Long ‐term ligature‐induced periodontitis exacerbates development of bisphosphonate‐related osteonecrosis of the jaw in mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 22, 2022 Category: Orthopaedics Authors: Drake Winslow Williams, Katie Ho, Allison Lenon, Sol Kim, Terresa Kim, Yousang Gwack, Reuben H. Kim Tags: Original Article Source Type: research

Automated opportunistic osteoporosis screening in routine computed tomography of the spine – comparison with dedicated quantitative CT
In conclusion, opportunistic osteoporosis screening in routine CT of various scanner setups is feasi ble and may demonstrate high diagnostic accuracy for prevalent VFs. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 22, 2022 Category: Orthopaedics Authors: Nico Sollmann, Maximilian T. L öffler, Malek El Husseini, Anjany Sekuboyina, Michael Dieckmeyer, Sebastian Rühling, Claus Zimmer, Bjoern Menze, Gabby B. Joseph, Thomas Baum, Jan S. Kirschke Tags: Original Article Source Type: research

Incidence of Subsequent Hip Fracture and Mortality in Elderly Patients: A Multistate Population ‐Based Cohort Study in Eastern Spain
ABSTRACTOsteoporotic hip fractures in older people may confer an increased risk of subsequent hip fractures and death. The aim of this study was to estimate the cumulative incidence of both recurrent hip fracture and death in the Valencia region. We followed a cohort of 34,491 patients aged ≥65 years who were discharged alive from Valencia Health System hospitals after an osteoporotic hip fracture between 2008 and 2015, until death or end of study (December 31, 2016). Two Bayesian illness-death models were applied to estimate the cumulative incidences of recurrent hip fracture and death by sex, age, and year of dischar...
Source: Journal of Bone and Mineral Research - May 20, 2022 Category: Orthopaedics Authors: Fran Llopis ‐Cardona, Carmen Armero, Isabel Hurtado, Aníbal García‐Sempere, Salvador Peiró, Clara L Rodríguez‐Bernal, Gabriel Sanfélix‐Gimeno Tags: Original Article Source Type: research

Calcimimetics Alter Periosteal and Perilacunar Bone Matrix Composition and Material Properties in Early Chronic Kidney Disease
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 20, 2022 Category: Orthopaedics Authors: John G. Damrath, Sharon M. Moe, Joseph M. Wallace Tags: Original Article Source Type: research

Oral bisphosphonates are associated with increased risk of severe acute kidney injury in elderly patients with complex health needs: a self ‐controlled case series in the UK
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 17, 2022 Category: Orthopaedics Authors: Tetsuro Oda, Annika M. J ödicke, Danielle E. Robinson, Antonella Delmestri, Ruth H. Keogh, Daniel Prieto‐Alhambra Tags: Original Article Source Type: research

Incidence of fracture hospitalization and surgery in women increases steadily during the puerperal and lactation period: a retrospective register ‐based cohort study in Finland from 1999 to 2018
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 17, 2022 Category: Orthopaedics Authors: Lauri Nyrhi, Ilari Kuitunen, Ville Ponkilainen, Tuomas T. Huttunen, Ville M. Mattila Tags: Original Article Source Type: research

TREM2 R47H variant causes distinct age ‐ and sex‐dependent musculoskeletal alterations in mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 16, 2022 Category: Orthopaedics Authors: Alyson L. Essex, Joshua R. Huot, Padmini Deosthale, Alison Wagner, Jorge Figueras, Azaria Davis, John Damrath, Fabrizio Pin, Joseph Wallace, Andrea Bonetto, Lilian I. Plotkin Tags: Original Article Source Type: research

Mice lacking Wnt9a or Wnt4 are prone to develop spontaneous osteoarthritis with age and display alteration in either the trabecular or cortical bone compartment
AbstractOsteoarthritis (OA) is a common degenerative disease of the joint, with a complex multifactorial not yet fully understood etiology. Over the past years, the Wnt signaling pathway has been implicated in osteoarthritis. In a recent GWAS study, the chromosomal location on chromosome 1, linked to theWnt3a-Wnt9a gene locus, was identified as the most significant locus associated with a thumb osteoarthritis endophenotype. Previously, it was shown that WNT9a is involved in maintaining synovial cell identity in the elbow joint during embryogenesis. Here, we report that the conditional loss ofWnt9a in the Prx1-Cre expressin...
Source: Journal of Bone and Mineral Research - May 13, 2022 Category: Orthopaedics Authors: Stefan Teufel, Lena Wolff, Ulrich K önig, Akio Kobayashi, Richard Behringer, Christine Hartmann Tags: Original Article Source Type: research

Issue Information ‐Declaration of Helsinki
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 11, 2022 Category: Orthopaedics Tags: Issue Information ‐Declaration of Helsinki Source Type: research

Ed Bd, Masthead, Comm List and TOC
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 11, 2022 Category: Orthopaedics Tags: Issue Information Source Type: research

Journal of Bone and Mineral Research: Volume 37, Number 5, May 2022
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 11, 2022 Category: Orthopaedics Tags: Cover Source Type: research

Remembering Dr Arnold J Kahn: June 18, 1936 –June 16, 2021
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 9, 2022 Category: Orthopaedics Authors: Nicola C Partridge, Steven R Cummings, Alberta Zallone, Zvi Bar ‐Shavit, Steven L Teitelbaum Tags: In Memoriam Source Type: research

Osteomalacia as a Complication of Intravenous Iron Infusion: A Systematic Review of Case Reports
We report the results in a narrative summary. We identified 28 case reports, reporting 30 cases. Ages ranged from 28 to 80 years (median 50 years). Most patients (n = 18) received ferric carboxymaltose (FCM), whereas 8 received saccharated ferric oxide (SFO) and 3 received iron polymaltose (IPM). All but 2 cases had more than five infusions (range 2 to 198, median 17). The lowest phosphate levels ranged from 0.16 to 0.77 mmol/L (median 0.36 mmol/L). Inta ct FGF-23 (iFGF-23) was high when measured. Serum 25OH vitamin D was low in 10 of 21 cases measured and 1,25(OH)2 vitamin D in 12 of 18. Alkaline phosphatase was...
Source: Journal of Bone and Mineral Research - May 7, 2022 Category: Orthopaedics Authors: Tatiane Vilaca, Nalini Velmurugan, Christopher Smith, Bo Abrahamsen, Richard Eastell Tags: ORIGINAL ARTICLE Source Type: research

Loss of parathyroid hormone receptor signaling in osteoprogenitors is associated with accumulation of multiple hematopoietic lineages in the bone marrow
ABSTRACTOsteoblasts and their progenitors play an important role in the support of hematopoiesis within the bone marrow microenvironment. We have previously reported that parathyroid hormone receptor (PTH1R) signaling in osteoprogenitors is required for normal B cell precursor differentiation, and for trafficking of maturing B cells out of the bone marrow. Cells of the osteoblast lineage have been implicated in the regulation of several other hematopoietic cell populations, but the effects of PTH1R signaling in osteoprogenitors on other maturing hematopoietic populations have not been investigated. Here we report that numb...
Source: Journal of Bone and Mineral Research - May 1, 2022 Category: Orthopaedics Authors: Takaharu Kimura, Cristina Panaroni, Erinn B Rankin, Louise E. Purton, Joy Y. Wu Tags: Original Article Source Type: research

Serum AMH levels: an early reproductive marker for bone loss?
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 1, 2022 Category: Orthopaedics Authors: Jenny A. Visser Tags: Editorial Source Type: research