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Condition: Osteoporosis

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Total 136 results found since Jan 2013.

Serpina3n, dominantly expressed in female osteoblasts, suppresses the phenotypes of differentiated osteoblasts in mice.
In conclusion, we first found Serpina3n as the most female osteoblast-dominant gene. Serpina3n exerts a suppression of the osteoblast phenotypes such as Col1a1 expression and ALP activity in differentiated osteoblasts, which might partly explain sex differences of the osteoblast phenotypes in mice. PMID: 30304388 [PubMed - as supplied by publisher]
Source: Endocrinology - October 9, 2018 Category: Endocrinology Authors: Ishida M, Kawao N, Okada K, Tatsumi K, Sakai K, Nishio K, Kaji H Tags: Endocrinology Source Type: research

CRNDE impacts the proliferation of osteoclast by estrogen deficiency in postmenopausal osteoporosis.
CONCLUSIONS: We found that lncRNA CRNDE was closely related to the postmenopausal osteoporosis with estrogen deficiency. CRNDE may be involved in the development and progression of postmenopausal osteoporosis in the absence of estrogen and become a potential target for treating. PMID: 30280760 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - October 5, 2018 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Immunization with Na+/K+ ATPase DR peptide prevents bone loss in an ovariectomized rat osteoporosis model.
Abstract Osteoporosis is characterized by decreased bone strength and microarchitectural deterioration of bone tissue leading to an increase in bone fracture. Here we report a new agent named DR peptide, a conserved sequence of Na+/K+ ATPase (NKA), can be used to prevent osteoporosis. Our results showed that immunization with DR peptide conjunct with Keyhole limpet hemocyanin (DR-KLH) significantly strengthened trabecular bone and improved bone mineral density of femur and the 5th lumbar in the ovariectomized (OVX) rats when compared with those in OVX rats immunized with KLH alone. To study the underlying mechanis...
Source: Biochemical Pharmacology - August 19, 2018 Category: Drugs & Pharmacology Authors: Xiong S, Yang X, Yan X, Hua F, Zhu M, Guo L, Wu Z, Bian JS Tags: Biochem Pharmacol Source Type: research

LncRNA LINC00311 Promotes the Proliferation and Differentiation of Osteoclasts in Osteoporotic Rats Through the Notch Signaling Pathway by Targeting DLL3
Conclusions: Taken together, the key findings of the present study suggest that LINC00311 induces proliferation and inhibits apoptosis of osteoclasts via the regulation of the Notch signaling pathway by inhibiting DLL3 expression, ultimately demonstrating that LINC00311 and its target gene DLL3 may serve as independent factors in cases of osteoporosis.Cell Physiol Biochem 2018;47:2291 –2306
Source: Cellular Physiology and Biochemistry - July 5, 2018 Category: Cytology Source Type: research

Parathyroid hormone 1 ‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway.
Parathyroid hormone 1‑34 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m‑TOR pathway. Mol Med Rep. 2018 Jun 27;: Authors: Wang XY, Jiao LY, He JL, Fu ZA, Guo RJ Abstract Osteoporosis is closely associated with intervertebral disc degeneration. While parathyroid hormone (PTH) 1‑34, which is an established drug used to treatosteoporosis, is thought to inhibit the disc degeneration associated with osteoporosis, the precise mechanism involved remains unclear. In the present study, primary Sprague‑Dawley rat nucleus pulposus cells (NPCs) were cultured, phenotyped...
Source: Molecular Medicine Reports - July 1, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP-pathway.
Authors: Li M, Zhang C, Li X, Lv Z, Chen Y, Zhao J Abstract Isoquercitrin is widely present in fruits, vegetables and medicinal herbs. As a natural phytoestrogen, isoquercitrin has been considered a possible osteoporosis prevention option to avoid the risk of hormone therapy. In this work, we studied the effects of isoquercitrin on the cell proliferation and osteogenic differentiation of osteoblasts and bone mesenchymal stem cells (BMSCs), as well as the molecular mechanism of isoquercitrin action. The cell proliferation of osteoblasts and BMSCs was promoted by isoquercitrin at low concentrations. High concentratio...
Source: Connective Tissue Research - June 4, 2018 Category: Research Tags: Connect Tissue Res Source Type: research

MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression.
In conclusion, these data prove that the overexpression of miR-137 was associated with an altered risk of fracture in patients with osteoporosis, and can be used as a biomarker for the prediction of risk of fracture in osteoporosis. PMID: 29786747 [PubMed - as supplied by publisher]
Source: International Journal of Molecular Medicine - May 17, 2018 Category: Molecular Biology Authors: Liu X, Xu X Tags: Int J Mol Med Source Type: research

Leukotriene D4 induces cellular senescence in osteoblasts.
Abstract Aging is associated with the development of osteoporosis, in which cellular senescence in osteoblasts plays a key role. Leukotriene D4 (LTD4), an important cysteinyl leukotriene (cysLT), is a powerful pro-inflammatory mediator formed from arachidonic acid. However, little information regarding the effects of LTD4 on the pathogenesis of osteoporosis has been reported before. In the present study, we defined the physiological roles of LTD4 in cellular senescence in osteoblasts. Our results indicate that LTD4 treatment decreased the expression of SIRT1 in a dose-dependent manner in MC3T3-E1 osteoblastic cell...
Source: International Immunopharmacology - March 24, 2018 Category: Allergy & Immunology Authors: Wei J, Chen S, Guo W, Feng B, Yang S, Huang C, Chu J Tags: Int Immunopharmacol Source Type: research

MiR-106a increases granulosa cell viability and is down-regulated in women with diminished ovarian reserve.
Conclusions: Down-regulation of miR-106a may contribute to the pathogenesis of DOR by reducing granulosa cell viability and promoting apoptosis via enhanced ASK1 signaling. PMID: 29590425 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - March 23, 2018 Category: Endocrinology Authors: Hong L, Peng S, Li Y, Fang Y, Wang Q, Klausen C, Yin C, Wang S, Leung PCK, Yang X Tags: J Clin Endocrinol Metab Source Type: research

MiR-30a attenuates osteoclastogenesis via targeting DC-STAMP-c-Fos-NFATc1 signaling.
In conclusion, miR-30a attenuated osteoclastogenesis via suppression of DC-STAMP-c-Fos-NFATc1 signaling pathway. On these grounds, this study may reveal a new promising target for the treatment of osteoporosis and other osteopenic disorders. PMID: 29312525 [PubMed]
Source: American Journal of Translational Research - January 11, 2018 Category: Research Tags: Am J Transl Res Source Type: research

The flavonol glycoside icariin promotes bone formation in growing rats by activating the cAMP signaling pathway in primary cilia of osteoblasts Signal Transduction
In this study, using rat calvarial osteoblast culture and rat bone growth models, we demonstrated that icariin promotes bone formation by activating the cAMP/protein kinase A (PKA)/cAMP response element–binding protein (CREB) pathway requiring functional primary cilia of osteoblasts. We found that icariin increases the peak bone mass attained by young rats and promotes the maturation and mineralization of rat calvarial osteoblasts. Icariin activated cAMP/PKA/CREB signaling of the osteoblasts by increasing intracellular cAMP levels and facilitating phosphorylation of both PKA and CREB. Blocking cAMP/PKA/CREB signaling wit...
Source: Journal of Biological Chemistry - December 22, 2017 Category: Chemistry Authors: Wengui Shi, Yuhai Gao, Yuanyuan Wang, Jian Zhou, Zhenlong Wei, Xiaoni Ma, Huiping Ma, Cory J. Xian, Jufang Wang, Keming Chen Tags: Molecular Bases of Disease Source Type: research

Liraglutide, a glucagon-like peptide-1 receptor agonist, facilitates osteogenic proliferation and differentiation in MC3T3-E1 cells through phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), extracellular signal-related kinase (ERK)1/2, and cAMP/protein kinase A (PKA) signaling pathways involving β-catenin.
Abstract Previous studies have proven that Glucagon-like peptide-1 (GLP-1) and its receptor agonist exert favorable anabolic effects on skeletal metabolism. However, whether GLP-1could directly impact osteoblast-mediated bone forming is still controversial, and the underlying molecular mechanism remains to be elucidated. Thus in this paper, we investigated the effects of liraglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, on murine MC3T3-E1 preosteoblasts proliferation and differentiation and explored the potential cellular basis. Our study confirmed the presence of GLP-1R in MC3T3-E1, and demonstrate...
Source: Experimental Cell Research - September 14, 2017 Category: Cytology Authors: Wu X, Li S, Xue P, Li Y Tags: Exp Cell Res Source Type: research

Mangiferin protects osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling.
This study indicated that MAN can protect osteoblast against oxidative damage by modulation of ERK5/Nrf2 signaling, which can be new agent for osteoporosis. PMID: 28669729 [PubMed - as supplied by publisher]
Source: Biochemical and Biophysical Research communications - June 29, 2017 Category: Biochemistry Authors: Xia G, Li X, Yin X, Ding H, Qiao Y Tags: Biochem Biophys Res Commun Source Type: research

MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression
In this study, mouse primary bone marrow cells and osteoblast cell lines were used. Lucifer ase reporter assay and western blotting methods were employed to validate if miRNA-433-3p epigenetically regulated DKK1 translation. Rat bone marrow derived osteoblasts were infected with lentivirus vector in which miR-433-3p was constructed. The authors constructed lentivirus mediated miRNA-433-3p stable expression and examined the alkaline phosphatase (ALP) activity and mineral deposition level in vitro. In situ hybridization method was used to observe miR-433-3p in primary osteoblasts. We built up an OVX rat model to mimic postme...
Source: PLoS One - June 19, 2017 Category: Biomedical Science Authors: Xiaolin Tang Source Type: research

Bre Enhances Osteoblastic Differentiation by Promoting the Mdm2 ‐Mediated Degradation of p53
Abstract Bre is a conserved cellular protein expressed in various tissues. Its major function includes DNA damage repair and anti‐apoptosis. Recent studies indicate that Bre is potentially involved in stem cell differentiation although pathophysiological significance along with the molecular mechanisms is still unclear. Here, we report that Bre protein was substantially expressed in the bone tissue and its expression was highly upregulated during the osteogenic differentiation. To test a hypothesis that Bre plays functional roles in the process of osteogenic differentiation, we examined the expression of Bre in an osteop...
Source: Stem Cells - April 24, 2017 Category: Stem Cells Authors: Fujun Jin, Yiliang Wang, Xiaojing Wang, Yanting Wu, Xiaoyan Wang, Qiuying Liu, Yexuan Zhu, Enqi Liu, Jianglin Fan, Yifei Wang Tags: Tissue ‐Specific Stem Cells Source Type: research