HDAC6 inactivates Runx2 promoter to block osteogenesis of bone marrow stromal cells in age-related bone loss of mice

CONCLUSION: HDAC6 accumulation and histone hypoacetylation on Runx2 promoter contributed to the attenuation of in vitro osteogenic differentiation potential of BMSCs from aged mice. Through HDAC6 inhibition, we could activate Runx2 expression and osteogenic differentiation potential of BMSCs from aged mice and alleviate the age-related bone loss of aged mice. Our study will benefit not only for understanding the age-related bone loss, but also for finding new therapies to treat senile osteoporosis.PMID:34454588 | DOI:10.1186/s13287-021-02545-w

Source: Cell Research - August 29, 2021 Category: Cytology Authors: Chao Ma Juan Gao Jun Liang Weixiang Dai Zhenfei Wang Mengjiao Xia Tao Chen Sen Huang Jian Na Long Xu Shiming Feng Kerong Dai Guangwang Liu Source Type: research