Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root
CONCLUSION: Methanol extract of P. ginseng root culture did not show any significant anti-inflammatory effects on NO and IL-6 levels, but might potentially possess both anti-neuroinflammatory and pro-neuroinflammatory properties through the downregulation of TNF-α and IL-10 respectively.PMID:33825397 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Koay Chien Yi Ling Anna Pick Kiong Wong Ying Pei Koh Rhun Yian Hussein Sobri Source Type: research

Herbal formula of Bushen Jianpi combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle
CONCLUSION: Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent.PMID:33825398 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zhangjie Zhou Xinhua Liu Tingting Wu Zujue Que Zhonghua Wu Weizhong Wu Shujuan Fu Shiqiang Zhang Yun Yang Haiyan Jiang Xiaoting Xia Junqiang Lv Boqian Du Yun Li Tao Lu Zhihui Zhang Yi Zhong Source Type: research

Zichong granules promote differentiation of ovarian granulosa-like cells from human embryonic stem cells in vitro
CONCLUSION: In the ZCKL treatment of infertility, one mechanism by which ZCKL may act is by influencing ovarian granulosa cell differentiation and development, possibly through the follistatin and BMP/SMAD signaling pathways.PMID:33825399 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zouying Yao Jing Wang Hua Lu Limin Li Tianxiu Zhuo Qian Wan Shangmian Yie Source Type: research

Naoxintong capsules modulates tumor necrosis factor--induced endothelial senescence through silent information regulator 1 signaling
CONCLUSIONS: These findings suggest that sustained endothelial senescence can be induced by TNF-α stimulation via the SIRT1/FoxO-1/p53/p21 pathway. The protection of NXT against TNF- was partially mediated through its effects on SIRT1. This highlights the promise of NXT as a therapeutic for atherosclerosis.PMID:33825400 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qianyun Guo Bin Zhang Haitong Zhang Erli Zhang Yongjian Wu Source Type: research

Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro
CONCLUSION: Therefore, the analgesic and anti-inflammatory property of S. miltiorrhiza Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.PMID:33825401 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Jinghui Feng Kim Set Byeol Lee Hee Jung Sim Su Min Lim Soon Sung Suh Hong Won Source Type: research

Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor- α
CONCLUSION: LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα.PMID:33825402 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qi Chen Xu Qi Yu Fu Tingting Ji Ying Chao Jun Li Qinghai Meng Huimin Bian Yu Li Source Type: research

Effects of Qingguang'an containing serum on the expression levels of autophagy-related genes in human Tenon's fibroblasts induced by transforming growth factor beta 1
J Tradit Chin Med. 2021 Apr;41(2):236-245.ABSTRACTOBJECTIVE: To explore the effects of Qingguang'an () containing serum on the expression levels of autophagy related genes in the transforming growth factor beta 1 (TGF-β1)-activated human Tenon's fibroblasts (HTFs).METHODS: (a) Primary HTFs were stimulated by TGF-β1 and underwent immunohistochemistry, which established a cell model after Glaucoma filtration surgery (GFS). (b) The cell models were divided into 4 group: normal group (normal cells), model group (+TGF-β1),treatment group (+TGF-β1+ medicated serum), and positive control group (TGF-β1+ ra...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Juan Yu Fei Xia Xiang Li Qinghua Peng Source Type: research

Danlou Fang reduces microvascular obstruction through the endothelial/inducible nitric oxide synthase pathway in a rat model
J Tradit Chin Med. 2021 Apr;41(2):246-253.ABSTRACTOBJECTIVE: To investigate the efficacy of the Danlou Fang (DL) Traditional Chinese Medicine formula on microvascular obstruction (no-reflow) through the endothelial/inducible nitric oxide synthase (eNOS/iNOS) pathway in a rat model.METHODS: Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion (or sham procedure) followed by 2 h of reperfusion and were then divided into treatment groups: sham, model, DL (500 mg/kg), DL (500 mg/kg) + eNOS inhibitor L-nitroarginine (L-NNA; 7.5 mg/kg), and sodium nitroprusside (SNP; 0.5 mg/kg). There were 16 per group. Area...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xiangdong Dai Rui Chen Ting Chen Haifeng Yan Yanyan Wang Kun Zhou Xiting Zhang Yi Wang Source Type: research

Efficacy of Liangxue Guyuan decoction on radiation-induced intestinal injury in rats via the toll-like receptor 4/myeloid differentiation primary response 88/ nuclear factor-kappa B pathway
CONCLUSION: LGD increased the survival rate and inhibit weight loss of irradiated rats, and reduced inflammation and intestinal injury. The underlying mechanism may involve regulation of the TLR4/MyD88/NF-κB pathway.PMID:33825405 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Yuguo Wang Yongqi Dou Jian Feng Chengyong Xu Qian Wang Source Type: research

Efficacy of Sanqi (Radix Notoginseng) in treating cerebral hemorrhage in rats with traumatic brain injury
CONCLUSION: Sanqi (Radix Notoginseng) can decrease the expression of p-p65, increase t-PA/PAI-1, and stem traumatic intracranial hemorrhage in a TBI rat model.PMID:33825406 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Tao Jiang Xiaqing Zhou Huifang Jiang Rongbiao Ying Zhirong Zhang Danli Cai Yu Wu Haijun Fang Lingcong Wang Source Type: research

Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats
CONCLUSION: The present study demonstrated that the extract from O. spinosa was able to protect gastric mucosa from ethanol injury by at least 2 mechanisms, namely the induction of COX-2 and decreasing oxidative stress in the stomach.PMID:33825407 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Abbas Manal Ahmad Kandil Yasser Ibrahim Abbas Manal Mohammad Source Type: research

Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy
J Tradit Chin Med. 2021 Apr;41(2):276-283.ABSTRACTOBJECTIVE: To compare and observe the effects of three kinds of cephalic acupuncture therapies commonly used in the clinic on promoting nerve function rehabilitation in the brain microenvironment of rats with cerebral palsy.METHODS: A negative control group, positive control group, and three cephalic acupuncture groups based on the administration of three cephalic acupuncture therapies were established. Ten experimental rats were selected from each group at 1, 2, and 3 weeks after modeling. Neuromotor function after treatment was rated according to the Basso, Beattie, and B...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zixuan Wang Xiangwei Fan Kaiyun Chen Xuefeng Yu Jing Gao Source Type: research

Effects of Tianma (Rhizoma Gastrodiae) and Gouteng (Ramulus Uncariae Rhynchophyllae cum Uncis) on cytochrome P450 enzyme activities in rats
CONCLUSION: Tianma (Rhizoma Gastrodiae) has no significant effect on the six CYP450 subtypes. The activities of CYP3A4 and CYP2C9 were increased by Gouteng (Ramulus Uncariae Rhynchophyllae cum Uncis). The activities of CYP3A4 and CYP2C9 were increased, whereas the activity of CYP32E1 was reduced by combined Tianma (Rhizoma Gastrodiae) and Gouteng (Ramulus Uncariae Rhynchophyllae cum Uncis).PMID:33825409 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xin Liu Xinyu Wang Yinxuan Peng Xing Wang Source Type: research

Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage
CONCLUSION: The studies showed a crucial decrease in the amount of the DNA base damage products when antioxidants were used. The results showed that ferulic acid has better inhibition than chlorogenic acid for DNA oxidation. The methanol-water extract of Inula helenium root was determined to inhibit the oxidative DNA damage.PMID:33825410 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Aybast Er Nder Source Type: research

Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial
CONCLUSION: The present study showed a positive effect of Hemoheal cream in improving clinical signs and symptoms in patients with hemorrhoids.PMID:33825411 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zobeiri Mehdi Parvizi Fatemeh Rahimi Roja Heydarpour Fatemeh Sheikhan Hamid Reza Navabi Jafar Farzaei Mohammad Hosein Source Type: research

Clinical observation of Yiqi Qingdu prescription on the treatment of intermediate-stage and advanced non-small-cell lung cancer
J Tradit Chin Med. 2021 Apr;41(2):308-315.ABSTRACTOBJECTIVE: To observe the effects of the Yiqi Qingdu prescription () on intermediate-stage and advanced non-small-cell lung cancer (NSCLC).METHODS: In total, 300 patients with intermediate-stage or advanced NSCLC were randomly and equally divided into three groups using computer-generated random numbers as follows: Western medicine (WM), Chinese medicine (CM), and integrated Traditional Chinese and Western Medicine (IM). After 3 months of treatment, the overall response rate (ORR); disease control rate (DCR); symptom score (SS); Karnofsky performance status (KPS); adverse e...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qijun Liang Xiaoling Tang Jiong Yu Monian Xiong Huifang Zhu Linkai Xiong Ru Zeng Peiwen Yu Source Type: research

Abnormalcortical thickness in relapsing-remitting multiple sclerosis, correlations with cognition impairment, and effect of modified Bushenyisui decoction on cognitive function of multiple sclerosis
CONCLUSIONS: Gray matter atrophy and cortical thickness thinning were validated in RRMS. Cortical thickness thinning of temporal lobe and fusiform gyrus strongly related to cognitive deficits in RRMS. The modified BSYSD could promote the recovery of cognitive function in MS.PMID:33825413 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xuesong Zhao Tao Yang Fang Cheng Song Yang Wanlin Zhu Shaowu Li Yongping Fan Source Type: research

Effect of electroacupuncture at different acupoints in treating rapid gastric emptying: Zusanli (ST36) plus Zhongwan (CV12) versus Zhongwan (CV12) alone
J Tradit Chin Med. 2021 Apr;41(2):326-330.ABSTRACTOBJECTIVE: To evaluate the effect of electroacupuncture on rapid gastric emptying by comparing the effectiveness of electroacupuncture at both Zusanli (ST36) and Zhongwan (CV12) (He-Mu acupoints) versus electroacupuncture at Zhongwan (CV12) alone.METHODS: Sixty-five patients were randomly divided into two groups; 33 patients in the He-Mu acupoints group received electroacupuncture at both Zusanli (ST36) and Zhongwan (CV12), while 32 patients in the single acupoint group received electroacupuncture only at Zhongwan (CV12). Both groups were treated once daily for 30 min, five...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Gonglei Yue Xiaodong Yuan Xiaobin Ge Guangzhong Du Source Type: research

Effect of acupressure on procedural pain before heel lancing in neonates
J Tradit Chin Med. 2021 Apr;41(2):331-337.ABSTRACTOBJECTIVE: To investigate the effect of acupressure applied to UB60 and K3 acupuncture points in order to relieve the procedural pain caused by heel lancing blood sampling process in the term newborns.METHODS: The data were collected by using the Information Form and the Neonatal Infant Pain Scale. Acupressure applied for 3 min before heel lancing blood sampling in the newborns in the experimental group (n = 31). No intervention was applied to newborns in the control group (n = 32).RESULTS: A significant difference was found between mean scores of the newborns in the contro...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: O ğul Tanju Kurt Fatma Yilmaz Source Type: research

Mechanism underlying effect of Chaihu Shugan San on major depressive disorder: a network pharmacology-based study
CONCLUSION: There are multiple targets and signaling pathways are involved in the action of CHSGS in the treatment of MDD.PMID:33825416 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Jie Mu Shuang Zhang Feifei Tang Shuling Liu Qianyi Zhang Qianlei Du Xueqian Wang Qingguo Wang Fafeng Cheng Source Type: research

Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root
CONCLUSION: Methanol extract of P. ginseng root culture did not show any significant anti-inflammatory effects on NO and IL-6 levels, but might potentially possess both anti-neuroinflammatory and pro-neuroinflammatory properties through the downregulation of TNF-α and IL-10 respectively.PMID:33825397 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Koay Chien Yi Ling Anna Pick Kiong Wong Ying Pei Koh Rhun Yian Hussein Sobri Source Type: research

Herbal formula of Bushen Jianpi combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle
CONCLUSION: Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent.PMID:33825398 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zhangjie Zhou Xinhua Liu Tingting Wu Zujue Que Zhonghua Wu Weizhong Wu Shujuan Fu Shiqiang Zhang Yun Yang Haiyan Jiang Xiaoting Xia Junqiang Lv Boqian Du Yun Li Tao Lu Zhihui Zhang Yi Zhong Source Type: research

Zichong granules promote differentiation of ovarian granulosa-like cells from human embryonic stem cells in vitro
CONCLUSION: In the ZCKL treatment of infertility, one mechanism by which ZCKL may act is by influencing ovarian granulosa cell differentiation and development, possibly through the follistatin and BMP/SMAD signaling pathways.PMID:33825399 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zouying Yao Jing Wang Hua Lu Limin Li Tianxiu Zhuo Qian Wan Shangmian Yie Source Type: research

Naoxintong capsules modulates tumor necrosis factor--induced endothelial senescence through silent information regulator 1 signaling
CONCLUSIONS: These findings suggest that sustained endothelial senescence can be induced by TNF-α stimulation via the SIRT1/FoxO-1/p53/p21 pathway. The protection of NXT against TNF- was partially mediated through its effects on SIRT1. This highlights the promise of NXT as a therapeutic for atherosclerosis.PMID:33825400 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qianyun Guo Bin Zhang Haitong Zhang Erli Zhang Yongjian Wu Source Type: research

Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro
CONCLUSION: Therefore, the analgesic and anti-inflammatory property of S. miltiorrhiza Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.PMID:33825401 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Jinghui Feng Kim Set Byeol Lee Hee Jung Sim Su Min Lim Soon Sung Suh Hong Won Source Type: research

Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor- α
CONCLUSION: LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα.PMID:33825402 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qi Chen Xu Qi Yu Fu Tingting Ji Ying Chao Jun Li Qinghai Meng Huimin Bian Yu Li Source Type: research

Effects of Qingguang'an containing serum on the expression levels of autophagy-related genes in human Tenon's fibroblasts induced by transforming growth factor beta 1
J Tradit Chin Med. 2021 Apr;41(2):236-245.ABSTRACTOBJECTIVE: To explore the effects of Qingguang'an () containing serum on the expression levels of autophagy related genes in the transforming growth factor beta 1 (TGF-β1)-activated human Tenon's fibroblasts (HTFs).METHODS: (a) Primary HTFs were stimulated by TGF-β1 and underwent immunohistochemistry, which established a cell model after Glaucoma filtration surgery (GFS). (b) The cell models were divided into 4 group: normal group (normal cells), model group (+TGF-β1),treatment group (+TGF-β1+ medicated serum), and positive control group (TGF-β1+ ra...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Juan Yu Fei Xia Xiang Li Qinghua Peng Source Type: research

Danlou Fang reduces microvascular obstruction through the endothelial/inducible nitric oxide synthase pathway in a rat model
J Tradit Chin Med. 2021 Apr;41(2):246-253.ABSTRACTOBJECTIVE: To investigate the efficacy of the Danlou Fang (DL) Traditional Chinese Medicine formula on microvascular obstruction (no-reflow) through the endothelial/inducible nitric oxide synthase (eNOS/iNOS) pathway in a rat model.METHODS: Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion (or sham procedure) followed by 2 h of reperfusion and were then divided into treatment groups: sham, model, DL (500 mg/kg), DL (500 mg/kg) + eNOS inhibitor L-nitroarginine (L-NNA; 7.5 mg/kg), and sodium nitroprusside (SNP; 0.5 mg/kg). There were 16 per group. Area...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xiangdong Dai Rui Chen Ting Chen Haifeng Yan Yanyan Wang Kun Zhou Xiting Zhang Yi Wang Source Type: research

Efficacy of Liangxue Guyuan decoction on radiation-induced intestinal injury in rats via the toll-like receptor 4/myeloid differentiation primary response 88/ nuclear factor-kappa B pathway
CONCLUSION: LGD increased the survival rate and inhibit weight loss of irradiated rats, and reduced inflammation and intestinal injury. The underlying mechanism may involve regulation of the TLR4/MyD88/NF-κB pathway.PMID:33825405 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Yuguo Wang Yongqi Dou Jian Feng Chengyong Xu Qian Wang Source Type: research

Efficacy of Sanqi (Radix Notoginseng) in treating cerebral hemorrhage in rats with traumatic brain injury
CONCLUSION: Sanqi (Radix Notoginseng) can decrease the expression of p-p65, increase t-PA/PAI-1, and stem traumatic intracranial hemorrhage in a TBI rat model.PMID:33825406 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Tao Jiang Xiaqing Zhou Huifang Jiang Rongbiao Ying Zhirong Zhang Danli Cai Yu Wu Haijun Fang Lingcong Wang Source Type: research

Efficacy of extract from Ononis spinosa L. on ethanol-induced gastric ulcer in rats
CONCLUSION: The present study demonstrated that the extract from O. spinosa was able to protect gastric mucosa from ethanol injury by at least 2 mechanisms, namely the induction of COX-2 and decreasing oxidative stress in the stomach.PMID:33825407 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Abbas Manal Ahmad Kandil Yasser Ibrahim Abbas Manal Mohammad Source Type: research

Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy
J Tradit Chin Med. 2021 Apr;41(2):276-283.ABSTRACTOBJECTIVE: To compare and observe the effects of three kinds of cephalic acupuncture therapies commonly used in the clinic on promoting nerve function rehabilitation in the brain microenvironment of rats with cerebral palsy.METHODS: A negative control group, positive control group, and three cephalic acupuncture groups based on the administration of three cephalic acupuncture therapies were established. Ten experimental rats were selected from each group at 1, 2, and 3 weeks after modeling. Neuromotor function after treatment was rated according to the Basso, Beattie, and B...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zixuan Wang Xiangwei Fan Kaiyun Chen Xuefeng Yu Jing Gao Source Type: research

Effects of Tianma (Rhizoma Gastrodiae) and Gouteng (Ramulus Uncariae Rhynchophyllae cum Uncis) on cytochrome P450 enzyme activities in rats
CONCLUSION: Tianma (Rhizoma Gastrodiae) has no significant effect on the six CYP450 subtypes. The activities of CYP3A4 and CYP2C9 were increased by Gouteng (Ramulus Uncariae Rhynchophyllae cum Uncis). The activities of CYP3A4 and CYP2C9 were increased, whereas the activity of CYP32E1 was reduced by combined Tianma (Rhizoma Gastrodiae) and Gouteng (Ramulus Uncariae Rhynchophyllae cum Uncis).PMID:33825409 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xin Liu Xinyu Wang Yinxuan Peng Xing Wang Source Type: research

Efficacy of methanol-water extract of Inula helenium root against oxidative DNA damage
CONCLUSION: The studies showed a crucial decrease in the amount of the DNA base damage products when antioxidants were used. The results showed that ferulic acid has better inhibition than chlorogenic acid for DNA oxidation. The methanol-water extract of Inula helenium root was determined to inhibit the oxidative DNA damage.PMID:33825410 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Aybast Er Nder Source Type: research

Efficacy and safety of Hemoheal cream in patients with hemorrhoids: a randomized double-blind placebo controlled clinical trial
CONCLUSION: The present study showed a positive effect of Hemoheal cream in improving clinical signs and symptoms in patients with hemorrhoids.PMID:33825411 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zobeiri Mehdi Parvizi Fatemeh Rahimi Roja Heydarpour Fatemeh Sheikhan Hamid Reza Navabi Jafar Farzaei Mohammad Hosein Source Type: research

Clinical observation of Yiqi Qingdu prescription on the treatment of intermediate-stage and advanced non-small-cell lung cancer
J Tradit Chin Med. 2021 Apr;41(2):308-315.ABSTRACTOBJECTIVE: To observe the effects of the Yiqi Qingdu prescription () on intermediate-stage and advanced non-small-cell lung cancer (NSCLC).METHODS: In total, 300 patients with intermediate-stage or advanced NSCLC were randomly and equally divided into three groups using computer-generated random numbers as follows: Western medicine (WM), Chinese medicine (CM), and integrated Traditional Chinese and Western Medicine (IM). After 3 months of treatment, the overall response rate (ORR); disease control rate (DCR); symptom score (SS); Karnofsky performance status (KPS); adverse e...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qijun Liang Xiaoling Tang Jiong Yu Monian Xiong Huifang Zhu Linkai Xiong Ru Zeng Peiwen Yu Source Type: research

Abnormalcortical thickness in relapsing-remitting multiple sclerosis, correlations with cognition impairment, and effect of modified Bushenyisui decoction on cognitive function of multiple sclerosis
CONCLUSIONS: Gray matter atrophy and cortical thickness thinning were validated in RRMS. Cortical thickness thinning of temporal lobe and fusiform gyrus strongly related to cognitive deficits in RRMS. The modified BSYSD could promote the recovery of cognitive function in MS.PMID:33825413 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xuesong Zhao Tao Yang Fang Cheng Song Yang Wanlin Zhu Shaowu Li Yongping Fan Source Type: research

Effect of electroacupuncture at different acupoints in treating rapid gastric emptying: Zusanli (ST36) plus Zhongwan (CV12) versus Zhongwan (CV12) alone
J Tradit Chin Med. 2021 Apr;41(2):326-330.ABSTRACTOBJECTIVE: To evaluate the effect of electroacupuncture on rapid gastric emptying by comparing the effectiveness of electroacupuncture at both Zusanli (ST36) and Zhongwan (CV12) (He-Mu acupoints) versus electroacupuncture at Zhongwan (CV12) alone.METHODS: Sixty-five patients were randomly divided into two groups; 33 patients in the He-Mu acupoints group received electroacupuncture at both Zusanli (ST36) and Zhongwan (CV12), while 32 patients in the single acupoint group received electroacupuncture only at Zhongwan (CV12). Both groups were treated once daily for 30 min, five...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Gonglei Yue Xiaodong Yuan Xiaobin Ge Guangzhong Du Source Type: research

Effect of acupressure on procedural pain before heel lancing in neonates
J Tradit Chin Med. 2021 Apr;41(2):331-337.ABSTRACTOBJECTIVE: To investigate the effect of acupressure applied to UB60 and K3 acupuncture points in order to relieve the procedural pain caused by heel lancing blood sampling process in the term newborns.METHODS: The data were collected by using the Information Form and the Neonatal Infant Pain Scale. Acupressure applied for 3 min before heel lancing blood sampling in the newborns in the experimental group (n = 31). No intervention was applied to newborns in the control group (n = 32).RESULTS: A significant difference was found between mean scores of the newborns in the contro...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: O ğul Tanju Kurt Fatma Yilmaz Source Type: research

Mechanism underlying effect of Chaihu Shugan San on major depressive disorder: a network pharmacology-based study
CONCLUSION: There are multiple targets and signaling pathways are involved in the action of CHSGS in the treatment of MDD.PMID:33825416 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Jie Mu Shuang Zhang Feifei Tang Shuling Liu Qianyi Zhang Qianlei Du Xueqian Wang Qingguo Wang Fafeng Cheng Source Type: research

Anti-neuroinflammatory responses in lipopolysaccharide-stimulated BV2 microglial cells upon treatment with methanol extract of Panax ginseng root
CONCLUSION: Methanol extract of P. ginseng root culture did not show any significant anti-inflammatory effects on NO and IL-6 levels, but might potentially possess both anti-neuroinflammatory and pro-neuroinflammatory properties through the downregulation of TNF-α and IL-10 respectively.PMID:33825397 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Koay Chien Yi Ling Anna Pick Kiong Wong Ying Pei Koh Rhun Yian Hussein Sobri Source Type: research

Herbal formula of Bushen Jianpi combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle
CONCLUSION: Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent.PMID:33825398 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zhangjie Zhou Xinhua Liu Tingting Wu Zujue Que Zhonghua Wu Weizhong Wu Shujuan Fu Shiqiang Zhang Yun Yang Haiyan Jiang Xiaoting Xia Junqiang Lv Boqian Du Yun Li Tao Lu Zhihui Zhang Yi Zhong Source Type: research

Zichong granules promote differentiation of ovarian granulosa-like cells from human embryonic stem cells in vitro
CONCLUSION: In the ZCKL treatment of infertility, one mechanism by which ZCKL may act is by influencing ovarian granulosa cell differentiation and development, possibly through the follistatin and BMP/SMAD signaling pathways.PMID:33825399 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Zouying Yao Jing Wang Hua Lu Limin Li Tianxiu Zhuo Qian Wan Shangmian Yie Source Type: research

Naoxintong capsules modulates tumor necrosis factor--induced endothelial senescence through silent information regulator 1 signaling
CONCLUSIONS: These findings suggest that sustained endothelial senescence can be induced by TNF-α stimulation via the SIRT1/FoxO-1/p53/p21 pathway. The protection of NXT against TNF- was partially mediated through its effects on SIRT1. This highlights the promise of NXT as a therapeutic for atherosclerosis.PMID:33825400 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qianyun Guo Bin Zhang Haitong Zhang Erli Zhang Yongjian Wu Source Type: research

Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro
CONCLUSION: Therefore, the analgesic and anti-inflammatory property of S. miltiorrhiza Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.PMID:33825401 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Jinghui Feng Kim Set Byeol Lee Hee Jung Sim Su Min Lim Soon Sung Suh Hong Won Source Type: research

Liuwei Dihuang formula protect endothelial cells from apoptosis by up-regulating expression of estrogen receptor- α
CONCLUSION: LWDHF could improve endothelial function and protect HUVECs from apoptosis via increasing the expression of ERα.PMID:33825402 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Qi Chen Xu Qi Yu Fu Tingting Ji Ying Chao Jun Li Qinghai Meng Huimin Bian Yu Li Source Type: research

Effects of Qingguang'an containing serum on the expression levels of autophagy-related genes in human Tenon's fibroblasts induced by transforming growth factor beta 1
J Tradit Chin Med. 2021 Apr;41(2):236-245.ABSTRACTOBJECTIVE: To explore the effects of Qingguang'an () containing serum on the expression levels of autophagy related genes in the transforming growth factor beta 1 (TGF-β1)-activated human Tenon's fibroblasts (HTFs).METHODS: (a) Primary HTFs were stimulated by TGF-β1 and underwent immunohistochemistry, which established a cell model after Glaucoma filtration surgery (GFS). (b) The cell models were divided into 4 group: normal group (normal cells), model group (+TGF-β1),treatment group (+TGF-β1+ medicated serum), and positive control group (TGF-β1+ ra...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Juan Yu Fei Xia Xiang Li Qinghua Peng Source Type: research

Danlou Fang reduces microvascular obstruction through the endothelial/inducible nitric oxide synthase pathway in a rat model
J Tradit Chin Med. 2021 Apr;41(2):246-253.ABSTRACTOBJECTIVE: To investigate the efficacy of the Danlou Fang (DL) Traditional Chinese Medicine formula on microvascular obstruction (no-reflow) through the endothelial/inducible nitric oxide synthase (eNOS/iNOS) pathway in a rat model.METHODS: Sprague-Dawley rats were subjected to 60 min of coronary artery occlusion (or sham procedure) followed by 2 h of reperfusion and were then divided into treatment groups: sham, model, DL (500 mg/kg), DL (500 mg/kg) + eNOS inhibitor L-nitroarginine (L-NNA; 7.5 mg/kg), and sodium nitroprusside (SNP; 0.5 mg/kg). There were 16 per group. Area...
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Xiangdong Dai Rui Chen Ting Chen Haifeng Yan Yanyan Wang Kun Zhou Xiting Zhang Yi Wang Source Type: research

Efficacy of Liangxue Guyuan decoction on radiation-induced intestinal injury in rats via the toll-like receptor 4/myeloid differentiation primary response 88/ nuclear factor-kappa B pathway
CONCLUSION: LGD increased the survival rate and inhibit weight loss of irradiated rats, and reduced inflammation and intestinal injury. The underlying mechanism may involve regulation of the TLR4/MyD88/NF-κB pathway.PMID:33825405 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Yuguo Wang Yongqi Dou Jian Feng Chengyong Xu Qian Wang Source Type: research

Efficacy of Sanqi (Radix Notoginseng) in treating cerebral hemorrhage in rats with traumatic brain injury
CONCLUSION: Sanqi (Radix Notoginseng) can decrease the expression of p-p65, increase t-PA/PAI-1, and stem traumatic intracranial hemorrhage in a TBI rat model.PMID:33825406 (Source: Journal of Traditional Chinese Medicine)
Source: Journal of Traditional Chinese Medicine - April 7, 2021 Category: Complementary Medicine Authors: Tao Jiang Xiaqing Zhou Huifang Jiang Rongbiao Ying Zhirong Zhang Danli Cai Yu Wu Haijun Fang Lingcong Wang Source Type: research