Association between abdominal aortic calcification, bone mineral density and fracture in older women
In conclusion, older women with more marked AAC are at higher risk of fracture, not completely captured by bone structural predictors. These findings further support the concept that vascular calcification and bone pathology may share similar mechanisms of causation that remain to be fully elucidated.This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 16, 2019 Category: Orthopaedics Authors: Joshua R. Lewis, Celeste J. Eggermont, John T. Schousboe, Wai H. Lim, Germaine Wong, Ben Khoo, Marc Sim, MingXiang Yu, Thor Ueland, Jens Bollerslev, Jonathan M Hodgson, Kun Zhu, Kevin E. Wilson, Douglas P. Kiel, Richard L. Prince Tags: Original Article Source Type: research

Pamidronate Administration during Pregnancy and Lactation Induces Temporal Preservation of Maternal Bone Mass in a Mouse Model of Osteogenesis Imperfecta
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 16, 2019 Category: Orthopaedics Authors: Diana Olvera, Rachel Stolzenfeld, Emily Fisher, Bonnie Nolan, Michelle S. Caird, Kenneth M. Kozloff Tags: Original Article Source Type: research

Post ‐Fracture Risk Assessment: Target Central Sited Fractures First! A Sub‐Study of NoFRACT
The objectives of this cross‐sectional study were therefore to explore potential differences between central (vertebrae, hip, proximal humerus, pelvis) and peripheral (forearm, ankle, other) fractures. This sub‐study of the Norwegian Capture the Fracture Initiative (NoFRACT) included 495 women and 119 men ≥ 50 years with fragility fractures. They had bone mineral density (BMD) of the fe moral neck, total hip and lumbar spine assessed using dual energy x‐ray absorptiometry, trabecular bone score (TBS) calculated, concomitantly vertebral fracture assessment (VFA) with semiquantitative grading of vertebral fractures ...
Source: Journal of Bone and Mineral Research - July 16, 2019 Category: Orthopaedics Authors: Tove T Borgen, Åshild Bjørnerem, Lene B Solberg, Camilla Andreasen, Cathrine Brunborg, May‐Britt Stenbro, Lars M Hübschle, Anne Froholdt, Wender Figved, Ellen M Apalset, Jan‐Erik Gjertsen, Trude Basso, Ida Lund, Ann K Hansen, Jens‐Me Tags: Original Article Source Type: research

The Unmixing Problem: A Guide to Applying Single ‐Cell RNA Sequencing to Bone
ABSTRACTBone is composed of a complex mixture of many dynamic cell types. Flow cytometry and in vivo lineage tracing have offered early progress toward deconvoluting this heterogeneous mixture of cells into functionally well ‐defined populations suitable for further studies. Single‐cell sequencing is poised as a key complementary technique to better understand the cellular basis of bone metabolism and development. However, single‐cell sequencing approaches still have important limitations, including transcriptiona l effects of cell isolation and sparse sampling of the transcriptome, that must be considered during exp...
Source: Journal of Bone and Mineral Research - July 15, 2019 Category: Orthopaedics Authors: Matthew B Greenblatt, Noriaki Ono, Ugur M Ayturk, Shawon Debnath, Sarfaraz Lalani Tags: Review Source Type: research

Journal of Bone and Mineral Research: Volume 34, Number 7, July 2019
Journal of Bone and Mineral Research, Volume 34, Issue 7, Page C1-C1, July 2019. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 15, 2019 Category: Orthopaedics Tags: Cover Source Type: research

Issue Information ‐Declaration of Helsinki
Journal of Bone and Mineral Research, Volume 34, Issue 7, Page BMi-BMii, July 2019. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 15, 2019 Category: Orthopaedics Tags: Issue Information ‐Declaration of Helsinki Source Type: research

Ed Bd, Masthead, Comm List and TOC
Journal of Bone and Mineral Research, Volume 34, Issue 7, Page FMi-FMv, July 2019. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 15, 2019 Category: Orthopaedics Tags: Issue Information Source Type: research

Overestimation of the Limitations of Randomized Controlled Trials
Journal of Bone and Mineral Research, EarlyView. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 11, 2019 Category: Orthopaedics Authors: Jonathan Bergman, Anna Nordstr öm, Peter Nordström Tags: Letter to the Editor Source Type: research

Complementarity of Cohort Studies and Randomized Controlled Trials
Journal of Bone and Mineral Research, EarlyView. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 11, 2019 Category: Orthopaedics Authors: John A Eisman, Piet Geusens, Joop van den Bergh Tags: Reply Letter to the Editor Source Type: research

Absence of Dipeptidyl Peptidase 3 increases oxidative stress and causes bone loss
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 11, 2019 Category: Orthopaedics Authors: Ciro Menale, Lisa J Robinson, Eleonora Palagano, Rosita Rigoni, Marco Erreni, Alejandro J Almarza, Dario Strina, Stefano Mantero, Michela Lizier, Antonella Forlino, Roberta Besio, Marta Monari, Paolo Vezzoni, Barbara Cassani, Harry C Blair, Tags: Original Article Source Type: research

RANKL ‐inhibition in Fibrous Dysplasia of bone: A preclinical study in a mouse model of the human disease
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 11, 2019 Category: Orthopaedics Authors: Biagio Palmisano, Emanuela Spica, Cristina Remoli, Rossella Labella, Annamaria Di Filippo, Samantha Donsante, Fabiano Bini, Domenico Raimondo, Franco Marinozzi, Alan Boyde, Pamela Robey, Alessandro Corsi, Mara Riminucci Tags: Original Article Source Type: research

Design and Preclinical Development of TransCon PTH, an Investigational Sustained ‐Release PTH Replacement Therapy for Hypoparathyroidism
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 10, 2019 Category: Orthopaedics Authors: Lars Holten ‐Andersen, Susanne Pihl, Caroline E. Rasmussen, Joachim Zettler, Guillaume Maitro, Julia Baron, Stefan Heinig, Eric Hoffmann, Thomas Wegge, Mathias Krusch, Frank Faltinger, Steffen Killian, Kennett Sprogoe, David B. Karpf, Vibe Tags: Original Article Source Type: research

Denosumab improves glomerular filtration rate in osteoporotic patients with normal kidney function by lowering serum phosphorus
AbstractHigher serum phosphorus (Pi) increases the risk for chronic kidney disease (CKD). It was reported that a single administration of denosumab or zoledronate significantly suppressed serum Pi levels as well as those of bone resorption markers in serum. Also, previous evidences suggest a link between bone anti ‐resorptive therapy and vasoprotective/renoprotective effects through mechanisms that remain unexplored. The aim of this study is to assess the renoprotective effect of denosumab and involvement of denosumab‐induced reduction in serum Pi in osteoporotic patients. Osteoporotic patients (n=73) wit hout overt pr...
Source: Journal of Bone and Mineral Research - July 5, 2019 Category: Orthopaedics Authors: Daichi Miyaoka, Masaaki Inaba, Yasuo Imanishi, Noriyuki Hayashi, Masaya Ohara, Yuki Nagata, Masafumi Kurajoh, Shinsuke Yamada, Katsuhito Mori, Masanori Emoto Tags: ORIGINAL ARTICLE Source Type: research

Poor Vitamin K Status in Chronic Kidney Disease: An Indirect Indicator of Hip Fragility
Journal of Bone and Mineral Research, EarlyView. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 3, 2019 Category: Orthopaedics Authors: Toshihiro Sugiyama Tags: Letter to the Editor Source Type: research

Glycemic control and insulin treatment alter fracture risk in older men with type 2 diabetes mellitus
ABSTRACTDiabetes mellitus among older men has been associated with increased bone mineral density, but paradoxically increased fracture risk. Given the interactions among medication treatment, glycemic control, and diabetes ‐associated comorbidities, the relative effects of each factor remains unclear. This retrospective study includes 652,901 male Veterans age ≥65 years with diabetes and baseline hemoglobin A1c (HbA1c) value. All subjects received primary care in the Veterans Health Administration (VHA) from 2000 to 2010. Administrative data included ICD9 diagnoses and pharmacy records, and was linked to Medicare fee...
Source: Journal of Bone and Mineral Research - July 3, 2019 Category: Orthopaedics Authors: Richard H. Lee, Richard Sloane, Carl Pieper, Kenneth W. Lyles, Robert A. Adler, Courtney Houtven, Joanne LaFleur, Cathleen Col ón‐Emeric Tags: ORIGINAL ARTICLE Source Type: research

Regulation of the bone vascular network is sexually dimorphic
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 3, 2019 Category: Orthopaedics Authors: Alice Goring, Aikta Sharma, Behzad Javaheri, Rosanna CG Smith, Janos M Kanczler, Alan Boyde, Eric Hesse, Sumeet Mahajan, Bjorn R Olsen, Andrew A Pitsillides, Philipp Schneider, Richard OC Oreffo, Claire E Clarkin Tags: ORIGINAL ARTICLE Source Type: research

Treatment of Human Immunodeficiency Virus Infection With Tenofovir Disoproxil Fumarate –Containing Antiretrovirals Maintains Low Bone Formation Rate, But Increases Osteoid Volume on Bone Histomorphometry
We examined relationships between calciotropic hormones, urinary phosphate excretion, pro‐inflammatory and pro‐resorptive cytokines, and bone remodeling‐related proteins with changes in BMD and histomorphometry. Mean age was 29.6 ± 5.5 years , with mean CD4 + T cell count of 473 ± 196 cells/mm3. At baseline, decreased bone formation rate and increased mineralization lag time were identified in 16 (80%) and 12 (60%) patients, respectively. After 12 months, we detected a 2% to 3% decrease in lumbar spine and hip BMD by DXA. By histomorphometry, we observed no chan...
Source: Journal of Bone and Mineral Research - July 3, 2019 Category: Orthopaedics Authors: Janaina Ramalho, Carolina Steller Wagner Martins, Juliana Galv ão, Luzia N Furukawa, Wagner V Domingues, Ivone B Oliveira, Luciene M dos Reis, Rosa MR Pereira, Thomas L Nickolas, Michael T Yin, Margareth Eira, Vanda Jorgetti, Rosa MA Moyses Tags: Original Article Source Type: research

Journal of Bone and Mineral Research: Volume 34, Number 6, June 2019
Journal of Bone and Mineral Research, Volume 34, Issue 6, Page C1-C1, June 2019. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 1, 2019 Category: Orthopaedics Tags: Cover Source Type: research

Issue Information ‐Declaration of Helsinki
Journal of Bone and Mineral Research, Volume 34, Issue 6, Page BMi-BMii, June 2019. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 1, 2019 Category: Orthopaedics Tags: Issue Information ‐Declaration of Helsinki Source Type: research

Ed Bd, Masthead, Comm List and TOC
Journal of Bone and Mineral Research, Volume 34, Issue 6, Page FMi-FMv, June 2019. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - July 1, 2019 Category: Orthopaedics Tags: Issue Information Source Type: research

Conditional Activation of NF ‐κB Inducing Kinase (NIK) in the Osteolineage Enhances both Basal and Loading‐Induced Bone Formation
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 27, 2019 Category: Orthopaedics Authors: Jennifer L. Davis, Linda Cox, Christine Shao, Cheng Lyu, Shaopeng Liu, Rajeev Aurora, Deborah J. Veis Tags: ORIGINAL ARTICLE Source Type: research

Nerves in bone: evolving concepts in pain and anabolism
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 27, 2019 Category: Orthopaedics Authors: Jennifer M. Brazill, Alec T. Beeve, Clarissa S. Craft, Jason J. Ivanusic, Erica L. Scheller Tags: REVIEW Source Type: research

Rmrp mutation disrupts chondrogenesis and bone ossification in zebrafish model of cartilage ‐hair hypoplasia via enhanced Wnt/β‐catenin signaling
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 25, 2019 Category: Orthopaedics Authors: Xianding Sun, Ruobin Zhang, Mi Liu, Hangang Chen, Liang Chen, Fengtao Luo, Dali Zhang, Junlan Huang, Fangfang Li, Zhenhong Ni, Huabing Qi, Nan Su, Min Jin, Jing Yang, Qiaoyan Tan, Xiaolan Du, Bo Chen, Haiyang Huang, Shuai Chen, Liangjun Tags: ORIGINAL ARTICLE Source Type: research

Pain at multiple sites is associated with prevalent and incident fractures in older adults
This study aimed to describe the associations of number of painful sites with prevalent and incident fractures. Data from a longitudinal population‐based study of older adults (mean age 63 years) were util ised. Follow‐up was performed at 2.6, 5.1 and 10.7 years later, respectively. Presence/absence of pain at the neck, back, hands, shoulders, hips, knees and feet was assessed by questionnaire at baseline. Participants were classified into three groups according to the total number of painful sites (0‐2, 3‐4 and 5‐7 painful sites). Fractures were self‐reported at each time‐point. Bone mineral density (BMD) wa...
Source: Journal of Bone and Mineral Research - June 25, 2019 Category: Orthopaedics Authors: Feng Pan, Jing Tian, Dawn Aitken, Flavia Cicuttini, Graeme Jones Tags: ORIGINAL ARTICLE Source Type: research

A Lot of Progress, with More to Be Done: A Response to NIH Pathways to Prevention Report “Research Gaps for Long‐Term Drug Therapies for Osteoporotic Fracture Prevention”
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 25, 2019 Category: Orthopaedics Authors: Benjamin Z. Leder, Bart L. Clarke, Elizabeth Shane, Sundeep Khosla, Douglas P. Kiel Tags: PERSPECTIVE Source Type: research

Bone ‐Forming and Antiresorptive Effects of Romosozumab in Postmenopausal Women With Osteoporosis: Bone Histomorphometry and Microcomputed Tomography Analysis After 2 and 12 Months of Treatment
ABSTRACTSclerostin, a protein produced by osteocytes, inhibits bone formation. Administration of sclerostin antibody results in increased bone formation in multiple animal models. Romosozumab, a humanized sclerostin antibody, has a dual effect on bone, transiently increasing serum biochemical markers of bone formation and decreasing serum markers of bone resorption, leading to increased BMD and reduction in fracture risk in humans. We aimed to evaluate the effects of romosozumab on bone tissue. In a subset of 107 postmenopausal women with osteoporosis in the multicenter, international, randomized, double ‐blind, placebo...
Source: Journal of Bone and Mineral Research - June 24, 2019 Category: Orthopaedics Authors: Pascale Chavassieux, Roland Chapurlat, Nathalie Portero ‐Muzy, Jean‐Paul Roux, Pedro Garcia, Jacques P Brown, Cesar Libanati, Rogely W Boyce, Andrea Wang, Andreas Grauer Tags: ORIGINAL ARTICLE Source Type: research

Low vitamin D status is associated with impaired bone quality and increased risk of fracture ‐related hospitalization in older Australian women
ABSTRACTThe vitamin D debate relates in part to ideal public health population levels of circulating 25 ‐hydroxyvitamin D (25OHD) to maintain bone structure and reduce fracture. In a secondary analysis of 1,348 women aged 70‐85 years at baseline (1998) from the Perth Longitudinal Study of Aging in Women (PLSAW, a five‐year calcium supplementation trial followed by two five‐year extensions), we examined the dose‐response relations of baseline plasma 25OHD with hip DXA BMD at year 1, lumbar spine BMD and trabecular bone score (TBS) at year 5, and fracture‐related hospitalizations over 14.5 years obtained by healt...
Source: Journal of Bone and Mineral Research - June 24, 2019 Category: Orthopaedics Authors: Kun Zhu, Joshua R Lewis, Marc Sim, Richard L Prince Tags: ORIGINAL ARTICLE Source Type: research

Gaucher Disease in Bone: From Pathophysiology to Practice
ABSTRACTGaucher disease (GD) is a rare, genetic lysosomal disorder leading to lipid accumulation and dysfunction in multiple organs. Involvement of the skeleton is one of the most prevalent aspects of GD and a major cause of pain, disability, and reduced quality of life. Uniform recommendations for contemporary evaluation and management are needed. To develop practical clinical recommendations, an international group of experienced physicians conducted a comprehensive review of 20 years ’ of the literature, defining terms according to pathophysiological understanding and pointing out best practice and unmet needs rel...
Source: Journal of Bone and Mineral Research - June 24, 2019 Category: Orthopaedics Authors: Derralynn Hughes, Peter Mikosch, Nadia Belmatoug, Francesca Carubbi, TimothyM Cox, Ozlem Goker ‐Alpan, Andreas Kindmark, PramodK Mistry, Ludger Poll, Neal Weinreb, Patrick Deegan Tags: Review Source Type: research

Bone Quality Sleuths: Uncovering Tissue ‐Level Mechanisms of Bone Fragility in Human Type 2 Diabetes
Journal of Bone and Mineral Research, EarlyView. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 21, 2019 Category: Orthopaedics Authors: Tamara Alliston, Anne Schafer Tags: Editorial Source Type: research

Pentosidine Is Associated With Cortical Bone Geometry and Insulin Resistance in Otherwise Healthy Children
ABSTRACTPentosidine is an advanced glycation end product (AGE) associated with fracture in adults with diabetes. AGE accumulation in bone collagen contributes to bone fragility but might also adversely influence bone turnover and, consequently, bone geometry. The relationships between AGEs and bone health have yet to be studied in children. Thus, the objective of this study was to assess relationships between pentosidine and cortical bone volumetric density, geometry, and estimated strength in children. Participants were otherwise healthy black and white boys and girls, ages 9 to 13 years, who were at sexual maturation sta...
Source: Journal of Bone and Mineral Research - June 20, 2019 Category: Orthopaedics Authors: Joseph M Kindler, Emma M Laing, Weixi Liu, Joel A Dain, Richard D Lewis Tags: ORIGINAL ARTICLE Source Type: research

The effect of a screening and treatment program for the prevention of fractures in older women: a randomized pragmatic trial
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 20, 2019 Category: Orthopaedics Authors: Thomas Merlijn, Karin M.A. Swart, Natasja M. Schoor, Martijn W. Heymans, Babette C. Zwaard, Amber A. Heijden, Femke Rutters, Paul Lips P, Henri ëtte E. Horst, Christy Niemeijer, J. Coen Netelenbos, Petra J.M. Elders Tags: CLINICAL TRIAL Source Type: research

Ultrasound ‐Based Estimates of Cortical Bone Thickness and Porosity Are Associated With Nontraumatic Fractures in Postmenopausal Women: A Pilot Study
ABSTRACTRecent ultrasound (US) axial transmission techniques exploit the multimode waveguide response of long bones to yield estimates of cortical bone structure characteristics. This pilot cross ‐sectional study aimed to evaluate the performance at the one‐third distal radius of a bidirectional axial transmission technique (BDAT) to discriminate between fractured and nonfractured postmenopausal women. Cortical thickness (Ct.Th) and porosity (Ct.Po) estimates were obtained for 201 postme nopausal women: 109 were nonfractured (62.6 ± 7.8 years), 92 with one or more nontraumatic fractures (68.8 ± 9.2 years)...
Source: Journal of Bone and Mineral Research - June 19, 2019 Category: Orthopaedics Authors: J ‐G Minonzio, N Bochud, Q Vallet, D Ramiandrisoa, A Etcheto, K Briot, S Kolta, C Roux, P Laugier Tags: ORIGINAL ARTICLE Source Type: research

Changes in bone marrow adipose tissue one year after Roux ‐en‐Y gastric bypass ‐ a prospective cohort study
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 19, 2019 Category: Orthopaedics Authors: Ingvild Kristine Blom ‐Høgestøl, Tom Mala, Jon A Kristinsson, Ellen‐Margrethe Hauge, Cathrine Brunborg, Hanne Løvdal Gulseth, Erik Fink Eriksen Tags: ORIGINAL ARTICLE Source Type: research

Association of Bone Density Monitoring in Routine Clinical Practice with Anti ‐Osteoporosis Medication Use and Incident Fractures: A Matched Cohort Study
In conclusion, our findings suggest a possible role for BMD monitoring after initiating anti‐osteoporosis therapy in the routine clinical practice setting.This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 18, 2019 Category: Orthopaedics Authors: William D. Leslie, Suzanne N. Morin, Patrick Martineau, Mark Bryanton, Lisa M. Lix Tags: ORIGINAL ARTICLE Source Type: research

Osteocyte Death and Bone Overgrowth in Mice Lacking Fibroblast Growth Factor Receptors 1 and 2 in Mature Osteoblasts and Osteocytes
ABSTRACTFibroblast growth factor (FGF) signaling pathways have well ‐established roles in skeletal development, with essential functions in both chondrogenesis and osteogenesis. In mice, previous conditional knockout studies suggested distinct roles for FGF receptor 1 (FGFR1) signaling at different stages of osteogenesis and a role for FGFR2 in osteoblast maturati on. However, the potential for redundancy among FGFRs and the mechanisms and consequences of stage‐specific osteoblast lineage regulation were not addressed. Here, we conditionally inactivateFgfr1 andFgfr2 in mature osteoblasts with an Osteocalcin (OC) ‐Cre...
Source: Journal of Bone and Mineral Research - June 17, 2019 Category: Orthopaedics Authors: Jennifer McKenzie, Craig Smith, Kannan Karuppaiah, Joshua Langberg, Matthew J Silva, David M Ornitz Tags: ORIGINAL ARTICLE Source Type: research

Compromised Exercise Capacity and Mitochondrial Dysfunction in the Osteogenesis Imperfecta Murine (oim) Mouse Model
ABSTRACTOsteogenesis imperfecta (OI) is a heritable connective tissue disorder that most often arises from type I collagen —COL1A1 and COL1A2—gene defects leading to skeletal fragility, short stature, blue‐gray sclera, and muscle weakness. Relative to the skeletal fragility, muscle weakness is much less understood. Recent investigations into OI muscle weakness in both patients and mouse models have revealed the pr esence of an inherent muscle pathology. Understanding the mechanisms responsible for OI muscle weakness is critical, particularly in light of the extensive cross‐talk between muscle and bone via m...
Source: Journal of Bone and Mineral Research - June 13, 2019 Category: Orthopaedics Authors: Victoria L Gremminger, Youngjae Jeong, Rory P Cunningham, Grace M Meers, R Scott Rector, Charlotte L Phillips Tags: ORIGINAL ARTICLE Source Type: research

Growth Hormone Increases Bone Toughness and Decreases Muscle Inflammation in Glucocorticoid ‐Treated Mdx Mice, Model of Duchenne Muscular Dystrophy
This study evaluated the therapeutic potential of daily growth hormone therapy in growing mdx mice as a model of DMD. Growth hormone treatment on its own or in combination with glucocorticoids significantly improved muscle histology and function and decreased markers of inflam mation in mdx mice. Glucocorticoid treatment thinned cortical bone and decreased bone strength and toughness. Despite the minimal effects of growth hormone on bone microarchitecture, it significantly improved biomechanical properties of femurs and vertebrae, even in the presence of glucocorticoid tr eatment. Together these studies suggest that the us...
Source: Journal of Bone and Mineral Research - June 12, 2019 Category: Orthopaedics Authors: Sung ‐Hee Yoon, Marc D Grynpas, Jane Mitchell Tags: ORIGINAL ARTICLE Source Type: research

Undercarboxylated Osteocalcin Improves Insulin ‐Stimulated Glucose Uptake in Muscles of Corticosterone‐Treated Mice
ABSTRACTShort ‐term administration of glucocorticoids (GCs) impairs muscle insulin sensitivity at least in part via the reduction of undercarboxylated osteocalcin (ucOC). However, whether ucOC treatment reverses the GC‐induced muscle insulin resistance remains unclear. To test the hypothesis that ucOC directl y ameliorates impaired insulin‐stimulated glucose uptake (ISGU) induced by short‐term GC administration in mice muscle and to identify the molecular mechanisms, mice were implanted with placebo or corticosterone (CS) slow‐release pellets. Two days post‐surgery, insulin‐tolerance tests (ITT s) were perfor...
Source: Journal of Bone and Mineral Research - June 12, 2019 Category: Orthopaedics Authors: Xuzhu Lin, Lewan Parker, Emma McLennan, Alan Hayes, Glenn McConell, Tara C Brennan ‐Speranza, Itamar Levinger Tags: ORIGINAL ARTICLE Source Type: research

Chondrocyte ‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice
ABSTRACTRUNX2 is a transcription factor critical for chondrocyte maturation and normal endochondral bone formation. It promotes the expression of factors catabolic to the cartilage extracellular matrix and is upregulated in human osteoarthritic cartilage and in murine articular cartilage following joint injury. To date, in vivo studies of RUNX2 overexpression in cartilage have been limited to forced expression in osteochondroprogenitor cells preventing investigation into the effects of chondrocyte ‐specific RUNX2 overexpression in postnatal articular cartilage. Here, we used theRosa26Runx2 allele in combination with the ...
Source: Journal of Bone and Mineral Research - June 12, 2019 Category: Orthopaedics Authors: Sarah E Catheline, Donna Hoak, Martin Chang, John P Ketz, Matthew J Hilton, Michael J Zuscik, Jennifer H Jonason Tags: ORIGINAL ARTICLE Source Type: research

Growth Hormone Increases Bone Toughness and Decreases Muscle Inflammation in Glucocorticoid ‐Treated Mdx Mice, Model of Duchenne Muscular Dystrophy
This study evaluated the therapeutic potential of daily growth hormone therapy in growing mdx mice as a model of DMD. Growth hormone treatment on its own or in combination with glucocorticoids significantly improved muscle histology and function and decreased markers of inflam mation in mdx mice. Glucocorticoid treatment thinned cortical bone and decreased bone strength and toughness. Despite the minimal effects of growth hormone on bone microarchitecture, it significantly improved biomechanical properties of femurs and vertebrae, even in the presence of glucocorticoid tr eatment. Together these studies suggest that the us...
Source: Journal of Bone and Mineral Research - June 12, 2019 Category: Orthopaedics Authors: Sung ‐Hee Yoon, Marc D Grynpas, Jane Mitchell Tags: ORIGINAL ARTICLE Source Type: research

Chondrocyte ‐Specific RUNX2 Overexpression Accelerates Post‐traumatic Osteoarthritis Progression in Adult Mice
ABSTRACTRUNX2 is a transcription factor critical for chondrocyte maturation and normal endochondral bone formation. It promotes the expression of factors catabolic to the cartilage extracellular matrix and is upregulated in human osteoarthritic cartilage and in murine articular cartilage following joint injury. To date, in vivo studies of RUNX2 overexpression in cartilage have been limited to forced expression in osteochondroprogenitor cells preventing investigation into the effects of chondrocyte ‐specific RUNX2 overexpression in postnatal articular cartilage. Here, we used theRosa26Runx2 allele in combination with the ...
Source: Journal of Bone and Mineral Research - June 12, 2019 Category: Orthopaedics Authors: Sarah E Catheline, Donna Hoak, Martin Chang, John P Ketz, Matthew J Hilton, Michael J Zuscik, Jennifer H Jonason Tags: ORIGINAL ARTICLE Source Type: research

Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Yuyu Li, Zhenqi Shi, Joel Jules, Shenyuan Chen, Robert A. Kesterson, Dongfeng Zhao, Ping Zhang, Xu Feng Tags: ORIGINAL ARTICLE Source Type: research

A New Osteocytic Cell Line, Raising New Questions and Opportunities
Journal of Bone and Mineral Research, EarlyView. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Ivo Kalajzic Tags: EDITORIAL Source Type: research

Parathyroid Hormone Shifts Cell Fate of a Leptin Receptor ‐Marked Stromal Population from Adipogenic to Osteoblastic Lineage
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Mengyu Yang, Atsushi Arai, Nobuyuki Udagawa, Lijuan Zhao, Daisuke Nishida, Kohei Murakami, Toru Hiraga, Ryoko Takao ‐Kawabata, Koichi Matsuo, Toshihisa Komori, Yasuhiro Kobayashi, Naoyuki Takahashi, Yukihiro Isogai, Toshinori Ishizuya, Aki Tags: ORIGINAL ARTICLE Source Type: research

A Novel Osteogenic Cell Line That Differentiates Into GFP ‐Tagged Osteocytes and Forms Mineral With a Bone‐Like Lacunocanalicular Structure
ABSTRACTOsteocytes, the most abundant cells in bone, were once thought to be inactive, but are now known to have multifunctional roles in bone, including in mechanotransduction, regulation of osteoblast and osteoclast function and phosphate homeostasis. Because osteocytes are embedded in a mineralized matrix and are challenging to study, there is a need for new tools and cell models to understand their biology. We have generated two clonal osteogenic cell lines, OmGFP66 and OmGFP10, by immortalization of primary bone cells from mice expressing a membrane ‐targeted GFP driven by theDmp1‐promoter. One of these clones, Om...
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Kun Wang, Lisa Le, Brad M Chun, LeAnn M Tiede ‐Lewis, Lora A Shiflett, Matthew Prideaux, Richard S Campos, Patricia A Veno, Yixia Xie, Vladimir Dusevich, Lynda F Bonewald, Sarah L Dallas Tags: ORIGINAL ARTICLE Source Type: research

Expression of a degradation ‐resistant β‐catenin mutant in osteocytes protects the skeleton from mechanodeprivation‐induced bone wasting
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Whitney A. Bullock, April Hoggatt, Daniel J. Horan, Karl Lewis, Hiroki Yokota, Steven Hann, Matthew L. Warman, Aimy Sebastian, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling Tags: ORIGINAL ARTICLE Source Type: research

Specific RANK Cytoplasmic Motifs Drive Osteoclastogenesis
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Yuyu Li, Zhenqi Shi, Joel Jules, Shenyuan Chen, Robert A. Kesterson, Dongfeng Zhao, Ping Zhang, Xu Feng Tags: ORIGINAL ARTICLE Source Type: research

A New Osteocytic Cell Line, Raising New Questions and Opportunities
Journal of Bone and Mineral Research, EarlyView. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Ivo Kalajzic Tags: EDITORIAL Source Type: research

Parathyroid Hormone Shifts Cell Fate of a Leptin Receptor ‐Marked Stromal Population from Adipogenic to Osteoblastic Lineage
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Mengyu Yang, Atsushi Arai, Nobuyuki Udagawa, Lijuan Zhao, Daisuke Nishida, Kohei Murakami, Toru Hiraga, Ryoko Takao ‐Kawabata, Koichi Matsuo, Toshihisa Komori, Yasuhiro Kobayashi, Naoyuki Takahashi, Yukihiro Isogai, Toshinori Ishizuya, Aki Tags: ORIGINAL ARTICLE Source Type: research

Expression of a degradation ‐resistant β‐catenin mutant in osteocytes protects the skeleton from mechanodeprivation‐induced bone wasting
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - June 7, 2019 Category: Orthopaedics Authors: Whitney A. Bullock, April Hoggatt, Daniel J. Horan, Karl Lewis, Hiroki Yokota, Steven Hann, Matthew L. Warman, Aimy Sebastian, Gabriela G. Loots, Fredrick M. Pavalko, Alexander G. Robling Tags: ORIGINAL ARTICLE Source Type: research