Glucocorticoids disrupt skeletal angiogenesis through transrepression of NF ‐κB‐mediated preosteoclast Pdgfb transcription in young mice

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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research

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Background. Data on the prevention of fractures after heart transplant (HTx) are controversial in the literature. Understanding the effects of HTx on bone may guide appropriate treatments in this high-risk population. Methods. Seventy adult HTx patients were followed for 12 months. Clinical and laboratory parameters, bone mineral density, microarchitecture, and vertebral fractures were assessed at baseline (after intensive care unit discharge) and at 6 and 12 months. Patients received recommendations regarding calcium intake and vitamin D supplementation after HTx. Results. At baseline, 27% of patients had osteopor...
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research
Lung transplant recipients have the highest rates of osteoporosis and fragility fractures of any solid organ transplant population. Several single nucleotide polymorphisms in genes important for bone metabolism have been identified. We hypothesized that risk alleles in these genes would be associated with decreased bone mineral density (BMD) following lung transplantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (460) Source Type: research
AbstractPurpose of ReviewThe purpose is to review current literature on pain management strategies from initial presentation to postoperative care on common fracture types.Recent Findings- Hip fractures benefit from use of multimodal pain control for early mobility and decreased narcotic requirement.- Distal radius fracture pain during reduction can be managed with hematoma block. Postoperatively, a soft dressing is adequate, and use of a compression glove may improve pain control and edema.- Ankle fractures can be reduced with hematoma block, though use of procedural sedation may reduce reduction attempts for fracture dis...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
ABSTRACT Introduction: Use of androgen deprivation therapy (ADT) in carcinoma prostate (CaP) has deleterious effect on bone mineral density (BMD) leading to increase incidence of osteoporosis and skeletal-related events. We evaluated bone health status and impact of bone-directed therapy (BDT) and ADT on BMD in these patients from Jan 2015-Dec 2018. Materials and Method: Baseline bone health was assessed using Tc-99 MDP Bone scan/ DEXA scan for patients on ADT. Monthly zoledronic acid (ZA) was given to high-risk candidates (T-score ≤ 2.5 or previous hip/vertebral fracture) or Skel et al. metastatic patients who were rec...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
ABSTRACTAlthough strong evidence exists that certain activities can increase bone density and structure in people, it is unclear what specific mechanical factors govern the response. This is important because understanding the effect of mechanical signals on bone could contribute to more effective osteoporosis prevention methods and efficient clinical trial design. The degree to which strain rate and magnitude govern bone adaptation in humans has never been prospectively tested. Here, we studied the effects of a voluntary upper extremity compressive loading task in healthy adult women during a 12 ‐month prospective perio...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
This study was performed in 886 elderly men from the Swedish cohort of the Osteoporotic Fractures in Men (MrOS) study. Urinary samples, bone mineral density (BMD), smoking data, and other background information were obtained at baseline in 2002–2004. Urinary cadmium was analyzed in baseline samples and adjusted for creatinine. The cohort was followed up until August 2018 for fracture incidence, based on the X‐ray register. Medi ation analysis was conducted to evaluate the indirect effect (via cadmium) of smoking on both BMD and fractures. Time to first fracture was analyzed using the accelerated failure time (AFT) ...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ABSTRACTInvestigations into the effects of bone ‐targeted exercise programs on musculoskeletal health and function in men are limited. The purpose of the Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR‐M) trial was to examine the efficacy and safety of two novel, supervised, eight‐month, twice‐wee kly exercise programs in middle‐aged and older men with low BMD. Men with low proximal femur and/or LS BMD were recruited and randomized to high‐intensity progressive resistance and impact training (HiRIT) or machine‐based isometric axial compression (IAC). Intervention resp...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
This study assessed whether MBBF in the femoral neck (FN) is preserve d in the context of inhibited remodeling in subjects receiving denosumab.This open ‐label study enrolled postmenopausal women with osteoporosis who had received ≥2 doses of denosumab (60 mg subcutaneously Q6M) per standard of care and were planning elective total hip replacement (THR) owing to osteoarthritis of the hip. Transverse sections of the FN were obtained after THR and analyzed histomorphometrically. MBBF, based on fluorochrome labeling and presence of smooth cement lines, was evaluated in cancellous, endocortical, and periosteal envelopes o...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
ABSTRACTSeveral epidemiological studies have reported a relationship between statin treatment and increased bone mineral density (BMD) and reduced fracture risk, but the mechanism underlying the purported relationship is unclear. We used Mendelian randomization (MR) to assess whether this relationship is explained by a specific effect in response to statin use or by a general effect of lipid lowering. We utilized 400 single ‐nucleotide polymorphisms (SNPs) robustly associated with plasma lipid levels as exposure. The outcome results were obtained from a heel estimated BMD (eBMD) genomewide association study (GWAS) from t...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
ABSTRACTIn the growing skeleton, angiogenesis is intimately coupled with osteogenesis. Chronic, high doses of glucocorticoids (GCs) are associated with decreased bone vasculature and induce osteoporosis and growth failure. The mechanism of GC ‐suppression of angiogenesis and relationship to osteoporosis and growth retardation remains largely unknown. Type H vessels, which are regulated by preosteoclast (POC) platelet‐derived growth factor–BB (PDGF‐BB), are specifically coupled with bone formation and development. We determined th e effect of GCs on POC synthesis of PDGF‐BB in relation to type H vessel formati...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
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