MiR-155 inhibition alleviates suppression of osteoblastic differentiation by high glucose and free fatty acids in human bone marrow stromal cells by upregulating SIRT1.

In conclusion, the results suggest that miR-155 suppression promoted osteogenic differentiation of hBMSCs under HG-FFA conditions by targeting SIRT1. Inhibition of MiR-155 may provide a new therapeutic method for the prevention and treatment of diabetic osteoporosis. PMID: 32248286 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32248286?dopt=Abstract

Source: Pflugers Archiv : European Journal of Physiology - April 3, 2020 Category: Physiology Authors: Qu B, He J, Zeng Z, Yang H, Liu Z, Cao Z, Yu H, Zhao W, Pan X Tags: Pflugers Arch Source Type: research