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Condition: Osteoporosis
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Total 136 results found since Jan 2013.
A dual role of HIF1 α in regulating osteogenesis-angiogenesis coupling
CONCLUSION: The dual role of HIF1α in osteogenesis-angiogenesis coupling may depend on the ROS-mediated HIF1α-p53 relationship. New awareness about HIF1α will be conducive to its future application in senile osteoporosis.PMID:35123567 | DOI:10.1186/s13287-022-02742-1
Source: Cell Research - February 6, 2022 Category: Cytology Authors: Jingjing Shao Shibo Liu Min Zhang Shujiang Chen Shuaiqi Gan Chenfeng Chen Wenchuan Chen Lei Li Zhimin Zhu Source Type: research
Metastasis suppressor 1 controls osteoblast differentiation and bone homeostasis through regulating Src-Wnt/ β-catenin signaling
This study has unraveled that MTSS1 contributes to osteoblast differentiation and bone homeostasis through regulating Src-Wnt/β-catenin signaling. It also suggests the potential of MTSS1 as a new target for the treatment of osteoporosis.PMID:35094173 | DOI:10.1007/s00018-022-04147-y
Source: Cellular and Molecular Life Sciences : CMLS - January 30, 2022 Category: Cytology Authors: Meng Chen Liying Shan Ying Gan Lijie Tian Jie Zhou Endong Zhu Hairui Yuan Xiaoxia Li Baoli Wang Source Type: research
Phactr1 negatively regulates bone mass by inhibiting osteogenesis and promoting adipogenesis of BMSCs via RhoA/ROCK2
AbstractThe imbalance between osteogenic and adipogenic differentiation of Bone marrow-derived mesenchymal stem cells (BMSCs) is involved in the occurrence and development of osteoporosis (OP). Previous studies have indicated the potential of phosphatase and actin regulator 1 (Phactr1) in regulating osteogenic and adipogenic differentiation of BMSCs. The present study aims to investigate the function and mechanism of Phactr1 in regulating osteogenic and adipogenic differentiation of BMSCs. Herein, the expression of Phactr1 in bone and adipose tissue of OP rats was determined by immunohistochemical. BMSCs were subjected to ...
Source: Journal of Molecular Histology - October 28, 2021 Category: Laboratory Medicine Source Type: research
Resveratrol induces proliferation in preosteoblast cell MC3T3-E1 via GATA-1 activating autophagy
We examined the cell viability, colony formation, cell cyclin expression, autophagy level, and the expression levels of GATA-1 and adenosine 5'-monophosphate (AMP)-activated protein kinase α (AMPKα) in osteoblastic cell strain MC3T3-E1. The results showed that RSV promoted the proliferation process in MC3T3-E1 coupled with increased expression of GATA-1 and phosphorylated AMPKα and activated autophagy. When GATA-1 was interfered with siRNA, both autophagy and proliferation were decreased. Administration of the agonist of phosphorylated AMPKα1 (Thr172) promoted the translocation of GATA-1 into the nucleus. Based on the ...
Source: Acta Biochimica et Biophysica Sinica - October 12, 2021 Category: Biochemistry Authors: Xiang Liu Jun Tao Yueyi Yao Ping Yang Juhui Wang Mali Yu Jianhong Hou Ying Zhang L I Gui Source Type: research
HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice
CONCLUSION: HDAC6 accumulation and histone hypoacetylation on Runx2 promoter contributed to the attenuation of in vitro osteogenic differentiation potential of BMSCs from aged mice. Through HDAC6 inhibition, we could activate Runx2 expression and osteogenic differentiation potential of BMSCs from aged mice and alleviate the age-related bone loss of aged mice. Our study will benefit not only for understanding the age-related bone loss, but also for finding new therapies to treat senile osteoporosis.PMID:34454588 | DOI:10.1186/s13287-021-02545-w
Source: Cell Research - August 29, 2021 Category: Cytology Authors: Chao Ma Juan Gao Jun Liang Weixiang Dai Zhenfei Wang Mengjiao Xia Tao Chen Sen Huang Jian Na Long Xu Shiming Feng Kerong Dai Guangwang Liu Source Type: research
Prednisolone induces osteocytes apoptosis by promoting Notum expression and inhibiting PI3K/AKT/GSK3 β/β-catenin pathway
AbstractThe apoptosis of mature osteocytes is the main factor causing damage to the microstructure of cortical bone in glucocorticoid-induced osteoporosis (GIOP). Our previous research found damaged areas and empty osteocytes lacunae in the tibial cortical bone of GIOP mice. However, the specific mechanism has not been clarified. Recently, a study showed that the quality of the cortical bone significantly increased by knocking out Notum, a gene encoding α/β hydrolase. However, it is not clear whether Notum affects cortical bone remodeling by participating in glucocorticoids (GCs)-induced apoptosis of osteocytes. The pres...
Source: Journal of Molecular Histology - July 23, 2021 Category: Laboratory Medicine Source Type: research
lncRNA WT1-AS is upregulated in osteoporosis and regulates the apoptosis of osteoblasts by interacting with p53
Exp Ther Med. 2021 Jul;22(1):734. doi: 10.3892/etm.2021.10166. Epub 2021 May 9.ABSTRACTIn cervical cancer, cellular tumor antigen p53 (p53) interacts with long non-coding WT1 antisense RNA (WT1-AS) and this protein serves an important role in osteoporosis. The present study aimed to investigate the role of WT1-AS in osteoporosis. WT1-AS was upregulated in the plasma of patients with osteoporosis and was positively correlated with p53 expression. Altered expression of WT1-AS and p53 separated patients with osteoporosis from healthy controls. Expression levels of WT1-AS and p53 decreased with prolonged treatment. In osteobla...
Source: Experimental and Therapeutic Medicine - May 31, 2021 Category: General Medicine Authors: Chaoqun Wang Quan Xie Wen Sun Ying Zhou Yu Liu Source Type: research
