Uncarboxylated osteocalcin alleviates the inhibitory effect of high glucose on osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells by regulating TP63

CONCLUSIONS: Our results indicate that GluOC reduces the inhibitory effect of high glucose on osteoblast differentiation by regulating the TP63/PTEN/Akt/GSK3β pathway. TP63 is a potential novel target for the prevention and treatment of diabetic osteoporosis.PMID:33906607 | DOI:10.1186/s12860-021-00365-7

Source: Mol Biol Cell - April 28, 2021 Category: Molecular Biology Authors: Fangzi Gong Le Gao Luyao Ma Guangxin Li Jianhong Yang Source Type: research