Filtered By:
Condition: Osteoporosis

This page shows you your search results in order of date. This is page number 8.

Order by Relevance | Date

Total 136 results found since Jan 2013.

Hyperglycemia Suppresses RANKL-Induced Osteoclast Differentiation through LXR β Expression in RAW264.7 Cells.
Hyperglycemia Suppresses RANKL-Induced Osteoclast Differentiation through LXRβ Expression in RAW264.7 Cells. J Nutr Sci Vitaminol (Tokyo). 2017;63(1):28-34 Authors: Tanaka T, Takei Y, Zaima N, Moriyama T, Yamanouchi D Abstract There have been reports that hyperglycemia suppresses osteoclast (OCL) differentiation, although the underlying mechanism is poorly understood. Here we demonstrated that high glucose suppresses OCL differentiation through activation of liver X receptor (LXR) β, a recently reported glucose-sensing nuclear receptor. The effect of hyperglycemia on osteoclastogenesis was tested in ...
Source: Journal of Nutritional Science and Vitaminology - April 4, 2017 Category: Nutrition Tags: J Nutr Sci Vitaminol (Tokyo) Source Type: research

Role of plasminogen activator inhibitor-1 in glucocorticoid-induced muscle change in mice
In conclusion, our data suggest that paracrine PAI-1 is involved in GC-induced muscle wasting through the enhancement of muscle degradation in mice.
Source: Journal of Bone and Mineral Metabolism - March 19, 2017 Category: Orthopaedics Source Type: research

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway
Publication date: April 2017 Source:Biomedicine & Pharmacotherapy, Volume 88 Author(s): Yaping Ye, Xingzhi Jing, Na Li, Yingxing Wu, Bingbing Li, Tao Xu Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regul...
Source: Biomedicine and Pharmacotherapy - January 21, 2017 Category: Drugs & Pharmacology Source Type: research

Icariin promotes proliferation and osteogenic differentiation of rat adipose-derived stem cells by activating the RhoA-TAZ signaling pathway.
Abstract Icariin, the main active flavonoid glucoside isolated from Herba epimedii, has been demonstrated to be a potential alternative therapy to prevent postmenopausal osteoporosis. Icariin has also been shown to regulate the proliferation and osteogenic differentiation of rat bone marrow stromal cells (rBMSCs). However, the detailed molecular mechanism of icariin has remained largely unknown. Besides, no investigation has focused on the relevance of icariin in the regulation of rat adipose-derived stem cells (rASCs) proliferation and osteogenic differentiation. In the present study, we detected that icariin pro...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 21, 2017 Category: Drugs & Pharmacology Authors: Ye Y, Jing X, Li N, Wu Y, Li B, Xu T Tags: Biomed Pharmacother Source Type: research

FGF Suppresses Poldip2 Expression in Osteoblasts
This article is protected by copyright. All rights reserved
Source: Journal of Cellular Biochemistry - December 4, 2016 Category: Biochemistry Authors: Sakie Katsumura, Yayoi Izu, Takayuki Yamada, Kathy Griendling, Kiyoshi Harada, Masaki Noda, Yoichi Ezura Tags: Article Source Type: research

Increased PLEKHO1 within osteoblasts suppresses Smad ‐dependent BMP signaling to inhibit bone formation during aging
Summary Emerging evidence indicates that the dysregulation of protein ubiquitination plays a crucial role in aging‐associated diseases. Smad‐dependent canonical BMP signaling pathway is indispensable for osteoblastic bone formation, which could be disrupted by the ubiquitination and subsequent proteasomal degradation of Smad1/5, the key molecules for BMP signaling transduction. However, whether the dysregulation of Smad1/5 ubiquitination and disrupted BMP signaling pathway is responsible for the age‐related bone formation reduction is still underexplored. Pleckstrin homology domain‐containing family O member 1 (PLE...
Source: Aging Cell - November 30, 2016 Category: Cytology Authors: Jin Liu, Chao Liang, Baosheng Guo, Xiaohao Wu, Defang Li, Zongkang Zhang, Kang Zheng, Lei Dang, Xiaojuan He, Changwei Lu, Songlin Peng, Xiaohua Pan, Bao ‐Ting Zhang, Aiping Lu, Ge Zhang Tags: Original Article Source Type: research

Algal oligosaccharides ameliorate osteoporosis via up-regulation of parathyroid hormone 1-84 and vascular endothelial growth factor.
CONCLUSION: Algal oligosaccharides ameliorate osteoporosis via up-regulation of PTH1-84 and VEGF. Algal oligosaccharides should be developed as a potential drug for osteoporosis treatment. PMID: 27468548 [PubMed - in process]
Source: Journal of Traditional Chinese Medicine - May 31, 2016 Category: Complementary Medicine Authors: Wang L, Wang H, Fang N Tags: J Tradit Chin Med Source Type: research

Heterozygous PTCH1 Mutations Impact the Bone Metabolism in Patients with Nevoid Basal Cell Carcinoma Syndrome Likely by Regulating SPARC Expression
This study sought to investigate the mechanism underlying heterozygous PTCH1 mutation‐mediated abnormal bone metabolism in patients with NBCCS. Stromal cells were isolated from the fibrous capsules of patients with NBCCS‐associated or non‐syndromic keratocystic odontogenic tumors and non‐syndromic tumor stromal cells without PTCH1 mutations served as controls. Germline PTCH1 heterozygous mutations were confirmed in all NBCCS samples and differential protein expression was identified using tandem mass tag‐labeled proteomics analysis. Our findings revealed that osteonectin/SPARC expression was significantly downreg...
Source: Journal of Bone and Mineral Research - February 17, 2016 Category: Orthopaedics Authors: Yingying Hong, Jianyun Zhang, Heyu Zhang, Xuefen Li, Jiafei Qu, Jiemei Zhai, Lei Zhang, Feng Chen, Tiejun Li Tags: Original Article Source Type: research

Src siRNA prevents corticosteroid-associated osteoporosis in a rabbit model
In an established steroid-associated osteonecrosis (SAON) rabbit model we found recently that blockage Src by siRNA could improve reconstructive repair of osteonecrosis via enhancing osteogenesis and inhibiting bone resorption. The current study investigated if blocking Src was able to prevent steroid-associated osteoporosis (SAOP) in the same SAON animal model. Rabbits were treated with pulsed lipopolysaccharide (LPS) and corticosteroid methylprednisolone (MPS). At 2, 4, 6weeks after induction, Src siRNA, control siRNA and saline were intramedullary injected into proximal femur, respectively.
Source: Bone - November 17, 2015 Category: Orthopaedics Authors: Li-Zhen Zheng, Xin-Luan Wang, Hui-Juan Cao, Shi-Hui Chen, Le Huang, Ling Qin Tags: Original Full Length Article Source Type: research

Regulation of the osteogenic and adipogenic differentiation of bone marrow-derived stromal cells by extracellular uridine triphosphate: The role of P2Y2 receptor and ERK1/2 signaling.
Abstract An imbalance in the osteogenesis and adipogenesis of bone marrow-derived stromal cells (BMSCs) is a crucial pathological factor in the development of osteoporosis. Growing evidence suggests that extracellular nucleotide signaling involving the P2 receptors plays a significant role in bone metabolism. The aim of the present study was to investigate the effects of uridine triphosphate (UTP) on the osteogenic and adipogenic differentiation of BMSCs, and to elucidate the underlying mechanisms. The differentiation of the BMSCs was determined by measuring the mRNA and protein expression levels of osteogenic-...
Source: International Journal of Molecular Medicine - November 3, 2015 Category: Molecular Biology Authors: Li W, Wei S, Liu C, Song M, Wu H, Yang Y Tags: Int J Mol Med Source Type: research

Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation
Publication date: November 2015 Source:Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Volume 1852, Issue 11 Author(s): Kazuki Inoue, Yuuki Imai Osteoclast differentiation is associated with both normal bone homeostasis and pathological bone diseases such as osteoporosis. Several transcription factors can regulate osteoclast differentiation, including c-fos and Nfatc1. Using genome-wide DNase-seq analysis, we found a novel transcription factor, SREBP2, that participates in osteoclast differentiation in vitro . Here, we asked whether SREBP2 actually plays a role in controlling bone metabolism in vivo. ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - September 5, 2015 Category: Molecular Biology Source Type: research

The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo
Conclusions GPRC6A, the likely receptor of osteocalcin (OC), is expressed in mouse muscle. ucOC treatment augments insulin-stimulated skeletal muscle glucose uptake in C2C12 myotubes and following ex vivo muscle contraction. ucOC may partly account for the insulin sensitizing effect of exercise.
Source: Osteoporosis International - August 10, 2015 Category: Orthopaedics Source Type: research

MEK5 suppresses osteoblastic differentiation.
In this study, we have demonstrated the role of MEK5 in osteoblastic differentiation in mouse preosteoblastic MC3T3-E1 cells and bone marrow stromal ST2 cells. We found that treatment with BIX02189, an inhibitor of MEK5, increased alkaline phosphatase (ALP) activity and the gene expression of ALP, osteocalcin (OCN) and osterix, as well as it enhanced the calcification of the extracellular matrix. Moreover, osteoblastic cell proliferation decreased at a concentration of greater than 0.5 μM. In addition, knockdown of MEK5 using siRNA induced an increase in ALP activity and in the gene expression of ALP, OCN, and osterix. In...
Source: Biochemical and Biophysical Research communications - May 18, 2015 Category: Biochemistry Authors: Kaneshiro S, Otsuki D, Yoshida K, Yoshikawa H, Higuchi C Tags: Biochem Biophys Res Commun Source Type: research

MiR-21 overexpression improves osteoporosis by targeting RECK.
Abstract Osteoporosis is a kind of metabolic bone disorder. MicroRNA-21 (miR-21) has been proven to play an important role in bone formation, whereas its role in osteoporosis is unclear. In the present study, miR-21 expression was inhibited by TNF-α in mesenchymal stem cells (MSCs). TNF-α induced cell apoptosis, and inhibited cell proliferation and differentiation of MSCs. Whereas the effect was reversed by miR-21 mimics. Expression of reversion-inducing cysteine-rich protein with Kazal motifs (RECK) which is a predicted target of miR-21 was inhibited by miR-21 mimics. A luciferase reporter gene assay showed th...
Source: Molecular and Cellular Biochemistry - April 17, 2015 Category: Biochemistry Authors: Zhao W, Dong Y, Wu C, Ma Y, Jin Y, Ji Y Tags: Mol Cell Biochem Source Type: research

Identification of C‐terminal Hsp70‐interacting protein as a mediator of tumour necrosis factor action in osteoblast differentiation by targeting osterix for degradation
Abstract In patients with inflammatory arthritis, tumour necrosis factor (TNF)‐α are overproduced in inflamed joints. This leads to local erosion of cartilage and bone, periarticular osteopenia, as well as osteoporosis. But less is known regarding the molecular mechanisms that mediate the effect of TNF‐α on osteoblast function. The purpose of this study was to test that C terminus of Hsc70‐interacting protein (CHIP) has a specific role in suppressing the osteogenic activity of osteoblasts under inflammatory conditions. C2C12, MC3T3‐E1 and HEK293T cell lines were cultured and cotransfected with related plasmids. A...
Source: Journal of Cellular and Molecular Medicine - March 26, 2015 Category: Molecular Biology Authors: Jianmin Xie, Jieruo Gu Tags: Original Article Source Type: research