Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline ( ≥3 points) on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Associatio n between cognitive decline and (i) bone loss was estimated using mixed-effects models; and (ii) fracture risk was estimated using adjusted Cox models. Over 95% of part...
Source: Journal of Bone and Mineral Research - July 21, 2021 Category: Orthopaedics Authors: Dana Bliuc, Thach Tran, Jonathan D. Adachi, Gerald J. Atkins, Claudie Berger, Joop Bergh, Roberto Cappai, John A. Eisman, Tineke Geel, Piet Geusens, David Goltzman, David A. Hanley, Robert Josse, Stephanie Kaiser, Christopher S. Kovacs, Lis Tags: Original Article Source Type: research

Remembering Dr John D Termine
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Authors: Ernesto Canalis, Pamela Gehron Robey, Marian F. Young, T. John Martin Tags: In Memoriam Source Type: research

Issue Information ‐Declaration of Helsinki
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Tags: Issue Information ‐Declaration of Helsinki Source Type: research

Ed Bd, Masthead, Comm List and TOC
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Tags: Issue Information Source Type: research

Journal of Bone and Mineral Research: Volume 36, Number 7, July 2021
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Tags: Cover Source Type: research

Durability and delayed treatment effects of zoledronic acid on bone loss after spinal cord injury: A randomized, controlled trial
The objective of this study was to examine the effects of timing and frequency of ZOL over 2  years. In this double-blind, placebo-controlled trial, we randomized 60 individuals with acute SCI (
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Authors: W. Brent Edwards, Ifaz T. Haider, Narina Simonian, Joana Barroso, Thomas J. Schnitzer Tags: Clinical Trial Source Type: research

Sites of Cre ‐recombinase activity in mouse lines targeting skeletal cells
ABSTRACTThe Cre/Lox system is a powerful tool in the biologist's toolbox, allowing loss and gain-of-function studies, as well as lineage tracing, through gene recombination in a tissue-specific and inducible manner. Evidence indicates, however, that Cre transgenic lines have a far more nuanced and broader pattern of Cre activity than initially thought, exhibiting “off-target” activity in tissues/cells other than the ones they were originally designed to target. With the goal of facilitating the comparison and selection of optimal Cre lines to be used for the study of gene function, we have summarized in a singl...
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Authors: Greig Couasnay, Maria ‐Bernadette Madel, Joohyun Lim, Brendan Lee, Florent Elefteriou Tags: Review Source Type: research

Osteal macrophages support osteoclast ‐mediated resorption and contribute to bone pathology in a postmenopausal osteoporosis mouse model
ABSTRACTOsteal macrophages (osteomacs) support osteoblast function and promote bone anabolism, but their contribution to osteoporosis has not been explored. While mouse ovariectomy (OVX) models have been repeatedly used, variation in strain, experimental design and assessment modalities, have contributed to no single model being confirmed as comprehensively replicating the full gamut of osteoporosis pathological manifestations. We validated an OVX model in adult C3H/HeJ mice and demonstrated that it presents with human post-menopausal osteoporosis features with reduced bone volume in axial and appendicular bone and bone lo...
Source: Journal of Bone and Mineral Research - July 19, 2021 Category: Orthopaedics Authors: Lena Batoon, Susan M. Millard, Liza J. Raggatt, Andy C. Wu, Simranpreet Kaur, Lucas W.H. Sun, Kyle Williams, Cheyenne Sandrock, Pei Ying Ng, Katharine M. Irvine, Michal Bartnikowski, Vaida Glatt, Nathan J. Pavlos, Allison R. Pettit Tags: Original Article Source Type: research

Early inhibition of subchondral bone remodeling slows load ‐induced posttraumatic osteoarthritis development in mice
ABSTRACTPosttraumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral bone remodeling. Inhibiting altered remodeling immediately following joint damage can slow PTOA progression. Clinically, however, inhibiting remodeling when significant joint damage is already present has minimal effects in slowing further disease progression. We sought to determine the treatment window following PTOA initiation in which inhibiting remodeling can attenuate progression of joint damage. We hypothesized that the most effective treatment would be to inhibit remodeling immediately after PTOA initiation. We used an ...
Source: Journal of Bone and Mineral Research - July 17, 2021 Category: Orthopaedics Authors: Sophia N. Ziemian, Ana M. Witkowski, Timothy M. Wright, Miguel Otero, Marjolein C. H. van der Meulen Tags: Original Article Source Type: research

Forkhead box P1 (Foxp1) in osteoblasts regulates bone mass accrual and adipose tissue energy metabolism
In this study, we observed that bone also acts as an important endocrine source for AdipoQ, and its capacity in osteoblasts is controlled by the forkhead box P1 (FOXP1) transcriptional factor. Deletion of theFoxp1 gene in osteoblasts led to augmentation of AdipoQ levels accompanied by fueled energy expenditure in adipose tissues. In contrast, overexpression ofFoxp1 in bones impaired AdipoQ secretion and restrained energy consumption. Chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed thatAdipoQ expression, which increases as a function of bone age, is directly controlled by FOXP1. Our results indicate th...
Source: Journal of Bone and Mineral Research - July 8, 2021 Category: Orthopaedics Authors: Wei Zhang, Pei Liu, Shifeng Ling, Fuhua Wang, Shaojiao Wang, Tienan Chen, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Jiqiu Wang, Haley O. Tucker, Xizhi Guo Tags: Original Article Source Type: research

Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 5, 2021 Category: Orthopaedics Authors: David Cheishvili, Surabhi Parashar, Niaz Mahmood, Ani Arakelian, Richard Kremer, David Goltzman, Moshe Szyf, Shafaat A Rabbani Tags: ERRATUM Source Type: research

Notum deletion from late ‐stage skeletal cells increases cortical bone formation and potentiates skeletal effects of sclerostin inhibition
ABSTRACTWnt signaling plays a vital role in the cell biology of skeletal patterning, differentiation, and maintenance. Notum is a secreted member of the α/β-hydrolase superfamily that hydrolyzes the palmitoleoylate modification on Wnt proteins, thereby disrupting Wnt signaling. As a secreted inhibitor of Wnt, Notum presents an attractive molecular target for improving skeletal health. To determine the cell type of action for Notum's effect on the skeleton, we generated mice with Notum deficiency globally (Notum−/−) and selectively (Notumf/f) in limb bud mesenchyme (Prx1-Cre) and late osteoblasts/oste...
Source: Journal of Bone and Mineral Research - July 5, 2021 Category: Orthopaedics Authors: Roy B. Choi, Whitney A. Bullock, April M. Hoggatt, Daniel J. Horan, Emily Z. Pemberton, Jung Min Hong, Xinjun Zhang, Xi He, Alexander G. Robling Tags: Original Article Source Type: research

The diverse origin of bone ‐forming osteoblasts
AbstractOsteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the most important functions of these metabolically active cells is mineralized matrix production. As osteoblasts have a limited lifespan, they must be constantly replenished by pre-osteoblasts, their immediate precursors. As disruption of the regulation of bone-forming osteoblasts results in a variety of bone diseases, a better understanding of the origin of these cells by defining the mechanisms of bone development, remodeling, regeneration is central to the development of novel therapeutic approaches. In recent years, substan...
Source: Journal of Bone and Mineral Research - July 3, 2021 Category: Orthopaedics Authors: Toshihide Mizoguchi, Noriaki Ono Tags: Review Source Type: research

Remembering Dr. John D. Termine
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 1, 2021 Category: Orthopaedics Authors: Ernesto Canalis, Pamela Gehron Robey, Marian F. Young, T. John Martin Tags: In Memoriam Source Type: research

Dmp1Cre ‐directed knockdown of parathyroid hormone–related protein (PTHrP) in murine decidua is associated with a life‐long increase in bone mass, width, and strength in male progeny
We report here that this outcome depends on parental genotype. In contrast to our previous report using mice bred from heterozygous (flox/wild type)Dmp1Cre.Pthlhf/w parents, adult (16-week-old and 26-week-old) flox/flox (f/f)Dmp1Cre.Pthlhf/f mice from homozygous parents (Dmp1Cre.Pthlhf/f(hom)) have stronger bones, with 40% more trabecular bone mass and 30% greater femoral width than controls. This greater bone size was observed inDmp1Cre.Pthlhf/f(hom) mice as early as 12  days of age, when greater bone width was also found in male and femaleDmp1Cre.Pthlhf/f(hom) mice compared to controls, but not in gene-matched mic...
Source: Journal of Bone and Mineral Research - July 1, 2021 Category: Orthopaedics Authors: Niloufar Ansari, Tsuyoshi Isojima, Blessing Crimeen ‐Irwin, Ingrid J. Poulton, Narelle E. McGregor, Patricia W. M. Ho, Mark R. Forwood, Christopher S. Kovacs, Evdokia Dimitriadis, Jonathan H. Gooi, T. John Martin, Natalie A. Sims Tags: Original Article Source Type: research

Romosozumab Improves Lumbar Spine Bone Mass and Bone Strength Parameters Relative to Alendronate in Postmenopausal Women: Results From the ARCH Trial
ABSTRACTThe ARCH trial (NCT01631214) showed that romosozumab for 1  year followed by alendronate led to larger areal BMD (aBMD) gains and superior fracture risk reduction versus alendronate alone. aBMD correlates with bone strength but does not capture all determinants of bone strength that might be differentially affected by various osteoporosis therapeutic agen ts. We therefore used QCT and finite element analysis (FEA) to assess changes in lumbar spine volumetric BMD (vBMD), bone volume, bone mineral content (BMC), and bone strength with romosozumab versus alendronate in a subset of ARCH patients.In ARCH, 4093 po...
Source: Journal of Bone and Mineral Research - June 30, 2021 Category: Orthopaedics Authors: Jacques P. Brown, Klaus Engelke, Tony M. Keaveny, Arkadi Chines, Roland Chapurlat, A. Joseph Foldes, Xavier Nogues, Roberto Civitelli, Tobias De Villiers, Fabio Massari, Cristiano A. F. Zerbini, Zhenxun Wang, Mary K. Oates, Christopher Reckno Tags: Original Article Source Type: research

Association of sleep traits and heel bone mineral density: Observational and Mendelian randomization studies
This study aimed to 1) replicate the findings by examining observational association of sleep traits with low eBMD; 2) examine whether these associations were causal by using mendelian randomization (MR) analyses, and 3) investigate potential modulation effects of sex and menopause. 398,137 White British subjects (aged 39-73y) with valid BMD estimated by quantitative ultrasound of the heel (eBMD) at baseline were included. Linear regression analyses and inverse-variance weighted method were used as main methods for observational and one-sample MR analyses respectively, to investigate the associations between self-reported ...
Source: Journal of Bone and Mineral Research - June 30, 2021 Category: Orthopaedics Authors: Jie Chen, Jihui Zhang, Hon ‐Cheong So, Sizhi Ai, Ningjian Wang, Xiao Tan, Yun‐Kwok Wing Tags: Original Article Source Type: research

Runt ‐related transcription factor‐2 (Runx2) is required for bone matrix protein gene expression in committed osteoblasts in mice
This study demonstrated that Runx2 is required for the expression of the major bone matrix protein genes andTnfsf11 after commitment into osteoblasts in mice. © 2021 American Society for Bone and Mineral Research (ASBMR). (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 28, 2021 Category: Orthopaedics Authors: Xin Qin, Qing Jiang, Hisato Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori Tags: Original Article Source Type: research

Molecular and cellular mechanisms of delayed fracture healing in Mmp10 (Stromelysin 2) knockout mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 26, 2021 Category: Orthopaedics Authors: Jos é Valdés‐Fernández, Tania López‐Martínez, Purificación Ripalda‐Cemboráin, Isabel A. Calvo, Borja Sáez, Juan Antonio Romero‐Torrecilla, Javier Aldazabal, Emma Muiños‐López, Verónica Montiel, Josune Orbe, José Antonio Rod Tags: Original Article Source Type: research

Serum 25 ‐hydroxyvitamin D is associated with fracture risk only during periods of seasonally high levels in women with a high BMI
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 26, 2021 Category: Orthopaedics Authors: Karl Micha ëlsson, Liisa Byberg, Bodil Svennblad, Susanna C Larsson, John A Baron, Håkan Melhus Tags: Original Article Source Type: research

A Functional Three ‐Dimensional Microphysiological Human Model of Myeloma Bone Disease
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 26, 2021 Category: Orthopaedics Authors: Richard J. Visconti, Kyle Kolaja, Jessica Cottrell Tags: Original Article Source Type: research

Disruption of Jmjd3/p16Ink4a signaling pathway causes bizarre parosteal osteochondromatous proliferation (BPOP) ‐like lesion in mice
ABSTRACTBizarre parosteal osteochondromatous proliferation (BPOP), or Nora's lesion, is a rare benign osteochondromatous lesion. To the present, the molecular aetiology of BPOP remains unclear. JMJD3(KDM6B) is an H3K27me3 demethylase and counteracts polycomb-mediated transcription repression. Previously, Jmjd3 was showed to be critical for bone development and osteoarthritis. Here, we reported that conditional deletion of Jmjd3 in chondrogenic cells unexpectively resulted in BPOP-like lesion in mice. Biochemical investigations revealed that Jmjd3 inhibited BPOP-like lesion through p16Ink4a. Immunohistochemistry and RT-qPCR...
Source: Journal of Bone and Mineral Research - June 26, 2021 Category: Orthopaedics Authors: Feng Zhang, Yingmei Wang, Yuying Wang, Xinli Wang, Dawei Zhang, Xiong Zhao, Runmin Jiang, Yu Gu, Guifang Yang, Xin Fu, Longyong Xu, Longxia Xu, Liting Zheng, Jing Zhang, Zengshan Li, Qingguo Yan, Jianguo Shi, Albert Roessner, Zhe Wang, Tags: Original Article Source Type: research

Bariatric surgery increases the rate of major fracture: self controlled case series study in UK Clinical Practice Research Datalink
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 26, 2021 Category: Orthopaedics Authors: Danielle E Robinson, Ian Douglas, Garry D Tan, Antonella Delmestri, Andrew Judge, Cyrus Cooper, M Kassim Javaid, Victoria Y Strauss, Daniel Prieto ‐Alhambra Tags: Original Article Source Type: research

Individualized Bone ‐Protective Management in Long‐Term Cancer Survivors With Bone Metastases
ABSTRACTAntiresorptive therapy is an important component of a multimodal approach to treating patients with advanced malignancies and metastatic bone disease. Over the past decade, overall survival of affected patients has improved in most cancer entities, and long-term disease control is a realistic goal in many cases. There are emerging clinical studies showing the benefits of an initial antiresorptive therapy using bisphosphonates or denosumab. However, some adverse events of these therapies, such as osteonecrosis of the jaw, correlate with the cumulative doses given, and there is an increasing clinical need for new ant...
Source: Journal of Bone and Mineral Research - June 25, 2021 Category: Orthopaedics Authors: Tilman D Rachner, Robert Coleman, Peyman Hadji, Lorenz C Hofbauer Tags: Review Source Type: research

Discoidin Receptor 2 Controls Bone Formation and Marrow Adipogenesis
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 25, 2021 Category: Orthopaedics Authors: Chunxi Ge, Zhengyan Wang, Guisheng Zhao, Binbin Li, Jinhui Liao, Hanshi Sun, Renny T Franceschi Tags: Erratum Source Type: research

Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use
ABSTRACTAdolescent idiopathic scoliosis (AIS) is a common disease causing three-dimensional spinal deformity in as many as 3% of adolescents. Development of a method that can accurately predict the onset and progression of AIS is an immediate need for clinical practice. Because the heritability of AIS is estimated as high as 87.5% in twin studies, prediction of its onset and progression based on genetic data is a promising option. We show the usefulness of polygenic risk score (PRS) for the prediction of onset and progression of AIS. We used AIS genomewide association study (GWAS) data comprising 79,211 subjects in three c...
Source: Journal of Bone and Mineral Research - June 23, 2021 Category: Orthopaedics Authors: Nao Otomo, Hsing ‐Fang Lu, Masaru Koido, Ikuyo Kou, Kazuki Takeda, Yukihide Momozawa, Michiaki Kubo, Yoichiro Kamatani, Yoji Ogura, Yohei Takahashi, Masahiro Nakajima, Shohei Minami, Koki Uno, Noriaki Kawakami, Manabu Ito, Tatsuya Sato, Tags: Original Article Source Type: research

Nitrogen ‐containing bisphosphonates and lipopolysaccharide mutually augment inflammation via adenosine triphosphate (ATP)‐mediated and interleukin 1β (IL‐1β)‐mediated production of neutrophil extracellular traps (NETs)
ABSTRACTAmong the bisphosphonates (BPs), nitrogen-containing BPs (N-BPs) have much stronger anti –bone-resorptive actions than non-N–BPs. However, N-BPs have various side effects such as acute influenza-like reactions after their initial administration and osteonecrosis of the jawbones after repeated administration. The mechanisms underlying such effects remain unclear. To overcome these pr oblems, it is important to profile the inflammatory nature of N-BPs. Here, we analyzed the inflammatory reactions induced in mouse ear pinnae by the N-BPs alendronate (Ale) and zoledronate (Zol). We found the following: (i) ...
Source: Journal of Bone and Mineral Research - June 22, 2021 Category: Orthopaedics Authors: Kanan Bando, Toshinobu Kuroishi, Hiroyuki Tada, Takefumi Oizumi, Yukinori Tanaka, Tetsu Takahashi, Itaru Mizoguchi, Shunji Sugawara, Yasuo Endo Tags: Original Article Source Type: research

Erratum for Identification of an Epigenetic Signature of Osteoporosis in Blood DNA of Postmenopausal Women
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 22, 2021 Category: Orthopaedics Authors: Jessica Downey Tags: Erratum Source Type: research

Only the co ‐transcriptional activity of β‐catenin is required for the local regulatory effects in hypertrophic chondrocytes on developmental bone modeling
ABSTRACTIn hypertrophic chondrocytes, β-catenin has two roles. First, it locally suppresses the differentiation of osteoclasts at the chondro-osseous junction by maintaining the pro-osteoclastic factor RANKL at low levels. Secondly, it promotes the differentiation of osteoblast-precursors from chondrocytes. Yet, β-catenin is a dual-fu nction protein, which can either participate in cell–cell adherens junctions or serve as a transcriptional co-activator in canonical Wnt signaling interacting with TCF/LEF transcription factors. Hence, whenever studying tissue-specific requirements of β-catenin using a co...
Source: Journal of Bone and Mineral Research - June 22, 2021 Category: Orthopaedics Authors: Lena I. Wolff, Astrid Houben, Christine Fabritius, Melinda Angus ‐Hill, Konrad Basler, Christine Hartmann Tags: Original Article Source Type: research

Early inhibition of subchondral bone remodeling slows load ‐induced post‐traumatic osteoarthritis development in mice
ABSTRACTPost-traumatic osteoarthritis (PTOA) is associated with abnormal and increased subchondral bone remodeling. Inhibiting altered remodeling immediately following joint damage can slow PTOA progression. Clinically, however, inhibiting remodeling when significant joint damage is already present has minimal effects in slowing further disease progression. We sought to determine the treatment window following PTOA initiation in which inhibiting remodeling can attenuate progression of joint damage. We hypothesized that the most effective treatment would be to inhibit remodeling immediately after PTOA initiation. We used an...
Source: Journal of Bone and Mineral Research - June 22, 2021 Category: Orthopaedics Authors: Sophia N. Ziemian, Ana Witkowski, Timothy M Wright, Miguel Otero, Marjolein C. H. Meulen Tags: Original Article Source Type: research

Rictor is a novel regulator of TRAF6/TRAF3 in osteoclasts
ABSTRACTTumor necrosis factor receptor-associated factors (TRAFs) are crucial for receptor activator of nuclear factor- κB (RANK) activation in osteoclasts. However, the upstream mechanisms of TRAF members in the osteoclastic lineage remain largely unknown. Here, we demonstrated that Rictor, a key component of mechanistic target of rapamycin complex 2 (mTORC2), was crucial for TRAF6/TRAF3 expression in osteoclasts. Ourex vivo andin vivo studies showed that Rictor ablation from the osteoclastic lineage reduced osteoclast numbers and increased bone mass in mice. Mechanistically, we found that Rictor ablation restricted...
Source: Journal of Bone and Mineral Research - June 22, 2021 Category: Orthopaedics Authors: Song Xu, Shihai Li, Xianming Liu, Kang Tan, Jiahuan Zhang, Kai Li, Xiaochun Bai, Yue Zhang Tags: Original Article Source Type: research

Inhibition of ACLY leads to suppression of osteoclast differentiation and function via regulation of histone acetylation
AbstractATP citrate lyase (ACLY), generating most of the nucleocytosolic acetyl coenzyme A (acetyl-CoA) for histone acetylation, links cell metabolism to epigenetic regulation. Recent investigations demonstrated that ACLY activated by metabolic reprogramming played an essential role in both M1 and M2 macrophage activation via histone acetylation, previous studies also revealed that histone methylation and acetylation were critical for transcriptional regulation of osteoclast-specific genes. Considering that osteoclast differentiation also undergoes metabolic reprogramming and the activity of ACLY is always Akt-dependent, w...
Source: Journal of Bone and Mineral Research - June 22, 2021 Category: Orthopaedics Authors: Qian Guo, Honglei Kang, Jia Wang, Yimin Dong, Renpeng Peng, Hongjian Zhao, Wei Wu, Hanfeng Guan, Feng Li Tags: Original Article Source Type: research

Systematic review of major osteoporotic fracture to hip fracture incidence rate ratios worldwide: Implications to FRAX derived estimates
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 21, 2021 Category: Orthopaedics Authors: Marlene Chakhtoura, H Dagher, S Sharara, S Ajjour, JA Cauley, Z Mahfoud, R Boudreau, Ghada El Hajj Fuleihan Tags: Original Article Source Type: research

Issue Information ‐Declaration of Helsinki
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Tags: Issue Information ‐Declaration of Helsinki Source Type: research

Ed Bd, Masthead, Comm List and TOC
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Tags: Issue Information Source Type: research

Journal of Bone and Mineral Research: Volume 36, Number 6, June 2021
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Tags: Cover Source Type: research

Individualized bone protective management in long ‐term cancer survivors with bone metastases
AbstractAntiresorptive therapy is an important component of a multimodal approach to treating patients with advanced malignancies and metastatic bone disease. Over the past decade, overall survival of affected patients has improved in most cancer entities, and long-term disease control is a realistic goal in many cases. There are emerging clinical studies showing the benefits of an initial antiresorptive therapy using bisphosphonates or denosumab. However, some adverse events of these therapies, such as osteonecrosis of the jaw, correlate with the cumulative doses given, and there is an increasing clinical need for new ant...
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Authors: Tilman D. Rachner, Robert Coleman, Peyman Hadji, Lorenz C. Hofbauer Tags: Review Source Type: research

Monitoring Osteoporosis Therapy
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Authors: Ian R Reid Tags: Editorial Source Type: research

Vitamin D: good or bad for muscle strength?
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Authors: Roger Bouillon Tags: Editorial Source Type: research

Foxp1 in osteoblasts regulates bone mass accrual and adipose tissue energy metabolism
In this study, we observed that bone also acts as an important endocrine source for AdipoQ, and its capacity in osteoblasts is controlled by the FOXP1 transcriptional factor. Deletion of theFoxp1 gene in osteoblasts led to augmentation of AdipoQ levels accompanied by fueled energy expenditure in adipose tissues. In contrast, overexpression ofFoxp1 in bones impaired AdipoQ secretion and restrained energy consumption. ChIP-seq analysis revealed thatAdipoQ expression, which increases as a function of bone age, is directly controlled by FOXP1. Our results indicate that bones, especially aged bones, provide an important source ...
Source: Journal of Bone and Mineral Research - June 16, 2021 Category: Orthopaedics Authors: Wei Zhang, Pei Liu, Shifeng Ling, Fuhua Wang, Shaojiao Wang, Tienan Chen, Rujiang Zhou, Xuechun Xia, Zhengju Yao, Ying Fan, Niansong Wang, Jiqiu Wang, Haley O. Tucker, Xizhi Guo Tags: Original Article Source Type: research

Re: “Hip Fracture and Mortality: A Loss of Life Expectancy Interpretation” by Thao T Ho‐Le and Tuan V Nguyen
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 12, 2021 Category: Orthopaedics Authors: Cecilie Dahl, Kristin Holvik, Haakon E Meyer, Hein Stigum, Siri M Solbakken, Berit Schei, Anne ‐Johanne Søgaard, Tone Kristin Omsland Tags: REPLY LETTER TO THE EDITOR Source Type: research

Erythropoietin in dialysis: blood, bones, and hormones
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 10, 2021 Category: Orthopaedics Authors: Navdeep Tangri, William D. Leslie Tags: Editorial Source Type: research

Birth weight is positively associated with adult osteoporosis risk: observational and Mendelian randomization studies
ABSTRACTThe relationship between birth weight and osteoporosis was inconsistent in previous observational studies. Therefore, we performed a systematic evaluation to determine the inconsistent relationship and further make causal inference based on the UK Biobank datasets (~500,000 individuals) and individual/summary-level genetic datasets. Observational analyses found consistent negative associations either between birth weight and estimated bone mineral density (eBMD) or between genetic risk score (GRS) of birth weight and eBMD in total subjects, and sex-stratified subgroups. Mediation analyses detected significant media...
Source: Journal of Bone and Mineral Research - June 10, 2021 Category: Orthopaedics Authors: Xing ‐Hao Yu, Yong‐Yue Wei, Ping Zeng, Shu‐Feng Lei Tags: Original Article Source Type: research

Runx2 is required for bone matrix protein gene expression in committed osteoblasts in mice
This study demonstrated that Runx2 is required for the expression of the major bone matrix protein genes andTnfsf11 after commitment into osteoblasts in mice.This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 9, 2021 Category: Orthopaedics Authors: Xin Qin, Qing Jiang, Hisato Komori, Chiharu Sakane, Ryo Fukuyama, Yuki Matsuo, Kosei Ito, Toshihiro Miyazaki, Toshihisa Komori Tags: Original Article Source Type: research

Anabolic actions of PTH in murine models: Two decades of insights
ABSTRACTParathyroid hormone (PTH) is produced by the parathyroid glands in response to low serum calcium concentrations where it targets bones, kidneys, and indirectly, intestines. The N-terminus of PTH has been investigated for decades for its ability to stimulate bone formation when administered intermittently (iPTH) and is used clinically as an effective anabolic agent for the treatment of osteoporosis. Despite great interest in iPTH and its clinical use, the mechanisms of PTH action remain complicated and not fully defined. More than 70 gene targets in more than 90 murine models have been utilized to better understand ...
Source: Journal of Bone and Mineral Research - June 8, 2021 Category: Orthopaedics Authors: Laura E. Zweifler, Amy J. Koh, Stephanie Daignault ‐Newton, Laurie K. McCauley Tags: Original Article Source Type: research

Dmp1Cre ‐directed knockdown of PTHrP in murine decidua is associated with a life‐long increase in bone mass, width, and strength in male progeny
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 8, 2021 Category: Orthopaedics Authors: Niloufar Ansari, Tsuyoshi Isojima, Blessing Crimeen ‐Irwin, Ingrid J Poulton, Narelle E. McGregor, Patricia W. M. Ho, Mark R. Forwood, Christopher S Kovacs, Evdokia Dimitriadis, Jonathan H Gooi, T. John Martin, Natalie A. Sims Tags: Original Article Source Type: research