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Condition: Osteoporosis

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Total 136 results found since Jan 2013.

High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling
This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell f...
Source: Stem Cells - May 24, 2021 Category: Stem Cells Authors: Xiaowen Wu, Xiaochen Wang, Liying Shan, Jie Zhou, Xin Zhang, Endong Zhu, Hairui Yuan, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Harmine targets inhibitor of DNA binding-2 and activator protein-1 to promote preosteoclast PDGF-BB production
In conclusion, our data demonstrated a novel mechanism involving in the production of PDGF-BB increased by harmine, which may provide potential therapeutic targets for bone loss diseases.PMID:33960660 | DOI:10.1111/jcmm.16562
Source: J Cell Mol Med - May 7, 2021 Category: Molecular Biology Authors: Jie Huang You-You Li Kun Xia Yi-Yi Wang Chun-Yuan Chen Meng-Lu Chen Jia Cao Zheng-Zhao Liu Zhen-Xing Wang Hao Yin Xiong-Ke Hu Zheng-Guang Wang Yong Zhou Hui Xie Source Type: research

Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells by regulating TP63
CONCLUSIONS: Our results indicate that GluOC reduces the inhibitory effect of high glucose on osteoblast differentiation by regulating the TP63/PTEN/Akt/GSK3β pathway. TP63 is a potential novel target for the prevention and treatment of diabetic osteoporosis.PMID:33906607 | DOI:10.1186/s12860-021-00365-7
Source: Mol Biol Cell - April 28, 2021 Category: Molecular Biology Authors: Fangzi Gong Le Gao Luyao Ma Guangxin Li Jianhong Yang Source Type: research

Targeting long noncoding RNA PMIF facilitates osteoprogenitor cells migrating to bone formation surface to promote bone formation during aging
Conclusion: Toward translational medicine, this study hints that targeting lnc-PMIF to facilitate aged OPCs migrating to bone formation surface could be a brand-new anabolic strategy for aging-related osteoporosis.
Source: Theranostics - April 19, 2021 Category: Molecular Biology Authors: Dijie Li, Jin Liu, Chaofei Yang, Ye Tian, Chong Yin, Lifang Hu, Zhihao Chen, Fan Zhao, Ru Zhang, Aiping Lu, Ge Zhang, Airong Qian Tags: Research Paper Source Type: research

The miR-187 induced bone reconstruction and healing in a mouse model of osteoporosis, and accelerated osteoblastic differentiation of human multipotent stromal cells by targeting BARX2
CONCLUSIONS: The miR-187 might have a significant therapeutic effect in osteoporotic fractures. miR-187 accelerated osteogenic differentiation of hMSCs by directly regulating BARX2.PMID:33550149 | DOI:10.1016/j.prp.2021.153340
Source: Pathology, Research and Practice - February 7, 2021 Category: Pathology Authors: Jun Zhang Tao Zhang Bensen Tang Jing Li Zhengang Zha Source Type: research

Agrimophol suppresses RANKL-mediated osteoclastogenesis through Blimp1-Bcl6 axis and prevents inflammatory bone loss in mice.
In this study, we found that AGR inhibited RANKL-induced osteoclastogenesis, bone-resorption, F-actin ring formation, and the mRNA expression of osteoclast-associated genes such as CTSK, TRAP, MMP-9, and ATP6v0d2 in vitro. In addition, AGR suppressed RANKL-induced expression of c-Fos and NFATc1. However, AGR treatment did not affect NF-κB activation and MAPKs phosphorylation in RANKL-stimulated BMMs, which implicated that AGR might not influence the initial expression of NFATc1 mediated by NF-κB and MAPKs signaling. Our results further indicated that AGR did not alter phosphorylation levels of GSK3β and the expression o...
Source: International Immunopharmacology - November 13, 2020 Category: Allergy & Immunology Authors: Cao J, Wang S, Wei C, Lin H, Zhang C, Gao Y, Xu Z, Cheng Z, Sun WC, Wang HB Tags: Int Immunopharmacol Source Type: research

An emerging potential therapeutic target for osteoporosis: LncRNA H19/miR-29a-3p axis
This study might provide a better understanding of OP development and a potential therapeutic target for OP intervention.
Source: European Journal of Histochemistry - October 19, 2020 Category: Biomedical Science Authors: Ziqi Li, Zhinan Hong, Yuesheng Zheng, Yongwei Dong, Wei He, Yingjia Yuan, Junbiao Guo Source Type: research

Astragalus improve aging bone marrow mesenchymal stem cells (BMSCs) vitality and osteogenesis through VD-FGF23-Klotho axis.
This study confirmed that astragalus could inhibit the aging of BMSCs and improve the osteogenesis ability by regulating the VD-FGF23-Klotho pathway. This study provided a certain research basis for the therapeutic of traditional Chinese medicine (TCM) on primary osteoporosis. PMID: 32355520 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - May 3, 2020 Category: Pathology Authors: Pu X, Chai Y, Guan L, Li W, Gao J, Jiang Z, Li Q, Wu Y, Chen Y Tags: Int J Clin Exp Pathol Source Type: research

MiR-155 inhibition alleviates suppression of osteoblastic differentiation by high glucose and free fatty acids in human bone marrow stromal cells by upregulating SIRT1.
In conclusion, the results suggest that miR-155 suppression promoted osteogenic differentiation of hBMSCs under HG-FFA conditions by targeting SIRT1. Inhibition of MiR-155 may provide a new therapeutic method for the prevention and treatment of diabetic osteoporosis. PMID: 32248286 [PubMed - as supplied by publisher]
Source: Pflugers Archiv : European Journal of Physiology - April 3, 2020 Category: Physiology Authors: Qu B, He J, Zeng Z, Yang H, Liu Z, Cao Z, Yu H, Zhao W, Pan X Tags: Pflugers Arch Source Type: research

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 30, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Effect of lncRNA AK023948 on rats with postmenopausal osteoporosis via PI3K/AKT signaling pathway.
CONCLUSIONS: LncRNA AK0 can regulate the phosphorylation level of AKT in osteoblasts of rats with estrogen deficiency-related osteoporosis through the PI3K/AKT signaling pathway, thus regulating the proliferation of osteoblasts. It is speculated that lncRNA AK0 may be an important factor in regulating the PI3K/AKT signaling pathway. PMID: 32196569 [PubMed - as supplied by publisher]
Source: European Review for Medical and Pharmacological Sciences - March 21, 2020 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research