Differential diagnosis of vitamin D –related hypercalcemia using serum vitamin D metabolite profiling
ABSTRACTGenetic causes of vitamin D –related hypercalcemia are known to involve mutation of 25‐hydroxyvitamin D‐24‐hydroxylaseCYP24A1 or the sodium phosphate co ‐transporterSLC34A1, which result in excessive 1,25 ‐(OH)2D hormonal action. However, at least 20% of idiopathic hypercalcemia (IH) cases remain unresolved. In this case ‐control study, we used precision vitamin D metabolite profiling based on liquid chromatography–tandem mass spectrometry (LC‐MS/MS) of an expanded range of vitamin D metabolites to screen German and French cohorts of hypercalcemia patients, to identify patients with altere...
Source: Journal of Bone and Mineral Research - May 10, 2021 Category: Orthopaedics Authors: Martin Kaufmann, Karl ‐Peter Schlingmann, Linor Berezin, Arnaud Molin, Jesse Sheftel, Melanie Vig, John C. Gallagher, Akiko Nagata, Shadi Sedghi Masoud, Ryota Sakamoto, Kazuo Nagasawa, Motonari Uesugi, Marie Laure Kottler, Martin Konrad, G Tags: Original Article Source Type: research

Early discrimination between tumor ‐induced rickets/osteomalacia and X‐linked hypophosphatemia in Chinese children and adolescents: a retrospective case‐control study
AbstractIn children and adolescents distinguishing tumor ‐induced rickets/osteomalacia (TIR/O) from hereditary hypophosphatemic rickets/osteomalacia (HR/O) is a medical challenge. We retrospectively studied 10 Chinese children and adolescents with TIR/O who underwent surgery at a mean age of 17.4 ± 2.1 years, and compared their characteristics to 2 4 age‐ and gender‐matched patients with X‐linked hypophosphatemia (XLH). Positive family history of HR/O and dental problems, such as enamel hypoplasia and dental abscess, were reported in 8 (33.3%) and 5 (20.8%) patients with XLX, respectively, but ...
Source: Journal of Bone and Mineral Research - May 10, 2021 Category: Orthopaedics Authors: Ruizhi Jiajue, Xiaolin Ni, Chenxi Jin, Li Huo, Huanwen Wu, Yong Liu, Jin Jin, Wei Yu, Wei Lv, Lian Zhou, Yu Xia, Yue Chi, Lijia Cui, Qianqian Pang, Xiang Li, Yan jiang, Ou Wang, Mei Li, Xiaoping Xing, Xunwu Meng, Weibo Xia Tags: Original Article Source Type: research

A N ‐terminus domain determines amelogenin’s stability to guide the development of mouse enamel matrix
AbstractAmelogenins, the principal proteins in the developing enamel microenvironment, self ‐assemble into supramolecular structures to govern the remodeling of a proteinaceous organic matrix into longitudinally ordered hydroxyapatite nanocrystal arrays. Extensivein vitro studies using purified native or recombinant proteins have revealed the potential of N ‐terminal amelogenin on protein self‐assembly and its ability to guide the mineral deposition. We have previously identified a 14‐aa domain (P2) of N‐terminal amelogenin that can self‐assemble into amyloid‐like fibrilsin vitro. Here we investigated how thi...
Source: Journal of Bone and Mineral Research - May 7, 2021 Category: Orthopaedics Authors: Yulei Huang, Yushi Bai, Chih Chang, Margot Bacino, Ieong Cheng Cheng, Li Li, Stefan Habelitz, Wu Li, Yan Zhang Tags: Original Article Source Type: research

Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR ‐based functional screening of osteoporosis candidate genes
In conclusion, we show through faithful modeling of LRP5 ‐related primary osteoporosis, that crispant screening in zebrafish is a promising approach for rapid functional screening of osteoporosis candidate genes. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 6, 2021 Category: Orthopaedics Authors: Jan Willem Bek, Chen Shochat, Adelbert De Clercq, Hanna De Saffel, Annekatrien Boel, Juriaan Metz, Frans Rodenburg, David Karasik, Andy Willaert, Paul J. Coucke Tags: Original Article Source Type: research

Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome ‐wide association and Mendelian randomization study
AbstractRecent advances indicate that bone and energy metabolism are closely related. However, little direct evidence on causality has been provided in humans. We aimed to assess the association of three bone ‐related biomarkers 25 hydroxyvitamin D (25OHD), parathyroid hormone (PTH) and osteocalcin (OCN) with several metabolic phenotypes, and investigate any causal relevance to the associations using a Mendelian randomization (MR) study. Serum 25OHD, PTH and total OCN were measured at baseline in 5169 eligible Chinese participants in Changfeng study. Partial correlation and bivariate GREML analysis were used to estimate ...
Source: Journal of Bone and Mineral Research - May 6, 2021 Category: Orthopaedics Authors: Hailuan Zeng, Jieyu Ge, Wenjie Xu, Hui Ma, Lingyan Chen, Mingfeng Xia, Baishen Pan, Huandong Lin, Sijia Wang, Xin Gao Tags: Original Article Source Type: research

Insertion Mutation in Tnfrsf11a Causes a Paget's Disease –Like Phenotype in Heterozygous Mice and Osteopetrosis in Homozygous Mice
ABSTRACTEarly onset familial Paget's disease of bone (EoPDB), familial expansile osteolysis, and expansile skeletal hyperphosphatasia are related disorders caused by insertion mutations in exon 1 of theTNFRSF11A gene, which encodes receptor activator of nuclear factor κB (RANK) protein. To understand the mechanisms underlying these disorders, we developed a mouse model carrying the 75dup27 mutation which causes EoPDB. Mice heterozygous for the mutation (Tnfrsf11a75dup27/ −) developed a PDB ‐like disorder with focal osteolytic lesions in the hind limbs with increasing age. Treatment of these mice with zoledron...
Source: Journal of Bone and Mineral Research - May 6, 2021 Category: Orthopaedics Authors: Nerea Alonso, Sachin Wani, Lorraine Rose, Rob J. van't Hof, Stuart H. Ralston, Omar M.E. Albagha Tags: Original Article Source Type: research

An anti ‐oxidant sesquiterpene inhibits osteoclastogenesis via blocking IPMK/TRAF6 and counteracts OVX‐induced osteoporosis in mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 6, 2021 Category: Orthopaedics Authors: Shiyu Wang, Qingliang Ma, Ziang Xie, Yang Shen, Bingjie Zheng, Chao Jiang, Putao Yuan, Qin An, Shunwu Fan, Zhiwei Jie Tags: Original Article Source Type: research

Burosumab for Tumor ‐Induced Osteomalacia: Not Enough of a Good Thing
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 5, 2021 Category: Orthopaedics Authors: Iris R Hartley, Michael T Collins Tags: Letter to the Editor Source Type: research

Modification of COL1A1 in autologous adipose tissue ‐derived progenitor cells rescues the bone phenotype in a mouse model of osteogenesis imperfecta
AbstractOsteogenesis imperfecta (OI) is a congenital genetic disorder mainly manifested as bone fragility and recurrent fracture. Mutation ofCOL1A1/COL1A2 genes encoding the type I collagen are most responsible for the clinical patients. Allogenic mesenchymal stem cells (MSCs) provide the potential to treat OI through differentiation into osteoblasts. Autologous defective MSCs have not been utilized in OI treatment mainly because of their impaired osteogenesis, but the latent mechanism has not been well understood. Here, the relative signaling abnormality of adipose ‐derived mesenchymal stem cells (ADSCs) isolated from O...
Source: Journal of Bone and Mineral Research - May 5, 2021 Category: Orthopaedics Authors: Yi Liu, Zihan Wang, Mingyan Ju, Yuxia Zhao, Yaqing Jing, Jiaci Li, Chenyi Shao, Ting Fu, Zhe Lv, Guang Li Tags: Original Article Source Type: research

Impaired bone microarchitecture and strength in patients with tumor ‐induced osteomalacia
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - May 5, 2021 Category: Orthopaedics Authors: Mar ía Belén Zanchetta, Fernando Jerkovich, Selva Nuñez, Yamile Mocarbel, Analía Pignatta, Natalia Elías, Adriana Graciela Díaz, Juan Manuel Roganovich, Carlos Vigovich, María Celeste Balonga, Ana Carolina Cohen, Giselle Mumbach, Sofía Tags: Original Article Source Type: research

INZ ‐701 Prevents Ectopic Tissue Calcification and Restores Bone Architecture and Growth in ENPP1‐Deficient Mice
ABSTRACTEctonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular adenosine triphosphate (ATP) to generate pyrophosphate (PPi), an inorganic metabolite with potent anticalcification activity. Loss ‐of‐function mutations cause hypopyrophosphatemia and lead to a state of ENPP1 deficiency, which has an acute infantile phase known as generalized arterial calcification of infancy (GACI) and a pediatric to adult phase known as autosomal‐recessive hypophosphatemic rickets type 2 (ARHR2). ENPP1 deficiency manifests as ectopic calcification of multiple tissues, neointimal prolif...
Source: Journal of Bone and Mineral Research - May 5, 2021 Category: Orthopaedics Authors: Zhiliang Cheng, Kevin O'Brien, Jennifer Howe, Caitlin Sullivan, Denis Schrier, Angela Lynch, Steven Jungles, Yves Sabbagh, David Thompson Tags: Original Article Source Type: research

Lgr4 promotes aerobic glycolysis and differentiation in osteoblasts via the canonical Wnt/ β‐catenin pathway
AbstractLgr4, a G ‐protein‐coupled receptor, is associated with various physiological and pathological processes including oncogenesis, energy metabolism, and bone remodeling. However, whether Lgr4 is involved in osteoblasts' metabolism is not clear. Here we uncover that in preosteoblast cell line, lacking Lgr4 r esults in decreased osteogenic function along with reduced glucose consumption, glucose uptake, and lactate production in the presence of abundant oxygen, which is referred to as aerobic glycolysis. Activating canonical Wnt/β‐catenin signaling rescued the glycolytic dysfunction. Lgr4 promotes the exp...
Source: Journal of Bone and Mineral Research - May 5, 2021 Category: Orthopaedics Authors: Yu ‐Ying Yang, Yan‐Man Zhou, Jing‐Zun Xu, Li‐Hao Sun, Bei Tao, Weiqing Wang, Ji‐Qiu Wang, Hong‐Yan Zhao, Jian‐Min Liu Tags: Original Article Source Type: research

Erythropoietin treatment and the risk of hip fractures in hemodialysis patients
ABSTRACTErythropoietin (EPO) is the primary regulator of bone marrow erythropoiesis. Mouse models have provided evidence that EPO also promotes bone remodeling and that EPO ‐stimulated erythropoiesis is accompanied by bone loss independent of increased red blood cell production. EPO has been used clinically for three decades to treat anemia in end‐stage renal disease, and notably, although the incidence of hip fractures decreased in the United States generally afte r 1990, it rose among hemodialysis patients coincident with the introduction and subsequent dose escalation of EPO treatment. Given this clinical paradox an...
Source: Journal of Bone and Mineral Research - May 5, 2021 Category: Orthopaedics Authors: Sukanya Suresh, Elizabeth C. Wright, Daniel G. Wright, Kevin C. Abbott, Constance T. Noguchi Tags: Original Article Source Type: research

Prior loss of body mass index, low body mass index, and central obesity independently contribute to higher rates of fractures in elderly women and men
ABSTRACTWe aimed to comprehensively evaluate the association of body composition with fracture risk using longitudinal data from a Swedish cohort of 44,366 women and men (mean age of 70  years) and a subcohort of 5022 women. We estimated hazard ratios (HRs) of fracture for baseline body mass index (BMI), BMI change during the prior 12 and 18 years, baseline waist‐to‐height ratio, total and regional distribution of fat and lean mass, with and without areal bone mineral densi ty (BMD) adjustment. During follow‐up (median 8.7 years), 7290 individuals sustained a fracture, including 4279 fragility fr...
Source: Journal of Bone and Mineral Research - May 4, 2021 Category: Orthopaedics Authors: Rui Zheng, Liisa Byberg, Susanna C. Larsson, Jonas H öijer, John A. Baron, Karl Michaëlsson Tags: Original Article Source Type: research

RANKL ‐Induced Increase in Cathepsin K Levels Restricts Cortical Expansion in a Periostin‐Dependent Fashion: A Potential New Mechanism of Bone Fragility
ABSTRACTReceptor activator of nuclear factor ‐κΒ ligand (RANKL) is necessary and sufficient to promote osteoclastogenesis and a key pathogenic factor in osteoporosis. Failure of periosteal apposition to compensate for bone loss due to endosteal resorption further contributes to bone fragility. Whether these two processes are biologically r elated, however, remains unknown. Using high‐resolution peripheral quantitative computed tomography (HR‐pQCT), we first examined cortical bone parameters at distal radius and tibia in postmenopausal women (PMW) as well as in cadaveric human adult humeri. Increases in med...
Source: Journal of Bone and Mineral Research - May 4, 2021 Category: Orthopaedics Authors: Nicolas Bonnet, Eleni Douni, Genevi ève Perréard Lopreno, Marie Besse, Emmanuel Biver, Serge Ferrari Tags: Original Article Source Type: research

Hypermineralization of hearing ‐related bones by a specific osteoblast subtype
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 27, 2021 Category: Orthopaedics Authors: Yukiko Kuroda, Katsuhiro Kawaai, Naoya Hatano, Yanlin Wu, Hidekazu Takano, Atsushi Momose, Takuya Ishimoto, Takayoshi Nakano, Paul Roschger, St éphane Blouin, Koichi Matsuo Tags: Original Article Source Type: research

Incidence of Hip and Subtrochanteric/Femoral Shaft Fractures in Postmenopausal Women With Osteoporosis in the Phase 3 Long ‐Term Odanacatib Fracture Trial
ABSTRACTWe prospectively assessed, with predefined criteria, the location and rates of all femur fractures (hip, subtrochanteric/femoral shaft [ST/FS], including atypical [AFF] and distal fractures) in women at increased fracture risk during treatment with the cathepsin K inhibitor, odanacatib (ODN), or placebo over 5  years in the Long‐Term ODN Fracture Trial (LOFT and LOFT Extension [NCT00529373, EudraCT 2007‐002693‐66]). ODN was an investigational antiresorptive agent previously in development as an osteoporosis treatment that, unlike bisphosphonates, reduces bone formation only transiently. Women aged ≥...
Source: Journal of Bone and Mineral Research - April 27, 2021 Category: Orthopaedics Authors: Socrates Papapoulos, Henry Bone, Felicia Cosman, David W Dempster, Michael R McClung, Toshitaka Nakamura, Jos é Fernando Molina Restrepo, Mary L Bouxsein, Dosinda Cohn, Anne Papp, Rachid Massaad, Arthur Santora Tags: Clinical Trial Source Type: research

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 27, 2021 Category: Orthopaedics Authors: Uta R össler, Anna Floriane Hennig, Nina Stelzer, Shroddha Bose, Johannes Kopp, Kent Søe, Lukas Cyganek, Giovanni Zifarelli, Salaheddine Ali, Maja Hagen, Elisabeth Strässler, Gabriele Hahn, Michael Pusch, Tobias Stauber, Zsuzsanna Izsvák Tags: Original Article Source Type: research

Germline saturation mutagenesis induces skeletal phenotypes in mice
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 27, 2021 Category: Orthopaedics Authors: Jonathan J Rios, Kristin Denton, Jamie Russell, Julia Kozlitina, Carlos R Ferreira, Amy F Lewanda, Joshua E Mayfield, Eva Moresco, Sara Ludwig, Miao Tang, Xiaohong Li, Stephen Lyon, Anas Khanshour, Nandina Paria, Aysha Khalid, Yang Li, Xud Tags: Original Article Source Type: research

Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 27, 2021 Category: Orthopaedics Authors: Uta R össler, Anna Floriane Hennig, Nina Stelzer, Shroddha Bose, Johannes Kopp, Kent Søe, Lukas Cyganek, Giovanni Zifarelli, Salaheddine Ali, Maja Hagen, Elisabeth Strässler, Gabriele Hahn, Michael Pusch, Tobias Stauber, Zsuzsanna Izsvák Tags: Original Article Source Type: research

The Effect of Biochemical Remission on Bone Metabolism in Cushing's Syndrome: A 2 ‐Year Follow‐Up Study
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Leah T Braun, Martin Reincke Tags: Letter to the Editor Source Type: research

Reply to: Grade 1 vertebral fractures, bone mineral density, and the risk of fractures
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Lisa Johansson, Mattias Lorentzon Tags: REPLY LETTER TO THE EDITOR Source Type: research

INZ ‐701 prevents ectopic tissue calcification and restores bone architecture and growth in ENPP1 deficient mice
AbstractEctonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is the major enzyme that cleaves extracellular ATP to generate pyrophosphate (PPi), an inorganic metabolite with potent anti ‐calcification activity. Loss‐of‐function mutations cause hypopyrophosphatemia and lead to a state of ENPP1 deficiency, which has an acute infantile phase known as Generalized Arterial Calcification of Infancy (GACI) and a pediatric to adult phase known as Autosomal‐Recessive Hypophosphatemi c Rickets type 2 (ARHR2). ENPP1 deficiency manifests as ectopic calcification of multiple tissues, neointimal proliferation, premature mo...
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Zhiliang Cheng, Kevin O'Brien, Jennifer Howe, Caitlin Sullivan, Denis Schrier, Angela Lynch, Steve Jungles, Yves Sabbagh, David Thompson Tags: Original Article Source Type: research

Editorial Peer Reviewers as Shepherds, Rather Than Gatekeepers
ABSTRACTThe journals of theAmerican Society for Bone and Mineral Research (theJournal of Bone and Mineral Research (JBMR) and its sister journalJBMR Plus) recognize peer review, whether pre ‐ or post‐publication, as an essential guard of scientific integrity and rigor that shapes academic discourse in our field. In this Perspective, we present a vision and philosophy of peer review in a rapidly changing publishing landscape. We emphasize the importance of journal peer reviewers as active players in shaping collegial behavior in the musculoskeletal research community and provide information about benefits and resources ...
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Joel D Boerckel, Lilian I Plotkin, Natalie A Sims Tags: Perspective Source Type: research

Bisphosphonates in Kidney Disease —Safety First
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Pascale Khairallah, Thomas L Nickolas Tags: Editorial Source Type: research

Osteoblasts Generate Testosterone from DHEA and Activate Androgen Signaling in Prostate Cancer Cells
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Henry H. Moon, Katrina L. Clines, Patrick J. O'Day, Basel M. Al ‐Barghouthi, Emily A. Farber, Charles R. Farber, Richard J. Auchus, Gregory A. Clines Tags: Original Article Source Type: research

Phosphate restriction impairs mTORC1 signaling leading to increased bone marrow adipose tissue and decreased bone in growing mice
AbstractBone Marrow Stromal Cells (BMSCs) are multipotent cells that differentiate into cells of the osteogenic and adipogenic lineage. A striking inverse relationship between Bone Marrow Adipose Tissue (BMAT) and bone volume is seen in several conditions, suggesting that differentiation of BMSCs into bone marrow adipocytes diverts cells from the osteogenic lineage, thereby compromising the structural and mechanical properties of bone. Phosphate restriction of growing mice acutely decreases bone formation, blocks osteoblast differentiation and increases BMAT. Studies performed to evaluate the cellular and molecular basis f...
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Frank C. Ko, Margaret M. Kobelski, Wanlin Zhang, Gina M. Grenga, Janaina S Martins, Marie B. Demay Tags: Original Article Source Type: research

Neonatal osteomacs and bone marrow macrophages differ in phenotypic marker expression and function
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 26, 2021 Category: Orthopaedics Authors: Safa F. Mohamad, Andrea Gunawan, Rachel Blosser, Paul Childress, Alexandra Aguilar ‐Perez, Joydeep Ghosh, Jung Min Hong, Jianyun Liu, Deepa Kanagasabapathy, Melissa A. Kacena, Edward F. Srour, Angela Bruzzaniti Tags: Original Article Source Type: research

Treatment With Zoledronate Subsequent to Denosumab in Osteoporosis: A 2 ‐Year Randomized Study
ABSTRACTIncreased bone turnover and rapid bone loss follow discontinuation of denosumab. We investigated the long ‐term efficacy of zoledronate (ZOL) in maintaining bone mineral density (BMD) after discontinuation of denosumab. In this randomized, open‐label, interventional study, we included 61 postmenopausal women and men older than 50 years discontinuing denosumab after 4.6 ± 1.6 years. We admin istered ZOL 6 months (6 M) or 9 months (9 M) after the last denosumab or when bone turnover had increased (observation group [OBS]). ZOL was readministrated if p...
Source: Journal of Bone and Mineral Research - April 20, 2021 Category: Orthopaedics Authors: Anne Sophie S ølling, Torben Harsløf, Bente Langdahl Tags: Original Article Source Type: research

Grade 1 vertebral fractures, bone mineral density, and the risk of fractures
(Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 20, 2021 Category: Orthopaedics Authors: Eduardo Kanterewicz, Emma Puigoriol, Pilar Peris Tags: Letter to the Editor Source Type: research

Premature Growth Plate Closure Caused by a Hedgehog Cancer Drug Is Preventable by Co ‐Administration of a Retinoid Antagonist in Mice
ABSTRACTThe growth plates are key engines of skeletal development and growth and contain a top reserve zone followed by maturation zones of proliferating, prehypertrophic, and hypertrophic/mineralizing chondrocytes. Trauma or drug treatment of certain disorders can derange the growth plates and cause accelerated maturation and premature closure, one example being anti ‐hedgehog drugs such as LDE225 (Sonidegib) used against pediatric brain malignancies. Here we tested whether such acceleration and closure in LDE225‐treated mice could be prevented by co‐administration of a selective retinoid antagonist, based on previo...
Source: Journal of Bone and Mineral Research - April 20, 2021 Category: Orthopaedics Authors: Eiki Koyama, Christina Mundy, Cheri Saunders, Juliet Chung, Sarah E Catheline, Danielle Rux, Masahiro Iwamoto, Maurizio Pacifici Tags: Original Article Source Type: research

The Accuracy of Incident Vertebral Fracture Detection in Children Using Targeted Case ‐Finding Approaches
In this study, we examined the accuracy of case ‐finding strategies for detecting incident vertebral fractures (IVF) over 2 years in glucocorticoid‐treated children (n = 343) with leukemia, rheumatic disorders, or nephrotic syndrome. Two clinical situations were addressed: the prevalent vertebral fracture (PVF) scenario (when baseline PVF status was known), which assessed the utility of PVF and low lumbar spine bone mineral density (LS BMD;Z‐score
Source: Journal of Bone and Mineral Research - April 20, 2021 Category: Orthopaedics Authors: Jinhui Ma, Kerry Siminoski, Peiyao Wang, Jacob L Jaremko, Khaldoun Koujok, Mary Ann Matzinger, Nazih Shenouda, Brian Lentle, Nathalie Alos, Elizabeth A Cummings, Josephine Ho, Kristin Houghton, Paivi M Miettunen, Rosie Scuccimarri, Frank Rau Tags: Original Article Source Type: research

The Effect of Bolus Vitamin D3 Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial using HR ‐pQCT
ABSTRACTVitamin D is an important factor in bone metabolism. Animal studies have shown a positive effect of vitamin D3 supplementation on fracture healing, but evidence from clinical trials is inconclusive. A randomized controlled trial was performed to assess the effect of vitamin D3 supplementation on fracture healing using high ‐resolution peripheral quantitative computed tomography (HR‐pQCT) based outcome parameters. Thirty‐two postmenopausal women with a conservatively treated distal radius fracture were included within two weeks post‐fracture and randomized to a low‐dose (N = 10) and a high‐dose...
Source: Journal of Bone and Mineral Research - April 20, 2021 Category: Orthopaedics Authors: F.L. Heyer, J.J.A. Jong, P.C. Willems, J.J. Arts, S.G.P. Bours, S.M.J. Kuijk, J.A.P. Bons, M. Poeze, P.P. Geusens, B. Rietbergen, J.P. Bergh Tags: Clinical Trial Source Type: research

Differential diagnosis of vitamin D ‐related hypercalcemia using serum vitamin D metabolite profiling
AbstractGenetic causes of vitamin D ‐related hypercalcemia are known to involve mutation of 25‐hydroxyvitamin D‐24‐hydroxylaseCYP24A1 or the sodium phosphate co ‐transporterSLC34A1; which result in excessive 1,25 ‐(OH)2D hormonal action. However, at least 20% of idiopathic hypercalcemia (IH) cases remain unresolved. In this case ‐control study, we used precision vitamin D metabolite profiling based on LC‐MS/MS of an expanded range of vitamin D metabolites ‐ to screen German and French cohorts of hypercalcemia patients, to identify patients with altered vitamin D metabolism where involvement ofCYP24A1 orSL...
Source: Journal of Bone and Mineral Research - April 16, 2021 Category: Orthopaedics Authors: Martin Kaufmann, Karl ‐Peter Schlingmann, Linor Berezin, Arnaud Molin, Jesse Sheftel, Melanie Vig, John C. Gallagher, Akiko Nagata, Shadi Sedghi Masoud, Ryota Sakamoto, Kazuo Nagasawa, Motonari Uesugi, Marie Laure Kottler, Martin Konrad, G Tags: Original Article Source Type: research

RANKL ‐induced increase in cathepsin K levels restricts cortical expansion in a periostin dependent fashion: a potential new mechanism of bone fragility
This article is protected by copyright. All rights reserved. (Source: Journal of Bone and Mineral Research)
Source: Journal of Bone and Mineral Research - April 15, 2021 Category: Orthopaedics Authors: N Bonnet, E Douni, G Perr éard Lopreno, M Besse, E Biver, S Ferrari Tags: Original Article Source Type: research