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Condition: Osteoporosis

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Total 136 results found since Jan 2013.

Glucocorticoids Disrupt Skeletal Angiogenesis Through Transrepression of NF ‐κB–Mediated Preosteoclast Pdgfb Transcription in Young Mice
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formation, ...
Source: Journal of Bone and Mineral Research - March 12, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - February 27, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Tissue inhibitor of metalloproteinase 1 suppresses growth and differentiation of osteoblasts and differentiation of osteoclasts by targeting the AKT pathway.
In conclusion, our results demonstrate that TIMP1 can act as a suppressor of growth and differentiation of osteoblasts and differentiation of osteoclasts through the negative regulation of the AKT pathway. We propose that TIMP1 may serve as a potential target for low bone mass-related skeletal diseases, such as osteoporosis. PMID: 32113948 [PubMed - as supplied by publisher]
Source: Experimental Cell Research - February 26, 2020 Category: Cytology Authors: Xi Y, Huang H, Zhao Z, Ma J, Chen Y Tags: Exp Cell Res Source Type: research

Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice
This article is protected by copyright. All rights reserved.
Source: Journal of Bone and Mineral Research - February 21, 2020 Category: Orthopaedics Authors: Yi Peng, Shan Lv, Yusheng Li, Jianxi Zhu, Shijie Chen, Gehua Zhen, Xu Cao, Song Wu, Janet L. Crane Tags: Original Article Source Type: research

Decreased Expression of the Human Urea Transporter SLC14A1 in Bone is Induced by Cytokines and Stimulates Adipogenesis of Mesenchymal Progenitor Cells
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-1084-3888The human urea transporter SLC14A1 (HUT11/UT-B) has been suggested as a marker for the adipogenic differentiation of bone cells with a relevance for bone diseases. We investigated the function of SLC14A1 in different cells models from bone environment. SLC14A1 expression and cytokine production was investigated in bone cells obtained from patients with osteoporosis. Gene and protein expression of SLC14A1 was studied during adipogenic or osteogenic differentiation of human mesenchymal progenitor cells (hMSCs) and of the single-cell–derived hMSC line (SCP-1), as well as ...
Source: Experimental and Clinical Endocrinology and Diabetes - January 19, 2020 Category: Endocrinology Authors: Komrakova, Marina Blaschke, Martina Ponce, Maria Laura Kl üver, Anne K öpp, Regine H üfner, Michael Schieker, Matthias Miosge, Nicolai Siggelkow, Heide Tags: Article Source Type: research

Propionate promotes vitamin D receptor expression via yes-associated protein in rats with short bowel syndrome.
In this study, we aimed to investigate the effect of propionate on the expression of the vitamin D receptor (VDR) in the small intestine of rats with SBS. Firstly, IEC-6 (intestinal epithelioid cell line No. 6) cells were incubated in vitro with 1 mM sodium propionate for 24 h. This resulted in a significant increase in the expression of VDR and yes-associated protein (YAP) compared with that in the control group. Transfection of IEC-6 cells with YAP siRNA significantly down-regulated the expression of VDR. By contrast, after incubating IEC-6 cells with lysophosphatidic acid, an agonist of YAP, upregulation of VDR and...
Source: Biochemical and Biophysical Research communications - January 11, 2020 Category: Biochemistry Authors: Lin H, Huang Y, Tian T, Wang P, Li Y Tags: Biochem Biophys Res Commun Source Type: research

Lysophosphatidic acid receptor 4 regulates osteogenic and adipogenic differentiation of progenitor cells via inactivation of RhoA/ROCK1/ β‐catenin signaling
This study has demonstrated that ras homolog family member A (RhoA), along with its major effector, Rho ‐associated kinases 1 (ROCK1) activates β‐catenin signaling to promote osteogenic differentiation and restrain adipogenic differentiation. Lysophosphatidic acid (LPA) receptor 4 (LPAR4), one of the receptors of LPA, blocks the activation of RhoA/ROCK1/β‐catenin signaling pathway, and thereby reciprocally regulates osteogenic and adipogenic differentiation of mesenchymal progenitor cellsin vitro andin vivo. The study suggests the potential of LPAR4 as a pharmaceutical target to treat metabolic disorders such as osteoporosis.
Source: Stem Cells - November 27, 2019 Category: Stem Cells Authors: Yan Xie, Xiaochen Wang, Xiaowen Wu, Lijie Tian, Jie Zhou, Xiaoxia Li, Baoli Wang Tags: Tissue ‐Specific Stem Cells Source Type: research

Role of miR-199a-5p in osteoblast differentiation by targeting TET2.
CONCLUSION: MiR-199a-5p may promote the osteoblast differentiation and prevent OVX-induced osteoporosis by targeting TET2. PMID: 31669647 [PubMed - as supplied by publisher]
Source: Gene - October 25, 2019 Category: Genetics & Stem Cells Authors: Qi XB, Jia B, Wang W, Xu GH, Guo JC, Li X, Liu JN Tags: Gene Source Type: research

LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression.
CONCLUSIONS: Inhibiting lncRNA UCA1 can promote the proliferation and differentiation of osteoblasts by activating the BMP-2/(Smad1/5/8) signaling pathway in osteoblasts. Therefore, UCA1 is expected to be a new therapeutic target for OST. PMID: 31486475 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - September 7, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Lentiviral ‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling.
Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling. Mol Med Rep. 2019 Jul 31;: Authors: Jiang ZL, Jin H, Liu ZS, Liu MY, Cao XF, Jiang YY, Bai HD, Zhang B, Li Y Abstract Patients with diabetes tend to have an increased incidence of osteoporosis, which may be associated with hyperglycemia; however, the pathogenic mechanisms governing this interaction remain unknown. The present study sought to investigate whether elevated extracellular glucose levels of bone mesenchymal stem cells (BMSCs) could influence ...
Source: Molecular Medicine Reports - August 22, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

RNA-based Therapy for Osteogenesis
Publication date: Available online 5 August 2019Source: International Journal of PharmaceuticsAuthor(s): Pinpin Wang, Federico Perche, Delphine Logeart-Avramoglou, Chantal PichonAbstractNucleic acid-based therapy has shown great promise in accelerating bone regeneration as well as other diseases. Nucleic acids used in gene therapy mainly are either plasmid DNA (pDNA) or RNAs. Although pDNA therapy has been extensively studied for decades with encouraging preclinical and clinical results, side effects, and low efficiency associated with nuclear trafficking are hard to bypass. Unlike pDNA, RNAs (mRNA, siRNA, miRNA) exert the...
Source: International Journal of Pharmaceutics - August 6, 2019 Category: Drugs & Pharmacology Source Type: research

Silencing of LncRNA-ANCR Promotes the Osteogenesis of Osteoblast Cells in Postmenopausal Osteoporosis via Targeting EZH2 and RUNX2.
CONCLUSION: Silencing ANCR promotes the osteogenesis of PMOP osteoblast cells. The specific binding of ANCR with EZH2 suppressed RUNX2, thereby inhibiting osteogenesis. PMID: 31347330 [PubMed - in process]
Source: Yonsei Medical Journal - July 28, 2019 Category: Universities & Medical Training Authors: Cai N, Li C, Wang F Tags: Yonsei Med J Source Type: research

MicroRNA ‐155 inhibition up‐regulates LEPR to inhibit osteoclast activation and bone resorption via activation of AMPK in alendronate‐treated osteoporotic mice
AbstractOsteoporosis is characterized by a progressive increase in bone fragility, leading to low bone mass and structural deterioration of bone tissue. MicroRNA ‐155 (miR‐155) is highly expressed in osteoporosis. Thus, the current study aimed to investigate the effect of miR‐155 on the inhibition of osteoclast activation and bone resorption by targeting leptin receptor (LEPR) through the adenosine monophosphate activated protein kinase (AMPK) pathway in alendronate‐treated osteoporotic mice. An osteoporosis mouse model was established to examine the bone tension and bone density and the expression of miR‐155 in ...
Source: IUBMB Life - July 17, 2019 Category: Research Authors: Zhongxuan Mao, Yihai Zhu, Weimin Hao, Chao Chu, Hongmin Su Tags: RESEARCH COMMUNICATION Source Type: research