High ‐mobility group AT‐Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling

This study suggests that HMGA1 plays a role in osteoblast commitment and mediates the function of NFIX through transcriptionally activating canonical Wnt signaling.© AlphaMed Press 2021Significance StatementBone homeostasis depends largely on the number and function of osteoblasts. Osteoblasts and adipocytes are both derived from bone marrow mesenchymal stem cells, and a competitive relationship exists between adipogenesis and osteogenesis. We have identified a novel nuclear factor I/X (NFIX)-high-mobility group AT-Hook 1 (HMGA1)-wingless-type MMTV integration site (Wnt)/ β-catenin regulatory axis that governs the cell fate of marrow stromal progenitor cells, favoring osteoblast differentiation and blocking adipocyte formation. HMGA1, as a downstream target of NFIX, functions by transcriptionally regulating low-density lipoprotein receptor-related protein 5 expressi on and thereafter activating canonical Wnt signaling. The study suggests the potential of NFIX/HMGA1 as a novel therapeutic target for the treatment of metabolic bone disorders such as osteoporosis.
Source: Stem Cells - Category: Stem Cells Authors: Tags: Tissue ‐Specific Stem Cells Source Type: research