Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP-pathway.

Isoquercitrin promotes the osteogenic differentiation of osteoblasts and BMSCs via the RUNX2 or BMP-pathway. Connect Tissue Res. 2018 May 31;: Authors: Li M, Zhang C, Li X, Lv Z, Chen Y, Zhao J Abstract Isoquercitrin is widely present in fruits, vegetables and medicinal herbs. As a natural phytoestrogen, isoquercitrin has been considered a possible osteoporosis prevention option to avoid the risk of hormone therapy. In this work, we studied the effects of isoquercitrin on the cell proliferation and osteogenic differentiation of osteoblasts and bone mesenchymal stem cells (BMSCs), as well as the molecular mechanism of isoquercitrin action. The cell proliferation of osteoblasts and BMSCs was promoted by isoquercitrin at low concentrations. High concentrations of isoquercitrin promoted the osteogenic differentiation of osteoblasts and BMSCs. Further investigation showed that isoquercitrin regulated osteogenic differentiation via runt-related transcription factor 2 (RUNX2) expression in osteoblasts and via the bone morphogenetic protein (BMP) pathway in BMSCs. Inhibition of RUNX2 expression in osteoblasts by siRNA or addition of noggin to the culture medium of BMSCs reduced the effects of osteogenic differentiation induced by isoquercitrin. These data suggest that isoquercitrin is a natural potential osteoinductive compound and might be valuable for the prevention/treatment of bone disorders. PMID: 29852784 [PubMed - as supplied ...
Source: Connective Tissue Research - Category: Research Tags: Connect Tissue Res Source Type: research