Electrical pulse stimulation induces GLUT4 glucose transporter translocation in C2C12 myotubes that depends on Rab8A, Rab13 and Rab14.

In conclusion, EPS involves Rab8a, Rab13 and Rab14 to elicit GLUT4 translocation but not Rab10; moreover, Rab10 and Rab13 are not engaged by AMPK activation alone. C2C12-GLUT4HA cultures constitute a valuable in vitro model to investigate molecular mechanisms of contraction-stimulated GLUT4 translocation.
PMID: 29089333 [PubMed - as supplied by publisher]

Source: Am J Physiol Endocri... - October 31, 2017 Category: Endocrinology Authors: Li Z, Yue Y, Hu F, Zhang C, Ma X, Li N, Qiu L, Fu M, Chen L, Yao Z, Bilan PJ, Klip A, Niu W Tags: Am J Physiol Endocrinol Metab Source Type: research