Differential associations between appendicular and axial marrow adipose tissue with bone microarchitecture in adolescents and young adults with obesity
Marrow adipose tissue (MAT) in humans is distributed differentially across age and skeletal site. We have shown impaired microarchitecture and reduced bone strength at appendicular sites in conditions associated with high MAT of the axial skeleton in adults (including conditions of over- and undernutrition). Data are lacking regarding differences in MAT content of the appendicular versus the axial skeleton, and its relationship with bone microarchitecture and strength. Furthermore, data are conspicuously lacking in adolescents, a time when hematopoietic marrow is progressively converted to fatty marrow. (Source: Bone)
Source: Bone - August 11, 2018 Category: Orthopaedics Authors: Vibha Singhal, Landy P. Torre Flores, Fatima C. Stanford, Alexander T. Toth, Brian Carmine, Madhusmita Misra, Miriam A. Bredella Tags: Rapid Communication Source Type: research

Changes in vertebral dimensions in early adulthood – A 10-year follow-up MRI-study
In this study, we wanted to clarify the potential changes in the dimensions of the lumbar vertebrae during early adulthood. We used the Northern Finland Birth Cohort 1986 as our study material, with a final sample size of 375 individuals. We performed lumbar magnetic resonance imaging (MRI) when the participants were 20 and 30  years of age (baseline and follow-up, respectively). (Source: Bone)
Source: Bone - August 9, 2018 Category: Orthopaedics Authors: Elsi Autio, Petteri Oura, Jaro Karppinen, Markus Paananen, Jaakko Niinim äki, Juho-Antti Junno Tags: Full Length Article Source Type: research

The trabecular bone score: Relationships with trabecular and cortical microarchitecture measured by HR-pQCT and histomorphometry in patients with chronic kidney disease
The trabecular bone score (TBS) is a novel tool using grayscale variograms of the lumbar spine bone mineral density (BMD) to assess trabecular bone microarchitecture. Studies in patients with chronic kidney disease (CKD) suggest it may be helpful in assessing fracture risk. However, TBS has not been validated as a measure of trabecular architecture against transiliac bone biopsy with histomorphometry in CKD patients. We hypothesized that TBS would reflect trabecular architecture at the iliac crest in CKD patients. (Source: Bone)
Source: Bone - August 8, 2018 Category: Orthopaedics Authors: J. Ramalho, I.D.B. Marques, Didier Hans, David Dempster, Hua Zhou, Parth Patel, R.M.R. Pereira, V. Jorgetti, R.M.A. Moyses, Thomas L. Nickolas Tags: Full Length Article Source Type: research

Letter to Editor: F.S. Kaplan, et al., Early clinical observations on the use of imatinibmesylate in FOP: A report of seven cases, Bone (2017)
We read with great interest the article published by F.S. Kaplan et al. Early clinical observations on the use of imatinibmesylate in FOP: A report of seven cases, Bone (2017). Following this [1] we would like to present a case report of one our patient with FOP successfully responding to sunitinib. (Source: Bone)
Source: Bone - August 7, 2018 Category: Orthopaedics Authors: O. Rohleder, P. Mudry, J. Neradil, H. Noskova, O. Slaby, J. Sterba Tags: Correspondence Source Type: research

Marked alterations in the structure, dynamics and maturation of growth plate likely explain growth retardation and bone deformities of young Hyp mice
Mechanisms underlying growth impairment and bone deformities in X-linked hypophosphatemia are not fully understood. We here describe marked alterations in the structure, dynamics and maturation of growth plate in growth-retarded young Hyp mice, in comparison with wild type mice. Hyp mice exhibited reduced proliferation and apoptosis rates of chondrocytes as well as severe disturbance in the process of chondrocyte hypertrophy disclosed by abnormal expression of proteins likely involved in cell enlargement, irregular chondro-osseous junction and disordered bone trabecular pattern and vascular invasion in the primary spongiosa. (Source: Bone)
Source: Bone - August 7, 2018 Category: Orthopaedics Authors: Roc ío Fuente, Helena Gil-Peña, Débora Claramunt-Taberner, Olaya Hernández-Frías, Ángela Fernández-Iglesias, Francisco Hermida-Prado, Gonzalo Anes-González, Isabel Rubio-Aliaga, Jose Manuel Lopez, Fernando Santos Tags: Full Length Article Source Type: research

Factors associated with proximal femur fracture determined in a large cadaveric cohort
Many researchers have used cadaveric fracture tests to determine the relationship between proximal femur (hip) fracture strength and a multitude of possible explanatory variables, typically considered one or two at a time. These variables include subject-specific proximal femur variables such as femoral neck areal bone mineral density (aBMD), sex, age, and geometry, as well as physiological hip fracture event variables such as fall speed and angle of impact. However, to our knowledge, no study has included all of these variables simultaneously in the same experimental dataset. (Source: Bone)
Source: Bone - August 7, 2018 Category: Orthopaedics Authors: Dan Dragomir-Daescu, Tim Rossman, Asghar Rezaei, Kent D. Carlson, David Kallmes, John Skinner, Sundeep Khosla, Shreyasee Amin Tags: Full Length Article Source Type: research

Sclerosteosis: Report of type 1 or 2 in three Indian Tamil families and literature review
Sclerosteosis (SOST) refers to two extremely rare yet similar skeletal dysplasias featuring a diffusely radiodense skeleton together with congenital syndactyly. SOST1 is transmitted as an autosomal recessive (AR) trait and to date caused by ten homozygous loss-of-function mutations within the gene SOST that encodes the inhibitor of Wnt-mediated bone formation, sclerostin. SOST2 is transmitted as an autosomal dominant (AD) or AR trait and to date caused by one heterozygous or two homozygous loss-of-function mutation(s), respectively, within the gene LRP4 that encodes the sclerostin interaction protein, low-density lipoprote...
Source: Bone - August 2, 2018 Category: Orthopaedics Authors: Michael P. Whyte, S. Deepak Amalnath, William H. McAlister, Radhakrishna Pedapati, Vivekanandan Muthupillai, Shenghui Duan, Margaret Huskey, Vinieth N. Bijanki, Steven Mumm Tags: Full Length Article Source Type: research

Serum calcium concentration is maintained when bone resorption is suppressed by osteoprotegerin in young growing male rats
Serum calcium is maintained in a narrow range through regulation of Ca metabolism in the intestine, kidney, and bone. Calcium is incorporated and resorbed from bone during bone remodeling via cellular processes as well as by exchange. Both routes contribute to calcium homeostasis. To assess the magnitude of bone turnover contribution to calcium homeostasis we labeled bone with a Ca tracer and measured Ca release following stimulation or suppression of bone resorption. Young growing male rats (n  = 162) were dosed with 45Ca to label skeletal Ca. (Source: Bone)
Source: Bone - August 2, 2018 Category: Orthopaedics Authors: Emily E. Hohman, Joanna K. Hodges, Meryl E. Wastney, Pamela J. Lachcik, Chun-Ya Han, Denise Dwyer, Munro Peacock, Paul J. Kostenuik, Connie M. Weaver Tags: Full Length Article Source Type: research

Siglec-15-targeting therapy increases bone mass in rats without impairing skeletal growth
The treatment of juvenile osteoporosis has not been established due to a lack of data regarding the efficacy and adverse effects of therapeutic agents. The possible adverse effects of the long-term use of antiresorptive therapies on skeletal growth in children is of particular concern. Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is an immunoreceptor that regulates osteoclast development and bone resorption, and its deficiency suppresses bone remodeling in the secondary spongiosa, but not in the primary spongiosa, due to a compensatory mechanism of osteoclastogenesis. (Source: Bone)
Source: Bone - August 1, 2018 Category: Orthopaedics Authors: Dai Sato, Masahiko Takahata, Masahiro Ota, Chie Fukuda, Eisuke Tsuda, Tomohiro Shimizu, Akiko Okada, Yoshiharu Hiruma, Hiroki Hamano, Shigeto Hiratsuka, Ryo Fujita, Norio Amizuka, Tomoka Hasegawa, Norimasa Iwasaki Tags: Full Length Article Source Type: research

Variation of bone acquisition during growth hormone treatment in children can be explained by proteomic biomarkers, bone formation markers, body composition and nutritional factors
Growth hormone (GH) regulates both longitudinal growth and bone acquisition in children, and has profound metabolic effects. The aim was to investigate the association between proteomic biomarkers, body fat, nutrition and bone formation markers, and longitudinal growth in response to GH during the first year of treatment. The degree to which changes in these factors could explain variations in GH-dependent longitudinal growth and bone mineralization was also assessed. (Source: Bone)
Source: Bone - July 30, 2018 Category: Orthopaedics Authors: Diana Swolin-Eide, Bj örn Andersson, Gunnel Hellgren, Per Magnusson, Kerstin Albertsson-Wikland Tags: Full Length Article Source Type: research

Bone cortical thickness and porosity assessment using ultrasound guided waves: An ex vivo validation study
Several studies showed the ability of the cortex of long bones such as the radius and tibia to guide mechanical waves. Such experimental evidence has given rise to the emergence of a category of quantitative ultrasound techniques, referred to as the axial transmission, specifically developed to measure the propagation of ultrasound guided waves in the cortical shell along the axis of long bones. An ultrasound axial transmission technique, with an automated approach to quantify cortical thickness and porosity is described. (Source: Bone)
Source: Bone - July 26, 2018 Category: Orthopaedics Authors: J.-G. Minonzio, N. Bochud, Q. Vallet, Y. Bala, D. Ramiandrisoa, H. Follet, D. Mitton, P. Laugier Tags: Full length article Source Type: research

Growth, bone health & ambulatory status of boys with DMD treated with daily vs. intermittent oral glucocorticoid regimen
Oral glucocorticoids (GC) preserve muscle strength and prolong walking in boys with Duchenne muscular dystrophy (DMD). Although vertebral fractures have been reported in boys taking GC, fracture rates for different GC regimes have not been investigated. The aim of this pragmatic longitudinal study was to compare growth, body mass, bone mineral density (BMD), vertebral fractures (VF) and ambulatory status in boys with DMD on daily (DAILY) or intermittent (INTERMITTENT), oral GC regimens.A convenience sample of 50 DMD boys from two centres was included in the study; 25 boys each were on the DAILY or INTERMITTENT regimen. (Source: Bone)
Source: Bone - July 25, 2018 Category: Orthopaedics Authors: N.J. Crabtree, J.E. Adams, R. Padidela, N.J. Shaw, W. H ögler, H. Roper, I. Hughes, A. Daniel, M.Z. Mughal Tags: Full Length Article Source Type: research

Sclerostin and its association with insulin resistance in children and adolescents
Recent studies have shown that sclerostin, which is mainly known as a negative regulator of bone formation, could play an important role in the crosstalk between bone and glucose metabolism. The aim of this study was to investigate the relationship between sclerostin, other bone and fat related factors as osteocalcin (OC), Receptor Activator of Nuclear Factor NF- қB ligand (RANKL), leptin and adiponectin with glucose metabolism and insulin action in children and adolescents with obesity compared with healthy children and adolescents. (Source: Bone)
Source: Bone - July 25, 2018 Category: Orthopaedics Authors: Anna W ędrychowicz, Krystyna Sztefko, Jerzy B. Starzyk Tags: Full Length Article Source Type: research

Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes
Calcium ion concentration ([Ca2+]) in the systemic extracellular fluid, ECF-[Ca2+], is maintained around a genetically predetermined set-point, which combines the operational level of the kidney and bone/ECF interfaces. The ECF-[Ca2+] is maintained within a narrow oscillation range by the regulatory action of Parathyroid Hormone (PTH), Calcitonin, FGF-23, and 1,25(OH)2D3. This model implies two correction mechanisms, i.e. tubular Ca2+ reabsorption and osteoclast Ca2+ resorption. Although their alterations have an effect on the ECF-[Ca2+] maintenance, they cannot fully account for rapid correction of the continuing perturba...
Source: Bone - July 24, 2018 Category: Orthopaedics Authors: Christopher Dedic, Tin Shing Hung, Alan M. Shipley, Akira Maeda, Thomas Gardella, Andrew L. Miller, Paola Divieti Pajevic, Joseph G. Kunkel, Alessandro Rubinacci Tags: Full Length Article Source Type: research

In vivo identification of Bmp2-correlation networks during fracture healing by means of a limb-specific conditional inactivation of Bmp2
Bmp2 is known to play an essential role in the initiation of fracture healing via periosteal activation.Specifically, activation and subsequent differentiation of periosteal progenitor cells requires Bmp2 signaling for activation of the osteo-chondrogenic pathway. Here, we explored the interactive transcriptional gene-gene interplays between Bmp2 and 150 known candidate genes during fracture repair. We constructed the interactive Bmp2 signaling pathways in vivo, by comparing gene expression levels prior and 24  h post femur fracture, in presence (wild type) and in absence of Bmp2 (Bmp2c/c;Prx1::cre limb-specific conditio...
Source: Bone - July 23, 2018 Category: Orthopaedics Authors: Yau-Hua Yu, Katarzyna Wilk, PhiAnh L. Waldon, Giuseppe Intini Tags: Full Length Article Source Type: research

A comparative analysis of articular bone in large cohort of patients with chronic inflammatory diseases of the joints, the gut and the skin
In this study 476 subjects comprising healthy individuals and patients with anticitrullinated protein antibody (ACPA)-positive rheumatoid arthritis (RA), ACPA-negative RA, Crohn's disease (CD), ulcerative colitis (UC), psoriasis (PsO) and psoriatic arthritis (PsA) were subjected to high-resolution quantitative computed tomography (HR-pQCT) of the hand. (Source: Bone)
Source: Bone - July 23, 2018 Category: Orthopaedics Authors: David Simon, Arnd Kleyer, Matthias Englbrecht, Fabian Stemmler, Christoph Simon, Andreas Berlin, Roland Kocijan, Judith Haschka, Simon Hirschmann, Raja Atreya, Markus F. Neurath, Michael Sticherling, Juergen Rech, Axel J. Hueber, Klaus Engelke, Georg Sche Tags: Full Length Article Source Type: research

Editorial Board / Barcode
(Source: Bone)
Source: Bone - July 20, 2018 Category: Orthopaedics Source Type: research

Differential effects of high-fat diet and exercise training on bone and energy metabolism
Bone microarchitecture and strength are impaired by obesity and physical inactivity, but the underlying molecular regulation of bone metabolism in response to these factors is not well understood. Therefore, we analyzed bone and energy metabolism in male mice fed a high-fat or standard chow diet for 12  weeks with or without free access to running wheels.High-fat diet (HFD) mimicked the human condition of obesity and insulin resistance, including symptoms such as elevated serum glucose and insulin levels and reduced insulin-stimulated glucose uptake into muscle and adipose tissue. (Source: Bone)
Source: Bone - July 20, 2018 Category: Orthopaedics Authors: Ann-Kristin Picke, Lykke Sylow, Lisbeth L.V. M øller, Rasmus Kjøbsted, Felix N. Schmidt, Mikkel Wermer Steejn, Juliane Salbach-Hirsch, Christine Hofbauer, Matthias Blüher, Anja Saalbach, Björn Busse, Martina Rauner, Lorenz C. Hofbauer Tags: Full Length Article Source Type: research

GATA4 represses RANKL via multiple long-range enhancers to regulate osteoclast differentiation
GATA4 is a transcription factor that is responsible for tissue-specific gene regulation in many tissues, and more recent studies showed that it is necessary for osteoblast differentiation. Previously, we showed that in vivo deletion of Gata4 using Cre-recombinase under the control of the Col1a1 2.3  kb promoter, showed significantly reduced trabecular bone properties. To understand the role of GATA4 in more differentiated cells, GATA4fl/fl mice were crossed with mice expressing Cre-recombinase under the control of the osteocalcin promoter. (Source: Bone)
Source: Bone - July 19, 2018 Category: Orthopaedics Authors: Aysha B. Khalid, Alexandria V. Slayden, Jerusha Kumpati, Chanel D. Perry, Stuart B. Berryhill, Julie A. Crawford, Iram Fatima, Marco Morselli, Matteo Pellegrini, Gustavo A. Miranda-Carboni, Susan A. Krum Tags: Full Length Article Source Type: research

A two phase regulation of bone regeneration: IL-17F mediates osteoblastogenesis via C/EBP- β in vitro
T lymphocytes and pro-inflammatory cytokines, specifically interleukin-17F (IL-17F) have been identified as important regulators in bone regeneration during fracture repair. To better understand the molecular mechanisms of IL-17F-mediated osteoblastogenesis, a mouse pre-osteoblast cell line (MC3T3-E1) was utilized to characterize the intracellular signal transduction of IL-17F. Comparisons to the established canonical Wnt signaling pathway were made using Wnt3a ligand. Our results demonstrated greater bone marker gene expression in IL-17F-treated cells, compared to cells treated with Wnt3a. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Yufa Wang, Jieun Kim, Andrea Chan, Cari Whyne, Diane Nam Tags: Full Length Article Source Type: research

Identification of TGF β-related genes regulated in murine osteoarthritis and chondrocyte hypertrophy by comparison of multiple microarray datasets
Osteoarthritis (OA) is a joint disease characterized by progressive degeneration of articular cartilage. Some features of OA, including chondrocyte hypertrophy and focal calcification of articular cartilage, resemble the endochondral ossification processes. Alterations in transforming growth factor β (TGFβ) signaling have been associated with OA as well as with chondrocyte hypertrophy. Our aim was to identify novel candidate genes implicated in chondrocyte hypertrophy during OA pathogenesis by determining which TGFβ-related genes are regulated during murine OA and endochondral ossification. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Laurie M.G. de Kroon, Guus G.H. van den Akker, Bent Brachvogel, Roberto Narcisi, Daniele Belluoccio, Florien Jenner, John F. Bateman, Christopher B. Little, Pieter Brama, Esmeralda N. Blaney Davidson, Peter M. van der Kraan, Gerjo J.V.M. van Osch Tags: Full Length Article Source Type: research

High maternal osteocalcin levels during pregnancy is associated with low birth weight infants: A nested case-control study in China
Low birth weight infants (LBW) are at risk of chronic diseases in later life due to the disorder of energy metabolism during pregnancy. Osteocalcin (OC) has been identified as a hormone that regulate energy metabolism. However, few studies have researched on the associations between maternal serum OC levels and low birth weight infants. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Luyun Wei, Dehao Cao, Xiujuan Zhu, Yu Long, Chaoqun Liu, Shengzhu Huang, Jiarong Tian, Qingzhi Hou, Yaling Huang, Juan Ye, Bangzhu Luo, Ying Luo, Chunmei Liang, Mujun Li, Xiaobo Yang, Zengnan Mo, Jianfeng Xu Tags: Full Length Article Source Type: research

Pulsed electromagnetic fields modulate bone metabolism via RANKL/OPG and Wnt/ β-catenin pathways in women with postmenopausal osteoporosis: A pilot study
Pulsed electromagnetic fields (PEMFs) have been proven to enhance in vitro and in vivo osteogenesis with unknown mechanism. Aim of our study was to explore whether RANKL/OPG and Wnt/ β-Catenin pathways could be involved in bone response to PEMFs in a setting of postmenopausal osteoporotic women.Forty-three women (mean age 62.8 ± 4.5 yr.) were randomized into two groups. The PEMFs group received PEMFs treatment (50 min treatment session/day, 6 treatment sessions/week, f or a total of 25 times), by wearing a specific gilet applied to the trunk and connected to the electromagnetic device (Biosalus, by HSD ...
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Antonino Catalano, Saverio Loddo, Federica Bellone, Carmelo Pecora, Antonino Lasco, Nunziata Morabito Tags: Full Length Article Source Type: research

Dietary sugar intake does not pose any risk of bone loss and non-traumatic fracture and is associated with a decrease in all-cause mortality among Chinese elderly: Finding from an 11-year longitudinal study of Mr. and Ms. OS Hong Kong
The association of dietary sugar intake and skeletal health remains uncertain in the elderly. We aimed to investigate the association of sugar intake with the bone health and mortality of Chinese elderly. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Zhao-min Liu, Shelly Lap Ah. Tse, Bailing Chen, Dicken Chan, Carmen Wong, Jean Woo, Samuel Yeung-shan Wong Tags: Full Length Article Source Type: research

Impact of aging on bone, marrow and their interactions
Hematopoiesis in land dwelling vertebrates and marine mammals occurs within the bone marrow, continually providing mature progeny over the course of an organism's lifetime. This conserved dependency highlights the critical relationship between these two organs, yet the skeletal and hematopoietic systems are often thought of as separate. In fact, data are beginning to show that skeletal disease pathogenesis influences hematopoiesis and viceversa, offering novel opportunities to approach disease affecting bone and blood. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Corey M. Hoffman, Jimin Han, Laura M. Calvi Tags: Review Article Source Type: research

Real-world effectiveness of teriparatide on fracture reduction in patients with osteoporosis and comorbidities or risk factors for fractures: Integrated analysis of 4 prospective observational studies
Teriparatide significantly reduces fracture rates in clinical trials; however, those study populations were relatively restricted and included too few patients to analyze fracture outcomes within clinically important patient subgroups. We assessed fracture outcomes in subgroups of osteoporosis patients from 4 real-world teriparatide observational studies. (Source: Bone)
Source: Bone - July 15, 2018 Category: Orthopaedics Authors: Bente L. Langdahl, Stuart Silverman, Saeko Fujiwara, Ken Saag, Nicola Napoli, Satoshi Soen, Hiroyuki Enomoto, Thomas E. Melby, Damon P. Disch, Fernando Marin, John H. Krege Tags: Full Length Article Source Type: research

Serum 25-hydroxyvitamin D and bone mineral density among children and adolescents in a Northwest Chinese city
Although vitamin D is essential for bone health, little is known about prevalence of vitamin D deficiency and low bone mineral density (BMD) among children, especially those in developing countries. It also remains unclear whether serum 25-hydroxyvitamin D [25(OH)D] is associated with BMD among children. We investigated these questions among children and adolescents in Yinchuan (latitude: 38 ° N), Ningxia, an economically underdeveloped province in Northwest China. A total of 1582 children (756 boys and 826 girls), aged 6–18 years, were recruited from schools using the stratified random sampling method in fal...
Source: Bone - July 10, 2018 Category: Orthopaedics Authors: Jing Li, Wenqing Ding, Juan Cao, Lijiao Sun, Shanghong Liu, Jianjun Zhang, Haiping Zhao Tags: Full Length Article Source Type: research

Response to R. L. Nevin “Considerations in the repurposing of mefloquine for prevention and treatment of osteoporosis”
The authors would like to thank the reader for his interest in our article and his insightful feedback [1]. All of the points raised are important to take into consideration when looking at the possibility of using mefloquine to treat bone loss in aging. As correctly indicated by Dr. Nevin, the other members of the quinine family of drugs, but not mefloquine, have been used in humans to prevent skeletal complications. Our study was meant to be more of a proof of concept study based on the previous findings that other chloroquines effect bone mass. (Source: Bone)
Source: Bone - July 9, 2018 Category: Orthopaedics Authors: Hannah M. Davis, Rafael Pacheco-Costa, Lilian I. Plotkin Tags: Correspondence Source Type: research

Exploring the potential of tocotrienol from Bixa orellana as a single agent targeting metabolic syndrome and bone loss
This study aimed to investigate the effects of annatto tocotrienol as a single treatment for MetS and osteoporosis in high-carbohydrate high-fat (HCHF) diet-induced MetS animals. Three-month-old male Wistar rats were randomly divided into five groups. The baseline group was euthanized at the onset of the study. (Source: Bone)
Source: Bone - July 7, 2018 Category: Orthopaedics Authors: Sok Kuan Wong, Kok-Yong Chin, Farihah Hj Suhaimi, Fairus Ahmad, Soelaiman Ima-Nirwana Tags: Full Length Article Source Type: research

The diagnostic threshold for osteoporosis impedes fracture prevention in women at high risk for fracture: A registry-based cohort study
The diagnostic threshold for osteoporosis, a bone mineral density (BMD) T-score  ≤ −2.5, signals an increased risk for fracture. However, most fragility fractures arise among the majority of women with ‘osteopenia’ or ‘normal’ BMD. We hypothesized that a BMD T-score of −2.5, even if not intended as a treatment threshold, paradoxically may create disincentive t o initiating treatment of women with osteopenia or normal BMD at high risk for fracture. From a population-based BMD registry covering the Province of Manitoba, Canada, we identified 3735 untreated women aged ≥ 50 y...
Source: Bone - July 6, 2018 Category: Orthopaedics Authors: William D. Leslie, Ego Seeman, Suzanne N. Morin, Lisa M. Lix, Sumit R. Majumdar Tags: Full Length Article Source Type: research

Divergence from osteoporosis screening guidelines in older breast cancer patients treated with anti-estrogen therapy: A population-based cohort study
This study characterizes patterns and predictors of receiving guideline-recommended bone densitometry (BD) screening at AET initiation. (Source: Bone)
Source: Bone - July 5, 2018 Category: Orthopaedics Authors: David Henault, Tracy Westley, Sinziana Dumitra, Sue-Ling Chang, Richard Kremer, Robyn Tamblyn, Nancy Mayo, Ari N. Meguerditchian Tags: Full Lenght Article Source Type: research

Children with myelomeningocele do not exhibit normal remodeling of tibia roundness with physical development
This study analyzed computed tomography images of the tibia from 77 children with MM and 124 typically developing (TD) children between the ages of 6 and 16  years. (Source: Bone)
Source: Bone - July 4, 2018 Category: Orthopaedics Authors: Kyle P. Chadwick, Nicole M. Mueske, Rachel E. Horenstein, Sandra J. Shefelbine, Tishya A.L. Wren Tags: Full Length Article Source Type: research

Age trajectories of musculoskeletal morbidities in adults with cerebral palsy
Individuals with cerebral palsy (CP) are at an increased risk for age-related morbidities due to functional impairments, maladapted growth, and altered body composition. While musculoskeletal (MSK) deficits are present in children, little is understood about MSK morbidity throughout the lifespan in those with CP. The purpose of this study was to examine the age-related trajectories of MSK morbidity and multimorbidity throughout adulthood in those with CP. (Source: Bone)
Source: Bone - July 4, 2018 Category: Orthopaedics Authors: Daniel G. Whitney, Edward A. Hurvitz, Maureen J. Devlin, Michelle S. Caird, Zachary P. French, Elie C. Ellenberg, Mark D. Peterson Tags: Full Length Article Source Type: research

Sleep disordered breathing and fibroblast growth factor 23 in the Hispanic Community Health Study/Study of Latinos
Preclinical data suggest that hypoxia stimulates fibroblast growth factor 23 (FGF23) transcription and cleavage in osteocytes, resulting in elevated circulating c-terminal (cFGF23) levels but normal intact FGF23 (iFGF23) levels. We conducted a case-control study within the Hispanic Community Health Study/Study of Latinos to investigate whether sleep disordered breathing, as a model of hypoxemia, is independently associated with elevated cFGF23 levels in the general population and with elevated cFGF23 and iFGF23 levels in patients with chronic kidney disease (CKD), in whom FGF23 cleavage may be impaired. (Source: Bone)
Source: Bone - July 3, 2018 Category: Orthopaedics Authors: Rupal Mehta, Xuan Cai, Alexander Hodakowski, Bharat Thyagarajan, Donglin Zeng, Phyllis C. Zee, William Wohlgemuth, Susan Redline, James P. Lash, Myles Wolf, Tamara Isakova Tags: Full Length Article Source Type: research

Considerations in the repurposing of mefloquine for prevention and treatment of osteoporosis
I read with interest the recent paper by Pacheco-Costa and colleagues [1], which demonstrates that the antimalarial drug mefloquine can affect bone formation in a mouse model. The authors note that mefloquine may be able to at least partially reverse the deleterious consequences of aging in bone, suggesting the potential repurposing of this drug for prevention and treatment of osteoporosis. (Source: Bone)
Source: Bone - July 3, 2018 Category: Orthopaedics Authors: Remington L. Nevin Tags: Correspondence Source Type: research

Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma
Despite the potential biological importance of sympathetic activity in human bone metabolism, its effects on bone microarchitecture, a key determinant of bone quality, has not been thoroughly studied. In the present study, we investigated the lumbar spine trabecular bone score (TBS) as an indicator of skeletal deterioration in pheochromocytoma. Among 620 consecutive patients with newly diagnosed adrenal incidentaloma, 29 with histologically confirmed pheochromocytoma (a catecholamine-secreting neuroendocrine tumor) and 266 with nonfunctional adrenal incidentaloma were defined as cases and controls, respectively. (Source: Bone)
Source: Bone - July 2, 2018 Category: Orthopaedics Authors: Beom-Jun Kim, Mi Kyung Kwak, Jae Seung Kim, Seung Hun Lee, Jung-Min Koh Tags: Full Length Article Source Type: research

Cumulative radiation exposure from medical imaging and associated lifetime cancer risk in children with osteogenesis imperfecta
To estimate the cumulative effective dose of radiation (E) and additional lifetime attributable risk (LAR) of cancer from ionizing radiation in children with osteogenesis imperfecta (OI), who require frequent imaging for fractures and bone densitometry (DXA) surveillance. Also, to evaluate the pattern of long bone fractures. (Source: Bone)
Source: Bone - June 27, 2018 Category: Orthopaedics Authors: Amy Thorby-Lister, Wolfgang H ögler, Kirsten Hodgson, Nicola Crabtree, Peter Nightingale, Nick Shaw, Vrinda Saraff Tags: Full Length Article Source Type: research

Trabecular bone microarchitecture predicts fragility fractures in postmenopausal women on denosumab treatment
High-resolution peripheral quantitative computed tomography (HR-pQCT) represents a three-dimensional tool for the screening of osteoporosis patients i.e., regarding fracture risk. The purpose of this study was to determine the baseline and follow-up bone microarchitecture in relation to incident fracture risk in postmenopausal women on denosumab treatment. (Source: Bone)
Source: Bone - June 27, 2018 Category: Orthopaedics Authors: Sebastian Butscheidt, Tim Rolvien, Eik Vettorazzi, Isolde Frieling Tags: Full Length Article Source Type: research

Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis
Osteoarthritis is a joint disease characterized by cartilage degradation, altered gene expression and inflammation. NOTCH1 and NOTCH2 receptors and the JAGGED1 ligand regulate chondrocyte biology; however, the contribution of Notch signaling to osteoarthritis is controversial. Hajdu Cheney Syndrome (HCS) is a rare genetic disorder affecting the skeleton and associated with NOTCH2 mutations that lead to NOTCH2 gain-of-function. A murine model of the disease (Notch2tm1.1Ecan) was used to test whether the HCS mutation increases the susceptibility to osteoarthritis. (Source: Bone)
Source: Bone - June 22, 2018 Category: Orthopaedics Authors: S. Zanotti, J. Yu, D. Bridgewater, J.M. Wolf, E. Canalis Tags: Full Length Article Source Type: research

Homozygosity for CREB3L1 premature stop codon in first case of recessive osteogenesis imperfecta associated with OASIS-deficiency to survive infancy
Mutations of the endoplasmic reticulum (ER)-stress transducer OASIS (encoded by CREB3L1), cause severe recessive osteogenesis imperfecta (OI) not compatible with surviving the neonatal period, as has been shown in two unrelated families through a whole gene deletion vs. a qualitative alteration of OASIS. Heterozygous carriers in the described families have exhibited a mild phenotype. OASIS is a transcription factor highly expressed in osteoblasts, and OASIS −/− mice exhibit severe osteopenia and spontaneous fractures. (Source: Bone)
Source: Bone - June 21, 2018 Category: Orthopaedics Authors: Katarina Lindahl, Eva Åström, Anca Dragomir, Sofie Symoens, Paul Coucke, Sune Larsson, Eleftherios Paschalis, Paul Roschger, Sonja Gamsjaeger, Klaus Klaushofer, Nadja Fratzl-Zelman, Andreas Kindmark Tags: Full Length Article Source Type: research

Influence of weight gain on the modulation of wound healing following tooth extraction
This study assessed the association between obesity and alveoli repair after tooth extraction. (Source: Bone)
Source: Bone - June 20, 2018 Category: Orthopaedics Authors: Cristiane Furuse, Aline F. Almeida, Sidnei F. Costa, Ana Cl áudia E. Silva, Roberta Okamoto, Doris H. Sumida, Mariza A. Matsumoto, Fábio R.M. Leite Tags: Full Length Article Source Type: research

Novel WNT1 mutations in children with osteogenesis imperfecta: Clinical and functional characterization
Biallelic mutations in WNT1 can give rise to a rare form of moderate to severe OI. Here we report on 12 children (age 2 to 16  years; 5 girls) with biallelic WNT1 mutations. (Source: Bone)
Source: Bone - June 20, 2018 Category: Orthopaedics Authors: Yanqin Lu, Xiuzhi Ren, Yanzhou Wang, Ghalib Bardai, Marc Sturm, Yunzhang Dai, Olaf Riess, Yao Zhang, Hu Li, Tianyou Li, Naixiang Zhai, Jian Zhang, Frank Rauch, Jinxiang Han Tags: Full Length Article Source Type: research

BCL3 regulates RANKL-induced osteoclastogenesis by interacting with TRAF6 in bone marrow-derived macrophages
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is an essential component of the signaling complex that mediates osteoclastogenesis. As an adaptor protein of E3 ligase function, TRAF6 regulates NF- κB signaling via TAK1 and I-κB kinase (IKK) activation. Here, we investigated novel mechanisms by which TRAF6 signaling is regulated under receptor activator of nuclear factor-κB ligand (RANKL)-induced osteoclastogenesis. (Source: Bone)
Source: Bone - June 19, 2018 Category: Orthopaedics Authors: Kun Wang, Shuai Li, Yong Gao, Xiaobo Feng, Wei Liu, Rongjin Luo, Yu Song, JiTu, Yingle Liu, Cao Yang Tags: Full Length Article Source Type: research

Bone metabolic responses to low energy availability achieved by diet or exercise in active eumenorrheic women
We aimed to explore the effects of low energy availability (EA)[15  kcal·kg lean body mass (LBM)−1·d−1] achieved by diet or exercise on bone turnover markers in active, eumenorrheic women. (Source: Bone)
Source: Bone - June 19, 2018 Category: Orthopaedics Authors: Maria Papageorgiou, Daniel Martin, Hannah Colgan, Simon Cooper, Julie P. Greeves, Jonathan C.Y. Tang, William D. Fraser, Kirsty J. Elliott-Sale, Craig Sale Tags: Full Length Article Source Type: research

Mutations in the Neuroblastoma Amplified Sequence gene in a family affected by Acrofrontofacionasal Dysostosis type 1
Acrofrontofacionasal Dysostosis type 1 (AFFND1) is an extremely rare, autosomal recessive syndrome, comprising facial and skeletal abnormalities, short stature and intellectual disability. We analyzed an Indian family with two affected siblings by exome sequencing and identified a novel homozygous truncating mutation in the Neuroblastoma-Amplified Sequence (NBAS) gene in the patients' genome. Mutations in the NBAS gene have recently been associated with different phenotypes mainly involving skeletal formation, liver and cognitive development. (Source: Bone)
Source: Bone - June 18, 2018 Category: Orthopaedics Authors: Eleonora Palagano, Giulia Zuccarini, Paolo Prontera, Renato Borgatti, Gabriela Stangoni, Sandro Elisei, Stefano Mantero, Ciro Menale, Antonella Forlino, Paolo Uva, Manuela Oppo, Paolo Vezzoni, Anna Villa, Giorgio R. Merlo, Cristina Sobacchi Tags: Full Length Article Source Type: research

Iron overload involved in the enhancement of unloading-induced bone loss by hypomagnetic field
During deep-space exploration missions, astronauts will be exposed to abnormal space environments including microgravity and hypomagnetic field (HyMF) that is 10,000 times weaker than geomagnetic field (GMF). It is well known that microgravity in space can induce bone loss; however, it is ill-defined whether HyMF involved in this process. Herein, we aimed to investigate the combined effects of HyMF and microgravity on bone loss. A mouse model of hindlimb suspension (HLU) was adopted to simulate microgravity-induced bone loss, that was exposed to a hypomagnetic field of (Source: Bone)
Source: Bone - June 18, 2018 Category: Orthopaedics Authors: Jiancheng Yang, Xiaofeng Meng, Dandan Dong, Yanru Xue, Xin Chen, Shenghang Wang, Ying Shen, Gejing Zhang, Peng Shang Tags: Full Length Article Source Type: research

Bone and plasma citrate is reduced in osteoporosis
High concentration of citrate exists in bone of humans and all osteo-vertebrates, and citrate incorporation imparts important biomechanical and other functional properties to bone. However, which cells are responsible for citrate production in bone remains unclear and whether the citrate component changes with bone loss during osteoporosis is also not known. Here, we show that the citrate content is markedly reduced in the bone of mice or rats with age-related, ovariectomy-induced or retinoic acid-induced bone loss. (Source: Bone)
Source: Bone - June 18, 2018 Category: Orthopaedics Authors: Hongdong Chen, Yeyang Wang, Huaiqian Dai, Xinggui Tian, Zhong-Kai Cui, Zhenguo Chen, Le Hu, Qiancheng Song, Anling Liu, Zhiyong Zhang, Guozhi Xiao, Jian Yang, Yu Jiang, Xiaochun Bai Tags: Full Length Article Source Type: research

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Source: Bone - June 16, 2018 Category: Orthopaedics Source Type: research

Clinical utility of bone markers in various diseases
Measurements of bone markers (BMs) in peripheral blood or urine are a pivotal part of bone research within modern clinical medicine. In recent years the use of BMs increased substantially as they can be useful either to diagnose bone (related) disease and to follow its natural history, but also to monitor the effects of interventions. However, the use of BMs is still complicated mainly due to (pre)analytical variability of these substances, limited accessibility of assays, variable cut-off values in different countries and laboratories and heterogeneous results with regard to clinical implications of measuring BMs in sever...
Source: Bone - June 16, 2018 Category: Orthopaedics Authors: M.C. Vlot, M. den Heijer, R.T. de Jongh, M.G. Vervloet, W.F. Lems, R. de Jonge, B. Obermayer-Pietsch, A.C. Heijboer Tags: Review Article Source Type: research

The effect of glucocorticoids on bone mineral density in patients with rheumatoid arthritis: A systematic review and meta-analysis of randomized, controlled trials
The role of glucocorticoids in the treatment of rheumatoid arthritis (RA) is widely debated. Impairment of bone formation may be counter-balanced by reduced systemic inflammation. This review aims to assess the effect of prednisolone/prednisone on bone mineral density (BMD) in patients with RA analyzed in randomized, controlled trials. (Source: Bone)
Source: Bone - June 15, 2018 Category: Orthopaedics Authors: Anne-Birgitte Blavnsfeldt, Annette de Thurah, Malissa Dawn Thomsen, Simon Tarp, Bente Langdahl, Ellen-Margrethe Hauge Tags: Full Length Article Source Type: research