The effects of muscle contraction and recombinant osteocalcin on insulin sensitivity ex vivo

Conclusions GPRC6A, the likely receptor of osteocalcin (OC), is expressed in mouse muscle. ucOC treatment augments insulin-stimulated skeletal muscle glucose uptake in C2C12 myotubes and following ex vivo muscle contraction. ucOC may partly account for the insulin sensitizing effect of exercise.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research