Filtered By:
Drug: Insulin
This page shows you your search results in order of relevance. This is page number 18.
Order by Relevance | Date
Total 1048 results found since Jan 2013.
Inhibition of long noncoding RNA IGF2AS promotes angiogenesis in type 2 diabetes.
CONCLUSION: IGF2AS inhibition has angiogenic effect in diabetic GK mMVE cells. The functions of IGF2AS in type 2 diabetes are very likely through the inverse regulation of IGF2, but independent of IGF1.
PMID: 28570978 [PubMed - as supplied by publisher]
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 29, 2017 Category: Drugs & Pharmacology Authors: Zhao Z, Liu B, Li B, Song C, Diao H, Guo Z, Li Z, Zhang J Tags: Biomed Pharmacother Source Type: research
Adipose tissue conditioned media support macrophage lipid-droplet biogenesis by interfering with autophagic flux
Publication date: Available online 23 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Sapir Bechor, Dikla Nachmias, Natalie Elia, Yulia Haim, Maayan Vatarescu, Alicia Leikin-Frenkel, Martin Gericke, Tanya Tarnovsky, Guy Las, Assaf Rudich Obesity promotes the biogenesis of adipose tissue (AT) foam cells (FC), which contribute to AT insulin resistance. Autophagy, an evolutionarily-conserved house-keeping process, was implicated in cellular lipid handling by either feeding and/or degrading lipid-droplets (LDs). We hypothesized that beyond phagocytosis of dead adipocytes,...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - June 24, 2017 Category: Lipidology Source Type: research
Small Interfering RNA Inhibition of Cannabanoid-1 Receptor (CB1R) for Treating Type 2 Diabetes
The invention pertains to the use of glucan encapsulated non-immunostimulatory small interfering RNAs (siRNAs) to treat type-2 diabetes. Endocannabinoids (EC) are lipid signaling molecules that act on the same cannabinoid receptors that recognize and mediate the effects of endo- and phytocannabanoids. EC receptor CB1R activation is implicated in the development of obesity and its metabolic consequences, including insulin resistance and type 2 diabetes. Beta-cell loss has been demonstrated in a Zucker diabetic fatty (ZDF) rat model of type-2 diabetes through CB1R-mediated activation of a macrophage-mediated inflammatory res...
Source: NIH OTT Licensing Opportunities - September 19, 2013 Category: Research Authors: ajoyprabhu3 Source Type: research
Glucagon-like peptide-1 analog prevents obesity-related glomerulopathy by inhibiting excessive autophagy in podocytes.
CONCLUSION: Excess autophagy in podocytes was induced by inhibition of Glut4 translocation to the plasma membrane and was involved in the pathology of ORG. GLP-1 restored insulin sensitivity and ameliorated renal injury by decreasing the level of autophagy.
PMID: 29070572 [PubMed - as supplied by publisher]
Source: Am J Physiol Renal P... - October 25, 2017 Category: Urology & Nephrology Authors: Guo H, Wang B, Li H, Ling L, Niu J, Gu Y Tags: Am J Physiol Renal Physiol Source Type: research
Electrical pulse stimulation induces GLUT4 glucose transporter translocation in C2C12 myotubes that depends on Rab8A, Rab13 and Rab14.
In conclusion, EPS involves Rab8a, Rab13 and Rab14 to elicit GLUT4 translocation but not Rab10; moreover, Rab10 and Rab13 are not engaged by AMPK activation alone. C2C12-GLUT4HA cultures constitute a valuable in vitro model to investigate molecular mechanisms of contraction-stimulated GLUT4 translocation.
PMID: 29089333 [PubMed - as supplied by publisher]
Source: Am J Physiol Endocri... - October 31, 2017 Category: Endocrinology Authors: Li Z, Yue Y, Hu F, Zhang C, Ma X, Li N, Qiu L, Fu M, Chen L, Yao Z, Bilan PJ, Klip A, Niu W Tags: Am J Physiol Endocrinol Metab Source Type: research
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway
Publication date: Available online 25 December 2017 Source:Pharmacological Research Author(s): Jiting Yan, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Huijun Sun Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia. Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been reported to produce the effect of anti-diabetes in recent reports. The goal of the current study is to investigate the therapeutic effects of catalpol on hepatic insulin resistance in type 2 diabetes and elucidate the underlying cellular mechanisms. Type 2 di...
Source: Pharmacological Research - December 25, 2017 Category: Drugs & Pharmacology Source Type: research
Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy
Publication date: Available online 6 March 2018 Source:Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids Author(s): Ting Hong, Zhijuan Ge, Ran Meng, Hongdong Wang, Pengzi Zhang, Sunyinyan Tang, Jing Lu, Tianwei Gu, Dalong Zhu, Yan Bi Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine wh...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - March 7, 2018 Category: Lipidology Source Type: research
Erythropoietin alleviates hepatic Steatosis by activating SIRT1-mediated autophagy.
Abstract
Erythropoietin (EPO), besides its stimulatory effect on erythropoiesis, is beneficial to insulin resistance and obesity. However, its role in hepatic steatosis remains unexplored. Activating autophagy seems a promising mechanism for improving fatty liver disease. The present study investigated the role of EPO in alleviating hepatic steatosis and sought to determine whether its function is mediated by the activation of autophagy. Here, we show that EPO decreased hepatic lipid content significantly in vivo and in vitro. Furthermore, EPO/EPO receptor (EPOR) signalling induced autophagy activation in hepatocy...
Source: Biochimica et Biophysica Acta - March 6, 2018 Category: Biochemistry Authors: Hong T, Ge Z, Meng R, Wang H, Zhang P, Tang S, Lu J, Gu T, Zhu D, Bi Y Tags: Biochim Biophys Acta Source Type: research
Resistin upregulates MUC5AC/B mucin gene expression in human airway epithelial cells.
Abstract
Adipokines, a group of proteins including leptin, visfatin, resistin, and adiponectin, are produced by adipocytes. Among adipokines, resistin is implicated in insulin resistance and inflammatory response modulation. Mucus hypersecretion has been greatly linked to airway diseases, such as asthma, chronic obstructive pulmonary disease, and rhinosinusitis. Increasing evidence has indicated that adipokines, such as leptin and visfatin, play important regulatory roles in various biological processes involved in mucus secretion. However, the effects of resistin on mucin expression in human airway epithelial cel...
Source: Biochemical and Biophysical Research communications - March 28, 2018 Category: Biochemistry Authors: Kwak S, Kim YD, Na HG, Bae CH, Song SY, Choi YS Tags: Biochem Biophys Res Commun Source Type: research
Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF- κB/MAPK/ PI3K Signaling Systems
Conclusion: Collectively, our results show that palmitate induces CCL4 expression via activation of the TLR4-MyD88/NF-kB/MAPK/ PI3K signaling cascade. Thus, our findings suggest that the palmitate-induced CCL4 production might be an underlying mechanism of metabolic inflammation.Cell Physiol Biochem 2018;46:953 –964
Source: Cellular Physiology and Biochemistry - April 18, 2018 Category: Cytology Source Type: research
Up-regulation of microRNA-503 by high glucose reduces the migration and proliferation but promotes the apoptosis of human umbilical vein endothelial cells by inhibiting the expression of insulin-like growth factor-1 receptor.
CONCLUSIONS: The present study demonstrates that miR-503 expression in HUVECs is elevated in high glucose condition. Also, miR-503 reduces migration and proliferation, but promotes apoptosis of HUVECs by inhibiting IGF-1R expression.
PMID: 29917206 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - June 20, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.
CONCLUSIONS: IGF-I increased LAT1 mRNA level in myocytes. However, the role of LAT1 in IGF-I-induced mTORC1 activation and cell functions remains unclear.
PMID: 30273774 [PubMed - as supplied by publisher]
Source: Growth Hormone and IGF Research - September 23, 2018 Category: Endocrinology Authors: Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, Okimura Y Tags: Growth Horm IGF Res Source Type: research
PKA regulates HMGB1 through activation of IGFBP-3 and SIRT1 in human retinal endothelial cells cultured in high glucose
ConclusionsPKA requires active IGFBP-3 and SIRT1 to inhibit HMGB1 inflammatory actions in the retina vasculature. Activation of these pathways may offer new targets for therapy development.
Source: Inflammation Research - October 17, 2018 Category: Research Source Type: research
Sonic hedgehog promotes endothelial differentiation of bone marrow mesenchymal stem cells via VEGF-D.
Conclusions: This study demonstrated that Shh could promote endothelial differentiation of BMSCs via VEGF-D.
PMID: 30416797 [PubMed]
Source: Journal of Thoracic Disease - November 13, 2018 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Targeting Insulin-like Growth Factor in Multiple Myeloma: Novel Strategies in the Treatment of Proteasome Inhibitor Resistant Cells
Conclusion: The IGF1 signaling pathway is involved in proteasome inhibitor sensitivity and plays a key role in chemokine production of the HUVEC. Our data also suggested that administration of IGF1R inhibitor, linsitinib, might be a powerful strategy against myeloma cells and enhance cytotoxic effects of proteasome inhibitors in those residual MM cells.DisclosuresOhyashiki: MSD,: Honoraria, Research Funding; Bristol Meyer Squibb KK,: Honoraria, Research Funding; Kyowakko Kirin KK,: Research Funding; Celegene KK,: Honoraria, Research Funding; Pfizer KK,: Honoraria, Research Funding; Novartis KK,: Honoraria, Research Funding...
Source: Blood - November 21, 2018 Category: Hematology Authors: Tanaka, Y., Okabe, S., Tauchi, T., Ito, Y., Ohyashiki, K. Tags: 605. Molecular Pharmacology, Drug Resistance-Lymphoid and Other Diseases Source Type: research
