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CTC1 ‐STN1 coordinates G‐ and C‐strand synthesis to regulate telomere length
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 18, 2018 Category: Cytology Authors: Peili Gu , Shuting Jia , Taylor Takasugi , Eric Smith , Jayakrishnan Nandakumar , Eric Hendrickson , Sandy Chang Source Type: research

Oxidation resistance 1 is a novel senolytic target
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 16, 2018 Category: Cytology Authors: Xin Zhang , Suping Zhang , Xingui Liu , Yingying Wang , Jianhui Chang , Xuan Zhang , Samuel G. Mackintosh , Alan J. Tackett , Yonghan He , Dongwen Lv , Remi ‐Martin Laberge , Judith Campisi , Jianrong Wang , Guangrong Zheng , Source Type: research

Trimethylamine ‐N‐oxide promotes brain aging and cognitive impairment in mice
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 11, 2018 Category: Cytology Authors: Dang Li , Yilang Ke , Rui Zhan , Changjie Liu , Mingming Zhao , Aiping Zeng , Xiaoyun Shi , Liang Ji , Si Cheng , Bing Pan , Lemin Zheng , Huashan Hong Source Type: research

Acute tau knockdown in the hippocampus of adult mice causes learning and memory deficits
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 11, 2018 Category: Cytology Authors: Ramon Velazquez , Eric Ferreira , An Tran , Emily C. Turner , Ramona Belfiore , Caterina Branca , Salvatore Oddo Source Type: research

Issue Information
Aging Cell,Volume 17, Issue 3, June 2018. (Source: Aging Cell)
Source: Aging Cell - May 11, 2018 Category: Cytology Source Type: research

Announcement
Aging Cell,Volume 17, Issue 3, June 2018. (Source: Aging Cell)
Source: Aging Cell - May 11, 2018 Category: Cytology Source Type: research

Expression of p16INK4a is a biomarker of chondrocyte aging but does not cause osteoarthritis
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 10, 2018 Category: Cytology Authors: Brian O. Diekman , Garrett A. Sessions , John A. Collins , Anne K. Knecht , Susan L. Strum , Natalia K. Mitin , Cathy S. Carlson , Richard F. Loeser , Norman E. Sharpless Source Type: research

Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 10, 2018 Category: Cytology Authors: Kirsty Foote , Johannes Reinhold , Emma P. K. Yu , Nichola L. Figg , Alison Finigan , Michael P. Murphy , Martin R. Bennett Source Type: research

Metformin directly targets the H3K27me3 demethylase KDM6A/UTX
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 9, 2018 Category: Cytology Authors: Elisabet Cuy às , Sara Verdura , Laura Llorach‐Pares , Salvador Fernández‐Arroyo , Fedra Luciano‐Mateo , Noemí Cabré , Jan Stursa , Lukas Werner , Begoña Martin‐Castillo , Benoit Viollet , Jiri Neuzil , Jorge Jov Source Type: research

Antagonizing peroxisome proliferator ‐activated receptor γ facilitates M1‐to‐M2 shift of microglia by enhancing autophagy via the LKB1–AMPK signaling pathway
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 9, 2018 Category: Cytology Authors: Juan Ji , Teng ‐Fei Xue , Xu‐Dong Guo , Jin Yang , Ruo‐Bing Guo , Juan Wang , Ji‐Ye Huang , Xiao‐Jie Zhao , Xiu‐Lan Sun Source Type: research

HTRA1, an age ‐related macular degeneration protease, processes extracellular matrix proteins EFEMP1 and TSP1
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - May 6, 2018 Category: Cytology Authors: Michael K. Lin , Jin Yang , Chun Wei Hsu , Anuradha Gore , Alexander G. Bassuk , Lewis M. Brown , Ryan Colligan , Jesse D. Sengillo , Vinit B. Mahajan , Stephen H. Tsang Source Type: research

Overexpression of CYB5R3 and NQO1, two NAD+ ‐producing enzymes, mimics aspects of caloric restriction
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 29, 2018 Category: Cytology Authors: Alberto Diaz ‐Ruiz , Michael Lanasa , Joseph Garcia , Hector Mora , Frances Fan , Alejandro Martin‐Montalvo , Andrea Di Francesco , Miguel Calvo‐Rubio , Andrea Salvador‐Pascual , Miguel A. Aon , Kenneth W. Fishbein , Kevin J. Source Type: research

MicroRNAs in hereditary and sporadic premature aging syndromes and other laminopathies
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 26, 2018 Category: Cytology Authors: Diane Frankel , Val érie Delecourt , Karim Harhouri , Annachiara De Sandre‐Giovannoli , Nicolas Lévy , Elise Kaspi , Patrice Roll Source Type: research

Necroptosis increases with age and is reduced by dietary restriction
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 26, 2018 Category: Cytology Authors: Sathyaseelan S. Deepa , Archana Unnikrishnan , Stephanie Matyi , Niran Hadad , Arlan Richardson Source Type: research

Lifelong reduction in complex IV induces tissue ‐specific metabolic effects but does not reduce lifespan or healthspan in mice
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 26, 2018 Category: Cytology Authors: Sathyaseelan S. Deepa , Gavin Pharaoh , Michael Kinter , Vivian Diaz , Wilson C. Fok , Kaitlyn Riddle , Daniel Pulliam , Shauna Hill , Kathleen E. Fischer , Vanessa Soto , Constantin Georgescu , Jonathan D. Wren , Carlo Viscomi , Source Type: research

Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 19, 2018 Category: Cytology Authors: Siming Ma , Andrei S. Avanesov , Emily Porter , Byung Cheon Lee , Marco Mariotti , Nadezhda Zemskaya , Roderic Guigo , Alexey A. Moskalev , Vadim N. Gladyshev Source Type: research

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 16, 2018 Category: Cytology Authors: Jingqi Fang , Jiping Yang , Xun Wu , Gangming Zhang , Tao Li , Xi'e Wang , Hong Zhang , Chih ‐chen Wang , Guang‐Hui Liu , Lei Wang Source Type: research

Advanced oxidation protein products induce pre ‐osteoblast apoptosis through a nicotinamide adenine dinucleotide phosphate oxidase‐dependent, mitogen‐activated protein kinases‐mediated intrinsic apoptosis pathway
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 16, 2018 Category: Cytology Authors: Si ‐Yuan Zhu , Jing‐Shen Zhuang , Qian Wu , Zhong‐Yuan Liu , Cong‐Rui Liao , Shi‐Gan Luo , Jian‐Ting Chen , Zhao‐Ming Zhong Source Type: research

Glucagon ‐like peptide‐1 ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via the PPARα pathway
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 16, 2018 Category: Cytology Authors: Lujin Wu , Ke Wang , Wei Wang , Zheng Wen , Peihua Wang , Lei Liu , Dao Wen Wang Source Type: research

Activation of DNA demethylases attenuates aging ‐associated arterial stiffening and hypertension
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 16, 2018 Category: Cytology Authors: Kai Chen , Zhongjie Sun Source Type: research

Enhanced longevity and metabolism by brown adipose tissue with disruption of the regulator of G protein signaling 14
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 14, 2018 Category: Cytology Authors: Dorothy E. Vatner , Jie Zhang , Marko Oydanich , John Guers , Elena Katsyuba , Lin Yan , David Sinclair , Johan Auwerx , Stephen F. Vatner Source Type: research

Mice with reduced expression of the telomere ‐associated protein Ft1 develop p53‐sensitive progeroid traits
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 10, 2018 Category: Cytology Authors: Mattia La Torre , Chiara Merigliano , Romina Burla , Carla Mottini , Giorgia Zanetti , Simona Del Giudice , Mariateresa Carcuro , Ilaria Virdia , Elisabetta Bucciarelli , Isabella Manni , Gianluca Rampioni Vinciguerra , Giulia Piaggi Source Type: research

SUMO1 ‐conjugation is altered during normal aging but not by increased amyloid burden
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 7, 2018 Category: Cytology Authors: Trayana Stankova , Lars Piepkorn , Thomas A. Bayer , Olaf Jahn , Marilyn Tirard Source Type: research

Antileukotriene therapy by reducing tau phosphorylation improves synaptic integrity and cognition of P301S transgenic mice
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - April 1, 2018 Category: Cytology Source Type: research

Vascular smooth muscle cells direct extracellular dysregulation in aortic stiffening of hypertensive rats
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 30, 2018 Category: Cytology Source Type: research

Involvement of serum ‐derived exosomes of elderly patients with bone loss in failure of bone remodeling via alteration of exosomal bone‐related proteins
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 30, 2018 Category: Cytology Source Type: research

Circulating levels of monocyte chemoattractant protein ‐1 as a potential measure of biological age in mice and frailty in humans
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 29, 2018 Category: Cytology Source Type: research

nNOS –CAPON interaction mediates amyloid‐β‐induced neurotoxicity, especially in the early stages
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 25, 2018 Category: Cytology Source Type: research

The genetic component of human longevity: New insights from the analysis of pathway ‐based SNP‐SNP interactions
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 25, 2018 Category: Cytology Source Type: research

The effects of graded caloric restriction: XII. Comparison of mouse to human impact on cellular senescence in the colon
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 25, 2018 Category: Cytology Source Type: research

Genomewide mechanisms of chronological longevity by dietary restriction in budding yeast
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 25, 2018 Category: Cytology Source Type: research

Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 25, 2018 Category: Cytology Source Type: research

Increasing autophagy and blocking Nrf2 suppress laminopathy ‐induced age‐dependent cardiac dysfunction and shortened lifespan
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 25, 2018 Category: Cytology Source Type: research

Evidence that miR ‐146a attenuates aging‐ and trauma‐induced osteoarthritis by inhibiting Notch1, IL‐6, and IL‐1 mediated catabolism
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 24, 2018 Category: Cytology Source Type: research

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 24, 2018 Category: Cytology Source Type: research

The African turquoise killifish: A research organism to study vertebrate aging and diapause
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 24, 2018 Category: Cytology Source Type: research

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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 23, 2018 Category: Cytology Source Type: research

Profiling of m6A RNA modifications identified an age ‐associated regulation of AGO2 mRNA stability
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 23, 2018 Category: Cytology Source Type: research

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Aging Cell, Ahead of Print. (Source: Aging Cell)
Source: Aging Cell - March 23, 2018 Category: Cytology Source Type: research

Issue Information
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 13, 2018 Category: Cytology Source Type: research

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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 13, 2018 Category: Cytology Source Type: research

Issue Information
(Source: Aging Cell)
Source: Aging Cell - March 13, 2018 Category: Cytology Tags: ISSUE INFORMATION Source Type: research

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 8, 2018 Category: Cytology Source Type: research

Properties of the vastus lateralis muscle in relation to age and physiological function in master cyclists aged 55 –79 years
Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 8, 2018 Category: Cytology Source Type: research

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Aging Cell,Volume 17, Issue 2, April 2018. (Source: Aging Cell)
Source: Aging Cell - March 8, 2018 Category: Cytology Source Type: research

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood
Summary It is widely accepted that aging is accompanied by remodelling of the immune system including thymic atrophy and increased frequency of senescent T cells, leading to immune compromise. However, physical activity, which influences immunity but declines dramatically with age, is not considered in this literature. We assessed immune profiles in 125 adults (55–79 years) who had maintained a high level of physical activity (cycling) for much of their adult lives, 75 age‐matched older adults and 55 young adults not involved in regular exercise. The frequency of naïve T cells and recent thymic emigrants ...
Source: Aging Cell - March 8, 2018 Category: Cytology Authors: Niharika Arora Duggal, Ross D. Pollock, Norman R. Lazarus, Stephen Harridge, Janet M. Lord Tags: ORIGINAL ARTICLE Source Type: research

NHR ‐49/HNF4 integrates regulation of fatty acid metabolism with a protective transcriptional response to oxidative stress and fasting
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 5, 2018 Category: Cytology Source Type: research

Distinct chromatin signatures of DNA hypomethylation in aging and cancer
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 5, 2018 Category: Cytology Source Type: research

Molecular profiling of aged neural progenitors identifies Dbx2 as a candidate regulator of age ‐associated neurogenic decline
Aging Cell, EarlyView. (Source: Aging Cell)
Source: Aging Cell - March 5, 2018 Category: Cytology Source Type: research