, Lello S Tags: Climacteric Source Type: research

Endometriosis: seeking optimal management in women approaching menopause.
ieva S, Maneschi F, Martire F, Massarotti C, Mattei A, Muzii L, Ottolina J, Pagliardini L, Perandini A, Perelli F, Pino I, Porpora MG, Remorgida V, Scagnelli G, Seracchioli R, Solima E, Somigliana E, Sorrenti G, Ticino A, Venturella R, Viganò P, Vignali M, Zullo F, Zupi E Abstract The incidence of endometriosis in middle-aged women is not minimal compared to that in the reproductive age group. The treatment of affected women after childbearing age to the natural transition toward menopause has received considerably poor attention. Disease management is problematic for these women due to increased contraindi...
Source: Climacteric - January 10, 2019 Category: Geriatrics Authors: Alio L, Angioni S, Arena S, Bartiromo L, Bergamini V, Berlanda N, Bonanni V, Bonin C, Buggio L, Candiani M, Centini G, D'Alterio MN, De Stefano F, Di Cello A, Exacoustos C, Fedele L, Frattaruolo MP, Geraci E, Lavarini E, Lazzeri L, Luisi S, Maiorana A, Ma Tags: Climacteric Source Type: research

Higher intake of dietary n-3 PUFA and lower MUFA are associated with fewer menopausal symptoms.
CONCLUSION: Consuming diets low in MUFA intake, but high in n-3 PUFA, and with a more favorable ratio of n-3:n-6 PUFA may be helpful for improving menopausal symptoms. PMID: 30628472 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 10, 2019 Category: Geriatrics Authors: Abshirini M, Siassi F, Koohdani F, Qorbani M, Khosravi S, Aslani Z, Pak N, Sotoudeh G Tags: Climacteric Source Type: research

Postmenopausal androgen-secreting ovarian tumors: challenging differential diagnosis in two cases.
We present herein two cases with this condition; one with abnormal postmenopausal genital bleeding and mild increase in facial hair, and the second with slow-developing hirsutism and virilization. Both cases shared a notorious increase in libido. The laboratory tests showed high levels of testosterone (>100 ng/ml). A normal value of dehydroepiandrosterone sulfate and a normal cortisol level at 9 am after 1 mg of dexamethasone administered at midnight (Nugent test) made an adrenal etiology very unlikely. On the other hand, a high level of inhibine B oriented to an ovarian source. Transvaginal sonograph...
Source: Climacteric - January 9, 2019 Category: Geriatrics Authors: Arteaga E, Martinez A, Jaramilo J, Villaseca P, Cuello M, Valenzuela P, Gejman R, Blumel JE Tags: Climacteric Source Type: research

Assessment and hormonal management of osteoporosis.
res F Abstract Postmenopausal osteoporosis is a frequent health issue in women. Because osteoporosis-related fractures cause a significant increase in mortality and morbidity, it is clinically important to identify as soon as possible women at increased risk for future fracture so that preventive measures can be instituted. At the beginning of menopause, evaluation of the subsequent risk of fracture is not so easy. Most screening tools fail to accurately identify those women who will fracture within the next 10 years. A history of a prior fracture and low bone mineral density are the only major consistently...
Source: Climacteric - January 9, 2019 Category: Geriatrics Authors: Trémollieres F Tags: Climacteric Source Type: research

The etiology and management of recurrent urinary tract infections in postmenopausal women.
Abstract Urinary tract infections (UTIs) are one of the most common infections and affect up to 50% of women in their lifetime, with almost half of these women experiencing a recurrence in 6-12 months. Menopause predisposes women to recurrent UTI (rUTI), as normally lower levels of estrogen lead to changes in the urogenital epithelium and subsequently urogenital microbiome. The recently discovered urobiome is now known to have different compositions in both healthy and unhealthy bladders, including a role in the pathophysiology of rUTI, and may be a therapeutic target for prevention and treatment options fo...
Source: Climacteric - January 9, 2019 Category: Geriatrics Authors: Jung C, Brubaker L Tags: Climacteric Source Type: research

Atherosclerotic disease and cardiovascular risk factors in postmenopausal breast cancer survivors: a case-control study.
In this study, 96 women with BC (case group) were compared to 192 women without BC (control group), age range 45-75 years. The case group included women with a histological diagnosis of BC, amenorrhea ≥ 12 months, and age ≥ 45 years, without metastatic disease or cardiovascular disease (CVD). The control group consisted of women with amenorrhea ≥ 12 months and age ≥ 45 years, without BC or CVD. Total cholesterol, high-density lipoprotein, low-density lipoprotein, triglycerides, glucose, and insulin were measured. Atherosclerotic disease was determined by increased intima-media...
Source: Climacteric - January 9, 2019 Category: Geriatrics Authors: Terra Branco M, de Araujo Brito Buttros D, Carvalho-Pessoa E, Lima Sobreira M, Yukie Nakano Schincariol C, Nahas-Neto J, Nahas EAP Tags: Climacteric Source Type: research

Association of VDR and OPG gene polymorphism with osteoporosis risk in Chinese postmenopausal women.
CONCLUSIONS: Both VDR-rs2228570-T and OPG-rs3102735-G and their interactions are related to the increased risk of osteoporosis. PMID: 30624097 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 9, 2019 Category: Geriatrics Authors: Wu F, Zhou D, Shen G, Cui Y, Lv Q, Wei F Tags: Climacteric Source Type: research

Circulating androgen levels before and after oophorectomy in premenopausal and postmenopausal women.
CONCLUSION: The significant decrease in serum T in postmenopausal women following oophorectomy adds to the evidence that the postmenopausal ovary continues to produce T. PMID: 30612472 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 7, 2019 Category: Geriatrics Authors: Stanczyk FZ, Chaikittisilpa S, Sriprasert I, Rafatnia A, Nadadur M, Mishell DR Tags: Climacteric Source Type: research

Lower expression of prestin and MYO7A correlates with menopause-associated hearing loss.
CONCLUSION: Low estrogen levels may lead to reduced expression of prestin and MYO7A in cochlea, leading to a menopause-related hearing loss. PMID: 30612476 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - January 7, 2019 Category: Geriatrics Authors: Diao H, Zhao L, Qin L, Bai W, Wang K, Zhang J, Chen X, Jiang H, Mao L Tags: Climacteric Source Type: research